Annual Population Research Articles

The health impact of PM2.5 and O3 in Beijing modified by infiltration factors from 2014 to 2022.

PM2.5 and O3 are significant threats to the health of residents and modern residents spend more than 80% of their time indoors, so quantifying indoor exposure of residents has a positive influence on formulating policies and improving health indicators. Analysis of monitoring data shows a consistent decrease in the annual average concentration of outdoor PM2.5 in Beijing from 90.1 to 30.4μg/m3, and the equivalent human exposure concentration also declined from 55.2 to 18.6μg/m3 modified by infiltration factors from 2014 to 2022, while during the peak season, the average value of O3-8h concentration in Beijing has consistently remained between 159.3 and 225.3μg/m3; the equivalent human exposure concentration remained between 64.7 and 92.3μg/m3 modified by infiltration factors from 2014 to 2023. The equivalent exposure concentration is calculated by weighting the concentration of indoor and outdoor pollutants, the proportion of indoor and outdoor activity time of the population, and the permeability coefficient of outdoor pollutants into the room, so as to quantify the actual concentration of pollutants exposed to the human body in a certain time. Previous studies have primarily focused on the impact of annual changes in pollutant concentrations on health estimates, often neglecting indoor concentrations and behavior patterns. This limitation should be addressed. Therefore, this study utilized equivalent human exposure concentration and AirQ + , the authoritative software released by the World Health Organization (WHO), to evaluate quantitatively the impact of PM2.5 and O3 on the health of Beijing residents by combining pollutant concentration, annual population, and mortality of various diseases and other indicators to enhance the credibility of the study. The number of deaths related to PM2.5 has decreased from 28,182 people in 2014 to 10,250 people in 2022 (age ≥ 30). The number of premature deaths in 2022 was only 36.4 percent of that in 2014 and was decreasing by 1992 per year. The number of deaths related to O3 varies between 550 and 3358 people. Lowering PM2.5 and O3 concentrations can effectively reduce natural premature death as well as cardiovascular and respiratory diseases caused by air pollution. The government should persist in enhancing the regulation of PM2.5 and accord significance to the oversight of O3. Concurrently, there is a need to reinforce the cooperative regulation addressing both PM2.5 and O3.

Spatial–Temporal Characteristics, Source Apportionment, and Health Risks of Atmospheric Volatile Organic Compounds in China: A Comprehensive Review

Volatile organic compounds (VOCs) are ubiquitous in the atmosphere, posing significant adverse impacts on air quality and human health. However, current research on atmospheric VOCs mainly focuses on specific regions or industries, without comprehensive national-level analysis. In this study, a total of 99 articles on atmospheric VOCs in China published from 2015 to 2024 were screened, and data on their concentrations, source apportionment, and health risks were extracted and summarized. The results revealed that the annual average concentrations of TVOCs and their groups in China generally increased and then decreased between 2011 and 2022, peaking in 2018–2019. A distinct seasonal pattern was observed, with the highest concentrations occurring in winter, followed by autumn, spring, and summer. TVOC emissions were highly concentrated in northern and eastern China, mainly contributed by alkanes and alkenes. Source apportionment of VOCs indicated that vehicle sources (32.9% ± 14.3%), industrial emissions (18.0% ± 12.8%), and other combustion sources (13.0% ± 13.0%) were the primary sources of VOCs in China. There was a significant positive correlation (p < 0.05) between the annual mean VOC concentration and population size, and a notable negative correlation (p < 0.05) with GDP per capita. Atmospheric VOCs had no non-carcinogenic risk (HI = 0.5) but exhibited a probable carcinogenic risk (7.5 × 10−5), with relatively high values for 1,2-dibromoethane, 1,2-dichloroethane, and naphthalene. The health risk was predominantly driven by halocarbons. These findings are essential for a better understanding of atmospheric VOCs and for developing more targeted VOC control measures.

Estimating Young Adult Uptake of Smoking by Area Across the United Kingdom.

