Analysis Ofthe Data Research Articles

A thematic analysis of factors influencing small and medium enterprise adoption of social media marketing: a TOE framework perspective

Purpose This paper aims to examine the factors influencing the adoption of social media marketing by small and medium enterprises (SMEs) in Pakistan. By investigating the drivers and challenges/barriers affecting the adoption of social media marketing tools among SMEs, this study provides practical guidance to SMEs seeking to utilize social media platforms for marketing purposes in a developing context such as Pakistan. Design/methodology/approach Utilizing the Technology-Organization-Environment (TOE) framework as a theoretical framework, qualitative data were collected through semistructured interviews with representatives of SMEs in Pakistan, followed by thematic analysis of the data. Findings The research identifies several key factors influencing the adoption of social media marketing by Pakistani SMEs. These factors include doubts regarding the benefits of social media, alignment with regulatory requirements, challenges related to tracking social media performance, resistance from senior management (older employees), the positive influence of competitive pressure and the Covid-19 pandemic, political instability and increased government taxes on digital services. Stakeholders such as marketing professionals, academics, policymakers, government authorities and SME owners and managers can benefit from these findings. Originality/value This research contributes to the academic literature on the adoption of social media marketing by SMEs, especially within emerging economies. It enriches theoretical understanding of adoption processes and factors, filling gaps in existing knowledge and laying a foundation for future research in this domain. Using the TOE framework, the study reveals that when all factors are adequately considered, SMEs can transition from traditional marketing methods and embrace social media as a digital marketing strategy to enhance performance, profitability, and gain a competitive advantage over their rivals.

A Study of Financial Literacy of Rajkot District, Gujarat, India

Since the independence of our country, there has been major focus on policy development and financial reforms. Financial inclusion has become a priority for both the central government and the RBI. For a nation to achieve financial inclusion effectively, the population should be financially literate. A review of existing literature in this field reveals that most studies have focused on three key variables, viz., financial literacy, financial development and economic growth. To contribute to this existing body of research, this paper explores the distinction between ‘financial literacy’ and ‘financial awareness’ to better understand what can truly drive ‘financial inclusion’ in the country. Primary data from 130 respondents was collected from the district of Rajkot, Gujarat, of which 100 respondents were taken into consideration, followed by statistical analysis of the data. The study concludes that gender makes a significant impact on financial literacy, where males showed higher financial literacy as compared to females. Further, age and education of the people makes a significant impact of financial literacy of the population, which in turn, will lead to financial inclusion. There do exist a marginal correlation between financial awareness and financial literacy (r=0.054).

Role of intra-individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA® tests.

Sperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatments is still unclear. Few studies have focused on the intra-individual variation in DFI even though it may have an important role to play in terms of detection of thresholds and for misclassification rates. Results for Sperm Chromatin Structure Assay (SCSA®) tests performed for 70 European fertility clinics between January 1st, 2008 and December 31st, 2022 were examined. A small retrospective study included 406 couples receiving their first treatment with IVF or ICSI. These results were then used for a mathematical simulation to investigate the role of intra-individual variation. The large retrospective study included a total of 14,138 diagnostic tests and 637 tests from an IUI study. The distribution of DFI was assessed for the IUI cohort and cohorts of patients attending Sims IVF and Fertility Center Hamburg (FCH). Descriptive analysis of the data was performed regarding time of year, male age, and year. When DFI was above the thresholds of 15 and 25, a significant reduction in ongoing pregnancies after 12weeks of gestation was observed for IVF and ICSI treatments, respectively. For IVF treatments, the pregnancy rate was reduced from 45.1% to 24.6%, odds ratio=2.58 (p=0.004). For ICSI treatments, the pregnancy rate was reduced from 48.6% to 29.6%, odds ratio=2.00 (p=0.032). Intra-individual variation was significantly related to the misclassification rate and the sample size required to identify a threshold. The percentage of patients with a DFI below 15 was 64.8% for the IUI cohort and 51.7% and 41.6% for cohorts of patients attending Sims IVF and FCH, respectively. The median DFI for these cohorts differed significantly and was 11.6, 15.0 and 17.2, respectively. DFI shows a seasonal variation, and increases with male age. During the past 15 years, the median DFI has increased by 0.05% per year (p=0.02). Ongoing pregnancy rates are reduced significantly for both IVF and ICSI treatments when DFI is above the thresholds of 15 and 25, respectively. The misclassification rate and the required sample size increase with increasing intra-individual variation. Couples with a DFI above 15 are more likely to experience failed assisted reproductive technology(ART) cycles. DFI appears to have increased during the past 15 years.

