Abstract Forecasting the week 3/4 period presents many challenges, resulting in a need for improvements to forecast skill. At this distance from initial conditions, numerical models struggle to present skillful forecasts of temperature, precipitation, and associated extremes. One approach to address this is to utilize more predictable large-scale circulation regimes to make forecasts of temperature and precipitation anomalies, using the association between the regimes and surface weather obtained from reanalysis products. This study explores the utility of k-means cluster analysis on geopotential heights and their ability to make skillful regime predictions in the week 3/4 period. Using 14-day running means of European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis v5 (ERA5) 500-hPa geopotential heights for the wintertime December–February (DJF) period, circulation regimes are identified using k-means clustering. Each period is assigned a cluster number, allowing the compositing of any reanalysis or observation variable to form cluster maps. Maps of 500-hPa height, 2-m temperature, precipitation, and storm-track anomalies are some of the variables composited. The utility of these relationships in a dynamical forecast setting is tested via Global Ensemble Forecast System v12 (GEFSv12) hindcasts and real-time ensemble suite forecasts. Week 3/4 deterministic and probabilistic experimental forecasts are then derived from cluster assignments using several methods. We find, via a conditional skill analysis, forecasts strongly correlated with a cluster exhibit greater skill for both dynamical model and cluster-derived forecasts. Our preliminary results represent a step forward to aid forecasters make more skillful assessments of the circulation regime and its associated surface weather for this challenging forecast time scale. Significance Statement Our paper links the local statistics of 14-day precipitation and temperature within the United States to very broad preferred patterns of winds and pressure over the wide Pacific–North American region. Such patterns, known as “circulation regimes,” provide the background that heavily influences local surface conditions. We find that forecasts for which midatmospheric anomalies are closely aligned with one or more circulation regimes are better at predicting the U.S. weather probabilities than other week 3–4 forecasts. A tool based on this finding identifies forecasts for which confidence is higher. Future work will be designed to further exploit the links between circulation regimes and weather to improve the accuracy of week 3–4 forecasts.