Analysis Workstation Research Articles

Validation of a Recently Developed Fluoroscopic Video Analysis Workstation (Radwisp™) for the Reliable Diagnosis of Acute Pulmonary Thromboembolism.

Objective Radwisp™ is a fluoroscopic video analysis workstation recently developed to evaluate pulmonary circulation, thereby obviating the need for contrast medium or breath-holding. This study validated Radwisp as a diagnostic tool for acute pulmonary embolism (APE) and evaluated its potential utility in patients with symptoms of suspected APE. Methods The study included 10 patients (mean age, 69±16 years old) who were admitted to our hospital for suspected APE based on symptoms and physical examination findings between January 2020 and April 2021. Contrast-enhanced computed tomography (CT) and cineradiography, based on standard radiographs for the creation of a Radwisp image, were performed on the same day. Of the 10 cases of suspected APE, 7 were definitively diagnosed by CT with APE, and 3 were definitively diagnosed as not having APE. Fifty physicians (25 cardiologists and 25 residents) were blinded to patient information and CT images and asked to diagnose the presence of APE based solely on the Radwisp images. Results A total of 250 diagnoses were made by cardiologists and 250 by residents. Among the cardiologists, the sensitivity and specificity of the Radwisp-based analysis were 91% and 48%, respectively, and the positive and negative predictive values were 80% and 69%, respectively. Among the residents, the sensitivity and specificity were 88% and 35%, respectively, and the positive and negative predictive values were 76% and 55%, respectively. Conclusion This study showed an initial validation of Radwisp for diagnosing APE, revealing a high sensitivity but not yet achieving a high specificity. Further studies with a larger number of cases are needed to thoroughly evaluate the diagnostic performance.

Changes in epicardial adipose tissue volume before and after cryoballoon ablation in patients with atrial fibrillation: Supporting the “AF begets EAT” theory

BackgroundEpicardial adipose tissue (EAT) is closely associated with atrial fibrillation (AF), suggesting that it may be 1 of the causes of AF progression. However, it is unclear whether AF affects EAT. ObjectiveThis study aimed to demonstrate that sinus rhythm restoration reduces EAT volume (EATV) through left atrial reverse remodeling (LARR). MethodsWe analyzed data from 247 patients who underwent cryoballoon ablation for AF. EATV was assessed by contrast-enhanced computed tomography with a 3-dimensional analysis workstation, evaluating EATV surrounding the entire heart (total-EATV) and left atrium (LA-EATV) at baseline and 6 months after cryoballoon ablation. ResultsAt 6 months, all patients but 1 with persistent AF were in sinus rhythm. Total-EATV and LA-EATV were both significantly decreased in patients with persistent AF (n = 33; total-EATV: 148.8 ± 53.3 mL to 142.9 ± 53.5 mL [P = .01]; LA-EATV: 26.8 ± 11.3 mL to 25.2 ± 10.7 mL [P = .01]). No changes were observed in patients with paroxysmal AF (n = 214). Persistent AF was more strongly associated with LARR than paroxysmal AF (odds ratio, 2.34; 95% confidence interval, 1.01–5.44; P = .05). LARR showed an independent correlation with both total-EATV and LA-EATV reduction (odds ratio, 1.78 [P = .04] and 2.80 [P < .001], respectively). ConclusionThese findings suggest a novel “AF begets EAT” theory, complementing the previously accepted role of EAT as a cause of AF and supporting the “AF begets AF” mechanism.

New Assessment Method of Alveolar Bone Grafting Using Automatic Registration and AI-based Segmentation.