Analysis of access to amenities in peri-urban areas in West Africa: A GIS-based approach in Abomey-Calavi, Republic of Benin

Urban facilities and services are essential to human life. Access to them varies according to the geographical location of the population, whether urban, peri-urban or rural, and according to the modes of transport available. In view of the rapid development of peri-urban areas in developing countries, questions are being asked about the ability of the inhabitants of these areas to access these facilities and services. This study examines the ability of the inhabitants of Hêvié, Ouèdo and Togba, three peri-urban districts of Abomey-Calavi in the Republic of Benin, to access commercial, educational, school and health facilities. To this end, we have adopted a GIS-based methodology. It is a combination of isochronal method and accessibility utility measurement. The isochrones were produced according to the main modes of travel recorded on the study area and over a time t ≤ 20 min divided into intervals of 05 min. Analysis of the data enabled us to understand that the main modes of travel adopted by residents are walking, motorcycle and car. Access to educational and health facilities is conditioned by the mode of travel used. Access to commercial and entertainment facilities in t ≤ 20 min is not correlated with the modes of transport used.

Can spatial planning in the Polish Carpathians be enforced? How spatial chaos indicators depict a gap between scientific knowledge and practice

AbstractDespite their strategic hydrological importance for neighbouring areas, the Polish Carpathians are experiencing spatial chaos, which may weaken their adaptability to the progressive climate change. The article attempts to answer the question of whether spatial planning, which is supposed to guarantee spatial order, fulfils its role and whether the knowledge of the natural conditions of spatial development is respected in the spatial planning process. Using GIS techniques, up to 238 communes were analysed in terms of their spatial coverage, the degree of scattered settlement, and the violation of natural barriers by location of buildings in areas that are threatened with mass movements or floods; by settlement on excessively inclined slopes and in areas with adverse climatic conditions. Spearman non-parametric rank correlation analysis and the multidimensional Principal Component Analysis (PCA) technique were performed to investigate relations between spatial chaos indicators and the planning situation. The analysis of the data has revealed that spatial planning does not fulfil its role. Serious errors in location of buildings have been noted even though the communes are covered by local spatial development plans. Scientific knowledge is not sufficiently transferred into planning documents, and bottom-up initiatives cannot replace systemic solutions. There is a need for strengthening the role of environmental studies documents in the spatial planning system. This would facilitate the transfer of scientific knowledge into the planning process and help to protect mountain areas. The development of a special spatial strategy for the Polish Carpathians in compliance with the Carpathian Convention is also recommended.

Impacts of the large fusion test facility on tritium in environmental water and natural radiation levels.

In the progress of nuclear fusion development, environmental radiation monitoring in the vicinity of the facility would be an important issue. At the National Institute of Fusion Science (NIFS), the deuterium plasma experiment, which produces tritium and neutrons using d-d fusion reactions, was conducted from 2017 to 2022. Environmental radiation and tritium in environmental water were monitored before and during the deuterium plasma experiment for public acceptance. As a result, there was no significant change in the observed dose rate and tritium concentration in the rainwater, and no statistically significant difference was identified in the statistical analysis of the data observed before and during the deuterium plasma experiment. Therefore, the environmental impact of the deuterium plasma experiments at NIFS is considered to be negligible.

