Annals Of Otology Research Articles

Identifying Core Journals in Otolaryngology: A Bibliometric Analysis.

As research in otolaryngology continues to expand rapidly, it is important to identify core journals to keep clinicians updated with the latest advances. This study is the first to characterize core journals in otolaryngology. Using h-index and impact factor (IF), the top 15 NLM-indexed otolaryngology journals were selected for analysis. The references from all articles published in these journals in one randomized quarter were compiled into a citation rank list, with the most cited journal ranked the highest. Citation zonal distribution analysis was conducted to identify the zonal distribution of otolaryngology journals. A total of 3150 journals containing 26876 articles were cited in otolaryngology literature in April-June 2019. Laryngoscope was the most cited journal containing 1762 citations. IF is significantly associated with the h-index for the top 10 otolaryngology journals (p = 0.032). Three core journal zones were identified, with Zone 1 containing 8 journals, Zone 2 containing 36 journals, and Zone 3 containing 189 journals. A linear relationship between the log journal rank for Zones 1-3 and a cumulative number of citations was found (R2 = 0.9948). Eight core journals for otolaryngology were identified: Laryngoscope, Otolaryngology-Head and Neck Surgery, Otology & Neurotology, JAMA Otolaryngology-Head & Neck Surgery, Head & Neck, European Archives of Oto-Rhino-Laryngology, International Journal of Pediatric Otorhinolaryngology, Annals of Otology, Rhinology & Laryngology. In the face of rapidly evolving research and a multitude of journals, the high citation density within these core journals highlights their utility in updating busy clinicians. NA Laryngoscope, 133:3346-3352, 2023.

IATROGENIC MACROGLOSSIA FOLLOWING TRAUMATIC INTUBATION

TOPIC: Critical Care TYPE: Fellow Case Reports INTRODUCTION: Acute onset macroglossia is a rare yet life-threatening complication that may result from numerous etiologies including patient positioning while under anesthesia, oropharyngeal packing, local trauma, postoperative from surgery in the oral cavity, or secondary to allergic or nonallergic angioedema. Several management strategies have been described including utilization of reduction glossectomy. We present a rare case of acute onset macroglossia likely caused by traumatic intubation with multiple attempts and further potentiated by prone positioning. CASE PRESENTATION: Patient is a 55-year-old female with a past medical history of hypertension, COPD, OSA, HFpEF who presented with a one-week history of worsening shortness of breath. Vital signs showed T 97.6, BP 140/89, RR 24, O2 saturation 96% on 40% FiO2 on BiPAP. Physical exam demonstrated decreased air entry bilaterally with faint wheezing and crackles. Imaging suggested findings of pulmonary edema.Patient was treated for a working diagnosis of COPD and HF exacerbation with nebulizer treatments, steroids, and diuretics. Initial ABG showed pH 7.287, pCO2 77, pO2 124. However, her requirements on BiPAP worsened and a repeat ABG showed pH 7.156, pCO2 105.9, pO2 91 on 60% FiO2. Due to the underlying acidosis and deteriorating mental status, decision was made to intubate. Patient underwent a difficult intubation by anesthesia with at least three failed attempts due to patient's airway being hypertrophied and anterior. They were finally able to place a 6 Fr ETT over a bougie. Hospital course was further complicated by deteriorating respiratory status with ARDS and patient underwent multiple proning sessions. Around Day 7, patient was noted to have a protruding tongue that was undergoing excessive swelling. At its worse, the tongue was protruding three to four inches. The tongue was kept wet and covered with gauze. After stabilization, patient finally underwent tracheostomy about three weeks after intubation. Her status stabilized and she was transferred to another hospital for OMFS and ENT evaluation. Patient was treated with lingual compressive wraps as well as dexamethasone to normalization in a couple weeks. DISCUSSION: A review of literature did not show any cases that attributed multiple failed intubation attempts correlating with development of macroglossia. However, there have been some case reports attributing macroglossia to prone positioning. Typically, when macroglossia is of this magnitude, it requires reduction glossectomy by OMFS. However, our patient was treated conservatively with lingual compression wraps and steroids with return of tongue to baseline size making our case unique. CONCLUSIONS: Macroglossia is an extremely rare, yet almost forgotten complication that may be seen in intubated patients. The potential for it to be detrimental for the patient should always be in the back of our minds. REFERENCE #1: D. Saah, I. Braverman, J. Elidan, and B. Nageris, "Traumatic macroglossia," Annals of Otology, Rhinology & Laryngology, vol. 102, no. 9, pp. 729-730, 1993. REFERENCE #2: J. M. DePasse, M. A. Palumbo, M. Haque, C. P. Eberson, and A. H. Daniels, "Complications associated with prone positioning in elective spinal surgery," World Journal of Orthopaedics, vol. 6, no. 3, pp. 351–359, 2015. REFERENCE #3: R. Shanti, H. Braidy, and V. Ziccardi, "Application of maxillomandibular fixation for management of traumatic macroglossia: a case report," Craniomaxillofacial Trauma and Reconstruction, vol. 08, no. 04, pp. 352–355, 2015. DISCLOSURES: No relevant relationships by mohammed halabiya, source=Web Response No relevant relationships by William Meng, source=Web Response No relevant relationships by Richard Miller, source=Web Response No relevant relationships by Sushant Nanavati, source=Web Response No relevant relationships by Shawn Pate, source=Web Response No relevant relationships by Rutwik Patel, source=Web Response

