Analysis Ofthe Data Research Articles

Exploring the Characteristic of Good Catholic Teacher of the Sister of Saint Paul de Chartres in Thailand

This study aims to analyze the characteristics of good teachers at St. Paul de Chartres parish schools in Thailand including directors, heads of department, and teachers who make up the total population of 2,400 from 24 schools. A sample of 420 people was selected by stratified random sampling. The research tool was the Good Teacher Characteristics Questionnaire and Rating Scale. The statistics used to analyze the data included was exploratory factor analysis. The results were divided into two parts: The General sample data analysis of good teachers at the Sisters of St. Paul de Chartres Schools in Thailand was comprised of good teachers. 361 of the 420 teachers were female, 86.0% were between the ages of 36 and 45, and 111, or 26.4%, were female. When categorized by level of education, it was discovered that 334 teachers, or 79.5%, held the highest level of bachelor's degrees. There were 211 teachers or 50.2% with at least 16 years of experience, and 375 teachers, or 89.3%. were teachers at the school. And the analysis of the data was analyzed with good teacher characteristics component analysis and divided into 6 components as follows: knowledge (well-rounded), interpersonal skills (interpersonal skills), working spirit spirituality, lifelong learner, teacher leadership) and a good role model (role model).

Perspectives on online learning: Advantages and challenges in higher education

Online learning in higher education has established itself as a key educational strategy that transforms the teaching and learning process in universities. In this context, it is crucial to examine the different effects that this method can generate in order to identify both the opportunities and challenges that teachers face when adopting this modality. The aim of this research is to analyse the perspectives of online learning, focusing on the advantages and challenges it presents in higher education. The information was collected through semi-structured interviews with 47 teachers from the University of Cadiz and the University of Seville. The analysis of the data obtained highlights the benefits that online learning offers, such as flexibility and accessibility, as well as the difficulties related to technical problems and access to technology. The results underline the significant opportunities that online learning offers to improve the educational process, provided that the necessary teacher support and training is available. This study also provides valuable recommendations to guide future teachers and researchers in the effective integration of this method in higher education.

Citation Analysis of the Literature Review Sections of Dissertations at M.Phil. Level

The topic of the study conducted is Citation Analysis of Literature Review sections of dissertations at the M.Phil. level in the disciplines of literature and linguistics in English. The sample was comprised of ten theses, five each from literature and linguistics. The purpose of the study was to find out the citation pattern in the text of the LR chapter based on Swales’ (1990) work on citations. A mixed method approach was adopted for this purpose, which was contained in both quantitative as well as qualitative analysis of the data. Hence, the data was analyzed, organized and tabulated, and a number of conclusions were made on the basis of the findings that were deduced. The findings suggested that the writers of the sampled theses did not follow sense as was suggested by Swales (1990) in his work. Rather, they just reproduced other people’s arguments just for the sake of citations, irrespective of the logic behind various types of citations. The most preferred citation type was integral, while the most preferred reporting verbs were ‘say,’ ‘argue,’ ‘discuss,’ and ‘explain.’ It was suggested that genre genre-based or analytic-synthetic approach needs to be adopted for teaching academic writing.

The effect of pulverized glass waste particle sizes on the mechanical properties of AA6061-T6 friction stir welded joints.