Marital Adjustment, Spiritual Well-Being, and Locus of Control in Married Couples

The aim of this study is to examine the relationship between marital adjustment, spiritual well-being, and locus of control in married couples. A total of 526 married individuals living in İzmir, Turkey, 283 (53.8%) women and 243 (46.2%) men between the ages of 18 and 65, participated in the research. The married individuals were evaluated individually rather than as couples. The of control scale (LCS) developed by Dağ, the marital adjustment test (MAT) developed by Locke and Wallace and adapted into Turkish by Tutarel Kışlak, the spiritual well-being scale (SWBS) developed by Ekşi and Kardaş, and a socio-demographic information form were applied to the participants. SPSS 22.0 was used for statistical analysis of the data obtained in the study. The findings were evaluated at a 5% significance level within a 95% confidence interval (p < 0.05). The findings of the study revealed that the marital adjustment of male participants was higher than that of females, and that as spiritual well-being increased, marital adjustment also increased. A positive relationship was found between transcendence, one of the sub-dimensions of spiritual well-being, and marital adjustment and internal locus of control. Similarly, a positive correlation was identified between harmony with nature and marital adjustment and internal locus of control, while a negative relationship was found between anomie and marital adjustment and internal locus of control. Moreover, negative and significant relationships were found between marital adjustment and external locus of control determinants such as belief in luck, meaninglessness of making an effort, belief in an unjust world, and anomie, one of the sub-dimensions of spiritual well-being. Additionally, a positive relationship was found between higher education and internal locus of control, and a positive relationship between marriages conducted between the ages of 17 and 20 and an external locus of control.

The Effect of Different Obturation Techniques on the Sealing Ability of Root Canal Filling Materials

ABSTRACT Background: The performance of root canal filling materials in sealing is crucial for the effectiveness of endodontic procedures as it prevents the escape of microorganisms and guarantees the durability of the treatment. Materials and Methods: The present in vitro investigation included the preparation of 90 human single-rooted teeth using a standardized process. These teeth were then randomly separated into three groups (n = 30) according to the obturation technique: Group A (Lateral Compaction), Group B (Thermafil), and Group C (Continuous Wave of Condensation). Furthermore, each group was separated into two subgroups based on the specific kind of root canal filling material employed: Subgroup 1 (Gutta-Percha) and Subgroup 2 (Resilon). The sealing capacity was evaluated using a dye penetration technique, with measurements conducted at three specific time intervals: 24 hours, 1 week, and 4 weeks after the obturation process. Statistical analysis of the data was conducted using analysis of variance and post hoc tests to identify significant differences across groups. Results: The findings showed that the Continuous Wave of Condensation method (Group C) had the lowest dye penetration, with an average depth of penetration of 1.2 mm. The Thermafil technique (Group B) followed closely with a penetration depth of 1.8 mm, while the Lateral Compaction technique (Group A) achieved a penetration depth of 2.5 mm. In terms of sealing ability, Gutta-Percha demonstrated superior performance compared to Resilon, achieving average penetration depths of 1.5 mm and 2.0 mm, respectively. Statistical analysis showed statistically significant differences between the groups (P < 0.05), with the Continuous Wave of Condensation approach utilizing Gutta-Percha showing the highest level of sealing effectiveness. Conclusion: In conclusion, the Continuous Wave of Condensation approach showed a substantial improvement in the sealing efficacy of root canal fillings when compared to the Lateral Compaction and Thermafil procedures.

POSSIBILITIES OF AUTOREFKERATOMETRY

In modern ophthalmology, autorefkeratometry has long become a routine diagnostic study, without which it is impossible to imagine any examination. Computerized autorefkeratometers allow you to obtain a huge amount of information about the condition of the patient’s eye in a short time. At the same time, the information obtained is not always subjected to in-depth analysis.Refractometry data should be compared with keratometry data, compared with the indicators of the paired eye, and evaluate, if possible, the dynamics of changes and their tendency. Comparison of the obtained parameters with the average statistical indicators and the age norm make it possible to establish the presence of pathology that does not belong to the field of refractive errors. Thus, the occurrence of anisometropia with similar keratometry parameters suggests opacity of the lens or vitreous pathology. Direct astigmatism is typical for young people, and oblique or reverse astigmatism is typical for patients 65+. A shift in the irido-lens diaphragm is always accompanied by a change in refraction and its instability. Keratectasias are characterized by high variability in refraction and keratometry data, while sometimes maintaining high visual acuity that does not correspond to changes in optical power. Diopter syndrome is manifested by refractive transformations in accordance with changes in the anterior-posterior axis of the eye due to retinal edema. Dry eye syndrome can be manifested by noticeable refractive instability and errors in determining keratometric parameters.High-quality performance of autorefkeratometry, taking into account the nuances, and an in-depth analysis of the data obtained are necessary for making a diagnosis and assessing the dynamics of treatment of ocular pathology.