A RARE CASE OF PROGRESSIVE PULMONARY CAVITARY LESIONS

TOPIC: Chest Infections TYPE: Medical Student/Resident Case Reports INTRODUCTION: Recurrent respiratory papillomatosis (RRP) is a rare and often benign condition caused by a human papilloma virus (HPV) infection that results in papilloma growth throughout the respiratory tract. It is placed into 2 categories: juvenile (<18 years) and adult (>18 years) onset. The incidence of juvenile onset RRP (JORRP) is estimated to be 2 cases per 100,000 children. Here, we discuss a case of JORRP in a middle-aged male presenting with recurrent dyspnea and cough. CASE PRESENTATION: A 37-year-old male with a history of JORRP, diagnosed at age 2 with over 50 debulking procedures by the age of 28, presented to the pulmonary clinic with progressive dyspnea and cough. He was noted to be tachycardic with bilateral rales, room air oxygen saturation of 90% and other vital signs stable. Chest radiography revealed patchy ground-glass nodules, cavities and a mass-like opacification in the right lower lobe with air fluid levels. Flexible bronchoscopy revealed diffuse papillomas involving the laryngeal vestibule, glottis, subglottis and trachea down to carina as well as evidence of pus in his left mainstem bronchus. Treatment with antibiotics for post obstructive pneumonia resulted in symptomatic improvement. Weeks later, he represented with similar symptoms and was retreated for post obstructive pneumonia. Computed tomography (CT) chest revealed multiple bilateral peribronchovascular cavitary lesions, scattered solid nodules, dense airspace consolidation in the bilateral lower lobes and bulky bilateral subcarinal lymphadenopathy. Imaging was consistent with RRP but also concerning for infection or malignant transformation to squamous cell carcinoma (SCC). CT-guided lung biopsy showed squamous papilloma with areas of necrosis and rare foci suspicious for invasion. Given concern for malignant transformation, repeat biopsy revealed mild to moderate dysplasia but no evidence of invasion. PET-CT to evaluate for malignancy was recommended following completion of antibiotics. DISCUSSION: JORRP is an acquired infection that occurs during vaginal delivery with symptoms of respiratory obstruction starting in childhood. Dysphonia is commonly noted due to papilloma growth on the vocal cords disrupting normal vibration. It is primarily managed by surgical resection including micro-debridement and laser resection. Adjuvant therapies include interferon alpha, antivirals and bevacizumab. Malignant transformation of RRP into invasive SCC is reported to be 3-7% in adults and thought to be from a mutation in the HPV viral genome. CONCLUSIONS: JORRP is the most aggressive form of RRP with no curative therapy. Diagnosis is established by laryngoscopy and first seen in the vocal folds. Post-obstructive pneumonia and malignant transformation to SCC should always be considered given the nature of RRP. REFERENCE #1: Fortes, H. R et al.(2017).Recurrent respiratory papillomatosis:A state-of-the-art review. Resp. Medicine,126,116-121. REFERENCE #2: Ivancic, R. et al. (2018). Current and future management of recurrent respiratory papillomatosis. Laryngoscope Investigative Otolaryngology, 3(1), 22-34. REFERENCE #3: Karatayli-Ozgursoy, S. et al. (2015). Risk factors for dysplasia in recurrent respiratory papillomatosis in an adult and pediatric population. Annals of Otology, Rhinology & Laryngology, 125(3), 235-241. DISCLOSURES: No relevant relationships by Kathy Chan, source=Web Response No relevant relationships by George Moran, source=Web Response No relevant relationships by Sudhir Rajan, source=Web Response No relevant relationships by Eduardo Solbes, source=Web Response

The Relationship Between Open Access Article Publishing and Short-Term Citations in Otolaryngology.

The purpose of this study is to compare the number of citations received by open access articles versus subscription access articles in subscription journals in the Otolaryngology literature. Using the Dimensions research database, we examined articles indexed to PubMed with at least 5 citations published in 2018. Articles were included from Otolaryngology-Head and Neck Surgery, The Laryngoscope, JAMA Otolaryngology-Head and Neck Surgery, Annals of Otology, Rhinology, and Laryngology, and American Journal of Otolaryngology. Multivariate Poisson regression modeling was used to adjust for journal, article type, and topic. Practice guidelines, position statements, or retractions were excluded as potential outliers. 137 open access articles and 337 subscription access articles meeting inclusion criteria were identified, with a median citation number of 8 (IQR 6-11). The most common article type was original investigation (82.5%), and the most common study topic was head and neck (28.9%). Open access articles had a higher median number of citations at 9 (IQR 6-13) when compared to subscription access articles at 7 (IQR 6-10) (P = .032). Open access status was significantly associated with a higher number of citations than subscription access articles when adjusting for journal, article type, and topic (β = .272, CI 0.194-0.500, P < .001). Although comprising a minority of articles examined in this study of subscription journals, open access articles were associated with a higher number of citations than subscription access articles. Open access publishing may facilitate the spread of novel findings in Otolaryngology.

In Memoriam: Ugo Fisch March 3, 1931 to December 12, 2019

In Memoriam: Ugo Fisch March 3, 1931 to December 12, 2019

Factors Correlating to Burnout among Otolaryngology Residents.