There is majority support in parliament and across the United Kingdom to implement a "smoke-free generation" policy which would mean people born on or after January 1, 2009, could never legally be sold tobacco. To explore the potential impact this policy could have, we estimated the number of young adults (18-25 years) currently taking up smoking each year by area across the United Kingdom. Using data from the Office for National Statistics (ONS), Annual Population Survey (APS), and Smoking Toolkit Study (STS), we estimated the total number of 18- to 25-year-olds taking up smoking each year, based on national estimates of population size (ONS) and the proportion who reported ever having regularly smoked (STS). We used local data on adult smoking rates (APS) to apportion the national estimated number of young adults taking up smoking to specific areas. Around 127500 18- to 25-year-olds in the United Kingdom start smoking regularly each year (~350 each day); 105700 each year in England, 11500 in Scotland, 6500 in Wales, and 3800 in Northern Ireland. Uptake estimates varied across localities: for example, North East Lincolnshire had the highest proportion of young adults taking up smoking each year (3.9%) and Wokingham had the lowest (0.9%). Despite reductions in smoking prevalence over recent decades, hundreds of young adults in the United Kingdom start smoking every day. Data on rates of uptake among individual local authorities can be used to focus attention locally prior to the introduction of new age of sale laws.

Tuberculosis Elimination Forecast for Moscow Region

The objective: to assess the possibility of tuberculosis elimination in Moscow Region by 2035.Subjects and Methods. For the study, Federal Statistical Surveillance Form No. 8 Information on Active Tuberculosis cases, and Form No. 33 Information on Tuberculosis Patients for 015-2023 were selected, rates were calculated for the average annual population in the region. Changes in tuberculosis incidence in Moscow Region were analyzed.Results. Based on results of the study on possibility to eliminate tuberculosis in Moscow Region by 2035, it has been found that if the current epidemic situation persists, it is only possible to achieve the mortality target. To achieve the target results for other rates, additional measures to prevent tuberculosis among the population are needed.

Budget impact analysis of pembrolizumab versus the novel PD-1 inhibitor toripalimab in locally advanced or metastatic nonsquamous non-small cell lung cancer

ABSTRACT Aim To estimate the budget impact of adding a toripalimab regimen to the existing treatment mix of pembrolizumab, both with pemetrexed and carboplatin, in patients with locally advanced or metastatic nonsquamous NSCLC within two price inputs (wholesale acquisition cost (WAC) and average sales price (ASP)). Methods Budget impact analysis comparing a treatment mix “without” versus “with” the toripalimab regimen in the annual US nonsquamous NSCLC population treated with a PD-1 inhibitor, a 3-year time horizon, toripalimab market share of 1% in 2024, increasing to 4% (2025) and 5% (2026), and medication use adjustments for discontinuation or progression to estimate fully-treated-patient-equivalents. Cost inputs included drugs, administration, and grade 3/4 adverse event (AE) management. The models were replicated in a 1-million-member plan to estimate costs per-member-per-month (PMPM) and per-member-per-year (PMPY). One-way (OWSA) and probabilistic sensitivity analyses (PSA) as well as two scenario analyses were performed. Results In the “without” scenario, the 3-year WAC costs for the pembrolizumab regimen total $40,750,234,637 ($39,024,548,745 for treatment and $1,725,685,894 for managing AEs). In the “with” scenario, these costs decline to $39,341,379,081. Corresponding “with” costs for toripalimab are $1,186,027,704 (treatment) and $99,454,471 (AE management) for a total of $1,285,482,175. This yields annual net savings of between $10,779,362 (at 1% market share) in 2024 and $64,858,298 (5% market share) in 2026, for 3-year savings of $123,373,381. The associated savings in a 1-million-member plan are $0.030 PMPM and $0.363 PMPY. The ASP model shows similar patterns. Savings were demonstrated in 68% of PSA simulations; OWSAs and scenario analyses reveal how parameter variability impacts results. Conclusion Significant savings are likely achievable from treating between 1% (year 1) to 5% (year 3) of nonsquamous NSCLC patients with the toripalimab regimen. Projected 3-year savings range from $122 million (ASP) to $123 million (WAC); corresponding to savings of $0.030 PMPM and $0.363 PMPY.