Mapping lymphatic filariasis morbidities in 24 endemic districts of Ethiopia through the health extension program.

The primary strategy for achieving the second goal of the Global Program to Eliminate Lymphatic Filariasis (GPELF) is morbidity management and disability prevention (MMDP), aimed at alleviating the suffering of affected populations. A significant challenge in many LF-endemic areas is the effective registration and identification of individuals with LF, which is crucial for planning and ensuring access to MMDP services. This study seeks to map the geographical distribution of LF-related morbidities across 24 endemic districts in Ethiopia. A community-based cross-sectional study was conducted to identify individuals affected by LF in 24 endemic districts using primary health care units (PHCUs). The study involved 946 trained health extension workers (HEWs) conducting house-to-house visits to identify and register cases of lymphedema and hydrocele, with support from 77 trained supervisors and 87 team leaders coordinating the morbidity mapping. Certified surgeons performed confirmatory evaluations through clinical assessments on a randomly selected sample of cases to validate HEW diagnoses, ensuring accurate identification of lymphedema and hydrocele. Statistical analysis of the data, including the severity of lymphedema and acute attacks, was conducted using STATA 17. This study involved 300,000 households with nearly 1.2 million individuals, leading to the identification of 15,527 LF cases-14,946 (96.3%) with limb lymphedema and 581 (3.7%) with hydrocele. Among those with lymphedema, 8396 (54.1%) were women. Additionally, 13,731 (88.4%) patients resided in rural areas. Of the 14,591 cases whose acute attack information was recorded, 10,710 (73.4%) reported experiencing at least one acute attack related to their lymphedema in the past 6months, with a notable percentage of males (74.5%; n = 4981/6686). Among the 12,680 recorded cases of leg lymphedema, the percentage of acute attacks increased with severity: 64% (n = 5618) mild cases, 68% (n = 5169) moderate cases and 70% (n = 1893) severe cases. This study successfully mapped the geographical distribution of LF morbidities across 24 LF-endemic districts in Ethiopia, identifying a substantial number of lymphedema and hydrocele cases, particularly in rural areas where healthcare access is limited. The findings underscore the potential of Ethiopia's health extension program to identify affected individuals and ensure they receive necessary care. The findings inform targeted interventions and access to MMDP services, contributing to Ethiopia's goal of eliminating LF by 2027.

Investigating Fission Yeast Mutagenesis Using Canavanine Sensitivity Assays.

Fission yeast are genetically tractable and amenable to mutagenesis studies. Canavanine is a toxic antimetabolite that can be used to test mutation rate. Recent studies have shown that the molecular genetics of canavanine sensitivity are more complex than previously anticipated. However, genomics advances indicate that canavanine use to determine mutation remains an option. In this chapter, we provide methods to grow fission yeast and detect forward mutation in populations of canavanine-sensitive Schizosaccharomyces pombe. Wild-type S. pombe are functionally canavanine-sensitive and die in the presence of canavanine. These protocols use liquid cultures that are tested for density and viability through colony formation. The same cultures are plated onto canavanine-containing media. Cells are grown to find cells that can grow on the canavanine media. These resistant cells are compared to the number plated, and a mutation rate is calculated. While the protocol is straightforward, analysis and application of the data are evolving. These methods provide the ability to compare S. pombe mutant strains for the frequency and rate of mutation.

Exploring the experiences of medical students regarding the factors affecting academic achievement: a qualitative study.

