In this work, the structural geology and the tectonic conditions of the Zagros orogeny along the route of Qom to Kermanshah cities were investigated using the combined geophysical methods of the airborne magnetometry and the ground-based gravity data. Airborne magnetometry data of Iran with a line space of survey, 7.5km, were used to model the magnetic susceptibility property along the route. At first, the airborne magnetic data were stably 500-m downward continued to the ground surface in order to enhance minor changes of the Earth’s magnetic field over the studied region. Afterward, 3D inverse modeling of the magnetic data was implemented to the downward continued data, and subsequently the section of magnetic susceptibility variation along the desired route was extracted and imaged at depth. The acquired model could appropriately predict the observed magnetic data, showing low misfit values between the observation and the predicted data. The analytic signal filter was applied to the reduced-to-pole (RTP) magnetic data leading to the determination of the active and probable hidden faults in the structural zones of the Zagros, such as Sanandaj-Sirjan, Central Domain (CD) and Urumieh-Dokhtar based upon the generated peaks along the profile of analytic signal filter. In addition, the density variations of the subsurface geological layers were determined by 3D inverting of the ground-based gravity data over the whole study area, and extracting this property along the route. The joint models of magnetic susceptibility and density variation could appropriately localize the traces of faults along with the geologically and tectonically structural boundaries in the region. The locations of faults correspond well to the variation of geophysical parameters on the inverted sections. Probable direction, slope and extension at depth of these faults were also determined on the sections, indicating a high tectonized zone of the Sanandaj-Sirjan Zone (SSZ) parallel to the zone of the Urumieh-Dokhtar Magmatic Assemblage (UDMA). The UDMA zone increases the magnetic and the Bouguer anomalies by intruding into the CD zone as well.