Antisaccade Condition Research Articles

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

The respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in modulating social cognition and for therapeutic intervention in autism spectrum disorder have not been fully established. In particular, while numerous studies have demonstrated effects of oxytocin in promoting social attention the role of AVP has not been examined. The present study employed a randomized, double-blind, placebo (PLC)-controlled between-subject design to explore the social- and emotion-specific effects of AVP on both bottom-up and top-down attention processing with a validated emotional anti-saccade eye-tracking paradigm in 80 healthy male subjects (PLC = 40, AVP = 40). Our findings showed that AVP increased the error rate for social (angry, fearful, happy, neutral and sad faces) but not non-social (oval shapes) stimuli during the anti-saccade condition and reduced error rates in the pro-saccade condition. Comparison of these findings with a previous study (sample size: PLC = 33, OXT = 33) using intranasal oxytocin revealed similar effects of the two peptides on anti-saccade errors, although with some difference in effects of specific face emotions, but a significantly greater effect of AVP on pro-saccades. Both peptides also produced a post-task anxiolytic effect by reducing state anxiety. Together these findings suggested that both AVP and OXT decrease goal-directed top-down attention control to social salient stimuli but that AVP more potently increased bottom-up social attentional processing.

Speed of saccadic responses and intelligence: An exponential-Gaussian analysis

Individual differences in the speed of making rapid eye movements (saccades) may have potential for exploring the link between neural conduction and cognitive abilities. Participants (N = 56) performed tasks devised to measure the speed at which humans started to move an eye towards a stimulus which appeared in peripheral vision (saccade) or in the opposite direction (anti-saccade). Cognitive abilities were measured using the Wide Range Intelligence Test, and ex-Gaussian parameters from the eye-movement tasks were correlated with these abilities. The findings showed that scores on the pro- and anti-saccade tests correlated substantially and that the anti-saccade condition led to consistently longer, more variable and more skewed responses. None of the parameters correlated significantly with the cognitive abilities assessed. The findings do not support the theory that nerve conduction velocity explains the correlation between reaction times and cognitive abilities. However, the findings do provide evidence of the existence of individual differences in saccadic eye-movements that can be captured by ex-Gaussian analysis of reaction time and also show that saccadic movements do not follow Hick's Law when task difficulty is manipulated.

Dysfunctional attentional bias and inhibitory control during anti-saccade task in patients with internet gaming disorder: An eye tracking study

BackgroundAlthough internet gaming disorder (IGD) is considered an addictive disorder, evidence of the neurobiological underpinnings of IGD as an addictive disorder is currently lacking. We investigated whether attentional bias toward game-related stimuli was altered in IGD patients using an eye-tracking method during an anti-saccade task. MethodsTwenty-three IGD patients and 27 healthy control (HC) subjects participated in the anti-saccade task with game-related, neutral, and scrambled images during eye tracking. Participants rated subjective scores of valence, arousal, and craving for each image stimulus after finishing eye tracking. Mixed design analysis of variance was performed to compare the differences between eye movement latency and error rate in the pro-saccade and anti-saccade conditions according to image type across the IGD and HC groups. ResultsIn the anti-saccade task, the IGD group exhibited higher error rates in the case of game-related images than in neutral or scrambled images. However, ratings on valence, arousal, and craving did not vary among image types. The error rates of the HCs did not vary across image types, but higher arousal/craving and lower valence were reported with respect to the game-related images. ConclusionsIncreased error rate during anti-saccade tasks with game-related stimuli in IGD may be due to disabilities in goal-directed behavior or inhibitory control, as observed in other addictive disorders. These findings suggest that attentional bias toward game-related stimuli can be a sensitive biological marker of IGD as an addictive disorder.

A Comparison of Cognitive Load and Emotional Arousal on Liar's Pupil Diameter Changes

Pupil size is an easy-to-measure, non-invasive method to index various cognitive processes. Although a growing number of studies have incorporated measures of pupil size into clinical investigation, there have only been limited studies in Parkinson's disease (PD). Convergent evidence has suggested PD patients exhibit cognitive impairment at or soon after diagnosis. Here, we used an interleaved pro- and anti-saccade paradigm while monitoring pupil size with saccadic eye movements to examine the relationship between executive function deficits and pupil size in PD patients. Subjects initially fixated a central cue, the color of which instructed them to either look at a peripheral stimulus automatically (pro-saccade) or suppress the automatic response and voluntarily look in the opposite direction of the stimulus (anti-saccade). We hypothesized that deficits of voluntary control should be revealed not only on saccadic but also on pupil responses because of the recently suggested link between the saccade and pupil control circuits. In elderly controls, pupil size was modulated by task preparation, showing larger dilation prior to stimulus appearance in preparation for correct anti-saccades, compared to correct pro-saccades, or erroneous pro-saccades made in the anti-saccade condition. Moreover, the size of pupil dilation correlated negatively with anti-saccade reaction times. However, this profile of pupil size modulation was significantly blunted in PD patients, reflecting dysfunctional circuits for anti-saccade preparation. Our results demonstrate disruptions of modulated pupil responses by voluntary movement preparation in PD patients, highlighting the potential of using low-cost pupil size measurement to examine executive function deficits in early PD.