Academic achievement is one of the most important criteria in assessing students' ability to complete their university studies and reach the graduation stage. Students in medical sciences are considered the primary recipients of educational services and are the best source for identifying problems in medical or clinical education, as they are directly and indirectly involved in this interaction process. This study was conducted in the years 2022-2023 using conventional content analysis at Tabriz University of Medical Sciences. A total of 23 students from various faculties of this university were selected through purposive sampling, and their experiences and perspectives were utilized until data saturation was reached. Data was collected through semi-structured, in-depth individual interviews using an interview guide. Content analysis was performed using the conventional content analysis method. Two main themes were extracted with the titles "Facilitators of Academic Achievement" and "Barriers to Academic Achievement ". "Teacher-related Factors," "Assessment and Evaluation," "Student-related Factors," "Learning Environment," and "Support Systems" were the categories derived from the analysis of the data for academic achievement, and "Poor Educational Quality and Teaching Methods," "Lack of Interdisciplinary Collaboration and Integration," "Inappropriate Educational Planning and Administration," "Communication Issues," and "Contextual barriers," were the categories derived for "Barriers to Academic achievement" based on 238 codes and 36 subcategories. Since factors such as satisfaction with educational and welfare facilities and academic motivation impact the quality of education, examining these variables from students' perspectives is beneficial for formulating regulations, providing appropriate facilities, planning for the training of capable students, and selecting suitable educational and learning processes.

Investigation of Critical Aspects of Roughness Assessment for Airfield Pavements

One of the main priorities of airport authorities is to maintain a high level of serviceability of runway pavements due to the high safety requirements for aircraft at high speeds. Accordingly, the assessment of the functional condition of airfield pavements is crucial for the proper operation of an airport. The most critical functional parameter appears to be pavement roughness. It characterizes the condition of the runway surface and is directly related to the safety of aircraft flights, as it affects the handling characteristics and braking performance of the aircraft, the increase in operating costs, and the wear of the aircraft. Worldwide, there are several indices for assessing the roughness of airfield pavements. This study aims to compare some of these indices to assess their ability to capture the characteristics of airfield pavement roughness. For this purpose, roughness data were collected along a runway with flexible pavement at a regional airport in southeast Europe and corresponding indices were estimated. The analysis of the data leads to the most efficient index for assessing the roughness of airfield surfaces to date. However, the need for a new index that expresses the response of the aircraft remains a critical issue.

Abstract 4136788: Lipoprotein(a) Levels and the Risk of Ventricular Arrhythmia: Insights from a Comprehensive Retrospective Cohort Study

Background: Sustained ventricular arrhythmias (VAs) are associated with an elevated risk of sudden cardiac death (SCD). Lipoprotein(a) (Lp[a]) is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD), which in turn associated with increased risk of VAs. However, whether Lp(a) is linked with VAs independent of ASCVD remains unknown. Objective: To examine the association of Lp(a) with VAs in a population-based, retrospective cohort study utilizing data from the TriNetX Research Network. Methods: We conducted a retrospective analysis of the data from 89 healthcare organizations within the TriNetX Research Network. Patients over 18 years old with available serum Lp(a) measurement were included. Participants were divided into two cohorts based on their Lp(a) levels: cohort 1 (Lp(a) ≤75 nmol/L), and cohort 2 (Lp(a) ≥76 nmol/L). Follow-up time to VA occurrence was calculated from the time of Lp(a) level measurement within each cohort. The composite endpoint was the incidence of VAs to include ventricular tachycardia, ventricular fibrillation, ventricular flutter, or cardiac arrest due to underlying cardiac conditions. We compared the two cohorts using Kaplan-Meier survival analysis along with cox proportional hazard regression analysis after propensity score matching. Results: 50,752 patients were included in cohort 1 and 24,474 in cohort 2. After propensity score matching, both cohorts had 23,668 patients. In cohort 1, 307 patients experienced VAs, compared to 303 in cohort 2 (Table 1). The mean age was 53.3 ± 15.7 years, with 53.35% of participants being female, 10.75% being Black, and 69.89% being White. The Kaplan-Meier survival analysis showed a higher survival probability at the end of the study period for the Lp(a) ≤75 compared to the Lp(a) ≥76 cohort (95.11% vs 85.35%, p=0.002). The hazard ratio (HR) for VA was 0.768 (95% CI: 0.652-0.904, p = 0.002), indicating that lower Lp(a) levels are associated with reduced VA risk. Conclusion: This study shows that increased Lp(a) levels are independently associated with a higher incidence of VA. Future research should focus on the mechanisms underlying the relationship between Lp(a) levels and VA, and whether Lp(a) reduction can reduce the risk of VA and other cardiovascular outcomes.