Abstract The study sought to investigate the effect of pulverized glass waste (PGW) particle size as reinforcement for AA6061-T6 joints produced by Friction Stir Welding. The study utilized three particle sizes of 15 microns, 45 microns and 75 microns of the PGW as reinforcement alongside the established process parameters ranges of 900-1400rpm, 25-63mm/min and 1-2.5° in a Taguchi L9 orthogonal array for the welding process experimental design. The welding experiments were repeated for each reinforcement particle size mentioned above. Parallel-hole reinforcement strategy was used on all joints for the application of the PGW, Tensile strength, Hardness tests and Microstructural Analysis were carried out on the welded joints and subsequently, analysis of the data. For tensile strength, several sample sets showed a trend of higher tensile strength the smaller the PGW particles size (Figure 6). For hardness, however, there was no overall, discernable trend/pattern of increase in hardness as the particle size decreased. The highest average tensile strength value obtained was 85.25MPa. The lowest tensile strength was 14.26MPa. A distinguishing feature between the highest and lowest value for tensile strength is that the former was obtained with a traverse speed of 25 mm/min while the latter was obtained using a 40 mm/min traverse speed. The higher the rotational speed of the tool pin, the greater the heat of friction generated while the lower the traverse/welding speed, the greater the heat of friction generated as the tool pin spends enough time per unit length to generate sufficient heat and cause plastic deformation sufficiently high enough to cause grain refinement. Using imageJ, percentage distribution of PGW for each crucial zone (Nugget/Stir zone, Thermo mechanically affected zone and Heat affected zone) of the FSWed joint was generated for samples selected for microstructural analysis. The average value for each sample was obtained as well. The highest tensile strength value (85.25MPa) was obtained with a sample using the smallest PGW size (15 µm), in line with the trend (figure 6) in which tensile strength was greater the smaller the PGW size used. The highest hardness value (90.90 BHN) was obtained with the sample having the highest average value for percentage distribution of the PGW (58.06%). A distinct trend was noted in which the greater the percentage distribution of the PGW, the higher the hardness value obtained (figure 30).

Training of Teachers for Cadet Classes: Approaches and Successful Practices

The article offers an analysis of approaches and successful practices of teacher training for cadet classes. Various groups of methods were used in the course of the study, including the method of comparative analysis of normative and legal documents; analysis, systematization and generalization of the data obtained; complex analysis, classification and structuring of information and statistical data; modeling method; generalization of research results. As a result, system solutions for the training of teachers of cadet classes have been developed and theoretically substantiated. It should be noted that one of the conceptual ideas of teacher training for cadet classes is the idea of continuity and individualization of professional development of teachers in the field of education and socialization of students. Continuous professional development of teachers, including teachers of cadet classes, is carried out through the integration of formal and non-formal education, as well as through self-education and self-education. Teachers of cadet classes should have the competencies necessary for the full implementation of professional functions in the organization of education and socialization of students, since the teacher of the cadet class works not only with students, but also with cadet families, focusing on issues of social protection, education, formation of healthy public opinion and mood. The tasks of the educator of the training course include studying the mood, requests and needs of child-parent relations in cadet families and systematically informing the management and specialists of various services about the urgent tasks of working with cadet parents. The training of teachers of cadet classes is focused on the formation of a number of skills among educators: to analyze the academic performance and involvement of students in the educational process, to build effective communication, to organize activities to prevent negative manifestations and offenses.

Inclusive Higher Education in Kyrgyzstan for People with Physical and Intellectual Disabilities

Considering the importance of education as a socio-cultural human right, the issue of implementation of inclusive higher education for persons with disabilities is relevant, determined by a set of legal, socio-pedagogical, technical, and financial problems. The study aims to investigate specific organizational and pedagogical factors facilitating the implementation of an inclusive higher education model in the Kyrgyz Republic. The study employed methods that included questionnaires of the subjects of the educational process and statistical analysis of the data obtained in the course of the questionnaire. Including the understanding of inclusion, the role of educational institutions, and effective methodologies for implementing inclusive practices in the educational process, key theoretical aspects were identified as a result of the analysis of modern theoretical concepts and methodological approaches to inclusive higher education. Furthermore, challenges such as the lack of adaptive infrastructure required for students with disabilities, as well as the insufficient preparation of teaching staff to work with the diverse needs of students, were highlighted. The study also covered the social and legal aspects of inclusive higher education in Kyrgyzstan. The legislative framework regulating the rights of students with disabilities was analyzed, and public support and awareness of inclusion in education were assessed. Based on the findings, specific recommendations and strategies were developed to improve inclusive higher education in Kyrgyzstan. These recommendations cover various areas, including educational programs, the training of educators, the creation of accessible infrastructure, and the development of social support programs. The practical relevance of this work lies in the possibility of implementing the recommendations and strategies proposed in this work to improve inclusive higher education in Kyrgyzstan, which contributes to a more accessible and equitable educational environment for all students.

