Annual Meeting Research Articles

Featured research at the 2024 Society of Family Planning Annual Meeting

Featured research at the 2024 Society of Family Planning Annual Meeting

Listing of the Abstracts of the 2024 American Brachytherapy Society Annual Meeting

Listing of the Abstracts of the 2024 American Brachytherapy Society Annual Meeting

Malformations of Cortical Development: Updated Imaging Review.

Malformations of cortical development (MCD) are structural anomalies that disrupt the normal process of cortical development. Patients with these anomalies frequently present with seizures, developmental delay, neurologic deficits, and cognitive impairment, resulting in a wide spectrum of neurologic outcomes. The severity and type of malformation, in addition to the genetic pathways of brain development involved, contribute to the observed variability. While neuroimaging plays a central role in identifying congenital anomalies in vivo, the precise definition and classification of cortical developmental defects have undergone significant transformations in recent years due to advances in molecular and genetic knowledge. The authors provide a concise overview of embryologic brain development, recently standardized nomenclature, and the categorization system for abnormalities in cortical development, offering valuable insights into the interpretation of their neuroradiologic patterns. ©RSNA, 2024 Supplemental material is available for this article. The slide presentation from the RSNA Annual Meeting is available for this article.

The role of communication in the successful implementation of the Slovenian NCCP

Abstract Issue Cancer remains a significant global public health challenge, necessitating comprehensive strategies for effective control and management. Slovenian National Cancer Control Programme (NCCP) addresses this challenge by prioritizing proactive communication with various stakeholders engaged in cancer care planning, delivery and advocacy. The communication strategy within this programme plays a pivotal role in its successful implementation. Description of the problem Active engagement and collaboration among stakeholders is crucial for achieving the programme’s objectives. NCCP seeks to address this challenge through various communication activities by fostering dialogue, sharing best practices, and facilitating networking opportunities among oncology professionals throughout Slovenia. Additionally, it seeks to strengthen partnerships with sectors beyond health and prioritizes engagement with cancer patient advocacy groups. Results The programme has devised a long-term communication strategy, guiding annual communication plans to engage stakeholders and foster support for its objectives. Notable communication activities in the period 2022-2024 include: organizing annual meetings for different oncology stakeholders including cancer patient associations, hosting impactful professional events, conducting visits to regional cancer hospitals, distributing e-newsletters and managing a NCCP website. Initial outcomes indicate strengthened communication and collaboration among professionals and institutions in the field of oncology nationwide. Engagement with patient advocacy groups has facilitated discussions on topics important to patients. Lessons Effective communication with diverse stakeholders is crucial for comprehensive cancer control. Collaborating across sectors enhances the impact of cancer control initiatives. Enhanced networking fosters innovation and synergy among oncology professionals, positioning Slovenia for greater success in cancer control. Key messages • Slovenia’s NCCP prioritizes proactive communication, fostering collaboration among stakeholders. Annual events, newsletter, and partnerships strengthen awareness and drive comprehensive cancer control. • Long-term communication strategy of Slovenia’s NCCP drives stakeholder engagement, and supports strategic objectives. This proactive approach strengthens comprehensive cancer control efforts.

Northeastern Society of Plastic Surgeons Craniomaxillofacial Abstracts Presented at the 41st Annual Meeting

Northeastern Society of Plastic Surgeons Craniomaxillofacial Abstracts Presented at the 41st Annual Meeting

Therapeutic advances in hepatocellular carcinoma: an update from the 2024 ASCO annual meeting

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide. Recent advances in immunotherapies, targeted therapies, and combination treatments have significantly improved outcomes for many patients with HCC. This review summarizes key findings from the 2024 ASCO Annual Meeting, focusing on emerging therapies, including immune checkpoint inhibitors (ICIs), CAR-T cell therapies, oncolytic viruses, and locoregional treatments like transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC). ICIs, particularly when combined with other agents, have shown promising efficacy, though challenges such as immune-related adverse events and resistance mechanisms remain. CAR-T cell therapies and oncolytic viruses offer novel therapeutic avenues for advanced HCC, but their long-term efficacy in solid tumors is still under investigation. Locoregional therapies, especially in combination with systemic treatments, continue to play a critical role in managing unresectable HCC and improving conversion rates to surgical resection. Additionally, the potential of biomarkers, such as hypoxia scores and CTNNB1 mutations, is being explored to better personalize treatment and predict patient responses. These biomarkers could pave the way for more targeted and effective therapeutic strategies. Overall, the recent studies presented at the ASCO meeting highlight progress in HCC treatment, underscoring the importance of continued innovation. Future research should focus on overcoming resistance mechanisms, optimizing combination therapies, and integrating biomarker-driven approaches to improve patient outcomes and enhance personalized treatment strategies.