Nontuberculous mycobacterial pulmonary disease (NTM PD) incidence trends in the United States, 2010–2019

BackgroundNontuberculous mycobacteria (NTM) are ubiquitous environmental bacteria that cause chronic lung disease. Rates of NTM pulmonary disease (NTM PD) have increased over the last several decades, yet national estimates in the United States (US) have not been assessed since 2015.MethodsWe used a nationally representative population of Medicare beneficiaries aged ≥ 65 years to assess rates of NTM PD in a high-risk population from 2010 to 2019. Poisson generalized linear models were used to assess the annual percent change in incidence in the overall population and among key demographic groups such as sex, geography, and race/ethnicity. We evaluated the relative prevalence of various comorbid conditions previously found to be associated with NTM PD.ResultsWe identified 59,724 cases of incident NTM PD from 2010 to 2019 from an annual mean population of 29,687,097 beneficiaries, with an average annual incidence of 20.1 per 100,000 population. NTM PD incidence was overall highest in the South and among women, Asian individuals, and persons aged ≥ 80 years relative to other studied demographic groups. The annual percent change in NTM PD incidence was highest in the Northeast, at 6.5%, and Midwest, at 5.9%, and among women, at 6.5%. Several comorbid conditions were highly associated with concurrent NTM diagnosis, including allergic bronchopulmonary aspergillosis, bronchiectasis, and cystic fibrosis.ConclusionsHere we provide current estimates of NTM PD incidence and prevalence and describe increasing trends in the US from 2010 to 2019. Our study suggests a need for improved healthcare planning to handle an increased future caseload, as well as improved diagnostics and therapeutics to better detect and treat NTM PD in populations aged ≥ 65 years.

COVID-19 Pandemic Effects on Angler Effort and a Brown Trout Population in a Driftless Area Stream in Southeast Minnesota

Abstract Early opinions of the COVID-19 pandemic included equivocal notions of whether the pandemic would result in more or less angler effort and harvest in recreational fisheries. Early papers also suggested using changes in angling license sales to infer changes in angler effort but expressed concern about adequate assessment of pandemic effects on fisheries because of interruptions to routine assessment programs. To assess pandemic effects on angler effort at a stream trout fishery, a trail camera was installed, immediately prior to implementation of a statewide stay-at-home order, at a representative stream trout angling site that is part of a long-term fish monitoring program. The trail camera was deployed through the trout harvest angling season from the peak pandemic year of 2020 through cessation of most restrictions in 2022. Statewide sales of angling licenses and trout stamps were assessed through this time to compare with angler effort measured with the trail camera. Annual trout population assessments were examined for pandemic effects in conjunction with angler effort. Anglers were present on 84% of days in 2020, 66% in 2021 and 69% in 2022. Following the pandemic peak of 603 angler-hours in 2020, angler-hours declined by -23% between 2020 and 2021, and by -16% between 2020 and 2022; whereas statewide sales of licenses and trout stamps only declined by -4% between 2020 and 2021 and -11% between 2020 and 2022, suggesting more angler pressure at the study site than could be inferred by changes in license or trout stamp sales. Higher pressure during the pandemic was due in part to more anglers younger than 20 years old. Despite higher angler pressure in 2020, there was no long-term effect on the Brown Trout population, as adult abundance in 2021 and 2022 exceeded abundance in every year from 2017 to 2020. These data add to a limited number of similar field-based pandemic studies coupling changes in angler use with fish population responses and should provide further insight into the broader assessment of COVID-19 pandemic effects.

Work-related injuries and illnesses (WRII) presenting to Illinois hospitals, 2017-2021: The importance of emergency department (ED) data.