Physicians have high rates of burnout with an Otolaryngology burnout rate of 42%. The most studied burnout correlation is increased work hours. More recently, mindfulness training programs have been shown to decrease burnout and increase self-compassion. Regarding burnout studies specific to Otolaryngology residents, there have been few in the past decade. This study explores correlations between burnout and procedure involvement, non-clinical responsibilities and mindfulness practices along with gathering updated work hours data. A single survey question was shown to be a reliable substitute for Maslach Burnout Inventory in assessing burnout. A survey was sent to all US Otolaryngology residents to investigate the correlation of burnout to post-graduate year, work hours, procedure involvement, non-clinical responsibilities, and mindfulness practices. Residents were asked to answer questions regarding their previous year of training. Overall burnout was 50%. PGY-1 and PGY-5 were completed with a low burnout rate compared to other years. Increased work hours were confirmed to increase burnout. Increased involvement in procedures, decreased exercise, and increased time completing paperwork correlated with increased burnout. No other factors including mindfulness correlated with increased or decreased burnout. However, only 20% who practiced mindfulness training had this training offered by their department or university. Annals of Otology, Rhinology & Laryngology A 50% burnout rate is a concerning rate. Increased work hours and PGY-2 through PGY-4 correlated with increased burnout. Accessibility to mindfulness training was low. As mindfulness training is a proven activity to decrease burnout, more departments could benefit from providing these experiences to their residents.

Editorial introductions

Current Opinion in Otolaryngology & Head and Neck Surgery was launched in 1993. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The fields of otolaryngology and head and neck surgery are divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Section Editors for this issue. SECTION EDITORS Piero NicolaiFigurePiero Nicolai was born in Mantua, Italy, on November 12, 1954. He is Professor and Chairman of the Otorhinolaryngology – Head and Neck Surgery Unit and Director of the Department of Surgical Specialties, Radiologic Sciences, and Public Health of the University of Brescia, Italy. He received his MD degree at the University of Padua, Italy, where he also completed his residency programme in otolaryngology and subsequently in medical oncology. His clinical and research activities are mainly focused on head and neck oncology and endoscopic sinus and skull base surgery. Prof. Nicolai is an active member of several medical societies: Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Società Italiana del Basicranio, European Skull Base Society, American Academy of Otolaryngology – Head and Neck Surgery, European Rhinologic Society, European Laryngological Society, American Head and Neck Society, American Rhinologic Society, American Laryngological Association, Cartesian Society, European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, Associazione Italiana Oncologia Cervico Cefalica, and Italian Academy of Rhinology. He is currently serving as Secretary of the European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery and as Member of the Executive Committee of the European Skull Base Society. In 2009, he was awarded the American Academy of Otolaryngology-Head and Neck Surgery Honor Award in recognition of his volunteer contributions to the Academy and its Foundation. Prof. Nicolai has authored or co-authored 178 papers in peer-reviewed journals as well as 49 book chapters. He was co-Editor of a book on Imaging in Treatment Planning for Sinonasal Diseases, and Editor of 4 issues of Current Opinion in Otolaryngology & Head and Neck Surgery on Head and Neck Oncology. He is a member of the editorial board of 5 journals: Annals of Otology, Rhinology & Laryngology, Current Opinion in Otolaryngology & Head and Neck Surgery, Head & Neck, International Journal of Head and Neck Surgery, and The Laryngoscope. Cesare PiazzaFigureCesare Piazza is Assistant Professor of the Department of Otorhinolaryngology – Head and Neck Surgery at the University of Brescia, Italy. He received his MD degree at the University of Pavia, Italy and completed his residency programme in Otolaryngology in Brescia. His clinical and research activities are focused on head and neck oncology, with special emphasis to laryngeal, tracheal, oral (including laser and robotic surgery), and reconstructive microsurgery. Dr Piazza has been an active member of the European Laryngological Society since 2000 and part of its Scientific Council since September 2010. He has been a member of the European Board of Examination for Otorhinolaryngology – Head and Neck Surgery since November 2011. He has authored or co-authored 89 papers in peer-reviewed journals as well as 69 book chapters. He has delivered 605 papers and invited lectures in national and international congresses and courses. He has served as Section Editor of the Current Opinion in Otolaryngology & Head and Neck Surgery journal for the Head and Neck Oncology issue since 2010 and as a member of its Editorial Board since 2013.

Comparison of Titanium vs. Polycel Total Ossicular Replacement Prosthesis.

Even though modern technology progresses so rapidly, annals of otology are replete with so many challenging article, which often compare various types of prosthesis. Since there has not been a prospective randomized clinical trial study which compares the hearing result of total ossicular replacement prosthesis made of Titanium with omega connector and Polycel in the literature, we decided to perform a study encompassing this issue. 105 patients, who were in the 2nd stage of their operation and who needed total ossicular replacement prosthesis, were included in this prospective single blind randomized clinical trial study. Patients were classified in two groups: titanium Kurz (TTP™ -Vario system, Kurz GmbH, Dusslingen, Germany) with omega connector and Polycel (Sheehy Plastipore Polycel, Medtronic Xomed Inc). The duration of the follow up was 6-12 months. In order to evaluate hearing results, pure tone audiometric in 0.5, 1, 2, and 4 kHz were checked. In addition, speech reception threshold was recorded. A successful surgery was defined as having a postoperative air-bone gap within 20 dB. We accomplished successful hearing in 64.4% of patients with titanium and 65% of patients with a Polycel prosthesis.Improvement in speech reception threshold was 11.5 dB in the titanium group and 13 dB in the Polycel group. In other words, there was no significant difference between the two groups. In addition, air-bone gap improvement after ossiculoplasty was 11.2 dB in the patients with a titanium prosthesis and 12.4 dB in the Polycel group. In fact, the difference was not significant. We found that both the titanium and the Polycel prosthesis improve speech reception threshold and air-bone gap closure in a similar manner.