Body Shaming in Online Space: Systematic Review

The main aim of this research paper is to synthesize previous studies and offer a thorough review of the selected body shaming research. Our study summarized the findings of 9 studies that addressed the issues of body shaming, body image, and appreance dissatisfaction in relation to the online space among adolescents and young adults. A systematic review and meta-analysis were conducted following the PRISMA guidelines. In the study, we primarily focused on the age and gender of the participants, protective and risk factors as well as the consequences in connection with the investigated issue. Consequences included low self-esteem, negative feelings related to one's body image, anxiety, depression, shame, comparison, perfectionism about physical appearance, editing photos before sharing on social networks, etc. Interventions discuss positive results in self-compassion, which is directly related to body shaming and body-esteem from previous consequences. Aim The main aim of this research paper is to synthesize previous studies and offer a thorough review of the selected body shaming research. The frequent mentions of terms related to body image and self-esteem in the context of online media suggest a variety of negative consequences for individuals which speaks to the importance of mental health support for those affected by these issues . Methods This study summarized the findings of 9 studies that addressed the issues of body shaming, body image, and appreance dissatisfaction in relation to the online space among adolescents and young adults. The methodology describes the data collection procedure using the ASReview Lab system. A systematic review and meta-analysis were conducted following the PRISMA guidelines. The review we present includes a descriptive analysis of the data. The search strategy included searching abstracts of relevant studies. Automatic random selection was used to identify eligible studies. Abstracts were categorized as relevant or irrelevant according to the keywords entered. The selection process continued until a stopping criterion was reached. ResultsIn the study, we primarily focused on the age and gender of the participants, protective and risk factors as well as the consequences in connection with the investigated issue. Consequences included low self-esteem, negative feelings related to one's body image, anxiety, depression, shame, comparison, perfectionism about physical appearance, editing photos before sharing on social networks, etc. We perceive a correlation with individual consequences and interventions. Striving for positive changes and interventions can be considered as a direct response to the negative consequences mentioned above, such as body shame, low self-esteem, negative body perception, etc. Interventions discuss positive results in self-compassion, which is directly related to body shaming and body-esteem from previous consequences. Similarly, interventions with positive effects on body image are related to several already mentioned consequences, such as worse body image, dissatisfaction with appearance and negative perception of one's own body. Conclusions: The findings suggest an equally high need for prevention strategies and educational interventions that promote media literacy and critical thinking skills for safer interactions in the online space among adolescents and young adults. We believe that our study will be an inspiration for further research, either by supplementing the systematic review with additional studies or empirical interventions in the form of prevention or interventions in connection with the examined issue of physical appearance and online space.

Quality of Life Among Natural Menopausal Women and Early Surgical Menopausal Women: A Study from Greece

Background/Objectives: The general health and well-being of middle-aged women have become a major public health issue worldwide. More than 80% of women experience physical or psychological symptoms during the transition to menopause. This study aims to compare the effect of menopause on quality of life (QOL) in two groups of women undergoing natural and surgical menopause. Methods: The sample consisted of 100 female patients from a Greek hospital in Athens, with an average age of 44.5 years, half of whom had natural menopause, while the remaining women had iatrogenic menopause after surgery for any reason other than malignancy. A questionnaire related to the QOL in menopause was used to collect the data. The scale used to evaluate the QOL of women is the Utian QOL Scale (UQOL), translated into Greek. Results: From the analysis of the data, it was found that there is no statistically significant difference between the QOL of women with natural and surgical menopause. Menopausal symptoms, psychosocial and sexual health, as well as the general health of the two groups, showed similar rates (OR: 63.7–66.6, p = 0.248). The only statistically significant difference found was in weight gain, with natural menopausal women having greater weight gain compared to surgically menopausal women (p = 0.041). Conclusions: Menopausal symptoms are associated with a decrease in women’s QOL. However, QOL is affected regardless of the type of menopause transition. This study was not registered.