Research characterizing work-related injuries and illnesses (WRII) has predominantly focused on inpatients and deaths, despite evidence that 4% of WRII are admitted as inpatients and deaths are less than 0.2% of acute WRII. Our aim is to determine the usefulness of incorporating emergency department (ED) hospital data into current occupational health surveillance systems. Data on ED and admitted WRII treated in Illinois hospitals from 2017 to 2021 were analyzed. Demographic characteristics, primary diagnosis, procedures undertaken, and unique patient estimates are described. Multivariable logistic regression models were developed to evaluate predictors of treatment in the ED and multivariable median regression models determined associations of total hospital charges. Between 2017 and 2021 there were 488,033 hospital presentations (95.9% nonadmissions) for WRII in Illinois, equating to a crude annual population rate of 1502.1/100,000. Non-Hispanic Whites (NHW) were disproportionately treated for illnesses, while Hispanic or Latino workers were disproportionately treated for injuries. African-Americans had the highest rate of ED emergent presentations (incident rate ratio [IRR] = 1.3, ref = NHW) and were less likely to be admitted for emergent presentations (IRR = 0.7, ref = NHW). ED presentations were more likely to be female, present with an injury, and at a rural, versus urban, hospital. Radiological investigations compromised the majority of procedures for nonadmitted patients (n = 403,317), and 94.8% were coded for a body region CONCLUSION: Between 2017 and 2021 in Illinois, there were nearly 500,000 hospital visits charged to workers' compensation totaling over US$ four billion. ED data provide additional insights into work-related chronic conditions, health disparities, and the usage of diagnostic and therapeutic procedures for WRII.

Use of capture–recapture models to evaluate abundance and dynamics of a stocked Muskellunge population

AbstractTo evaluate the success of a stocking program in Fox Lake, Minnesota, adult (≥76 cm total length) Muskellunge were captured with large nearshore trap nets and individually marked with passive integrated transponder tags during the 2011–2013 and 2015–2017 spawning seasons; then, capture–recapture data were analyzed at two different time scales. Despite substantial sampling effort, daily capture histories within a single season only supported closed‐population abundance estimates for both sexes in half the years; estimates were imprecise, and there was evidence of trap shyness or violation of the short‐term closure assumption in some years. Jolly–Seber models over all years supported relatively precise abundance estimates for both sexes every year, as well as estimates of annual survival, recruitment, and population growth rate. Link–Barker Jolly–Seber models provided estimates of population growth rate λ ≈ 1 indicating that per‐capita annual recruitment rates of only about 0.15–0.20 were adequate to maintain the adult population given the high annual apparent survival rates of 0.80 for adult females and 0.89 for adult males. POPAN Jolly–Seber models revealed that about 80 adult females and 90–126 adult males were vulnerable to capture each year in the 385 ha lake, and about 16–18 fish of each sex recruited to the adult population annually. This study illustrates the importance of open‐population models with multiple years of data to evaluate the abundance and population dynamics of a low‐density, long‐lived species.

Epidemiology of sporadic and outbreak-associated hepatitis A infections in Ontario, Canada: A descriptive summary, 2015-2022.

Hepatitis A is a disease of public health significance that typically causes acute, self-limiting infection. Understanding the risk factors and demographics associated with individual infections and outbreaks can guide public health communication and interventions. To assess the number of hepatitis A cases and outbreaks in Ontario from January 1, 2015, to November 22, 2022, and to identify common risk factors associated with sporadic and outbreak-associated infections in Ontario. Confirmed and probable hepatitis A cases reported between January 1, 2015, and November 22, 2022, were extracted from the Ontario electronic reporting system. Descriptive analyses were used to summarize and compare risk factors reported by sporadic and outbreak-associated hepatitis A cases. Annual rates of infection for individual public health units were calculated using annual population estimates for Ontario health regions. During the study period, 938 cases of hepatitis A were reported in Ontario (an average annual rate of 0.9 cases per 100,000 population), with 31.3% (n=294) of cases linked to one of 18 unique outbreaks of hepatitis A. Four of 13 local outbreaks were associated with elementary school settings. Reported risk factors differed between sporadic cases (predominantly travel-related) and cases linked to known outbreaks (anal-oral contact, illicit drug use, diapering/assisting in toileting, close contact with a case). Rates of sporadic infection differed across public health units in Ontario over the study period. Public health interventions that aim to increase awareness of hepatitis A risk factors and increase vaccine uptake among those at increased risk of exposure could help to reduce the incidence of both locally acquired and travel-related sporadic infections and outbreaks.