Editorial introductions

Current Opinion in Otolaryngology & Head and Neck Surgery was launched in 1993. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The fields of otolaryngology and head and neck surgery are divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Section Editors for this issue. SECTION EDITORS Piero NicolaiPiero NicolaiPiero Nicolai was born in Mantua, Italy, on November 12, 1954. He is Professor and Chairman of the Otorhinolaryngology – Head and Neck Surgery Unit and Director of the Department of Surgical Specialties, Radiologic Sciences, and Public Health of the University of Brescia, Italy. He received his MD degree at the University of Padua, Italy, where he also completed his residency programme in otolaryngology and subsequently in medical oncology. His clinical and research activities are mainly focused on head and neck oncology and endoscopic sinus and skull base surgery. Prof. Nicolai is an active member of several medical societies: Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Società Italiana del Basicranio, European Skull Base Society, American Academy of Otolaryngology - Head and Neck Surgery, European Rhinologic Society, European Laryngological Society, American Head and Neck Society, American Rhinologic Society, American Laryngological Association, Cartesian Society, European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, Associazione Italiana Oncologia Cervico Cefalica, and Italian Academy of Rhinology. He is currently serving as Secretary of the European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery and as Member of the Executive Committee of the European Skull Base Society. In 2009, he was awarded the American Academy of Otolaryngology - Head and Neck Surgery Honor Award in recognition of his volunteer contributions to the Academy and its Foundation. Prof. Nicolai has authored or co-authored 178 papers in peer-reviewed journals as well as 49 book chapters. He was co-Editor of a book on Imaging in Treatment Planning for Sinonasal Diseases, and Editor of 4 issues of Current Opinion in Otolaryngology & Head and Neck Surgery on Head and Neck Oncology. He is a member of the editorial board of 6 journals: Annals of Otology, Rhinology & Laryngology, Current Opinion in Otolaryngology & Head and Neck Surgery, Head & Neck, International Journal of Head and Neck Surgery, and The Laryngoscope. Cesare PiazzaCesare PiazzaCesare Piazza is Assistant Professor of the Department of Otorhinolaryngology – Head and Neck Surgery at the University of Brescia, Italy. He received his MD degree at the University of Pavia, Italy and completed his residency programme in otolaryngology in Brescia. His clinical and research activities are focused on head and neck oncology, with special emphasis to laryngeal, tracheal, oral (including laser and robotic surgery), and reconstructive microsurgery. Dr Piazza has been an active member of the European Laryngological Society since 2000 and part of its Scientific Council since September 2010. He has been a member of the European Board of Examination for Otorhinolaryngology – Head and Neck Surgery since November 2011. He has authored or co-authored 80 papers in peer-reviewed journals as well as 66 book chapters. He has delivered 524 proffered papers and invited lectures in national and international congresses and courses. He has served as Section Editor of the Current Opinion in Otolaryngology & Head and Neck Surgery journal for the Head and Neck Oncology issue since 2010 and as a member of its Editorial Board since 2013.

Editorial introductions

Current Opinion in Otolaryngology & Head and Neck Surgery was launched in 1993. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The fields of otolaryngology and head and neck surgery are divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Section Editors for this issue. SECTION EDITORS Piero NicolaiPiero NicolaiPiero Nicolai, MD is Professor and Chairman of the Otorhinolaryngology – Head and Neck Surgery Unit and Director of the Department of Surgical Specialties, Radiologic Sciences, and Public Health at the University of Brescia, Italy. He received his MD degree at the University of Padua, Italy, where he also completed his residency programme in Otolaryngology and subsequently in Medical Oncology. His clinical and research activities are mainly focused on head and neck oncology and endoscopic sinus and skull base surgery. Prof. Nicolai is an active member of several medical societies: Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Società Italiana del Basicranio, European Skull Base Society, American Academy of Otolaryngology - Head and Neck Surgery, European Rhinologic Society, European Laryngological Society, American Head and Neck Society, American Rhinologic Society, American Laryngological Association, Cartesian Society, European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, Associazione Italiana Oncologia Cervico Cefalica, and Italian Academy of Rhinology. He is currently serving as Secretary of the European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery and as member of the Executive Committee of the European Skull Base Society. In 2009, he was awarded the American Academy of Otolaryngology-Head and Neck Surgery Honor Award in recognition of his volunteer contributions to the academy and its foundation. Prof. Nicolai has authored or co-authored 160 papers in peer-reviewed journals as well as 49 book chapters. He was co-editor of a book on Imaging in Treatment Planning for Sinonasal Diseases, and Editor of three issues of Current Opinion in Otolaryngology & Head and Neck Surgery on Head and Neck Oncology. He is a member of the editorial board of five journals: Annals of Otology, Rhinology & Laryngology, Current Opinion in Otolaryngology & Head and Neck Surgery, Head & Neck, International Journal of Head and Neck Surgery, and The Laryngoscope. Cesare PiazzaCesare PiazzaCesare Piazza, MD is Assistant Professor of the Department of Otorhinolaryngology – Head and Neck Surgery at the University of Brescia, Italy. He received his MD degree at the University of Pavia, Italy, and he completed his residency programme in Otolaryngology in Brescia. His clinical and research activities are focused on head and neck oncology, with special emphasis to laryngeal, tracheal, oral, and reconstructive surgery. Dr Piazza is an active member of the European Laryngological Society since 2000 and part of its Scientific Council since September 2010. He is member of the European Board of Examination for Otorhinolaryngology – Head and Neck Surgery since November 2011. He authored or co-authored 70 papers in peer-reviewed journals as well as 63 book chapters. He delivered 443 proffered papers and invited lectures in national and international Congresses and Courses. He serves as Editor of the Current Opinion in Otolaryngology & Head and Neck Surgery journal for the Head and Neck Oncology issue since 2010 and is member of its Editorial Board since 2013.

