Analysis Of Relative Frequencies Research Articles

Exploring Anatomical Variations of the Vermiform Appendix on Multidetector CT

Acute appendicitis is the most common cause of acute abdominal pain requiring urgent abdominal surgical intervention. Computed tomography (CT) is the preferred imaging examination for the evaluation of patients due to its high sensitivity and specificity. The appendix is a highly variable organ with many possible configurations of its location. Depending on the position of the appendix, the signs and symptoms of appendicitis may also vary and mimic other surgical conditions. Diagnosing appendicitis requires an understanding of the anatomy of the vermiform appendix, which may vary from patient to patient. This study aims to describe the prevalence of anatomical variations of the vermiform appendix on multidetector CT (MDCT). Methods: A retrospective review of consecutive abdominal CT exams (age ≥ 15) performed over eleven months was done. The final study population consisted of 669 patients, 317 men and 352 women, mean age of 51.85 years ± 16.39 (SD), age range, 15-91 years. A classification system was used to describe the different positions of the appendix apex. Results: The most common location of appendix apex was subcecal in 180 (26.9%), followed by pelvic in 153 (22.9%), midline in 130 (19.4%), retrocecal in 100 (14.9%), postileal in 29 (4.3%), paracecal in 20 (3%), others in 19 (2.8%), antececal in 18 (2.7%), hepatic in 14 (2.1%), preileal in 6 (0.9%). Analysis of relative frequencies of appendix locations in relation to patient gender using a chi-square test showed that the pelvic and post-ileal positions of the appendix were statistically significantly higher in females compared to males (p<0.0001, P=0.0158 respectively). The most common

El autocuidado de salud en adolescentes del interior argentino

Adolescent health is currently undergoing a serious deterioration. The aim of this study was to identify the self-care practices in adolescents between 15 and 18 years of age attending secondary schools in four departments of the interior of the province of La Rioja, Argentina. descriptive cross-sectional and analytical study; data collected between October and November 2022 by non-probabilistic convenience sampling, with analysis of absolute and relative frequencies, multivariate logistic regression analysis and Odds ratio with 95% CI statistical significance of p= ˂0.05. Exploratory factor analysis (EFA) using the Principal Components method as extraction and the Orthogonal Varimax method as rotation. Analysis software, SPSS version 26. There are discordances between the self-perception of health care and the practice carried out by the adolescents. Gender disparity in self-care is identified. The factors that increase self-care are the use of digital health applications, annual or shorter medical check-ups, and maintaining positive thinking habits. The main concern in relation to self-care among adolescents was the consumption of alcoholic beverages.

CBCT Assessment of Gubernacular Canals on Permanent Tooth Eruption in Down's Syndrome.

The gubernacular canal (GC) is an important dental structure that enables the alveolar bone ridge cohesion of permanent teeth, although GC absence may indicate a dental eruption that might be associated with certain syndromes such as Down's syndrome. This study aims to correlate the eruptive delay of permanent teeth in individuals with Down's syndrome (Ds) and the gubernacular canal (GC) through cone-beam computed tomography (CBCT). This cross-sectional study was conducted between January and July 2022 with a total of 31 individuals (G1 = 16 nonsyndromic and G2 = 15 Down's syndrome) who went through imaging evaluation using CBCT with the following acquisition parameters: tube voltage of 95 kVp, tube current of 7 mA, exposure time of 5.9 s and voxel sizes and field of view 0.15 mm and 0.30 mm, respectively. The imaging evaluation was to assess whether all teeth analyzed had the presence of GC and/or teeth eruption disturbance, with a descriptive statistical analysis of relative frequencies and quantitative variables as well as the p-value (p < 0.005) by G Test. A total of 618 teeth among 31 individuals were analyzed, 475 (76.8%) GC were detected by CBCT in 23/31 patients and of these, 6 belonged to G2. G2 had a decreased GC detection rate (n = 180-37.9%) and the most common tooth with GC detected was the mandibular 1st molar (21 GC/25 teeth-84%) and the absence of GC was most frequently observed in impacted and delayed/unerupted teeth of Ds individuals. We concluded that GC absence was higher among Ds individuals, explaining the increased rates of unerupted or impacted teeth in Ds individuals.

