The restrictions during COVID-19 seem to have had an unequal impact on the mental health and habits of the population in terms of gender. The literature states that crises such as this have a more negative impact on women. We explored perceived overload due to household chores and informal caregiving in a sample of Andalusian women, their perception of an increase in this overload after the pandemic, and its possible effect on mental health. To do this, we administered an online retrospective questionnaire to explore the perception of 166 women on care economy variables by estimating hours, effort, overload, and sharing of chores at three different times: before the onset of the pandemic, during lockdown, and at the time of data collection (one year after lockdown). We also measured depression, anxiety, stress, and life satisfaction at the time of data collection through validated scales. Results showed that women estimated significantly more time and effort on household chores and caregiving for the lockdown period. The retrospective estimation of the sharing of tasks was similar over the three moments but women perceived that they did more than their heterosexual partners. One in four women perceived an increase in caregiving overload after the pandemic. Women who felt mental overload due to caregiving scored higher in depression than those who felt physical overload. Considering these findings, and despite the limitations of this study, the pandemic may have led to an increase in informal caregiving overload for many women. Furthermore, the relation between depression and overload one year after lockdown was demonstrated. Measures are required to reduce the impact of gender in crises by designing prevention policies and programs that promote co-responsibility.