Taking a shear wall structure in a high-intensity area of 20 floors as an example, the seismic reduction scheme of the structure was determined, and the Etabs software was used to conduct time history analysis on the seismic and non-seismic structures. The floor shear force, overturning moment, and short-term surface pressure of the isolation support were obtained. The results showed that under frequent earthquake action, the average maximum floor shear force in the X direction of the isolated upper structure was only about 28 % of that of the non-isolated structure. The maximum inter story shear ratio was 0.34, and the maximum floor shear force in the Y direction was only about 25 % of that of the non-isolated structure. The maximum inter story shear ratio was 0.31. The average maximum overturning moment of the upper structure in the X direction after isolation is about 30 % of that of the non-isolated structure. The maximum overturning moment ratio is 0.36, and the average overturning moment of the maximum floor in the Y direction is about 22 % of that of the non-isolated structure. The maximum overturning moment ratio is 0.26. Under rare earthquake action, the maximum inter story displacement angles in the X and Y directions of each floor of the seismic isolation structure are 1/302 and 1/446, respectively. The maximum surface pressure value of the isolation bearing under rare earthquake is 28.9 MPa, the minimum surface pressure value is 5.58 MPa, and the maximum displacement is 579 mm, which meets the requirements of the specifications. Overall, the seismic performance of the seismic isolation structure is good, and the isolation scheme is feasible.