AbstractThe objective was to evaluate the efficacy of computerized‐controlled local anaesthesia delivery (CCLAD) system for extraction of maxillary teeth using the anterior middle superior alveolar (AMSA) nerve block technique in comparison to injection with a self‐aspirating syringe. A randomized, controlled trial with a split‐mouth design was conducted where each study sample (n = 17) was part of two groups. In group E (experimental group), AMSA nerve block was given using the CCLAD system and in group C (control group), AMSA nerve block was given using a self‐aspirating syringe for the extraction of orthodontically indicated maxillary premolar with age ranging from 18 to 25 years. The parameters assessed were pain during needle insertion and solution deposition, the profoundness of anaesthesia, the amount of local anaesthetic (LA) used, and the number of additional injections required. There was a statistically significant difference seen for amount of local anaesthetic used (p = 0.03, p < 0.05). Injection with self‐aspirating syringe was superior in terms of amount of LA used in injection with the CCLAD system. There was no relation between CCLAD and self‐aspirating syringe for the remaining criteria.