The Impact of Quality Public Service Delivery on Customer Satisfaction: In Case of Nekemte Town Police Administration, Nekemte, Oromia, Ethiopia

This research involved 397 participants selected through stratified and simple random sampling methods. The objective was to assess the influence of service quality delivery on customer satisfaction within Nekemte Town Police Administration, utilizing the SERVQUAL model. To fulfill this goal, a quantitative research study incorporating both descriptive and causal (inferential) research designs was conducted. Questionnaires with a five-point Likert scale were employed, drawing from the annual target population of 51,480 Nekemte Town Police Administration customers. Data was gathered through personally administered questionnaires, and subsequent analysis was performed using the Statistical Package for the Social Sciences (SPSS) version 27, employing descriptive and inferential statistics. The findings indicated minimal customer satisfaction, making it challenging to precisely determine customers' expectations and perceptions regarding service quality dimensions. Notably, all service quality dimensions positively influenced satisfaction levels. Specifically, responsiveness, assurance, and empathy emerged as significant contributors to customer satisfaction, while reliability and tangibility had a comparatively lesser impact. In light of these results, the researcher recommends that the Nekemte Town Police Administration implement training, corrective measures to enhance responsiveness, motivational initiatives, and the utilization of fault-free technologies to improve overall customer satisfaction.

Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011-2022.

No epidemiologic studies have formally assessed the incidence of primary progressive aphasia (PPA) and primary progressive apraxia of speech (PPAOS). Thus, we decided to assess the incidence of these disorders in Olmsted County, MN, between 2011 and 2022, and to characterize clinical, radiographic, and pathologic characteristics of these patients. This was a retrospective examination of data from a population-based cohort of patients with PPA and PPAOS prospectively identified in Olmsted County, MN, from 2011 to 2022. The incidence of PPA among adults (older than 18 years) was calculated for Olmsted County as the number of patients per 100,000 person-years during the study period. The adult population of Olmsted County was determined by the annual catchment population reported by the Rochester Epidemiological Project for each year 2011-2022. A behavioral neurologist verified the clinical diagnoses and determined subtypes. We identified 10 patients (60% female) within the study period (median age of symptoms onset: 70 years; range: 66-73), 8 with PPA and 2 with PPAOS. Of the 8 patients with PPA (6 female patients, 2 male patients), 2 met criteria for non-fluent variant PPA (nfvPPA), 3 for logopenic variant PPA (lvPPA), and 3 for semantic variant (svPPA). Speech evaluation confirmed the clinical diagnoses in all patients and all showed typical imaging findings consistent with their respective subtype. Six patients (2 PPAOS, 2 nfvPPA, 2 lvPPA) died and 3 underwent autopsy (2 PPAOS, 1 nfvPPA), confirming the pathologic diagnosis of progressive supranuclear palsy. The incidence of PPA + PPAOS was 0.70 persons per 100,000 person-years (95% CI 0.34-1.29 persons per 100,000) during the study period. The incidence of PPAOS was 0.14 persons per 100,000 person-years (95% CI 0.02-0.55 persons per 100,000), whereas for the 8 patients with PPA, the incidence was 0.56 persons per 100,000 person-years (95% CI 0.24-1.10 cases per 100,000). The incidence of nfvPPA was 0.14 persons per 100,000 person-years (95% CI 0.02-0.55), 0.21 persons per 100,000 person-years (95% CI 0.04-0.61) for lvPPA, and 0.21 persons per 100,000 person-years (95% CI 0.04-0.61) for svPPA. As a group, PPA and PPAOS are a relatively rare group of diseases. PPAOS has a slightly lower incidence than PPA as a group but similar incidence to the individual PPA variants.

Cancer screening uptake by women from India's largest state Uttar Pradesh: district-wise analysis from the fifth round of National Family Health Survey (2019-2021).