Documentation of Genetic Diversity by Insulin-Like Growth Factor1 Receptor (Exon2) Gene for Fallow Deer (Dama dama) in Iraq.

Insulin-Like Growth Factor1 Receptor (Exon2) (IGF1R) gene plays a vital role in physiological impacts, such as growth, development, reproduction, and metabolism. A significant difference was noted between the IGR1R (exon 2) gene and the body weight of Dama dama. In addition, the heterozygosity pattern (AB) was significantly higher than the other pattern (AA). There are three single nucleotide polymorphisms (SNPs; 144G>C, 147A>G, and 210A>C) within the IGF-1R (exon 2) locus. The statistical analyses indicated the presence of three different haplotypes (GAA, CAA, and GGC). The analysis of relative frequencies indicated that the most frequent haplotype in the studied Dama dama population was Hap3 (GGC) (43.4782%) out of the three observed haplotypes. The results of SSCP-PCR revealed the variability of the target gene between the genotype frequencies in Fallow deer (Dama dama) with a high level of significance (P≤0.01) with two patterns (AA and AB) and an absence of BB pattern. The allele frequency of AA record a high level (71.74%) than the other genotype (AB) (28.26%), with a high-frequency level of the A allele (0.86) than the B allele (0.14). In current findings, SSCP genotyped in the Dama dama DNA observed an estimated 72% monomorphic loci and 28% polymorphic loci approximately. Hardy Weinberg equilibrium test (HW) was applied to the SSCP-PCR data matrix, and the statistical test was based on a chi-square (χ2) test. Chi-square was (55.928%) with a highly significant level (P≤0.01) recorded in the present study. As related to AA and AB genotypes mean, a significant difference (P≤0.05) was noted between IGF1R (exon 2) gene with a body weight of Dama dama, as well as the heterozygosity pattern (AB), was significantly (P≤0.05) higher than the other pattern (AA) (30.34±3.01kg versus 24.85±1.94kg), respectively. A significant impact (P≤0.05) between IGF1R (exon2) polymorphism and heart girth was founded to be related to the AB pattern (heterozygous) (76.92 ± 3.20 cm), whereas the lower value was related to the AA pattern (71.33 ± 2.49 cm). No significant differences in effects were shown in relation to body length and height at the shoulder. The present study is also interested in genetic characterization by calculating (Ne) as a tool for genetic diversity. Therefore, the number of alleles detected (Na) indicates that two alleles only were unique in the population of the study, with (1.3204) being the number of efficient alleles (Ne). Moreover, Shannon's Information index was recorded at 0.4073. The observed homozygosity (O.Hom.) and heterozygosity (HO) were (0.7174 and 0.2826), respectively. The values of expected homozygosity (E.Hom.) and heterozygosity (HE) were 0.7547 and 0.2453, respectively. The genetic diversity of Nei was 0.2427. The results showed an unexpected influx of IGF1R diversity measured by Fis and recorded the value (- 0.1646). In this sense, the results of the current study may be considered an approximation to the total genetic diversity of the population of Dama dama in Iraq, but the information obtained is relevant to proposing the strategies of conservation for the genetic diversity observed.

Clinical-Epidemiological Profile of Congenital And Acquired Heart Diseases Admitted To A Private Hospital

Objectives To characterize the clinical-epidemiological profile of children with heart diseases (congenital, acquired and arrhythmias), conducted by the pediatric cardio group of a private general hospital, from January 2016 to March 2020. Method Retrospective longitudinal observational interference study, with quantitative design, carried out in a private hospital. A total of 502 patients were selected according to the following inclusion criteria: patients who had congenital heart disease, acquired heart disease and arrhythmia, all managed by the pediatric cardiomyopathy group. Descriptive analysis of absolute and relative frequencies were represented through tables and graphs. Results Of the 502 patients included in the study, 86.5% had congenital heart disease, 7.7% acquired heart disease and 5.8% arrhythmias. 50.2% were female, 49.6% male and 0.2% were not defined so far. Prematurity occurred in 19.3% of cases, presence of syndromes in 31.2 % and associated comorbidities in 34.7%. In total, 530 procedures were performed, of which 77% were surgeries, 18.5% hemodynamic procedures and 4.5% hybrid procedures. A risk score called RACHS-1 (adjusted risk for surgery and congenital heart disease) was used to categorize the surgeries. There was a predominance of category 3 (38.4%), followed by category 2 (28.6%), category 1 (18.2%), category 4 (9.6%) and category 6 (5.2%). Conclusions The complexity of the profile of the found heart diseases reiterates that measures are needed for an integrated approach of different specialties and professionals for the treatment of these patients.