Changing the Direction of Sleep Medicine: Business can Boom, but it is Not as Usual

Changing the Direction of Sleep Medicine: Business can Boom, but it is Not as Usual

Editorial introductions

Current Opinion in Otolaryngology & Head and Neck Surgery was launched in 1993. It is one of a successful series of review journals whose unique format is designed to provide a systematic and critical assessment of the literature as presented in the many primary journals. The fields of otolaryngology and head and neck surgery are divided into 11 sections that are reviewed once a year. Each section is assigned a Section Editor, a leading authority in the area, who identifies the most important topics at that time. Here we are pleased to introduce the Journal's Section Editors for this issue. SECTION EDITORS Piero NicolaiPiero NicolaiPiero Nicolai, MD is Professor and Chairman of the Otorhinolaryngology – Head and Neck Surgery Unit; and Director of the Department of Surgical Specialties, Radiologic Sciences, and Public Health at the University of Brescia, Italy. He received his MD degree at the University of Padua, Italy, where he also completed his residency programme in otolaryngology and subsequently in medical oncology. His clinical and research activities are mainly focused on head and neck oncology and endoscopic sinus and skull base surgery. Prof. Nicolai is an active member of several medical societies: Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Società Italiana del Basicranio, European Skull Base Society, American Academy of Otolaryngology-Head and Neck Surgery, European Rhinologic Society, European Laryngological Society, American Head and Neck Society, American Rhinologic Society, American Laryngological Association, Cartesian Society, European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, Associazione Italiana Oncologia Cervico Cefalica, and Italian Academy of Rhinology. He is currently serving as Secretary of the European Academy of Oto-Rhino-Laryngology, Head and Neck Surgery and as member of the Executive Committee of the European Skull Base Society. In 2009, he was awarded the American Academy of Otolaryngology-Head and Neck Surgery Honor Award in recognition of his volunteer contributions to the Academy and its Foundation. Prof. Nicolai has authored or co-authored 149 papers in peer-reviewed journals as well as 46 book chapters. He was co-editor of the book Imaging in Treatment Planning for Sinonasal Diseases, and Section Editor of three issues of Current Opinion in Otolaryngology & Head and Neck Surgery for the Head and Neck Oncology section. He is a member of the editorial board of five journals: Annals of Otology, Rhinology & Laryngology, Current Opinion in Otolaryngology & Head and Neck Surgery, Head & Neck, International Journal of Head and Neck Surgery, and The Laryngoscope. Cesare PiazzaCesare PiazzaCesare Piazza, MD is Assistant Professor of the Department of Otorhinolaryngology – Head and Neck Surgery at the University of Brescia, Italy. He received his MD degree at the University of Pavia, Italy, and he completed his residency programme in otolaryngology in Brescia. His clinical and research activities are focused on head and neck oncology, with special emphasis to laryngeal, tracheal, oral, and reconstructive surgery. Dr Piazza has been an active member of the European Laryngological Society since 2000 and part of its Scientific Council since September 2010. He has been a member of the European Board of Examination for Otorhinolaryngology – Head and Neck Surgery since November 2011. He has authored or co-authored 63 papers in peer-reviewed journals as well as 63 book chapters. He delivered 362 proffered papers and invited lectures in national and international congresses and courses. He serves as Section Editor of the Current Opinion in Otolaryngology & Head and Neck Surgery journal for the Head and Neck Oncology issue since 2010 and is a member of its Editorial Board since 2013.

Measurable Progress in Female Authorship in Otolaryngology

To identify contemporary trends in female authorship in the otolaryngology literature. Analysis of 4 otolaryngology journals. All articles published in Annals of Otology, Rhinology and Laryngology, Archives of Otolaryngology-Head and Neck Surgery, Laryngoscope, and Otolaryngology-Head and Neck Surgery in 2008 were reviewed and compared with prior data from 1978, 1988, and 1998. Each published article's authorship panel was examined for the number of authors and each author's sex, degree, and the subspecialty area of publication. Year-to-year comparisons were conducted for the rates and characteristics of female authorship. A total of 544, 629, 713, and 785 articles from 1978, 1988, 1998, and 2008, respectively, were analyzed. From 1998 to 2008, the overall percentage of female authors increased from 14.5% to 22.5% (P < .001). Similarly, the percentage of articles with a female first author increased from 12.9% to 21.3% (P < .001). Whereas previously pediatric otolaryngology had the highest female first author percentage (range, 6.9%-19.4%), in 2008 all other subspecialties demonstrated significant increases in female first author percentages: otology (18.6%), general (22.3%), head and neck (22.2%), plastics (18.9%), and pediatrics (19.4%) (P = .885). A significant number of female first authors continue to be nonphysicians (19.2% in 2008, P < .001). Female authorship has shown significant and steady increases in the otolaryngology literature, particularly in the past decade. Increased rates of publication from female otolaryngologists within most subspecialties have resulted in similar rates of publication across the subspecialties.