Update on HPV-associated head and neck cancers-highlights of the 2024 ASCO Annual Meeting

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is becoming increasingly important in head and neck oncology. At this year's conference of the American Society of Clinical Oncology (ASCO), alarge number of papers were presented on the topic of HPV-associated HNSCC, particularly with regard to neoadjuvant treatment approaches, radiation de-escalation strategies, therapeutic vaccines, and treatment monitoring. In this context, study results on the treatment of HPV-related recurrent respiratory papillomatosis (RRP) were also presented. Based on contributions to the 2024 ASCO Annual Meeting, an insight into the latest developments in HPV-associated diseases of the head and neck is provided. The papers were reviewed for clinical relevance and contextualized based on current therapeutic concepts. Alarge number of studies on liquid biopsies (LB) were presented. It was shown that although the methods for analyzing LBs for HPV-positive patients are well developed and can be used for diagnostics, risk classification, treatment management, or tumor follow-up, the methods vary considerably, and their clinical application has not yet been sufficiently validated. With regard to therapeutic HPV vaccination, three large studies were presented for the treatment of recurrent/metastatic HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). The only randomized study was on the vaccine ISA101b (peltopepimut-S) and did not reach its primary endpoint; however, the vaccine seemed to be highly effective in patients with a combined positive score (CPS) ≥ 20. Furthermore, data from aphaseIstudy on PRGN2012, an adenovirus-based immunotherapy used therapeutically for the treatment of recurrent respiratory papillomatosis (RRP), were presented. PRGN2012 led to areduction in surgical interventions for RRP, and the US Food and Drug Administration (FDA) designated PRGN2012 as abreakthrough therapy and orphan drug. However, the vaccine is not yet approved for the treatment of RRP.

Review of the European Association for the Study of Diabetes (EASD) Annual Meeting 2024

Review of the European Association for the Study of Diabetes (EASD) Annual Meeting 2024

Industrial Genotoxicology Group (IGG): 36th Annual Meeting Report.

The proceedings of the 36th annual meeting of the Industrial Genotoxicology Group (IGG) are shared here. The meeting held at Lhasa Limited, Leeds, UK on 28th November 2023, focussed two aspects; New Approach Methodologies (NAM's), including those for the assessment of non-standard modalities such as gas-vapour assessments and nanomaterials, and addressing the regulatory challenges associated with understanding the genotoxic and carcinogenic potential of N-nitrosamines and N-nitrosamine impurities. New approach methodologies, such as error-corrected sequencing and enhanced Ames tests that may help address these challenges were also discussed.

An analysis regarding the ultimate outcome of abstracts presented at the European Paediatric Surgeons' Association (EUPSA) Congresses.

The objective of this study is to analyze the conversion rate of abstracts presented at the European Paediatric Surgeons' Association (EUPSA) congress into full-text publications and to conduct a thorough analysis of the attributes and quality of the papers published. Abstract books including the years 2017 to 2022 were reviewed. Searches on PubMed and Google Scholar, utilizing keywords from the titles and the author names, were conducted to trace subsequent full-text publications. A categorical analysis detected variations and trends, with a significance threshold of P < 0.05. Quantitative data were presented as means ± standard deviations (SD), while categorical data were represented as counts (n) and percentages (%). A total of 2,139 abstracts were presented at the EUPSA annual meetings during five consecutive congresses. The average number of presented abstracts was 427.6 ± 20.4 per year from across 63 different countries. European countries contributed the majority (71%). The presentations included both oral (n=817, 38.2%) and poster presentations (n=1322, 61.8%). They predominantly focused on clinical topics (90.6%). Single-center retrospective studies were the most common study design (43.7%). Out of all abstracts presented, 1033 (48.3%) were published within an average time interval of 1.39 ± 1.19 years after presentation. Most journals had an impact factor (IF) between 1 and 5 (74.5%). There was no significant year-to-year variation in publication rates (p=1). Basic science studies were published in journals with significantly higher IF compared to clinical studies (p<0.001). The publication rate of abstracts presented at the EUPSA annual congress stands at 48.3%, aligning with the rates observed in other similar studies. This suggests that abstracts submitted to the EUPSA congresses were evaluated and scored rigorously, adhering to international selection criteria. Furthermore, the majority of these abstracts were published in journals with moderate to high impact factors, providing quantitative evidence of the scientific quality of research within the field of pediatric surgery.