When is inhibition of return input- or output-based? It depends on how you look at it.

Two important diagnostics have been used to infer whether the effect of inhibition of return, when preceded by a saccade, is primarily upon input (i.e., attentional/perceptual level) or output (i.e., response/decision level) processes. Data from antisaccade paradigms involving luminance targets in peripheral vision suggest input effects whereas data from spatially compatible manual responses to centrally presented arrow targets suggest output effects. Here, we combine these diagnostics to resolve the discrepancy. In separate conditions participants made a pro- or antisaccade to a peripheral stimulus. Upon returning gaze to the original fixation, left and right manual responses were made to left- and right-pointing arrows at fixation, respectively. The primary objective of the prosaccade condition was to determine whether an eye movement toward a visual stimulus that was not associated with a manual localization response would bias spatially compatible manual responses against the prior saccade vector. Manual responses were slowest in the direction of the prior saccade, consistent with an output-based attribution (e.g., Posner, Rafal, Choate, & Vaughan, 1985). The primary objective of the antisaccade condition was to determine whether an eye movement away from a visual stimulus would also bias subsequent manual responses. No apparent response bias was detected, consistent with an input-based attribution (e.g., Fecteau, Au, Armstrong, & Munoz, 2004). Collectively, the findings indicate that there are 2, dissociable forms of inhibition depending on saccadic response demands. Converging evidence from other paradigms is discussed. (PsycINFO Database Record

Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism.

Prosaccade and antisaccade errors in the context of social and nonsocial stimuli were investigated in youth with autism spectrum disorder (ASD; n=19) a matched control sample (n=19), and a small sample of youth with obsessive compulsive disorder (n=9). Groups did not differ in error rates in the prosaccade condition for any stimulus category. In the antisaccade condition, the ASD group demonstrated more errors than the control group for nonsocial stimuli related to circumscribed interests, but not for other nonsocial stimuli or for social stimuli. Additionally, antisaccade error rates were predictive of core ASD symptom severity. Results indicate that the cognitive control of visual attention in ASD is impaired specifically in the context of nonsocial stimuli related to circumscribed interests.

Attention allocation before antisaccades.

In the present study, we investigated the distribution of attention before antisaccades. We used a dual task paradigm, in which participants made prosaccades or antisaccades and discriminated the orientation of a visual probe shown at the saccade goal, the visual cue location (antisaccade condition), or a neutral location. Moreover, participants indicated whether they had made a correct antisaccade or an erroneous prosaccade. We observed that, while spatial attention in the prosaccade task was allocated only to the saccade goal, attention in the antisaccade task was allocated both to the cued location and to the antisaccade goal. This suggests parallel attentional selection of the cued and antisaccade locations. We further observed that in error trials--in which participants made an incorrect prosaccade instead of an antisaccade--spatial attention was biased towards the prosaccade goal. These erroneous prosaccades were mostly unnoticed and were often followed by corrective antisaccades with very short latencies (<100 ms). Data from error trials therefore provide further evidence for the parallel programming of the reflexive prosaccade to the cue and the antisaccade to the intended location. Taken together, our results suggest that attention allocation and saccade goal selection in the antisaccade task are mediated by a common competitive process.

Disruption of pupil size modulation correlates with voluntary motor preparation deficits in Parkinson's disease