Study of the rapid variability of a dwarf nova SS Cyg at different brightness levels

Observations of the dwarf nova SS Cyg were made in the period 2019–2021 at different brightness values (V~ 10–12m) both at the stage of falling radiation flux after the flare maximum, and in the inactive state between flares. Data were obtained in filtersRc(~8650 observations, 3 sets), andV(~50 000 points, 22 sets). The value of the system’s orbital period in 2019–2021 (Porb= 0.27408(2)d) used in this study is 0.4% less than the value obtained in 1983–1996. The time resolution between two successive measurements is 6–14 s depending on the equipment used. An extensive database of new observational data allowed us to perform a quantitative analysis of observations. Analysis of the data after taking into account orbital variability and other trends associated with changes in the system’s radiation flux during the night showed the presence of cyclic fluctuations in brightness, usually 4–10 events per orbital cycle — flickering. For most series of observations, the Lafleur-Kinman method determined such a value of the oscillation period at which convolution of observations with it showed a single wave. The obtained values of the characteristic flickering times and their amplitudes show their dependence on the average brightness level of the system. With increasing luminosity of the system, both of these quantities decreased linearly. From the component size ratios SS Cyg it was shown that the source of flickering is located in the region of interaction of the gas flow with the near-disk halo: only this region in the SS Cyg system with parameters (q,i,Rd), defined by the authors earlier, can be eclipsed at large radii disk, and is clearly visible in all other orbital phases of the system.

MC-VMD-CNN-BiLSTM short-term wind power prediction considering rolling error correction

Abstract Wind energy is a clean and renewable source that has the potential to alleviate the global fossil fuel crisis and environmental pollution by generating electricity. However, accurately predicting wind energy output remains challenging due to its inherent uncertainty. To enhance the accuracy of wind power prediction, a short-term wind power forecasting method for power systems, MC-VMD-CNN-BiLSTM, is proposed, which considers error rolling correction. The method begins with feature selection and outlier handling using the quadrature method. Then, wind power data is decomposed into multiple sub-sequences using the Variational Mode Decomposition (VMD) technique to reduce the raw volatility of wind power. Then, a Convolutional Neural Network (CNN) followed by a Bidirectional Long Short-Term Memory (BiLSTM) model is used for wind power prediction. Finally, the proposed method utilizes the Monte Carlo method for rolling error correction by using known errors from previous time frames to correct subsequent predictions. The MC-VMD-CNN-BiLSTM proposed in this paper considering error rolling correction is compared with ELM, SVM, PSO-BP and ARIMA models through an example analysis of the data of a city, and the proposed model in this paper reduces 61.78%, 50.35%, 62.30% and 73.05% in the NRMSE index in the spring as an example, respectively. The results show that the prediction model proposed in this paper has higher prediction accuracy compared with the traditional prediction model.

“It’s the Only World We’ve Got.” Children’s Responses to Chris Jordan’s Images about SDG 14: Life Below Water

Abstract Broad and complex ideas about sustainability can be communicated through the Arts. Australian curriculum documents support the integration of Arts education with education for sustainability. Responding to artworks as a viewer is a key aspect of Arts education in Australian schools. Chris Jordan is a US artist whose online media galleries communicate ideas about environmental and social justice themes. This paper reports interview data from a larger project exploring children’s responses to Chris Jordan’s artworks. Conversations were held with 28 children aged between 4 and 12 as they navigated Jordan’s website to explore the images they encountered. Data relating to SDG14: Life below water were selected for the specific focus of this paper. Thematic analysis of the data revealed five themes: connections to prior experience and knowledge, links with local contexts and places, emotional engagement with the images, solutions and action-taking and ideas related to post-humanism and the human-nature binary. These findings endorse the power of Arts-based experiences for enhancing education for sustainability in primary schools and early childhood contexts.