Manajemen Keuangan Madrasah dalam Pengadaan Sarana dan Prasarana Pendidikan

This study underscores the importance of effective financial management in the procurement of educational facilities and infrastructure at MA Al Washoya Ngoro Jombang, aiming to support optimal learning processes. Effective financial management is essential to ensure that the madrasah can provide adequate facilities in line with established educational standards. The objective of this research is to analyze how financial management is implemented at MA Al Washoya, focusing on planning, inventory, and evaluation related to the procurement of educational facilities and infrastructure.The research employs a qualitative descriptive approach, using data collection techniques such as observation, interviews, and documentation. The study examines the financial planning process involving the Waka Sarpras, fund allocation based on annual work meetings, and how inventory and financial evaluation are conducted to ensure proper and efficient use of funds.The findings reveal that financial management at MA Al Washoya is functioning reasonably well; however, there are areas requiring improvement, particularly in optimizing procurement and maintenance of existing facilities and infrastructure. The evaluation indicates that, although facilities and infrastructure have been planned and procured, better maintenance is needed to ensure their sustainability. The study recommends that the madrasah be more proactive in financial planning and asset maintenance strategies to ensure the achievement of high-quality and sustainable educational outcomes.

Shared anthropology of the Middle East: Essays on media in honor of Faye Ginsburg

AbstractThe articles in this special issue are the outcome of the panel: “Papers in Honor of Faye Ginsburg: Visual and Media Anthropology in the Middle East,” which was held virtually for the American Anthropological Association Annual Meetings of November 2021. The reach of Ginsburg's work as well as her mentorship through the creation of NYU's Graduate Program in Culture &amp; Media has shaped the ethnography of media and visual anthropology across a diversity of geographic regions. In this particular issue, we bring together scholars of SWANA (Southwest Asia and North Africa, a term that more broadly encompasses what is often referred to as the Middle East) whose projects are deeply influenced by Ginsburg's scholarship on shared anthropology, collaborative media practices and cultural activism. This introduction includes excerpts from a conversation with Ginsburg.

Abstracts of the 54th Annual Meeting of the Behavior Genetics Association, London, UK : Program chair: Prof. Chandra Reynolds.

Abstracts of the 54th Annual Meeting of the Behavior Genetics Association, London, UK : Program chair: Prof. Chandra Reynolds.

Predictive, integrative, and regulatory aspects of AI-driven computational toxicology – Highlights of the German Pharm-Tox Summit (GPTS) 2024

The 9th German Pharm-Tox Summit (GPTS) and the 90th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) took place in Munich from March 13–15, 2024. The event brought together over 700 participants from around the world to discuss cutting-edge developments in the fields of pharmacology and toxicology as well as scientific innovations and novel insights. A key focus of the conference was on the rapidly increasing role of computational toxicology, artificial intelligence (AI), and machine learning (ML) into the field, marking a shift away from traditional methods and allowing the reduction of animal testing as primary tool for toxicological risk assessment. Tools such as Toxometris.ai showcased the potential of AI-based risk assessments for predicting carcinogenicity, offering more ethical and efficient alternatives. Additionally, computer-driven models like computer-aided pattern analysis (C@PA) for drug toxicity prediction were presented, emphasizing the growing role of chem- and bioinformatic applications in computational sciences. Throughout the summit, there was a strong focus on the need for regulatory innovation to support the adoption of these advanced technologies and ensure the safety and sustainability of chemical substances and drugs.

