Abstract The world of animal husbandry began in ancient times when humans began to carry out animal domestication activities used spices to maintain animal health. This research aimed to see the development of the spice use for livestock health. The method used is a literature study from various research results related to the use of spices for livestock health. The result indicated that the treatment of livestock has been known since Borobudur Temple was built with depictions of reliefs about herbal medicine. Recent research, the first literature study is a mixture of bitter, betel, ginger, and nutmeg formula that can function as an anti-cholesterol agent. In the second study, it turns out that spices cinnamon, coconut, and olive oil can also be used to treat lice. The third study found a spice formula that is efficacious as an anthelmintic in livestock. The formula consists of meeting mango, ginger, turmeric. The conclusion of this study is revealed and proven to have inherited the ancestral heritage listed in the reliefs of Borobudur temple in the 4.0 era. Spices are medicinal raw materials that are environmentally friendly and their availability is sustainable.