The Role Of Organizational Culture In Career Development For Improving Employee Performance At Perumda Tirta Pakuan Bogor

The success of Perumda Tirta Pakuan Bogor is greatly influenced by the performance of its employees. Good work results can help Perumda Tirta Pakuan Bogor in achieving the goals and objectives that have been set. In other words, the better the employee's performance, the easier it will be to achieve the goals of Perumda Tirta Pakuan Bogor. On the other hand, if employee performance is low, it is not easy for Perumda Tirta Pakuan Bogor to achieve its goals. So the role of employee performance is a factor that cannot be separated from the objectives of Perumda Tirta Pakuan Bogor so that the quality of employee performance will influence the achievement of the objectives of Perumda Tirta Pakuan Bogor. This research aims to determine and analyze the role of organizational culture and career development in improving the performance of Perumda Tirta Pakuan employees in Bogor City. This research uses descriptive qualitative, with the data collected mostly in the form of words or images rather than numbers. The objects of this research are employees at Perumda Tirta Pakuan, Bogor. The research carries out analysis of the data obtained through interviews and other documents by combining and selecting data that is close to suitability related to the research study. The research results show that the role of organizational culture in improving employee performance at Perumda Tirta Pakuan Bogor is based on a talent management strategy which is an integrated system, designed to improve performance through the process of attracting and selecting, developing, utilizing and retaining employees who have skills and talents. in order to meet current and future organizational needs. The role of career development in improving the performance of Perumda Tirta Pakuan employees in Bogor is known that career development is an activity for future career planning by the employees themselves or the company concerned so that the company can also develop itself optimally.

EFEKTIVITAS MEDIA ULAR TANGGA EDUKASI TERHADAP HASIL BELAJAR DALAM PEMBELAJARAN IPAS PADA KELAS IV SD ATTIN NAMOSAIN

This research is a quantitative research, this research aims to determine the effect of the effectiveness of snakes and ladders media on the learning outcomes of class IV students in science and science learning at Attin Namosain Elementary School. The type of Quasi Experimental Design approach is Pretest Posttest Nonequivalent Control Group Design. This research used a population and sample, namely all class IV students consisting of 44 students (22 control class students and 22 experimental class students). The data collection techniques used were test techniques and observation sheets for the implementation of learning media. Based on the analysis of the data results, it shows that the sig (2-tailed) value is 0.000<0.005, with a significance level = 0.05(5%). Furthermore, the results of the N-Gain Score test in the experimental class which applied snakes and ladders media was 71.16% and was included in the effective category. There is a significant influence of snakes and ladders media on the learning outcomes of class IV students in science learning at Attin Namosain Elementary School.

Improving Interpersonal Communication Skills In Forming Organizational Commitment At Telekomedika Vocational High School In Bogor

Interpersonal communication is communication between a communicator and a communicant. This type of communication is considered the most effective in changing someone's attitude, opinion or behavior, because of its dialogic nature in the form of a conversation. Commitment to the organization means the level of trust and acceptance of the workforce towards the goals of the organization and the desire to remain in the organization which is ultimately reflected in the problems above. This research has several objectives, namely to analyze interpersonal communication skills between school principals and Telekomedika Vocational School teachers and to analyze the organizational commitment of Telekomedika Vocational School teachers. This research uses descriptive qualitative, with the data collected mostly in the form of words or images rather than numbers. The subjects in this research were leaders, teachers and staff at Bogor Telekomedika Vocational School. The research carries out analysis of the data obtained through interviews and other documents by combining and selecting data that is close to suitability related to the research study. The results of the research show that interpersonal communication can be done by improving communication so that they are more motivated to complete the work given by the organization, developing a positive attitude and attention to work in each teacher, setting work goals and trying to improve teachers' work knowledge. It is known that teachers' organizational commitment at Telekomedika Vocational Schools means that teachers as educators and instructors should have a commitment to the organization as a process that is not only limited to creating new ideas or thoughts. The idea must be implemented through an adoption process, and adoption is the decision to use commitment to the organization as a whole as the best course of action.