Medication Errors in Psychiatric Hospitals: A Nationwide Real-World Evidence Study in Saudi Arabia

Background: Medication errors are among the most prevalent medical errors and result in significant morbidity and mortality. They pose a major threat to patient safety in psychiatric hospitals. However, the lack of a comprehensive investigation into the root causes of these errors restricts the development of effective corrective measures. Objective: This study aimed to characterize the types of errors, determine the stages of the medication use process, and identify factors associated with errors occurring among government psychiatric hospitals in Saudi Arabia. Methods: This cross-sectional study was conducted from August 2019 to June 2020. All medication error reports submitted to the Ministry of Health General Administration of Pharmaceutical Care database from 18 government psychiatric hospitals in Saudi Arabia were assessed. The database is de-identified and contains information on all medication errors, including patient demographics, medication information, error information, causes of errors, and reporter information. Medication use was categorized as ordering/prescribing, transcribing, dispensing, administration, and monitoring. The present findings represent a descriptive analysis of the data using Statistical Analysis Software (SAS) version 9.4. Result: A total of 23,355 medication error reports were reported to the database during the study period. Among Saudi Arabian cities, Riyadh (n = 8972, 38.4%) had the highest medication error reporting rate, followed by Taif (n = 3705, 15.9%) and Jeddah (n = 2621, 11.2%). Most reported errors were frequently made by physicians (n = 20,284, 86.9%) and were primarily detected by pharmacists (n = 20,974, 89.8%). Approximately half of them (n = 13,150, 56.3%) were classified as “Category B” that occurred, but they did not reach patients. Most medication errors were reported in adults (n = 22,589, 96.7%) and male patients (n = 16,393, 70.2%). Most error reports were detected at the prescription stage (n = 16,481; 70.6%) during the medication-use process. Work overload of the staff (n = 2911, 12.8%) and drug labeling, packaging, and nomenclature (n = 2826, 12.1%) were the most common contributing factors associated with the reported errors. Olanzapine (n = 1650, 7.1%), omeprazole (n = 1350, 5.8%), and quetiapine (n = 1273, 5.5%) were the most common medications associated with medication errors. Conclusions: Preventable medication errors are typical in psychiatric hospitals and may result in severe consequences. Increased efforts are needed to control and minimize prescribing errors and improve reporting in Saudi Arabia.

SURG-11. COMPARATIVE RISK ANALYSIS OF DEVELOPMENT OF ANEMIA IN RADIOTHERAPY-TREATED VS. NON-TREATED MULTIPLE SCLEROSIS PATIENTS: A MULTICENTER RETROSPECTIVE COHORT STUDY

Abstract INTRODUCTION The use of RT in patients who are diagnosed with multiple sclerosis (MS) is controversial due to adverse effects such as inflammation. Simultaneously, the relationship between oncologic RT and worsening anemia is well established. However, there is not a clear understanding of the risk associated with undergoing RT due to their oncologic diagnosis in MS patients for developing anemia. OBJECTIVE This study aims to analyze the risk of developing anemia for patients with MS who have been treated with RT versus who have not. METHODS This retrospective study consists of analysis of the data acquired from TriNetX, a database that houses clinical data from 92 healthcare organizations. Cohort 1 included MS patients with history of RT, while cohort 2 included MS patients without any history of RT. The cohorts were propensity score matched for demographics such as age, sex, race, and ethnicity. All neoplasms were also matched to eliminate cancer as a confounding variable. The analysis included outcomes of interest, ICD-10 code D64 (Other anemia), up to 6 months after the first occurrence of the index event. RESULTS 4,844 patients were identified for each cohort post-propensity score matching. The mean age was 65.4 and 67.3 years old, and most patients were white at 76.3% and 77.0% for the MS with RT and without RT cohorts, respectively. Cohort 1 had 628 patients who developed anemia, while cohort 2 only had 511 patients. The odds ratio was 1.263 with 95% confidence interval of 1.116 to 1.430 showing the statistically significant difference between the cohorts. CONCLUSION This study demonstrates that there is a significant increase in the likelihood of developing broadly categorized anemia for multiple sclerosis patients with or without radiation therapy. Further study is warranted to understand other potential factors leading to an increased risk of developing anemia in the irradiated cohort.