Finite element modelling of the insertion of an electrode array into the cochlear scala tympani with lubricant

Cochlear implants, consisting of electrode arrays for electrically stimulating the auditory nerve fibres, have been developed to restore hearing for profoundly deaf people. The insertion of a straight electrode array into the spiral cochlear scala tympani has unfortunately been found to damage delicate structures within the inner ear, such as the spiral ligament and the basilar membrane. Although a number of studies suggested the use of lubricant for smooth insertion, little attempt has been made to quantify the effect of lubricant on the damage by the electrode array to the cochlear structures. We develop a mathematical model, using the finite element method, to predict the trajectories of the Nucleus standard straight electrode array during insertion into the scala tympani, and associated contact stresses exerted by the array on the cochlear structures. Results from the model show that the use of a lubricant, such as glycerine, reduces the contact stresses exerted by the tip of the array on the spiral ligament from 0.31 to 0.2MPa, whereas the contact stresses on the basilar membrane reduce from 0.075MPa (without lubricant) to 0.025MPa (with lubricant). These results suggest that the use of a lubricant is clinically important for minimising the likelihood of damage by the electrode array to the cochlear structures. References B. K. Chen, G. M. Clark, and R. Jones. Evaluation of trajectories and contact pressures for the straight nucleus cochlear implant electrode array --- a two-dimensional application of finite element analysis. Medical Engineering and Physics, 25:141--147, 2003. doi:10.1016/S1350-4533(02)00150-9. G. M. Clark. Cochlear implants --- Fundamentals and Applications. Springer-Verlag, New York, 2003. L. T. Cohen, J. Xu, S. A. Xu, and G. M. Clark. Improved and simplified methods for specifying positions of the electrode bands of a cochlear implant array. American Journal of Otology, 17:859--865, 1996. H. N. Kha and B. K. Chen. Determination of frictional conditions between electrode array and endosteum lining for use in cochlear implant models. Journal of Biomechanics, 39(9):1752--1756, 2006. doi:10.1016/j.jbiomech.2005.04.031. H. N. Kha, B. K. Chen, G. M. Clark, and R. Jones. Stiffness properties for {N}ucleus standard straight and {C}ontour electrode arrays. Medical Engineering and Physics, 26:677--685, 2004. doi:10.1016/j.medengphy.2004.05.001. R. Laszig, G. J. Ridder, and M. Fradis. Intracochlear insertion of electrodes using hyaluronic acid in cochlear implants. Journal of Laryngology Otology, 116:371--372, 2002. doi:10.1258/0022215021910816. E. Lehnhardt. In B. Fraysse and O. Deguine, editors, Cochlear implants: new perspectives, volume 48 of Advances in Otorhinolaryngology, pages 62--64. Karger, Basel, 1993. Noran Engineering Inc. NE/Nastran Version 8.2 User's Manual, 2002. J. J. T. Roland, T. M. Magardino, J. T. Go et al. Effects of glycerine, hyaluronic acid, and hydroxypropyl methylcellulose on the spiral ganglion of the guinea pig cochlea. Annals of Otology, Rhinology and Laryngology Supplement, 166:64--68, 1995. R. K. Shepherd, G. M. Clark, B. C. Pyman, and R. L. Webb. Banded intracochlear electrode array: Evaluation of insertion trauma in human temporal bones. Annals of Otology, Rhinology and Laryngology, 94:55--59, 1985. C. Todd, F. Naghdy, and M. Svehla. Force application during cochlear implant insertion: An analysis for improvement of surgeon technique. IEEE Transactions on Biomedical Engineering, 54(7):1247--1255, 2007. doi:10.1109/TBME.2007.891937. M. Tykocinski, E. Saunders, L. T. Cohen, C. Treaba, R. J. Briggs, P. Gibson, G. M. Clark, and R. S. Cowan. The Contour electrode array: safety study and initial patient trials of a new perimodiolar design. Otology Neurotology, 22:33--41, 2001. P. Wardrop, D. Whinney, S. J. Rebscher, J. T. J. Roland, W. Luxford, and P. A. Leake. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. {I}: comparison of {N}ucleus banded and {N}ucleus {C}ontour electrodes. Hearing Research, 203:54--67, 2005. doi:10.1016/j.heares.2004.11.006.

Audiologists’ Role in Early Diagnosis of Usher Syndrome

Audiologists’ Role in Early Diagnosis of Usher Syndrome

New Bone-Anchored Amplification Options for Children

New Bone-Anchored Amplification Options for Children

Evaluation of a simplified phonetic annotation scheme for disordered speech

Attempts to train a computer to mimic a vocal pathology expert's perception of perceivable voice problems have had limited success. A recent study successfully used a Cepstrum-based calculation (CPPs) to detect dysphonic speech, but it made significant false negative and false positive errors [1]. Appropriate training data could improve calculation accuracy, but logistical and legal issues from the medical domain render large amounts of detailed, consistent training data difficult to produce. A simple scheme has been developed based on labeling one point in time for each of a few vowels in a read statement. Calculations from [1] and [2], centered on neighborhoods of these vowels will augment the CPPs classifier. The annotation scheme will be evaluated with respect to its ability to assist a classifier to automatically predict perceptual labels [1] from data, and practicalities such as inter/intra-annotator agreement. 1. Heman-Ackah, Y.D., Heuer, R.J., Michael, D.D., Ostrowski, R., Horman, M., Baroody, M., Hillenbrand, J.M., and Sataloff, R.T. (2003). "Cepstral peak prominence: A more reliable measure of dysphonia," Annals of Otology, Rhinology, and Laryngology, 112, 324-333. 2. "Perceived Level of Noise by Mark VII and Decibels (E)" S. S. Stevens, J. Acoustical Soc. Am. v. 51(2, part 2) 1972. pp. 575-602.