The four Cs of physician leadership: A key to academic physician success

Leadership is increasingly recognized as important in medicine. Physician leadership impacts healthcare delivery and quality. Little work has been done to determine how physician leadership in practice aligns with established models in leadership theory. We conducted 40 semi-structured, 50-minute interviews of physicians who had achieved the rank of professor in our school of medicine and were serving, or had served, in leadership positions. We used an inductive content analysis approach to identify content categories, with leadership emerging as one such category. Subsequently, for the present study, we performed a secondary analysis of the data. To do this, we reviewed all transcripts, seeking to identify if and how participants discussed leadership in relation to success in academic medicine. Following identification of subcategories related to leadership, we performed qualitative content analysis. We then used a deductive content analysis approach to determine how participants’ discussions of leadership aligned with major leadership theories. Then, the principal investigator conducted a secondary inductive content analysis revealing leadership themes that were synthesized into a new model of physician leadership. Twenty-nine participants spontaneously discussed leadership and leadership-related topics as important to their own academic success and comprised the present study cohort. Participants identified contributors to leadership success that aligned with multiple major leadership theories, including leadership traits, skills, behaviors styles, and situational leadership. None of the leadership theories aligned completely with our physician leaders’ discussions, suggesting an alternate leadership framework was operating. Further analysis revealed a new model of leadership comprised of the “Four Cs of Physician Leadership”: character, competence, caring, and communication. Our participant group of academic physicians identified leadership capabilities as being important in their academic success. While they discussed leadership in ways that fit to varying degrees with the major leadership theories, their discussions revealed a novel, more holistic leadership framework. Further work will be beneficial to determine if this model of leadership is specific to physicians or is more generalizable.

A system of ODEs for representing trends of CGM signals

Diabetes Mellitus is a metabolic disorder which may result in severe and potentially fatal complications if not well-treated and monitored. In this study, a quantitative analysis of the data collected using CGM (Continuous Glucose Monitoring) devices from eight subjects with type 2 diabetes in good metabolic control at the University Polyclinic Agostino Gemelli, Catholic University of the Sacred Heart, was carried out. In particular, a system of ordinary differential equations whose state variables are affected by a sequence of stochastic perturbations was proposed and used to extract more informative inferences from the patients’ data. For this work, Matlab and R programs were used to find the most appropriate values of the parameters (according to the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC)) for each patient. Fitting was carried out by Particle Swarm Optimization to minimize the ordinary least squares error between the observed CGM data and the data from the ODE model. Goodness of fit tests were made in order to assess which probability distribution was best suitable for representing the waiting times computed from the model parameters. Finally, both parametric and non-parametric density estimation of the frequency histograms associated with the variability of the glucose elimination rate from blood were conducted and their representative parameters assessed from the data. The results show that the chosen models succeed in capturing most of the glucose fluctuations for almost every patient.

Solvation free energy in governing equations for DNA hybridization, protein-ligand binding, and protein folding.

This work examines the thermodynamics of model biomolecular interactions using a governing equation that accounts for the participation of bulk water in the equilibria. In the first example, the binding affinities of two DNA duplexes, one of nine and one of 10 base pairs in length, are measured and characterized by isothermal titration calorimetry (ITC) as a function of concentration. The results indicate that the change in solvation free energy that accompanies duplex formation (ΔGS) is large and unfavorable. The duplex with the larger number of G:C pairings yields the largest change in solvation free energy, ΔGS = +460 kcal·mol-1per base pair at 25 °C. A van't Hoff analysis of the data is complicated by the varying degree of intramolecular base stacking within each DNA strand as a function of temperature. A modeling study reveals how the solvation free energy alters the output of a typical ITC experiment and leads to a good, though misleading, fit to the classical equilibrium equation. The same thermodynamic framework is applied to a model protein-ligand interaction, the binding of ribonuclease A with the nucleotide inhibitor 3'-UMP, and to a conformational equilibrium, the change in tertiary structure of α-lactalbumin in molar guanidinium chloride solutions. The ribonuclease study yields a value of ΔGS = +160 kcal·mol-1, whereas the folding equilibrium yields ΔGS ≈ 0, an apparent characteristic of hydrophobic interactions. These examples provide insight on the role of solvation energy in binding equilibria and suggest a pivot in the fundamental application of thermodynamics to solution chemistry.

Thermoporometry measurements of human hair via differential scanning calorimetry.