The Government of India (GOI) has launched a nationwide cervical, breast and oral cancer prevention and control program. However, the fifth round of the National Family Health Survey (NFHS-5), a nationwide survey conducted by the Ministry of Health and Family Welfare (MoHFW), GOI, has shown concerning results on screening uptake by both men and women across India. This study was conducted to describe the uptake of cancer screening by women residing in Uttar Pradesh (UP), the largest state of India. We analyzed NFHS-5 data available in public domain to determine the number of women (aged 30-49 years) participating in cancer screening across the 71 districts in UP state. We utilized population projections for the year 2021 provided by the population projections for India and states for calculating the number of women. The district-wise estimation was done using a projection of district-level annual population. Although the GOI has made screening available for common cancers, NFHS-5 results indicated that the screening uptake among women aged 30-49 years is a cause for concern. The data revealed less than 1% of women underwent screening, and some of the districts showed no screening uptake. GOI has laid down a framework for cancer screening; however, poor participation among women calls for research to understand the barriers to cancer screening and to develop interventions to address these barriers.

Population Dynamics of Bactrocera dorsalis (Diptera: Tephritidae) in Four Counties of Yunnan, China, by Electronic Monitoring System.

Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is a global economic pest that poses a serious threat to the fruit industry. In the southwest of China, Yunnan Province sustains a severe infestation of B. dorsalis. An automated monitoring system designed for B. dorsalis was employed in this study to elucidate the annual population dynamics of B. dorsalis in four counties: Yuanjiang, Huaping, Guangnan, and Ludian in Yunnan. The system utilizes sex parapheromone and image recognition technology. The data uploaded by the device are used to analyze the annual population dynamics of B. dorsalis in different regions. The results showed that the populations of adult B. dorsalis in all four counties peaked twice annually, with Yuanjiang experiencing the earliest peak periods, followed by Huaping, Guangnan, and Ludian. Adult B. dorsalis occurred in Yuanjiang throughout the year, and Yuanjiang had the highest number of B. dorsalis monitored. In Huaping, adult B. dorsalis occurred in March-December and was highly active, with a high population density in 2019. Bactrocera dorsalis did not occur in December in Guangnan but only in May-October in Ludian. Bactrocera dorsalis abundance was correlated with temperature in all four areas. The outcomes of this experiment provide a practical foundation for developing control strategies targeting B. dorsalis in various orchards across each county.

Long-term trends of occupational physical activity intensity in Japan

Objectives Although physical inactivity is a global concern, quantitative data on its long-term trends in physical activity (PA) are limited. This study aimed to estimate long-term trends in the intensity of occupational PA, constituting the largest portion of PA in Japan.Methods Data on the number of workers in Japan by occupational category were obtained from the Labour Force Survey. PA intensity (metabolic equivalents [METs]) was assigned to 329 occupations in the Japanese Standard Occupational Classification based on the methods and data of Tudor-Locke et al. (2011), and representative intensity values for 11 occupational categories were calculated. Based on intensity, occupational categories were reclassified into sedentary (≤1.5 METs), light (1.6-2.9 METs), and moderate (≥3 METs). Trends in the prevalence of workers in each category were analyzed, along with the annual mean occupation-related METs from 1953 to 2022. The mean occupation-related METs represented the weighted average of PA intensity, calculated based on the annual worker population for each occupational category. Results From 1953-2022, the prevalence of moderate-intensity occupations significantly declined, whereas sedentary and light-intensity occupations increased. The mean occupation-related METs decreased continuously for 70 years. During the 48-year period from 1962 to 2010, when there were no major changes in occupational classification methods, there was a decline of 0.25 METs, representing a 9.6% decrease, from 2.60 to 2.35 METs.Conclusion Over the past 70 years, occupations in Japan have transitioned to ones with lower PA intensity. Consequently, the average PA intensity across all occupations decreased by at least one-tenth. Since this study assumes a constant intensity for each occupation, the actual decline in occupational PA intensity may be even more significant because of societal automation.

Lateral Ankle Ligament Repair Is Not Only for Young Patients: Trends in Incidence and Demographics.