The aim of this Technical note is to present a new assessment method of alveolar bone grafts after secondary alveolar bone grafting using automatic registration and artificial intelligence (AI)-based segmentation. A total of 7 Japanese patients (4 men and 3 women) with a unilateral cleft lip, alveolus, and/or palate, who underwent secondary alveolar bone grafting between March 2021 and August 2022 were evaluated. Computed tomography (CT) analyses were performed about 1 month before the surgery, and 1 day and 6 months after the surgery. All CT images were imported into a 3-dimensional analysis workstation. CT images from after the surgery were superimposed onto CT images from before the surgery, by automatic rigid image registration. The segmentation of bone tissues was automatically performed by the AI-based function. Grafted bone was extracted by subtraction of the bone tissue after the surgery from the bone tissue before the surgery. The volumes and Hounsfield units (HUs) of the grafted bones were calculated. The intraclass correlation coefficient (ICC) was reviewed to assess inter-rater reliability. The ICCs (2,1) of the volumes and HUs measured by the observers immediately after the surgery were 0.95 and 0.99, respectively. On the other hand, the ICCs (2,1) of the volumes and HUs measured by the observers 6 months after the surgery were 0.81 and 0.57, respectively. Our new assessment method enables simple and quick evaluation of residual grafted bone after secondary alveolar bone grafting and demonstrated relatively high inter-rater reliability.

Assessment Methods and Intervention Strategies for Cleft-Related Lateral Misarticulation in Chinese-Speaking Children.

The aim of this study was to analyze the characteristics and error speech features of cleft-related lateral misarticulation and provide a basis for clinical evaluation and rational intervention. Participants who were diagnosed with lateral misarticulation after cleft palate repairment were 126 children aged 4, 6 to 16, and 11, and they had complete palatopharyngeal closure, no abnormalities in their speech organs and occlusion, and no hearing or intellectual impairments. The Chinese standard pronunciation clarity word list, the American KAY CSL4500, the Beijing Yangchen YF-16 computer speech analysis workstation, soundproof rooms, Wechsler scales of intelligence-fourth edition, and audiometers were used to evaluate the cleft-related lateral misarticulation. Statistical analysis was performed on the age, gender, error rate, corner of the mouth deviation direction, comorbidity, duration of intervention, period of treatment, and therapeutic effect of concentrated or normal intervention group in different patients. Our results showed that 2 to 3 straight stripes were visible at the onset of consonants /ti:/ /t'i:/, and 3 clear straight lines were visible in /tʂ/, indicating that the lateralized sound had 2 or 3 bursts and lasted for 1 to 2ms. The onset age of lateralized sound was mostly below 12 years old. Chinese lateralized sound mainly occurred in vowel /i:/, and the occurrence rate of consonants with tongue surface /tɕ]/ /tɕ'/ /ɕ/ was the highest. In addition, the corner of the mouth deviation was also an indicator of lateralization sound, and other types of speech disorders mostly accompanied it. There was a significant difference in the improvement of speech clarity between the concentrated intervention group and the normal group before and after treatment. The 2 groups' average duration and course of treatment were not significantly different. Still, the period of concentrated intervention was shortened considerably, and the speech clarity of both groups of children after treatment exceeded 96%, reaching a normal level.

Diagnostic performance of fluoroscopic video analysis for pulmonary embolism: a prospective observational study.

Dynamic chest radiography using X-ray fluoroscopic video analysis has shown potential for the diagnosis of pulmonary embolism (PE), but its diagnostic performance remains uncertain. We aimed to evaluate the diagnostic performance of fluoroscopic video analysis for diagnosing PE. A prospective single-center observational study was conducted between October 2020 and January 2022. Fifty consecutive adult patients, comprising definitive PE, pulmonary hypertension (PH), or suspected PH, were enrolled. The study population was classified into 23 PE and 27 non-PE cases by contrast-enhanced computed tomography, lung scintigraphy, right heart catheterization, and pulmonary angiography. Cineradiographic images of 10-second breath-holds were obtained and analyzed using a fluoroscopic video analysis workstation to generate pulmonary circulation images. Two blinded cardiologists qualitatively assessed the presence or absence of perfusion defects on the pulmonary circulation images. The diagnosis obtained from the fluoroscopic analysis was compared with the definitive diagnosis. The primary outcomes included sensitivity, specificity, positive and negative predictive values, and overall accuracy for diagnosing PE. Perfusion defects were observed in 21 of 23 PE patients and 13 of 27 non-PE patients. The diagnostic performance of fluoroscopic video analysis for diagnosing PE showed a sensitivity of 91%, specificity of 52%, positive predictive value of 62%, negative predictive value of 88%, and overall accuracy of 70%. The high sensitivity of the fluoroscopic video analysis suggests its potential usefulness in ruling out PE without the need for contrast media or radionuclide; however, its specificity and overall accuracy remain limited.

