The Serra Leste region, located in the northeast portion of Carajas Mineral Province (PA), hosts important chrome-PGE, Au–Pd–Pt, Cu–Mo–Au, iron, and manganese deposits and occurrences related to different geological settings. We present a regional prospective model with focus on PGE mineralizations based on airborne geophysics (magnetometry, gamma-ray spectrometry and time domain electromagnetometry) and geological data. Geological and geophysics data analysis indicate a plausible correspondence between areas with meta-mafic–ultramafic rocks and low values in gamma spectrometry, mainly for the thorium channel. The meta-ultramafic units of the complexes, the main host rock of the PGE mineralization, are well defined by analytic signal from the anomalous magnetic field and by the apparent conductance anomalies derived from the GEOTEM system. The combination of the derivative products with updated geological data of the Serra Leste region and PGE-Luanga deposit enable to establish a regional prospective model for PGE and the identification of new targets within the studied area.