The purpose of this study was to examine the changes in annual incidence and patient population undergoing lateral ankle ligament repair (LALR) for the surgical treatment of chronic ankle instability. The IBM Watson Health MarketScan Database was queried for patients who underwent LALR from January 2009 to December 2019 based on CPT code 27698. Volume and incidence per 100 000 population were determined for annual sums, gender, age, and geographical regions based on population estimates from the United States Census Bureau. Future annual volumes were statistically projected with linear regression modeling to the year 2032. Overall, 160 457 LALR procedures were identified in the database from 2009 to 2019. Annual incidence increased 76.6% from 3.46 to 6.11 cases per 100 000 population, while estimates of annual volumes are projected to increase 61.5% from 19 829 to 32 033 procedures to the year 2032. Interestingly, the greatest increase in incidence was observed among patients above 70 years old, which might suggest older patients are staying active longer and desiring elective procedures to maintain their activity levels. As the incidence of LALR increases in older patients, more research will be needed to understand the unique surgical considerations and risk factors impacting patient-reported outcomes.Level of Evidence: Level IV.

Mortality due to falls by county, age group, race, and ethnicity in the USA, 2000–19: a systematic analysis of health disparities

Fall-related mortality has increased rapidly over the past two decades in the USA, but the extent to which mortality varies across racial and ethnic populations, counties, and age groups is not well understood. The aim of this study was to estimate age-standardised mortality rates due to falls by racial and ethnic population, county, and age group over a 20-year period. Redistribution methods for insufficient cause of death codes and validated small-area estimation methods were applied to death registration data from the US National Vital Statistics System and population data from the US National Center for Health Statistics to estimate annual fall-related mortality. Estimates from 2000 to 2019 were stratified by county (n=3110) and five mutually exclusive racial and ethnic populations: American Indian or Alaska Native (AIAN), Asian or Pacific Islander (Asian), Black, Latino or Hispanic (Latino), and White. Estimates were corrected for misreporting of race and ethnicity on death certificates using published misclassification ratios. We masked (ie, did not display) estimates for county and racial and ethnic population combinations with a mean annual population of less than 1000. Age-standardised mortality is presented for all ages combined and for age groups 20-64 years (younger adults) and 65 years and older (older adults). Nationally, in 2019, the overall age-standardised fall-related mortality rate for the total population was 13·4 deaths per 100 000 population (95% uncertainty interval 13·3-13·6), an increase of 65·3% (61·9-68·8) from 8·1 deaths per 100 000 (8·0-8·3) in 2000, with the largest increases observed in older adults. Fall-related mortality at the national level was highest across all years in the AIAN population (in 2019, 15·9 deaths per 100 000 population [95% uncertainty interval 14·0-18·2]) and White population (14·8 deaths per 100 000 [14·6-15·0]), and was about half as high among the Latino (8·7 deaths per 100 000 [8·3-9·0]), Black (8·1 deaths per 100 000 [7·9-8·4]), and Asian (7·5 deaths per 100 000 [7·1-7·9]) populations. The disparities between racial and ethnic populations varied widely by age group, with mortality among younger adults highest for the AIAN population and mortality among older adults highest for the White population. The national-level patterns were observed broadly at the county level, although there was considerable spatial variation across ages and racial and ethnic populations. For younger adults, among almost all counties with unmasked estimates, there was higher mortality in the AIAN population than in all other racial and ethnic populations, while there were pockets of high mortality in the Latino population, particularly in the Mountain West region. For older adults, mortality was particularly high in the White population within clusters of counties across states including Florida, Minnesota, and Wisconsin. Age-standardised mortality due to falls increased over the study period for each racial and ethnic population and almost every county. Wide variation in mortality across geography, age, and race and ethnicity highlights areas and populations that might benefit most from efficacious fall prevention interventions as well as additional prevention research. US National Institutes of Health (Intramural Research Program, National Institute on Minority Health and Health Disparities; National Heart, Lung, and Blood Institute; Intramural Research Program, National Cancer Institute; National Institute on Aging; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Office of Disease Prevention; and Office of Behavioral and Social Sciences Research).