NADPH Oxidases: New Regulators of Old Functions

Antioxidants & Redox SignalingVol. 8, No. 9-10 Forum EditorialNADPH Oxidases: New Regulators of Old FunctionsKathy K. GriendlingKathy K. GriendlingSearch for more papers by this authorPublished Online:20 Sep 2006https://doi.org/10.1089/ars.2006.8.1443AboutSectionsPDF/EPUB ToolsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited ByTwenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease16 October 2020 | Clinical Science, Vol. 134, No. 19Apocynin and catalase prevent hypertension and kidney injury in Cyclosporine A-induced nephrotoxicity in rats16 April 2020 | PLOS ONE, Vol. 15, No. 4Redox Systems Biology of Nutrition and Oxidative Stress5 April 2019 | The Journal of Nutrition, Vol. 149, No. 4The natural phenolic compounds as modulators of NADPH oxidases in hypertensionPhytomedicine, Vol. 55New Therapies for the Treatment of Renal Fibrosis9 August 2019A Systematic Review on Natural Antioxidant Properties of Resveratrol1 September 2018 | Natural Product Communications, Vol. 13, No. 9Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction24 February 2016 | Basic Research in Cardiology, Vol. 111, No. 2Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome-Derived Platelet HyperactivityOxidative Medicine and Cellular Longevity, Vol. 2016Upregulation of Intermediate-Conductance Ca2+-Activated K+ Channels (KCNN4) in Porcine Coronary Smooth Muscle Requires NADPH Oxidase 5 (NOX5)21 August 2014 | PLoS ONE, Vol. 9, No. 8Potential approaches to reverse or repair renal fibrosis11 February 2014 | Nature Reviews Nephrology, Vol. 10, No. 4Caffeic Acid Phenethyl Ester Inhibits Diesel Exhaust Particle—Induced Inflammation of Human Middle Ear Epithelial Cells via NOX4 Inhibition1 September 2013 | Annals of Otology, Rhinology & Laryngology, Vol. 122, No. 9Environmental Toxicology: Oxidative Stress4 December 2012Molecular and cellular mechanisms of pulmonary fibrosis23 July 2012 | Fibrogenesis & Tissue Repair, Vol. 5, No. 1Cell oxidant stress delivery and cell dysfunction onset in type 2 diabetesBiochimie, Vol. 94, No. 9Diabetic Vascular DiseaseReactive Oxygen Species and Oxidative StressThe Oxidative Function of Diferric TransferrinBiochemistry Research International, Vol. 2012Environmental Toxicology: Oxidative StressMolecular Medicine, Vol. 17, No. 11-12Redox regulation of Nox proteinsRespiratory Physiology & Neurobiology, Vol. 174, No. 3Effect of Early Particulate Air Pollution Exposure on Obesity in MiceArteriosclerosis, Thrombosis, and Vascular Biology, Vol. 30, No. 12NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts19 November 2009 | Journal of the American Society of Nephrology, Vol. 21, No. 1Reactive Oxygen Species, Oxidative Stress, and Hypertension17 August 2010The Role of Oxidative Stress in Endothelial Dysfunction and Vascular InflammationRole of p47 phox in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cellsAmerican Journal of Physiology-Cell Physiology, Vol. 297, No. 6Resveratrol Improves Endothelial FunctionArteriosclerosis, Thrombosis, and Vascular Biology, Vol. 29, No. 8Air pollution and cardiac remodeling: a role for RhoA/Rho-kinaseAmerican Journal of Physiology-Heart and Circulatory Physiology, Vol. 296, No. 5Regulation of NADPH Oxidase in Vascular Endothelium: The Role of Phospholipases, Protein Kinases, and Cytoskeletal Proteins Srikanth Pendyala, Peter V. Usatyuk, Irina A. Gorshkova, Joe G.N. Garcia, and Viswanathan Natarajan24 February 2009 | Antioxidants & Redox Signaling, Vol. 11, No. 4Identification of a Retinal Aldosterone System and the Protective Effects of Mineralocorticoid Receptor Antagonism on Retinal Vascular PathologyCirculation Research, Vol. 104, No. 1Wound healing essentials: Let there be oxygenWound Repair and Regeneration, Vol. 17, No. 1The involvement of reactive oxygen species (ROS) in the cell cycle activation (G 0 -to-G 1 transition) of plant cells28 October 2014 | Plant Signaling & Behavior, Vol. 3, No. 10Radical-free biology of oxidative stressAmerican Journal of Physiology-Cell Physiology, Vol. 295, No. 4Reactive Oxygen Species and Hypertension: A Complex Association Rhian M. Touyz and Ernesto L. Schiffrin28 March 2008 | Antioxidants & Redox Signaling, Vol. 10, No. 6Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype13 March 2008 | Cancer Research, Vol. 68, No. 6NADPH Oxidases, Reactive Oxygen Species, and HypertensionDiabetes Care, Vol. 31, No. Supplement_2The evolution of coenzyme QBioFactors, Vol. 32, No. 1-4 Volume 8Issue 9-10Sep 2006 InformationCopyright 2006, Mary Ann Liebert, Inc.To cite this article:Kathy K. Griendling.NADPH Oxidases: New Regulators of Old Functions.Antioxidants & Redox Signaling.Sep 2006.1443-1445.http://doi.org/10.1089/ars.2006.8.1443Published in Volume: 8 Issue 9-10: September 20, 2006PDF download