Pupil size is an easy-to-measure, non-invasive method to index various cognitive processes. Although a growing number of studies have incorporated measures of pupil size into clinical investigation, there have only been limited studies in Parkinson's disease (PD). Convergent evidence has suggested PD patients exhibit cognitive impairment at or soon after diagnosis. Here, we used an interleaved pro- and anti-saccade paradigm while monitoring pupil size with saccadic eye movements to examine the relationship between executive function deficits and pupil size in PD patients. Subjects initially fixated a central cue, the color of which instructed them to either look at a peripheral stimulus automatically (pro-saccade) or suppress the automatic response and voluntarily look in the opposite direction of the stimulus (anti-saccade). We hypothesized that deficits of voluntary control should be revealed not only on saccadic but also on pupil responses because of the recently suggested link between the saccade and pupil control circuits. In elderly controls, pupil size was modulated by task preparation, showing larger dilation prior to stimulus appearance in preparation for correct anti-saccades, compared to correct pro-saccades, or erroneous pro-saccades made in the anti-saccade condition. Moreover, the size of pupil dilation correlated negatively with anti-saccade reaction times. However, this profile of pupil size modulation was significantly blunted in PD patients, reflecting dysfunctional circuits for anti-saccade preparation. Our results demonstrate disruptions of modulated pupil responses by voluntary movement preparation in PD patients, highlighting the potential of using low-cost pupil size measurement to examine executive function deficits in early PD.

Pupil size reveals preparatory processes in the generation of pro-saccades and anti-saccades.

The ability to generate flexible behaviors to accommodate changing goals in response to identical sensory stimuli is a signature that is inherited in humans and higher-level animals. In the oculomotor system, this function has often been examined with the anti-saccade task, in which subjects are instructed, prior to stimulus appearance, to either automatically look at the peripheral stimulus (pro-saccade) or to suppress the automatic response and voluntarily look in the opposite direction from the stimulus (anti-saccade). Distinct neural preparatory activity between the pro-saccade and anti-saccade conditions has been well documented, particularly in the superior colliculus (SC) and the frontal eye field (FEF), and this has shown higher inhibition-related fixation activity in preparation for anti-saccades than in preparation for pro-saccades. Moreover, the level of preparatory activity related to motor preparation is negatively correlated with reaction times. We hypothesised that preparatory signals may be reflected in pupil size through a link between the SC and the pupil control circuitry. Here, we examined human pupil dynamics during saccade preparation prior to the execution of pro-saccades and anti-saccades. Pupil size was larger in preparation for correct anti-saccades than in preparation for correct pro-saccades and erroneous pro-saccades made in the anti-saccade condition. Furthermore, larger pupil dilation prior to stimulus appearance accompanied saccades with faster reaction times, with a trial-by-trial correlation between dilation size and anti-saccade reaction times. Overall, our results demonstrate that pupil size is modulated by saccade preparation, and neural activity in the SC, together with the FEF, supports these findings, providing unique insights into the neural substrate coordinating cognitive processing and pupil diameter.

Pro- and antisaccades in children elicited by visual and acoustic targets - does modality matter?

BackgroundChildren are able to inhibit a prepotent reaction to suddenly arising visual stimuli, although this skill is not yet as pronounced as it is in adulthood. However, up to now the inhibition mechanism to acoustic stimuli has been scarcely investigatedMethodsReflexive (prosaccade) and inhibitory (antisaccade) responses to visual and acoustic targets were examined with an eye tracker system in 31 children between seven and twelve years of age using a gap-overlap task and two target eccentricities.ResultsAcoustically cued saccades had longer reaction times than visually cued saccades. A gap effect (i.e., shorter reaction time in the gap than the overlap condition) was only found for visually elicited saccades, whereas an eccentricity effect (i.e., faster saccades to more laterally presented targets - 12° vs. 6° or rather 90° vs. 45°) was only present in the acoustic condition. Longer reaction times of antisaccades compared to prosaccades were found only in the visual task. Across both tasks the typical pattern of elevated error rates in the antisaccade condition was found. Antisaccade errors declined with age, indicating an ongoing development of inhibitory functions.ConclusionsThe present results lay the ground for further studies of acoustically triggered saccades in typically as well as atypically developing children and it might thus be possible to upgrade physiological diagnostic tools.

Non-lateralised deficits in anti-saccade performance in patients with hemispatial neglect

We tested patients suffering from hemispatial neglect on the anti-saccade paradigm to assess voluntary control of saccades. In this task participants are required to saccade away from an abrupt onset target. As has been previously reported, in the pro-saccade condition neglect patients showed increased latencies towards targets presented on the left and their accuracy was reduced as a result of greater undershoot. To our surprise though, in the anti-saccade condition, we found strong bilateral effects: the neglect patients produced large numbers of erroneous pro-saccades to both left and right stimuli. This deficit in voluntary control was present even in patients whose lesions spared the frontal lobes. These results suggest that the voluntary control of action is supported by an integrated network of cortical regions, including more posterior areas. Damage to one or more components within this network may result in impaired voluntary control.

Eye–head coordination in moderately affected Huntington’s Disease patients: do head movements facilitate gaze shifts?