Comparison of Relationships Between the Number of Deaths Due to the 10 Leading Causes and Air Temperature in Hokkaido and Okinawa, Japan.

Background Some literature reports an association between air temperature and mortality in certain diseases. However, the relationships between air temperature parameters and all causes of death have not been thoroughly explored in Japan. Objective This study examined the relationships between the number of deaths from the 10 leading causes and air temperature parameters in Hokkaido (the northernmost region) and Okinawa (the southernmost region) prefectures in Japan. Methods We collected monthly data on the number of deaths from the 10 leading causes and air temperature parameters in Hokkaido and Okinawa prefectures from January 2008 to December 2022 using information from official sources. Annual population data for each prefecture were also obtained. The relationships between the number of deaths and air temperature parameters were assessed through an ecological study. Results The mean air temperature was 9.59 ± 9.23 °C in Hokkaido and 23.46 ± 4.37 °C in Okinawa, with all temperature parameters significantly lower in Hokkaido than in Okinawa. The number of deaths from the 10 leading causes, excluding aspiration pneumonia, was significantly higher in Hokkaido for both sexes compared to Okinawa. In Hokkaido, deaths due to heart disease, cerebrovascular disease, pneumonia, accidents, and renal failure showed a significant correlation with all air temperature parameters for both sexes. In Okinawa, heart disease and cerebrovascular disease deaths were correlated with all air temperature parameters for both sexes. Conclusions The relationships between the number of deaths from the 10 leading causes and air temperature parameters differed between Hokkaido and Okinawa prefectures in Japan.

Analysis of the incidence of uterine fibroid in Yekaterinburg

Background. Uterine fibroid (UF) is a benign tumor of the myometrium and is considered as one of the criteria for the state of women’s reproductive health. Objective information about the incidence of UF in a modern megalopolis allows us to assess the level of health of the female population, characterize the availability and quality of medical care, and plan its development.Aim. To analyze the incidence and prevalence of UF according to the data of medical organizations in Yekaterinburg in 2016–2022.Materials and methods. An epidemiological study of the incidence and prevalence of the adult female population of the city of Yekaterinburg in 2016–2022 was conducted. For the analysis, we used Form No. 12 of the Federal Statistical Observation of Medical Organizations located in the city. The incidence rates were calculated for the average annual female population aged 18 years and over, expressed in 0/0000. Absolute growth (decrease), growth rate (decrease), growth rate (decrease), average growth rate (decrease) were studied. The long-term dynamics of the indicators was determined using the average growth rate.Results. The incidence of UF was 130.890/0000, and the prevalence was 735.800/0000 in 2016. During the pre-pandemic period, the indicators increased significantly in 2019 compared to the baseline year 2016 (р < 0.001). The incidence increased by 1.96 times, the prevalence – by 1.39 times. The indicators decreased to the level of 2016 during the pandemic of new coronavirus infection (2020–2022) (р >0.05).Conclusion. The obtained dynamics of incidence and prevalence of UF in the population of women in a modern megalopolis is considered as a criterion for the state of women’s health, accessibility and quality of preventive and planned medical care for gynecological patients. The results of the study are recommended for planning medical care for women and can form the basis for continuing epidemiological studies.

The heritability of fitness in a wild annual plant population with hierarchical size structure.

The relative magnitude of additive genetic vs. residual variation for fitness traits is important in models for predicting the rate of evolution and population persistence in response to changes in the environment. In many annual plants, lifetime reproductive fitness is correlated with end-of-season plant biomass, which can vary significantly from plant to plant in the same population. We measured end-of-season plant biomasses and obtained single nucleotide polymorphism (SNP) genotypes of plants in a dense, natural population of the annual plant species Impatiens capensis with hierarchical size structure. These data were used to estimate the amount of heritable variation for position in the size hierarchy and for plant biomass. Additive genetic variance for a position in the size hierarchy and plant biomass were both significantly different from zero. These results are discussed in relationship to the theory for the heritability of fitness in natural populations and ecological factors that potentially influence heritable variation for fitness in this species.