PROFASA-a web-based protein fragment and structure analysis workstation.

Introduction: In the field of bioinformatics and computational biology, protein structure modelling and analysis is a crucial aspect. However, most existing tools require a high degree of technical expertise and lack a user-friendly interface. To address this problem, we developed a protein workstation called PROFASA. Methods: PROFASA is an innovative protein workstation that combines state-of-the-art protein structure visualisation techniques with cutting-edge tools and algorithms for protein analysis. Our goal is to provide users with a comprehensive platform for all protein sequence and structure analyses. PROFASA is designed with the idea of simplifying complex protein analysis workflows into one-click operations, while providing powerful customisation options to meet the needs of professional users. Results: PROFASA provides a one-stop solution that enables users to perform protein structure evaluation, parametric analysis and protein visualisation. Users can use I-TASSER or AlphaFold2 to construct protein models with one click, generate new protein sequences, models, and calculate protein parameters. In addition, PROFASA offers features such as real-time collaboration, note sharing, and shared projects, making it an ideal tool for researchers and teaching professionals. Discussion: PROFASA's innovation lies in its user-friendly interface and one-stop solution. It not only lowers the barrier to entry for protein computation, analysis and visualisation tools, but also opens up new possibilities for protein research and education. We expect PROFASA to advance the study of protein design and engineering and open up new research areas.

Impact of ground glass opacity in a three-dimensional analysis for pathological findings and prognosis in stage IA pure solid lung cancer.

We investigated whether a three-dimensional (3D) analysis could correct the discrepancy between conventional computed tomography findings and pathological findings and contribute to prognostic stratification in early pure solid lung cancer. A total of 370 patients with two-dimensional (2D) pure solid, clinical stage IA non-small cell lung cancer (NSCLC) who underwent complete resection at our hospital between January 2010 and March 2021 were included in the present study. We classified the patients into the 3D solid group and the 3D ground glass opacity (GGO) group according to the consolidation volume/tumor volume ratio (C/T volume ratio) measured using a Synapse Vincent 3D analysis workstation, and compared the pathological findings and prognosis between the two groups. There were 142 (38.4%) patients in the 3D GGO group. Lepidic lesions were significantly more frequent in the 3D GGO group (27.6% vs. 59.2%, P<0.001). Lymphatic invasion, vascular invasion and lymph node metastasis were significantly more frequent in the 3D solid group (52.2% vs. 27.5%, P<0.001; 67.5% vs. 43.0%, P<0.001; 22.3% vs. 11.2%, P=0.04). A Cox proportional hazards multivariate analysis for overall survival (OS) and recurrence-free survival (RFS) showed that 3D solid was an independent poor prognostic factor [hazard ratio (HR): 1.981, P=0.02; HR: 1.815, P=0.02]. Kaplan-Meier curves for 5-year OS (74.1% vs. 87.8%, P<0.001) and 5-year RFS (65.6% vs. 84.9%, P<0.001) showed significant differences between the two groups. The C/T volume ratio determined by a 3D analysis detects GGO and reflects the pathological findings, and further prognostic stratification is possible in early 2D pure solid lung cancer.

Notch-Jagged1 signaling and response to bevacizumab therapy in advanced colorectal cancer: A glance to radiomics or back to physiopathology?

