The studies aimed to examine the impact of water abstractions on runoff and streamflow using the MIKE 11 NAM model. A field survey of water abstraction was conducted to ascertain the actual withdrawal from the Weyib watershed. The baseline period from 1986-2000 was considered based on low human interventions of water abstractions to simulate existing from 2013 to 2022, short-term from 2026 to 2035, and 2036 to 2045 for long-term developments. The annual water withdrawals for those development periods were 10.22, 31.25, and 77.42 Mm3, respectively. The mean annual streamflow in the baseline period was 15.16 m3/s, whereas for existing, short-term, and long-term developments depicted as 10.81 m3/s, 9.55 m3/s, and 8.42 m3/s, respectively. The mean annual runoff for the natural baseline was 132.53 mm, and it dropped down by 37.64 mm, 48.70 mm and 58.54 mm for existing, short-term and long-term developments, respectively. In comparison to the baseline period (7177.93 Mm3), the cumulative volume streamflow of the river was decreased by 2038.01, 2637.12, and 3169.84 Mm3 owing to the development periods, respectively. The streamflow and surface runoff dropped significantly due to increasing water abstraction. The beneficiaries need to employ efficient irrigation water extraction practices for sustainable water development. To cope up with the challenges of water abstraction, the long-term development plan needs to be revised, and Ethiopia's proposed irrigation water charges policy must be implemented. Article highlights MIKE 11 NAM model sensitive parameters identified and performance evaluated for future studies in data-scare regions. Estimation of water balance for Weyib watershed. Impacts of water abstractions on the runoff and streamflow assessed.