The article examines the institution of responsibility in the field of economic competition protection, which is used in the American and European systems. It has been established that the issue of liability for offenses in the field of competition regulation and competition protection is a special issue on Ukraine's path to European integration. This problem is important because in the modern Ukrainian economy, its institutional support - in the form of rules, economic mechanisms and tools, as well as organizational forms - ensure the interaction of the market and the state, because neither the market nor the state, taken by themselves, with development along the line of progress, they are unable to cope. The issue of competition regulation and liability for violations in the field of competition protection is of particular importance for the European integration of Ukraine. After all, after the historical challenges faced by Ukraine, only mutually agreed and regulated relations in this sphere can become a guarantee of social and national development. It was determined that competitiveness in the modern world cannot be ensured only on a liberal basis, that is, on a purely market basis. Effective regulation of competition protection is necessary for understanding the main mechanisms of interaction of various participants in the market. Established rules that apply to different types of markets are inseparable from the economic mechanisms that underlie them. One of the violations in the field of protection of economic competition is the abuse of a monopoly position. It has been established that two doctrines are currently used as a basis for developing approaches to competition regulation: American and European. The article lists the categories of prohibitions in the anti-competitive behavior of the USA and the EU. It is proven that highly developed countries strengthen their dominant role due to the use of the latest knowledge and the introduction of innovations, which makes them more competitive. Other countries that do not possess this knowledge and skills become dependent on them. And this dependence consists in calculating the benefits of civilization with cheap labor, natural resources and other national wealth. Key words: competition, competitiveness, responsibility, enterprises, benchmarking, internationalization, protection.