The Salares Norte (SN) Au–Ag belt is here defined as an Upper Miocene-Pliocene metallogenic area, extending for nearly 200 km, located NE of the northern end of the Upper Oligocene-Lower Miocene Maricunga Belt in the central Andes of northern Chile. The belt is located just east of the main reverse NS fault systems which are part of the Sierra Castillo, Potrerillos Mine and Claudio Gay Cordillera faults, limited to the north and south by the NW-striking oblique to the arc Imilac and Wheelwright-Incahuasi regional faults systems.The epithermal deposits within the SN belt are intimately associated with the occurrence of Middle Miocene volcaniclastic basins and Middle to Upper Miocene phreatomagmatic vents and their related high-sulfidation hydrothermal systems. The volcanostratigraphy of the SN epithermal belt comprises volcaniclastic sequences, subvolcanic and volcanic rocks ranging between the Lower Miocene and the Pliocene. High-angle NS reverse faults involving Paleozoic and lower Cenozoic units form the western-southwestern limit of the belt. Folded and faulted Middle Miocene volcaniclastic and volcanic sequences form the main host rock of at least 4 phreatomagmatic events that generated maar-diatreme fields and discrete maar vents, with their related subvolcanic facies, within the widespread Upper Cenozoic volcanic arc, ranging in age between ca. 15 and ca. 4 Ma. These four phreatomagmatic events are spatially and temporarily associated to 4 main high-sulfidation hydrothermal events which have altered both the phreatomagmatic rocks and the Cenozoic country rock of the explosive activity. These hydrothermal systems have formed dozens of discrete hydrothermally altered areas where argillic, advance argillic, silicification and steam-heated alteration are common. Most of the maar fields and the hydrothermal alteration systems are emplaced within a strike-slip tectonic regime with NE-trending shortening which is accommodated in the NW-striking sinistral-normal faults and NE-striking extension structures. These fault systems crosscutting interaction favor the hydrothermal fluid circulation and migration, as well as mineral precipitation on structural and/or primary lithological traps and on NE-striking tension cracks.In summary, the SN epithermal belt is an almost 200 km long and 60 km wide area, mainly NNE-oriented, where epithermal deposits have formed during the Upper Miocene and Pliocene (ca. 13-4 Ma), emplaced within Middle to Upper Miocene volcanic and volcaniclastic sequences associated to small volcanotectonic basins oriented in NS, NE-SW and NW-SE directions, in which most of the high-sulfidation systems are associated to discrete or repetitive structurally-controlled Upper Miocene-Pliocene phreatomagmatic vents and maar fields.