The potential for predicting neonatal disabilities in preterm infants

The urgent task of modern pediatricians and neonatologists is to predict the course of the early neonatal period, during which the basic adaptive mechanisms of newborn children are in an unstable state. This is particularly important for the study of premature newborns, who are at high risk for an unfavorable outcome.Purpose. The aim of this study was to investigate the nature of early neonatal adaptation in children born between 32- and 36-weeks’ gestation, from mothers with burdened obstetric and gynecological histories and concomitant medical conditions.Material and methods. Out of 75 patients, we divided children born against a background of placental abruption and pre-eclampsia into separate groups. We provide a comparative analysis of their obstetric, gynecological, and medical histories, as well as their pre-dictive factors, somatic status dynamics, and laboratory and instrumental examinationsResults. Analysis of the data showed that in late preterm newborns, the presence of placental abruption in the history of 100% of cases led to the development of general somatic distress, with deterioration in hemodynamic and respiratory parameters, requiring transfer to the second phase of care. In children born preterm due to severe preeclampsia or other causes, stable severe conditions were observed in 33.3 and 39.6%, respectively, and 53.9 to 60% of infants required respiratory support.Conclusion. These findings allow for individualized assessment of a newborn’s condition in the first few days of life, based on predictive factors that may lead to a breakdown in compensatory responses.

Comparative analysis of the expression of р16, PD-L1 in squamous cell carcinoma of the oropharynx and CUP syndrome

Introduction. metastases in the absence of a primary tumor (cancer of unknown primary (Cup) syndrome) are diagnosed in 2–4 % of malignant tumor cases. This pathology is characterized by early metastatic dissemination, weak response to conventional chemotherapy, and aggressive progression. The use of checkpoint inhibitors targeting programmed cell death protein 1 (pD-1) and its ligand (pD-L1) has shown good results in treatment of various cancers including oropharyngeal squamous cell carcinoma (OpSCC). In Cup syndrome, the effectiveness of checkpoint inhibitors is rarely investigated, and pD-L1 expression is often not measured.Aim. To compare the frequency of p16 and pD-L1 hyperexpression in OpSCC and Cup syndrome, and to analyze dependency of survival rates on the level of expression of p16, the most important prognostic marker.Materials and methods. The study included 121 patients (59 with OpSCC and 62 with Cup syndrome) who received medical treatment in the multidisciplinary medical Center “medical City” (Tyumen) and Chelyabinsk Oncological Center of Oncology and Nuclear medicine between 2019 and 2023. Immunohistochemical examination was performed using the vENTANA Benchmark gX with primary antibodies against pD-L1 (clone Sp263, uSA) and р16 (uS Biological, uSA). Statistical analysis of the data was performed using SpSS 26 software. Long-term treatment outcomes were evaluated using 1-, 3-, 5-year survival rates and median survival. Overall survival was analyzed using the kaplan-meier method. Statistical significance of the differences was evaluated using the Cox model.Results. The studied groups did not differ by sex (p = 0.472), age (р = 0.640), and N stage (р = 0.262). patient age in the whole population varied between 42 and 81 years (median age 61.89 ± 11.9 years; mean age 60.81 ± 9.8 years). pD-L1 expression rate was higher in Cup syndrome at 92 % compared to 73 % in OpSCC (statistically significant difference; р = 0.01). Analysis of the association of ORSCC and Cup syndrome with human papilloma virus showed statistically significant difference in p16 hyperexpression: patients with OpSCC had p16-positive status more frequently (53 % of cases) while patients with Cup syndrome mostly had p16-negative status (73 % of cases). mean life expectancy of patients with OpSCC and p16-positive status was 62.65 months (95 % confidence interval 54.98–70.31), minimal observation period was 12 months, maximal was 70 months. mean life expectancy of patients with Cup syndrome and positive p16 status was 66.22 months (95 % confidence interval 56.35–76.10), minimal observation period was 12 months, maximal was 70 months. No statistically significant differences in survival rates of patients with OpSCC and Cup syndrome were found (р = 0.999).Conclusion. The study showed higher pD-L1 expression in patients with Cup syndrome compared to patients with OpSCC: 92 and 73 %, respectively (р = 0.01). The obtained results highlight the importance of routine pD-L1 expression evaluation in patients with Cup syndrome. The frequency of p16 hyperexpression was higher in OpSCC compared to Cup syndrome: 53 % versus 27 % (р = 0.02) which agrees with the worldwide epidemiological data: among all malignant neoplasms of the head and neck, Hpv infection is most common in OpSCC. Therefore, it serves as an important sign of hidden oropharyngeal cancer in Cup syndrome.