Cellular correlates of age-related endocochlear potential reduction in a mouse model

Age-related degeneration of cochlear stria vascularis and resulting reduction in the endocochlear potential (EP) are the hallmark features of strial presbycusis, one of the major forms of presbycusis, or age-related hearing loss (ARHL) (Schuknecht, H.F., 1964. Further observations on the pathology of presbycusis. Archives of Otolaryngology 80, 369–382; Schuknecht, H.F., 1993. Pathology of the Ear. Lea and Febiger, Philadelphia; Schuknecht, H.F., Gacek, M.R., 1993. Cochlear pathology in presbycusis. Annals of Otology, Rhinology and Laryngology 102, 1–16). It is unclear whether there are multiple forms of strial ARHL having different sequences of degenerative events and different risk factors. Human temporal bone studies suggest that the initial pathology usually affects strial marginal cells, then spreads to other strial cell types. While inheritance studies support a moderate genetic influence, no contributing genes have been identified. Establishment of mouse models of strial ARHL may promote the identification of underlying genes and gene/environment interactions. We have found that BALB/cJ mice show significant EP reduction by 19 months of age. The reduction only occurs in a subset of animals. To identify key anatomical correlates of the EP reduction, we compared several cochlear lateral wall metrics in BALBs with those in C57BL/6J (B6) mice, which show little EP reduction for ages up to 26 months. Among the measures obtained, marginal cell density and spiral ligament thickness were the best predictors of both the EP decline in BALBs, and EP stability in B6. Our results indicate that the sequence of strial degeneration in BALBs is like that suggested for humans. Additional strain comparisons we have performed suggest that genes governing strial melanin production do not play a role.

Factors Predicting the Occurrence of Hypothyroidism After Hemithyroidectomy

ThyroidVol. 16, No. 7 Letters to the EditorFactors Predicting the Occurrence of Hypothyroidism After HemithyroidectomyPedro Weslley Rosário, LÚcio Flávio Pereira, Michelle Aparecida Borges, Maria Flávia Alves, and Saulo PurischPedro Weslley RosárioSearch for more papers by this author, LÚcio Flávio PereiraSearch for more papers by this author, Michelle Aparecida BorgesSearch for more papers by this author, Maria Flávia AlvesSearch for more papers by this author, and Saulo PurischSearch for more papers by this authorPublished Online:4 Aug 2006https://doi.org/10.1089/thy.2006.16.707AboutSectionsPDF/EPUB ToolsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail "Factors Predicting the Occurrence of Hypothyroidism After Hemithyroidectomy." , 16(7), p. 707FiguresReferencesRelatedDetailsCited ByRisk factors for hypothyroidism and thyroid hormone replacement after hemithyroidectomy in papillary thyroid carcinoma10 May 2021 | Langenbeck's Archives of Surgery, Vol. 406, No. 4Postoperative thyroid hormone supplementation rates following thyroid lobectomyThe American Journal of Surgery, Vol. 221, No. 4Postoperative thyroid hormone supplementation rates following thyroid lobectomyThe American Journal of Surgery, Vol. 220, No. 5Prevalence of and risk factors for hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis7 July 2020 | Endocrine, Vol. 70, No. 2Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinionArchives of Endocrinology and MetabolismPre-Operative Ultrasound Identification of Thyroiditis Helps Predict the Need for Thyroid Hormone Replacement After Thyroid LobectomyEndocrine Practice, Vol. 19, No. 6Thyroid lobectomy for indeterminate FNA: not without consequencesJournal of Surgical Research, Vol. 184, No. 1Thyroid Hormone Replacement Therapy, Surveillance Ultrasonography, and Fine-Needle Aspiration after Hemithyroidectomy1 July 2013 | Annals of Otology, Rhinology & Laryngology, Vol. 122, No. 7Hemithyroidectomy: A Meta-Analysis of Postoperative Need for Hormone Replacement and ComplicationsORL, Vol. 75, No. 1Decision Analysis of Discordant Thyroid Nodule Biopsy Guideline CriteriaThe Journal of Clinical Endocrinology & Metabolism, Vol. 93, No. 8 Volume 16Issue 7Jul 2006 InformationCopyright 2006, Mary Ann Liebert, Inc.To cite this article:Pedro Weslley Rosário, LÚcio Flávio Pereira, Michelle Aparecida Borges, Maria Flávia Alves, and Saulo Purisch.Factors Predicting the Occurrence of Hypothyroidism After Hemithyroidectomy.Thyroid.Jul 2006.707-707.http://doi.org/10.1089/thy.2006.16.707Published in Volume: 16 Issue 7: August 4, 2006PDF download