In addition to many other symptoms, Huntington's Disease (HD) also causes an impairment of oculomotor functions. In particular, saccadic eye movements become progressively slower and more difficult to initiate; ultimately, patients are forced to recur to large head thrusts as means to initiate gaze shifts. We wondered whether, as a precursor of this condition, head movements would facilitate gaze shifts already in early stages of the disease. We studied horizontal head movements and eye-head coordination in 29 early stage HD patients (Ps) and 24 age matched controls (Cs). Subjects tracked random horizontal steps of visual or auditory targets while their heads were either stabilised (saccade amplitudes <or=40 degrees) or free to move (amplitudes <or=160 degrees). Subjects were to react either immediately (reactive mode), or wait until a go signal was sounded (delayed mode), or by antisaccades. Ps' head velocity was found to depend on the age of disease onset in a similar way as their saccadic eye velocity does, being clearly reduced in early affected Ps, but increasing to normal levels in lately affected Ps. Yet, saccade and head velocity were only loosely correlated although both exhibited a negative correlation with the severity of Ps' genetic condition (number of Ps' CAG repeats). Eye-head coordination turned out to be identical in Ps and Cs except for quantitative differences caused by the lower saccade and head velocities of Ps. Specifically, the timing between head and eyes and the head contribution to gaze shifts were similar in both groups. Moreover, preventing head movements did not affect the saccade latency or accuracy of Ps. Although Ps made more small involuntary head movements in this condition than Cs, these movements were not instrumental in generating saccades since they occurred only late after saccade onset. Thus, the head manoeuvres of severely affected patients must be considered a late adaptive behaviour. Finally, the ability of both Ps and Cs to suppress immediate reactions in the delayed and antisaccade conditions diminished as target distance decreased, with failure rates in Ps being much larger than in Cs. Unlike eye and head velocity, these failure rates were not correlated with age and, by the same token, neither with the variations in head and eye velocity nor with the number of CAG repeats. Hence, the pattern of brain areas prominently affected by HD is likely to vary significantly among individuals.

Prosaccades and antisaccades to onsets and color singletons: evidence that erroneous prosaccades are not reflexive

In the present study participants searched for an onset target or a color singleton target and were required to execute a saccade toward (prosaccade) or away (antisaccade) from the search target. The results showed that participants often made erroneous saccades toward the onset or color singleton when they were the search target in the antisaccade condition, but not when they were presented as task-irrelevant distractors. This suggests that task-relevance plays a critical role in the production of erroneous prosaccades and provides evidence that these saccades are not completely reflexive. Furthermore, it was found that the antisaccade cost (latency difference between prosaccades and antisaccades) was greater for color singleton search targets than for onset search targets. The present findings have implications for our understanding of the processes involved in the programming of antisaccades and the causes of erroneous prosaccades.

Latency of Prosaccades and Antisaccades in Professional Shooters

This study evaluated hypothesis that the faster saccadic reaction time in professional clay-target shooters found in a previous study was because of a superiority of athletes arising at the attention level or at level of saccadic motor preparation. Ten shooters with at least 6 yr of shooting training in Olympic shotgun disciplines and 10 control subjects participated in the experiments. In the first experiment, prosaccades were studied by comparing the saccadic latencies obtained from the overlap and gap paradigms. In the overlap paradigm, a target was presented randomly at one of four cardinal positions with the fixation point presented throughout the trial duration. In the gap paradigm, the fixation point was removed at the time of target presentation. In the second experiment, subjects were instructed to saccade as quickly as possible in the direction opposite to that of the target location (antisaccades). Shooters had shorter saccadic latency than controls, both with gap and overlap conditions in the first experiment and in the antisaccade condition of the second experiment. This result indicates that athletes' advantage in saccadic reaction times cannot be attributed to improvement of the attentional mechanism of disengagement. Present results support the hypothesis that shooters develop shorter motor preparation to saccades.

Timing and magnitude of frontal activity differentiates refixation and anti-saccade performance.

EEG data were recorded while 10 subjects generated refixation saccades towards a visual target and antisaccades away from a visual cue. Theoretically, the same basic neural circuitry supports refixation and correct anti-saccade performances, with additional activity in primarily dorsolateral prefrontal cortex circuitry supporting antisaccade-associated inhibitory processes. Analyses demonstrated that sensory registration of visual stimuli is similar for refixation and anti-saccade conditions. Increased frontal brain activity at 5 and 15 Hz was observed preceding correct antisaccades when compared to refixation saccades. These analyses provide specific information suggesting that 160-60 ms before saccade generation is the critical period for response inhibition.