The motion characteristics of Janus in the flow are studied numerically using the lattice Boltzmann method based on the squirmer model. The effects of velocity ratio J on the right and left hemisphere surface of Janus, particle Reynolds number Rep, flow Reynolds number Rec, initial orientation angle φ0 on Janus trajectory, and lateral equilibrium position yeq/H are analyzed. The results showed that, for the motion of Janus in stationary power-law fluids in a channel, Janus moves randomly in a small space in shear-thickening fluids when Rep is low and exhibits three motion modes at Rep = 5. The larger the J value, the easier it is for Janus to reach yeq/H. The higher the Rep, the closer the yeq/H is to the lower wall. In shear-thinning fluids, the motion of Janus exhibits significant randomness at Rep = 0.5 and 1, reaches the same yeq/H at Rep = 2 and 3, and tends toward yeq/H near the centerline and along the upper wall, respectively, at Rep = 4 and 5. For the motion of Janus particles in a channel flow of power-law fluids, in shear-thinning fluids, no matter what value J is, Janus reaches yeq/H on the centerline. The lower the Rep, the closer the yeq/H is to the wall. Two particles move toward yeq/H when Rep ≥ 1. The higher the Rep, the closer the yeq/H is to the centerline. The two particles will exhibit the upstream mode at Rep = 2. Two particles eventually reach yeq/H at different Rec. When φ0 > 0°, the two particles first eventually tend toward yeq/H = 0.2 and 0.8. When the value of φ0 is negative, the larger the absolute value of φ0 and higher the Rep, the more likely particles are to exhibit upstream mode.