Urinary tract infection (UTI) can be considered one of the most frequent bacterial infections, and among the main indications for antibiotic use, in children. UTIs affect as much as 2% of the population admitted to community hospitals. Objective: The main objective of this randomized control trial was the assessment of the role of prophylactic antibiotics in preventing urinary tract infections following urological procedures. Methods: This randomized control trial was conducted at Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from February 2023 to February 2024. Data were collected from 185 patients. Data were collected at baseline, immediately post-procedure, and during follow-up visits at 7, 14, and 30 days postoperatively. Baseline data included demographic information, medical history, and details of the urological procedure. Results: Data were collected from 185 patients according to inclusion and exclusion criteria. The average ages were 55.2 ± 12.3 and 54.8 ± 11.9 years, respectively. Both groups had a comparable gender distribution with approximately 70% male and 30% female. BMI was also similar, with averages of 26.7 ± 4.5 for the intervention group and 26.9 ± 4.3 for the control group. The intervention group (n=93) had 7 patients (7.5%) who experienced antibiotic-related adverse events, while the control group (n=92) reported no adverse events (0%).Conclusion: It is concluded that prophylactic antibiotics significantly reduce the incidence of postoperative urinary tract infections in patients undergoing urological procedures.