AbstractThe relation of plate kinematics to the structural record of arc plutons and their host rocks is complex and still not fully understood. We address this issue through a combination of field mapping, structural analysis, anisotropy of magnetic susceptibility analysis, and fabric modeling in the Late Cretaceous Tuolumne Intrusive Complex, Sierra Nevada, California. A pattern of anti‐clockwise rotation from ∼NNW–SSE to WNW–ESE steep foliations and change in fabric ellipsoid shape from oblate to prolate was revealed in successively emplaced Kuna Crest (∼95–92 Ma), Half Dome (∼92–89 Ma), and Cathedral Peak (∼89–84 Ma) granodiorites. The numerical model indicates that the Kuna Crest was emplaced in a transpressional setting with an angle of convergence α = 60–40°, whereas the Half Dome and Cathedral Peak required simultaneous vertical constriction overprinted by transpression with α = 35–15°. This transition, which occurred at ∼92 Ma, is accompanied by a shallowing of the lineation plunge observed also in other ∼88–84 Ma central Sierra Nevada plutons. Provided that the Cretaceous Sierra Nevada arc was constructed during overall dextral transpression, these transitions reflect significant changes in kinematics, where ∼107–92 Ma plutons were emplaced during pure shear‐dominated transpression, which was followed by a transition to wrench‐dominated transpression recorded in ∼92–84 Ma plutons. Such a transition in kinematics is explained as a result of progressively increasing obliquity of the relative convergence of the Farallon plate subducting beneath the North American continental margin, in agreement with most paleogeographic reconstructions.