The Notch intracellular domain (NICD) and its ligands Jagged-1(Jag1), Delta-like ligand (DLL-3) and DLL4 play an important role in neoangiogenesis. Previous studies suggest a correlation between the tissue levels of NICD and response to therapy with bevacizumab in colorectal cancer (CRC). Another marker that may predict outcome in CRC is radiomics of liver metastases. The aim of this study was to investigate the expression of NICD and its ligands and the role of radiomics in the selection of treatment-naive metastatic CRC patients receiving bevacizumab. Immunohistochemistry (IHC) for NICD, Jag1 and E-cadherin was performed on the tissue microarrays (TMAs) of 111 patients with metastatic CRC treated with bevacizumab and chemotherapy. Both the intensity and the percentage of stained cells were evaluated. The absolute number of CD4+ and CD8+ lymphocytes was counted in three different high-power fields and the mean values obtained were used to determine the CD4/CD8 ratio. The positivity of tumor cells to DLL3 and DLL4 was studied. The microvascular density (MVD) was assessed in fifteen cases by counting the microvessels at 20x magnification and expressed as MVD score. Abdominal CT scans were retrieved and imported into a dedicated workstation for radiomic analysis. Manually drawn regions of interest (ROI) allowed the extraction of radiomic features (RFs) from the tumor. A positive association was found between NICD and Jag1 expression (p< 0.001). Median PFS was significantly shorter in patients whose tumors expressed high NICD and Jag1 (6.43 months vs 11.53 months for negative cases; p = 0.001). Those with an MVD score ≥5 (CD31-high, NICD/Jag1 positive) experienced significantly poorer survival. The radiomic model developed to predict short and long-term survival and PFS yielded a ROC-AUC of 0.709; when integrated with clinical and histopathological data, the integrated model improved the predictive score (ROC-AUC of 0.823). These results show that high NICD and Jag1 expression are associated with progressive disease and early disease progression to anti VEGF-based therapy; the preliminary radiomic analyses show that the integration of quantitative information with clinical and histological data display the highest performance in predicting the outcome of CRC patients.

Analysis Workstation in Manufacturing Industry using Occupational Repetitive Action (OCRA) Index Method to Reduce Risk of Work-Related Musculoskeletal Disorder

Analysis Workstation in Manufacturing Industry using Occupational Repetitive Action (OCRA) Index Method to Reduce Risk of Work-Related Musculoskeletal Disorder

Creation of Manual for Three-dimensional Image Creation Using a Web Hosting Service

Three-dimensional (3D) images, which are acquired by X-ray computed tomography (CT), are widely used in medical diagnosis and treatment. Recently, advances in image processing functions of 3D image analysis workstations have made it possible to confirm actual procedures, approach lesions from directions that are not visible during surgery, and observe important structures by moving images on the workstation. This is useful in providing a variety of information on the pathology in advance. However, depending on the manipulation of the creator, the 3D images provided can vary greatly in terms of the omission of blood vessels and tumors, the background color, the colors of organs, and the presentation including rotation directions and angles. In this study, we decided to create a manual for 3D image creation using our web hosting service to standardize the 3D images to be provided. In particular, dynamic content using the HyperText Markup Language (HTML) was created and posted to provide a useful support tool for 3D image creation. In addition, the data can be accessed via the Internet within the hospital, making them widely available in clinical and educational settings.

757 Cardio-TC role in patients selection for transcatheter edge to edge tricuspid repair

Abstract Aims Anatomic knowledge of the tricuspid valve (TV) is the first step in the management of patients with tricuspid regurgitation (TR) who are candidates for transcatheter tricuspid valve intervention (TTVI). Echocardiography is undoubtedly the first approach in assessing the aetiology and severity of TR and the size and function of the right chambers. Computed tomography (CT) provides a detailed morphological visualization of the cardiac structures owing to acquisition of 3D data with high spatial resolution. These findings may undoubtedly help in decision-making progress for novel transcatheter therapies. The purpose of the present study was to assess the geometrical changes of the TV complex using CT images, in patients suffering from functional TR and lead-induced TR. Methods The study population consisted of 21 consecutive patients with symptomatic severe TR referred to Policlinico Universitario Campus Biomedico between November 2020 and October 2021. Patients were prospectively included in the study only if they presented severe TR, diagnosed by echocardiography and underwent cardiac CT study dedicated to the right-chambers. The reconstructions were transferred to an external workstation for off-line image analysis. The following measurements were reported: tricuspid annulus area, perimeter, septal–lateral and antero-posterior diameters. Commissures were identified as antero-septal (AS), postero-septal (PS) and anteroposterior (AP). Were measured the inferior vena cava ostium to tricuspid valve centroid distance, anatomic regurgitant orifice area (AROA) and its position respect to the centroid, and the right chambers. Results All 21 patients underwent CT scan using Siemens SOMATOM Definition AS 128 Slice CT Machine. The measurements were calculated off-line using the 3mensio workstation. In our study population, the annulus resulted enlarged in the annulus area, perimeter, septal-lateral and anterior-posterior dimensions. Measurements did not differ significantly, except for the septal-lateral diameter that was smaller in systole (52.80 ± 7.28 mm vs. 47.83 ± 6.83 mm (P=0.027). Also, distances between the commissures were similar except for the AP-AS distance that was shorter in systole (45.26 ± 3.48 mm vs. 42.13 ± 3.73, P=0.007). The AROA resulted to be central in 7 patients, the IVC ostium to TV centroid distance was 23±3 mm. Right chambers and IVC resulted very enlarged in all patients. Conclusions CT provides a complete morphologic imaging of the heart structures, thanks to a high spatial resolution with excellent capacity to define the endocardial border and allows acquisition of three-dimensional data with high spatial resolution of the TV and provides valuable information about the geometric variations of the tricuspid complex in patients with TR. Image quality for analysis should be optimized with specific CT acquisition protocols that focus on the right ventricles.