29th Annual Meeting of the German Finance Association (DGF)

29th Annual Meeting of the German Finance Association (DGF)

OS09.7.A GBM AGILE PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GBM: RESULTS OF FIRST EXPERIMENTAL ARM, REGORAFENIB

Abstract BACKGROUND GBM AGILE (NCT03970447;https://www.gcaresearch.org/research/gbm-agile) is a phase 3 Bayesian adaptive platform trial that efficiently tests multiple arms against common control, with 6 arms included to date. Primary endpoint is overall survival (OS). Stage 1 experimental arms are adaptively randomized against other arms. Demonstrated efficacy in stage 1 leads to fixed randomization stage 2. Stages 1 and 2 are combined for registration. Control randomization is fixed. Regorafenib, a multikinase-inhibitor, entered into GBM AGILE as the first arm and therefore was equally randomized against control. Regorafenib showed OS benefit in recurrent disease (RD) in randomized phase 2 REGOMA trial. MATERIAL AND METHODS Patient subtypes in GBM AGILE are newly diagnosed unmethylated (NDU), RD, and—not considered for regorafenib—ND methylated (NDM). Arm indications (signatures) are combinations of subtypes. Control is temozolomide (ND) and lomustine (RD). Efficacy is assessed by OS hazard ratio(HR), arm/control. Efficacy is demonstrated when Bayesian probability of benefit (HR&amp;lt; 1.00) ≥ 98% (roughly analogous P-value: 0.02). Futility occurs at any monthly analysis when Bayesian predictive power (PP) is &amp;lt; 25% for all signatures. Follow-up continues for 12 months after arm’s accrual stops. RESULTS When PP for all 3 pre-defined signatures was &amp;lt; 25%, regorafenib’s accrual was stopped for futility. Regorafenib/control sample sizes were 49/51, 127/128, 176/179 for signatures NDU, RD, and both. Respective PPs: 0.138, 0.030, 0.025—none close to 0.25. Respective mean HRs: 1.26, 1.25, 1.23. Probabilities of benefit (HR&amp;lt; 1.00): 0.35, 0.18, 0.17. At final analysis, mean HRs were 1.07, 1.08, 1.08 with final probabilities of benefit (HR&amp;lt; 1.00) equal to 0.421, 0.312, 0.296—none close to 0.98. CONCLUSION GBM AGILE efficiently and compellingly addressed regorafenib’s role in GBM, in RD and NDU. These findings are germane as they fail to confirm the REGOMA results in RD. GBM AGILE continues to efficiently assess other therapies, including utilizing concurrent and previously accrued controls. This abstract was accepted and previously presented at the 2023 SNO Annual Meeting and published in Neuro-Oncology, Volume 25, Issue Supplement_5, November 2023, Pages v97-v98.

Individual attendance data for over 30 years of international climate change talks

The international community has formally negotiated over climate change since 1991. The annual meetings that host these negotiations have seen an ever-growing number of individuals representing countries, international organizations, or non-governmental organizations. These meetings and their attendees have accordingly become the focal point of international climate change cooperation for both the international community and scholars studying climate change politics. Yet, researchers have been unable to access and analyze comprehensive attendee-level data pertaining to these negotiations in terms of attendees’ names, genders, job titles, delegations, divisions, and affiliations. In applying text-as-data techniques to attendance roster PDFs, we extract and build attendee-level datasets for all annual negotiations held under the United Nations Framework Convention on Climate Change and its precursor, 1991–2023. These data include original language and English-translated information on 27,470 unique delegations and 310,200 attendees over a 32-year period. Summaries and validations in turn highlight the promise of our data for the study of attendance patterns and characteristics across delegations and over time.

Seeing is believing: Do face‐to‐face meetings between independent directors and investors enhance corporate ESG performance?

