Healthcare, like many other industries, has been significantly influenced by big data and predictive analytics. The vast volume, velocity, and variety of information within big data sets have transformed the way we approach patient care and medical innovation. From predicting disease outbreaks to delivering personalized treatment plans, big data analytics offers immense potential for revolutionizing healthcare. This review explores the significant impact of big data and predictive analytics on the U.S. healthcare system. It delves into hospitals' ability to effectively leverage complex information and assess the potential benefits they may reap from successful implementation. The introduction defines big data and predictive analytics in the context of healthcare and outlines the paper's objectives. It further discusses the evolution of big data and analytics in healthcare, its key applications, and the challenges it presents. Additionally, we explore potential solutions and ethical considerations surrounding big data analytics in healthcare. Overall, this paper underscores the transformative power of big data and predictive analytics in revolutionizing U.S. healthcare delivery and improving patient outcomes.