Kerley A-lines represent thickened septal plates between lung segments in patients with lymphangitic carcinomatosis: confirmation using 3D-CT lung segmentation analysis

PurposeKerley A-lines are generally apparent in patients with pulmonary edema or lymphangitic carcinomatosis. There are two main thoughts regarding the etiology of Kerley A-lines, but no general agreement. Specifically, the lines are caused by thickened interlobular septa or dilated anastomotic lymphatics. Our purpose was to determine the anatomic structure represented as Kerley A-lines using 3D-CT lung segmentation analysis.Materials and methodsWe reviewed 139 charts of patients with lymphangitic carcinomatosis of the lung who had CT and X-ray exams with a maximum interval of 7 days. The presence of Kerley A-lines on X-ray was assessed by a radiologist. The A-lines on X-ray were defined as follows: dense; fine (< 1 mm thick); ≥ 2 cm in length, radiating from the hilum; no bifurcation; and not adjacent to the pleura. For cases with Kerley A-lines on X-ray, three radiologists agreed that the lines on CT corresponded with Kerley A-lines. The incidence of A-lines and the characteristics of the lines were investigated. The septal lines between lung segments were identified using a 3D-CT lung segmentation analysis workstation. The percentage of agreement between the A-lines on CT and lung segmental lines was assessed.ResultsOn chest X-ray, 37 Kerley A-lines (right, 16; left, 21) were identified in the 22 cases (16%). Of these, 4 lungs with 12 lines were excluded from analysis due to technical reasons. Nineteen of the 25 lines (76%) corresponded to the septal lines on CT. Of these, 11 lines matched with automatically segmented lines (intersegmental septa, 4; intersubsegmental septa, 7) by the workstation. Two lines (8%) represented fissures. Four lines corresponded to the bronchial wall/artery (3 lines, 12%) or vein (1 line, 4%).ConclusionKerley A-lines primarily represented thickened and continued interlobular septal lines that corresponded to the septa between lung segments and subsegments.

Diagnostic potential of a novel fluoroscopic video analysis workstation (Radwisp) in patients with acute pulmonary thromboembolisms