Hair fibres possess an inherently porous structure, which is affected by physical and chemical agents from the environment, as well as those from cosmetic treatments. The present work aims to investigate the potential of a calorimetric method for evaluating the changes of hair porosity, in terms of pore size and size distribution. The temperature of the phase transition from solid to liquid is known to be depressed if the liquid is confined within a pore. This shift in temperature can be measured by a calorimetric method like differential scanning calorimetry, DSC. This method is termed thermoporometry and it is the tool used for investigating hair porosity in this work. Virgin and bleached hair fibres are measured by DSC and, by using the equations developed for water behaviour confined in pores of a solid, the size and size distribution of the hair pores are evaluated, and the influence of the cosmetic treatment on the pores is discussed. Thermoporometry measurements of hair produced results in good agreement with those obtained by other methods for measuring hair porosity. The analysis of the data suggests that the fibre pores are mostly of a radius of 4 nm, and that the bleaching process increases the total volume of pores through the addition of smaller pores. A prolonged bleaching process appears to reduce the amount of fine pores produced by the first short process, resulting in fewer, but larger, cavities, most likely through a process of pore-merging.

Investigating the Role of Leadership Styles on Organizational Culture and Innovation

Innovation and organizational environment are greatly influenced by leadership styles. Innovation-friendly workplaces are fostered by leaders because of their emphasis on inspiration and vision. The leaders place more emphasis on structure and compensation, which might have a distinct effect on organizational environment (OE) and creativity. The variations in leadership styles and how they are applied in various organizational settings. The connection among organizational environment, innovative creativity and leadership styles might be influenced by industry-specific aspects. The study’s aim is to comprehend how various leadership styles affect the organizational environment and corporate innovations (CI). This study included a total of 233 participants, including male (120) female (110) and non-binary/other (3) for leadership styles. Utilizing SPSS software, a statistical analysis of the data was carried out. The data was analyzed using a t-test, ANOVA, and regression analyses. These analysis demonstrated the leadership style fostering an innovative organization.The studyemphasizes the organizational environment and corporate innovationstrongly influenced by leadership styles. Creating an atmosphere that encourages creative thinking and a collaborative culture through leadership styles.

Reframing design in education: Proposing a framework to support pre-service teachers in adopting designerly stances

ABSTRACT Background K12 teachers need a wider range of design approaches to foster feasible qualitative improvements in all students’ schooling experiences. We propose a framework for conceptualizing pre-service teachers’ stances toward designerly thinking. Methods We developed the framework following Crismond and Adams’ scholarship of integration approach combined with an inductive content analysis of 43 pre-service teachers’ conceptualizations of design across two versions of a design course. Results The resulting framework focuses on six dimensions including: (a) co-evolution of problem frames and possible solutions, (b) problem complexity and structure, (c) idea fluency and scope, (d) inquiry and stakeholder engagement, (e) conceptualization of the design process, and (f) attitude toward ambiguity. Each dimension articulates anchor points and examples based on the literature and grounded content analysis of the data. The analysis and discussion consider the conceptual accessibility of the framework’s goals for pre-service teachers and whether they considered the goals feasible to implement in the context of curricular mandates. Contribution The proposed framework provides the foundation for a hypothetical learning trajectory that can be elaborated and validated through future research to support K12 teachers in their development as informed designers who might better serve the needs of all their students.

Abstract C005: Exploratory biomarker evaluation of the randomized Phase 2 cohort of CM24 in combination with nivolumab and chemotherapy in advanced/metastatic pancreatic cancer

