Due to the effects of swing motion, the performances and internal flow characteristics of marine centrifugal pump undergo some unsteady variations in the marine environment. The hydraulic test system with six degree of freedom parallel motion platform is established to study the pump performance characteristics at the different heel angles of steady roll position and pitch position. The pump head gradually decreases as heel angle increases. The pump head has decreased by 7% to reach the minimum at the 15° heel angle of roll position. At the same heel angle, the head at the roll position is lower than that at the pitch position under the rated flow condition. The fluid in the impeller passage is subjected to the additional inertial force of roll motion or pitch motion under unsteady swing motion, inducing some flow bias phenomena in the velocity field. The unsteady development of flow velocity induces the intense vortex motion, and the shedding and dissipation of interblade vortices are affected. The periodic flow-induced pulsation characteristics obviously appear in the impeller passage. The pulsation periodicity and pressure amplitude are influenced due to the swing motion. The pitch motion induces the greater hydraulic excitation and fluid-induced vibration amplitude. In addition to the pressure pulsation at the low frequencies, the pulsation amplitude at 20 times the shaft frequency is evident under pitch motion.