Abstract Background Pulmonary thromboembolisms (APEs) are one of the leading causes of death, and they are increasing worldwide. Contrast-enhanced chest computed tomography (CT) is the most robust imaging tool for diagnosing APEs, but a fluoroscopic video analysis workstation (Radwisp™) was newly developed to evaluate the pulmonary circulation without using contrast medium (Figure), and it can be useful as a diagnostic device in APEs. Nonetheless, it has not been validated whether Radwisp has the potential to accurately diagnose APEs. Methods In this study, 10 consequence suspected APE patients (male:female ratio, 1:1, mean age 68.5±16 years) in our hospital were enrolled between January 2020 and April 2021. All patients were suspected of having APEs from their symptoms and physical examinations, and therefore, were scheduled for contrast-enhanced CT and cineradiographic imaging based on standard X-rays on the same day. The cineradiographic images were taken with a 20 second breath-hold followed by breathing. The cineradiographic X-ray images were moved to the fluoroscopic video analysis workstation (Radwisp™). Blinded to the patient information and contrast-enhanced CT images, four cardiologists evaluated the presence or absence of APEs, and if APEs were diagnosed, the extent of pulmonary artery filling defects due to thrombi, solely from the Radwisp-based images. We compared the findings from the Radwisp-based images to those from the contrast-enhanced CT imaging. Results Of a total of 10 patients, 7 were diagnosed with APEs from the contrast-enhanced CT imaging, while 3 were not. All images were created within 5 minutes and the image quality was high even during breathing. three doctors accurately diagnosed 7 patients with APEs and 3 without APEs. In all 7 patients, contrast-enhance CT imaging after treatment (rivaroxaban 30mg for average 12±4 days) identified full recovery of the pulmonary circulation over both lungs, which was correctly identified on the Radwisp image by 3 doctors. Conclusions In this validation study, the diagnostic accuracy of the Radwisp™ for APEs was reliably high. In addition, this imaging could correctly identify filling defects in pulmonary arteries. This novel Radwisp-based imaging can be a simple and reliable diagnostic tool for identifying not only APE patients, but also the severity of the pulmonary circulation caused by thrombi, and its therapeutic effects, especially in patients with severe dyspnea and renal disfunction. Radwisp™ can enable further diagnosis of the site of embolism and determination of therapeutic effect. Further studies will be needed to obtain a consistent diagnostic accuracy of APEs in patients with other pulmonary diseases. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): Paramevia Pte. Ltd A Radwisp analysis show pulmonary defect

Magnetic Resonance Image Characterization of Knee Meniscus Signal Intensity using Crue’s Approach: Results from a Multi-centre Evidence

This study aimed to characterize knee meniscus signal-intensity using magnetic resonance imaging. Our research included knee MR images of 138 subjects from multi-centres in Nigeria, between September 2016 and December 2017. Knee images were retrieved from patients' folder of MRI scanners and transfered to a DICOM workstation (Onis 2.6) for image analysis. Knee meniscus was characterized into 0, 1, 2 &amp; 3 grades using Crue’s grading approach. Our research revealed 58% incidence of meniscal lesion. Study yielded a significant relationship between meniscal lesion and gender (p &lt;.005) with a greater proportion of these lesions in women than in men. Meniscal lesions showed significant association with osteoarthritis (OA) (p &lt; 0.05). Grade 3 lesions (actual tears) were largely of horizontal configuration.

On the Use of Virtual Reality for Medical Imaging Visualization.

Advanced visualization of medical imaging has been a motive for research due to its value for disease analysis, surgical planning, and academical training. More recently, attention has been turning toward mixed reality as a means to deliver more interactive and realistic medical experiences. However, there are still many limitations to the use of virtual reality for specific scenarios. Our intent is to study the current usage of this technology and assess the potential of related development tools for clinical contexts. This paper focuses on virtual reality as an alternative to today's majority of slice-based medical analysis workstations, bringing more immersive three-dimensional experiences that could help in cross-slice analysis. We determine the key features a virtual reality software should support and present today's software tools and frameworks for researchers that intend to work on immersive medical imaging visualization. Such solutions are assessed to understand their ability to address existing challenges of the field. It was understood that most development frameworks rely on well-established toolkits specialized for healthcare and standard data formats such as DICOM. Also, game engines prove to be adequate means of combining software modules for improved results. Virtual reality seems to remain a promising technology for medical analysis but has not yet achieved its true potential. Our results suggest that prerequisites such as real-time performance and minimum latency pose the greatest limitations for clinical adoption and need to be addressed. There is also a need for further research comparing mixed realities and currently used technologies.