AbstractThis article explores the topic of whether face‐to‐face communication between independent directors and investors can help them obtain firm‐specific information and promote management to improve corporate environmental, social, and governance (ESG) performance. Our findings revealed a notable positive correlation between the frequency of independent directors attending shareholder meetings (IDASM) and ESG performance. The underlying mechanism for this correlation is that IDASM increases investment in research and development (R&amp;D) and green patent applications, which can drive long‐term firm value. Further analysis reveals that independent directors attending annual shareholder meetings can more effectively enhance a company's ESG performance. Independent directors attending shareholder meetings also exhibits a more noticeable impact on improving corporate governance performance than environment performance and social performance. The effect becomes more pronounced when independent directors possess an accounting background, have shorter tenures, when the meetings attended by more minority shareholders, the degree of enterprise information asymmetry is high. The research results have reference significance for improve the information disadvantage position of independent directors, restrain short‐sighted behavior of management, and improving the role of shareholder meetings in protecting investor interests.

The new informality? The financialization of informal housing as a parasitic relation (2023) Plenary Commentary

ABSTRACT This paper responds to Raquel Rolnik's Urban Geography Plenary Lecture, delivered at the 2023 American Association of Geographers Annual Meeting, titled “The Empire Strikes Back.” Rolnik's essay introduces the idea that a “new informality” has begun in Latin American cities. She uses this concept to understand how financial innovations like digital platforms and state-backed rental assistance programs draw informal housing into bankable debt relations without needing to convert them into cadastral property. This paper uses Marx's distinction between formal and real subsumption, and Gidwani's theorization of the parasitism of capital, to reframe Rolnik's provocative argument via the noncapital–capital relation. It then raises three questions about the empirical “next steps” of research into the financialization of informal housing that need to be explored to understand the novelty of financialization in the global South. These pertain to (i) the normative logics governing racialized and other forms of difference upon which financialization feeds and depends, (ii) the scale at which financial innovations should be studied and the presumed coherence “high finance” should be granted as an analytical category, and (iii) the fictions used to generate and sustain political buy-in for financial capital's attempt to subsume/consume informal lifeworlds.

Is Our Limited Understanding of the Effects of Nerve Stimulation Resulting in Poor Outcomes and the Need for Better "Rescue Programming" in SNM and PTNS, and Lost Opportunities for New Sites of Stimulation? ICI-RS 2024.

Sacral neuromodulation (SNM) and percutaneous tibial nerve stimulation (PTNS) are strongly recommended by international guidelines bodies for complex lower urinary tract dysfunctions. However, treatment failure and the need for rescue programming still represent a significant need for long-term follow-up. This review aimed to describe current strategies and future directions in patients undergoing such therapies. This is a consensus report of a Think Tank discussed at the Annual Meeting of the International Consultation on Incontinence - Research Society (ICI-RS), June 6-8, 2024 (Bristol, UK): "Is our limited understanding of the effects of nerve stimulation resulting in poor outcomes and the need for better 'rescue programming' in SNM and PTNS, and lost opportunities for new sites of stimulation?" Rescue programming is important from two different perspectives: to improve patient outcomes and to enhance device longevity (for implantable devices). Standard SNM parameters have remained unchanged since its inception for the treatment of OAB, nonobstructive urinary retention, and voiding dysfunction. SNM rescue programming includes intermittent stimulation (cycling on), increased frequency and changes in pulse width (PW). The effect of PW setting on SNM outcomes remains unclear. Monopolar configurations stimulate more motor nerve fibers at lower stimulation voltage; hence, this could be an option in patients who failed bipolar stimulation in the long term. Unfortunately, there is little evidence for rescue programming for PTNS. However, the development of implantable devices for intermittent stimulation of the tibial nerve may increase long-term adherence to therapy and increase interest in alternative programming. There has been recent promising neurostimulation targeting the pudendal nerve (PNS), especially in BPS/IC. More recently, preliminary data addressed the benefits of high-frequency bilateral pudendal nerve block for DESD and adaptive PNS on both urgency and stress UI in women. The exploration of rescue programming and new stimulation sites remains underutilized, and there are opportunities that could potentially expand the therapeutic applications of nerve stimulation. By broadening the range of target sites, clinicians may be able to tailor treatments according to individual patient needs and underlying conditions, thereby improving overall outcomes. However, further studies are still needed to increase the level of evidence, potentially allowing for an individualized treatment both in patients who are candidates for electrostimulation and in those who have already received surgical implants but seek a better outcome.