Abstract The life and contributions of Pandit Kabiraj Dr. Ananta Tripathy Sharma, a luminary in the field of Ayurveda, unfold in a multifaceted narrative that encompasses his ancestral roots, educational journey, professional achievements, political endeavors, and enduring legacy. Born on February 10, 1905, in Jagannathapur Sasana, Odisha, Pandit Kabiraj Dr. Ananta Tripathy Sharma’s family lineage, deeply entrenched in Ayurvedic traditions, guided him toward a career dedicated to ancient healing art. In his early years, influenced by his grandfather, Pandit Kabiraj Dr. Ananta Tripathy Sharma’s commitment to Ayurveda became the cornerstone of his professional journey. His academic pursuits began in Sanskrit and culminated in the prestigious “Sahitya Shiromani” degree in 1925. However, it was his later immersion in Ayurveda that defined the trajectory of his life. Beyond academic achievements, Pandit Kabiraj Dr. Ananta Tripathy Sharma ventured into social reform, notably challenging the prevalent practice of child marriage. His collaboration with like-minded individuals led to the formation of the Sanskaraka group, advocating against early marriage for girls. Post-independence, their efforts bore fruit, contributing to the repeal of the Sarada Act 1929. His commitment to making Ayurveda accessible led to the establishment of dispensaries in different parts of Odisha and the expansion of the “Bheshaja Mandir,” a pharmacy established by him. His foray into politics, driven by a commitment to Ayurveda, saw him elected as a Member of the Legislative Assembly and later as a Member of Parliament, where he championed the cause of Ayurveda at both state and national levels. A significant chapter in his legacy unfolded with the establishment of the Kaviraj Ananta Tripathy Sharma Ayurveda College and Hospital in Brahmapur. Driven by his unwavering commitment, he overcame challenges to realize his vision and the institution stands as a living tribute to his dedication to Ayurveda. His literary pursuits included impactful books in both Sanskrit and Odia, reflecting his versatile talents. Awards and distinctions adorned his illustrious career, recognizing his expertise in Ayurveda and literature. His principles, deeply rooted in Dharma, guided his approach to healing, emphasizing the importance of treating rich and poor patients alike. In his later years, despite his poor vision, Pandit Kabiraj Dr. Ananta Tripathy Sharma persisted in translating Ayurvedic texts for the benefit of future generations.