A Novel Diagnostic Method for Acute Pulmonary Thromboembolisms: An X-Ray Fluoroscopic Video Analysis Workstation

Contrast-enhanced chest computed tomography is obviously the most frequently used method for diagnosing acute pulmonary thromboembolism (APE). We present a case in which a fluoroscopic video analysis workstation could potentially diagnose an APE and evaluate the improvement in the pulmonary circulation after anticoagulant therapy without either contrast media or a breath hold. (Radwisp PTE; jRCTs032200098) (Level of Difficulty: Advanced.)

Three-Dimensional Quantitative Analysis of Chronic Obstructive Pulmonary Lesions on CT Images

In this paper, the three-dimensional segmentation of pulmonary honeycomb lesions and the function of image biomarkers are integrated into a quantitative analysis module of the lung, and integrated into the PACS image diagnosis workstation for the quantitative analysis of doctors. It is difficult to segment honeycomb lesions in lung CT images because of its diffuse and blurred edges, but it has good texture characteristics. Based on this feature, this paper converts honeycomb lesions into a texture classification problem. Firstly, the lung parenchyma is extracted by automatic threshold segmentation and region growing method, and then the lung parenchyma is divided into several small regions according to the texture by watershed method. Then, according to the texture characteristics of each small area, the trained support vector machine is used to classify. Finally, the correlation between gray level and spatial position of slice data is used to correct the classification results, so as to reduce false positive areas. In order to expand the study of imaging biomarkers of chronic lung diseases to more extensive major diseases, a sample database was established for a wide range of multiple lesions. Through feature extraction and feature analysis of multiple lesions in database, potential feature differences can be excavated, which lays a solid foundation for further study of image biomarkers of multiple lesions.

Visible-Light-Driven Methane Conversion with Oxygen Enabled by Atomically Precise Nickel Catalyst

It remains an extreme challenge to activate thermodynamically unfavorable, chemically inert methane molecules under mild conditions. Herein, we report a molecular-like nickel-thiolate hexameric clu...

Application of 3D reconstruction through CT to measure the abdominal cavity volume in the treatment of external abdominal hernia.

To evaluate 3D reconstruction through CT in the measurement of abdominal cavity volume. From January 1, 2019 to December 31, 2019, 61 patients diagnosed as external abdominal hernia were included in this prospective study. Multislice computed tomography (MSCT) was applied to patients scanning, and the images were transferred to post-processing workstation for further analysis. We measured the abdominal cavity volumes using volume rendering (VR) method and diameter rendering (DR) method, and the results were used to test whether there is a correlation between them. In addition, the time required for the measurement was recorded and analyzed. In this study, we found that there was no significant difference in the abdominal cavity volumes between these two groups (VR vs. DR = 7857.316 ± 2035.786cm3 vs. 7967.268 ± 2925.792cm3, P > 0.05). Besides, the correlation analysis between the measured values of VR method and DR method showed there was a significant positive correlation (r = 0.922, P < 0.01). The linear regression equation based on the scatter plot was established as follows: y = 0.6417x + 2745, R2 = 0.8504. Furthermore, this regression equation was simplified as follows: y = 0.64x + 2800, R2 = 0.8499. Meanwhile, the time required for measurement of VR was significantly longer than that of DR (VR vs. DR = 64.3 ± 7.1min vs. 2.6 ± 0.6min, P < 0.01). In conclusion, the DR method can quickly measure and calculate the abdominal cavity volume, and its accuracy can more suitable for clinical requirement.

특성곡선법을 이용한 단기통 디젤엔진의 비정상 가스유동 해석

As environmental pollution reduction devices were installed in diesel engines, a gas flow analysis of intake and exhaust systems is required. A gas flow analysis in 3D format needs a high-resolution workstation and enormous time for analysis. Therefore, the method of characteristics was used for a gas flow analysis with a fast calculation time and a low-resolution workstation. An experiment was conducted on single cylinder diesel engine to measure cylinder pressure and exhaust pipe pressure. In order to validate a gas flow analysis using the method of characteristics, the results analyzed under the same conditions as the experiment were compared. As the results of the analysis using the method of characteristics, the cylinder pressure showed accuracy; however, the exhaust pipe pressure was inaccurate. In the future, the shortcomings of the analysis using the method of characteristics will be supplemented by using the 1D-3D coupling method.