Abstract Background: CM24 (mAb) blocks CEACAM1 interactions, has key roles in cancer progression, immune escape and metastasis. CEACAM1 is part of the neutrophil extracellular trap (NET) complex, involved in tumor immune evasion, metastasis and cancer-associated thrombosis, affecting patient survival. We demonstrated that CM24 binds to NET and suppresses NET-induced migration of cancer cells (AACR Cancer Metastasis Nov.2022) and that CM24+nivolumab (nivo) treatment of pancreatic ductal adenocarcinoma (PDAC) patients markedly reduced serum levels of the NET marker, Myeloperoxidase (MPO; AACR on pancreatic cancer Sept.2023). In a Phase 2 study (NCT04731467) 31 patients with advanced/metastatic PDAC progressed after 1st line therapy, were randomized for CM24 (20mg/kg q2wk), nivo (240mg/kg q2wk) and liposomal irinotecan, 5 fluorouracil and leucovorin (Nal-IRI/5FU/LV, q2wk) treatment (experimental arm) vs Nal-IRI/5FU/LV only (control arm). Interim analysis of the data showed Median OS for the experimental arm was 7.72m (95% CI: 4.00-8.11) vs. 5.62m (95% 3.22 -7.89) for the control arm (HR: 0.74; 95% CI: 0.31-1.77). Median PFS for the experimental group was 3.8m (95% 1.8-5.0) vs. 1.9m (95% 0.9, 3.6) for the control arm (HR 0.72; 95% CI: 0.33-1.60) (ASCO2024-LBA4143). Here we present a subgroup analysis evaluating serum MPO as a potential biomarker for CM24-based therapy. Methods: Patients were randomized as described above. Pre-dose serum samples were collected from 30 out of 31 pts and serum MPO levels were evaluated using ELISA (Cayman), where the measured mean serum MPO in healthy subjects (n=30) was 53 +/-7[SE]. NET-induced blood coagulation was tested using platelet aggregation assay. Results: Mean pre-dose MPO level in patients (n=30) was 359 +/- 46 [SE] and was selected as a threshold for biomarker analysis. OS for patients with MPO levels below the threshold (n=9/16) was 8.1 mo in the experimental arm (HR 0.34; (95% CI: 0.099-1.149)) vs 4.5mo in the control (n=9/15). PFS for patients with MPO levels below the threshold was 4.2mo in the experimental arm vs. 1.7 mo in the control (HR 0.24 (95% CI: 0.20-1.59)). NET-associated blood coagulation and the inhibitory effect of CM24 were tested in vitro. NETs induced platelet aggregation in a dose-dependent manner, and CM24 significantly reduced it (50-70% reduction, p value < 0.0001) at NET levels related to the selected biomarker range (MPO<357) but was less effective at higher NET levels (MPO>500), which relate to MPO above the threshold. These results are in line with the proposed CM24 MoA, affecting NET-related cancer complications. Conclusions: Exploratory biomarker analysis suggests serum MPO as a potential predictive biomarker for CM24-based therapy showing prolonged median OS, PFS and 66% reduction in risk of death vs control in PDAC patients with MPO levels below threshold compared to interim analysis that estimated OS and PFS risk reduction of 26% and 28%, respectively. These findings will be further evaluated in upcoming clinical studies. Citation Format: Teresa Macarulla, Michael Cecchini, Rocio Garcia-Carbonero, Talia Golan, Ruth Perets, Erkut Borazanci, Manuel Pedegral, Mariano Ponz-Sarvisé, Mohammed Najeeb Al Hallak, Shubham Pant, Valentina Boni, Omar Saavedra, María José de Miguel-Luken, Alexis D. Leal, Andrés J. Muñoz Martín, Tamara Sauri-Nadal, Michael Schickler, Hava Ben David, Hadas Reuveni. Exploratory biomarker evaluation of the randomized Phase 2 cohort of CM24 in combination with nivolumab and chemotherapy in advanced/metastatic pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr C005.

Challenges of conducting qualitative social work research with older adults

ABSTRACT This study was conducted using a qualitative descriptive design to explore the challenges encountered by researchers who have conducted social work research with older adults using qualitative research methods. Within the scope of the research, in-depth interviews were conducted with 18 researchers who have conducted qualitative social work research on older adults. Following the thematic analysis of the data obtained, three themes were identified: challenges encountered in the preparation process, challenges related to the researcher, and challenges related to old age. The research findings suggest that researchers may encounter various challenges when conducting qualitative social work research with older adults, despite the fact that a prior educational background in social work provides an advantage. It is anticipated that the visibility of qualitative research experiences with older individuals will contribute to the design of studies that are responsive to the general characteristics of the old age period and the problems and requirements of this period.