Percepción y actitudes frente a la atención de planificación familiar en tiempos de Covid-19 en mujeres de asentamientos humanos de Piura – Sullana , 2020

Aim. Determine if there is an association between perception and attitudes towards Family Planning care in times of Covid-19 in women from 18 to 45 years of age in Human Settlements of Piura-Sullana, 2020. Materials and Methods. Correlational descriptive study, simple random probabilistic sampling was used, for the simple and bivariate descriptive analysis of the study variables relative and absolute frequencies were used. Results. The studied sample revealed 44.32% aged between 25-34 years, 63.01% were cohabitants, 57.66% with a secondary education degree; 91.24% come from the coast; 73.29% are Catholic and 58.34% are housewives. The perception and attitude towards family planning care in times of Covid-19 was reported as bad and inadequate with 34.57% and 53.84% respectively. When relating the variables, it was shown that 34.57% who manifested a bad perception level, in 25.78% their attitude was inadequate. conclusions. The Chi square test showed a high statistically significant association between perception and attitudes towards family planning care in times of Covid-19, confirming the alternative hypothesis.

Incidence of inpatient cases with mental disorders due to use of cannabinoids in Germany: a nationwide evaluation.

BackgroundQuantitative (e.g. increasing recreational cannabinoid use) and qualitative (e.g. increasing availability and use of synthetic cannabinoids and cannabis preparations with increased tetrahydrocannabinol content) changes in cannabinoid use may be associated with changes in the prevalence of cannabinoid-related mental and behavioural disorders and, accordingly, changes in the need for medical care. We aimed to investigate if there are changes in the number of inpatient cases (ICs) due to cannabinoid-related disorders in Germany.MethodsData were obtained from the Federal Statistical Office of Germany (Destatis) and comprised type and number of hospital main diagnoses (according to ICD-10) of all ICs in Germany in the period 2000–18. Linear trend analysis of absolute and relative annual frequencies (AFs) of ICs with diagnoses related to the use of cannabinoids (DRUCs), and, as controls, alcohol-related psychiatric disorders and schizophrenia-spectrum disorders was performed.ResultsAbsolute AFs of ICs with DRUCs increased statistically significantly (P<0.0001, trend analysis) in Germany between 2000 and 2018 and corresponding relative AFs increased considerably (4.8-fold increase when comparing 2000 and 2018). Specifically, absolute AFs of ICs with cannabinoid intoxications (P<0.0001), harmful use (P=0.0005), dependence syndrome (P< 0.0001), withdrawal state (P<0.0001), psychotic disorders (P< 0.0001) and residual and late-onset psychotic disorder (P<0.0001) statistically significantly increased. Absolute AFs of schizophrenia-spectrum disorders slightly, but statistically significantly decreased (P=0.008), and alcohol dependence did not statistically significantly change (P=0.844).ConclusionsOur evaluation demonstrates increasing numbers of ICs with mental and behavioural disorders due to use of cannabinoids in Germany and emphasizes the need for adequate prevention of such disorders.

Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT

BackgroundTo determine locations, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis from hepatocellular carcinoma (HCC) on 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET CT.MethodsFDG PET CT scans of 224 consecutive patients of HCC acquired between 2010 and 2018 were reviewed. Fifty-six patients detected with extrahepatic metastasis on FDG PET CT were retrospectively analyzed. Findings were correlated with prior/follow-up imaging studies, clinical findings, FNAC, or biopsy findings whenever available. Descriptive analysis of location, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis was done.ResultsCommonest were metastatic pulmonary nodules (55.3% patients), most of them being well-defined solid lesions (53.5%) with bilateral involvement in 44.6% patients and lower lobes of lungs along with other lobes being more frequently involved (41.0% patients). While in 7.14% patients lung nodules were FDG avid, 23.2% patients had both FDG avid and non-avid pulmonary nodules. Second most common were regional metastatic lymph nodes in 44.65% of patients seen at aortocaval (25%), paraaortic (23.21%), portocaval (21.4%), and left gastric nodal (17.8% of patients) stations. Twenty-five percent of patients had FDG avid lymph nodes and 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Distant metastatic lymph nodes were third most common in 39.2% of patients seen at paratracheal (2.5%), juxtaphrenic (8.9%), and mesenteric lymphnodal (7.1%) stations. Twenty-five percent of patients had FDG avid lymph nodes while 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Skeletal involvement was seen in 32.1% of patients. Commonest sites are vertebrae (16.7%), pelvis (14.2%), and ribs (10.7% patients). Six out of 7 patients had unilateral adrenal gland involvement. Bilateral adrenal gland involvement was seen in 1 patient. FDG non-avid peritoneal/omental metastases was seen in 2 patients. Brain, spleen, and muscle metastatic lesions were seen in 1 patient each out of 56 patients (1.79%).ConclusionsLungs, regional and distant lymph nodes and skeleton are the most frequently involved sites of extrahepatic metastatic hepatocellular carcinoma. Adrenal glands, muscles, brain and peritoneum are also involved but to a lesser extent.

Oral health and incidence of nosocomial infection and mortality in patients undergoing elective cardiac surgery

Objective: To analyze the relationship between oral disease and the risk of developing hospital pneumonia, mediastinitis, endocarditis, surgical site infection and hospital death in patients undergoing elective cardiac surgery. Assess which risk factors would be related to the risk of nosocomial infection and death after cardiac surgery. Methodology: It was an analytical, observational, prospective study, carried out from January to December 2018. The study included 46 patients candidates for elective cardiac surgery and evaluated as to the type of heart disease, type of surgery, associated comorbidities, age, NYHA classification, BMI, ICU stay days, oral health assessment by a dental surgeon, occurrence of infection and hospital death. The analysis was done through analysis of absolute and relative frequencies, estimation of odds ratios, chi-square test and Mann-Whitney test. Results: Of the 46 patients analyzed, 11 (23.9%) of them had hospital infections and 4 (8.7%) died, there was no statistically significant difference in the variables studied with the occurrence of infection or death. The heterogeneity of the findings in the oral evaluation that ranged from edentulous patients with partial or total dentures, partial edentulous with or without prosthesis and varying degrees of oral disease that ranged from gingivitis, periodontitis to abscesses. The prostheses had varying degrees of conservation and hygiene. This great variability of findings may have implied no statistical significance in the variables. Conclusion: There was no statistical difference in the occurrence of hospital pneumonia, mediastinitis, endocarditis, surgical site infection and hospital death according to the patients' oral health condition.

Analysis of congenital syphilis notifications in a university hospital in the city of Niterói from 2016 to 2020

Introduction: The elimination of congenital syphilis is a challenge in the field of public health worldwide. The failure of previous global plans forces authorities to rethink detection and control strategies, with compulsory notification being an important tool for obtaining data. Objective: To analyze the notifications of congenital syphilis made by Departamento de Vigilância Epidemiológica do Hospital Universitário Antônio Pedro (Department of Epidemiological Surveillance at Antônio Pedro University Hospital), between January 2016 and August 2020. Methods: Retrospective, descriptive, and quantitative study of data from congenital syphilis notification forms in Hospital Universitário Antônio Pedro from January 2016 to August 2020. In the descriptive analysis of categorical variables, absolute and relative frequencies were used; for numerical measures, central tendency and dispersion measures were used. Spearman correlation, Mann-Whitney test and Fisher’s exact test were performed in the R software (version 4.0.3). Hills’ criteria for causality were also considered. Results: Of the 67 forms examined, two were excluded due to duplication, and 48 variables were analyzed. No form was completely filled out, and some data were missing on more than 90% of them. According to maternal data, patients were mostly from Niterói (60%), had an average age of 23.09 years, and were brown (32.31%), while 13.85% did not finish 5th to 8th grade and 80% had prenatal care, but less than half had appropriate treatment indicated. As for the children: 55.38% were female, 40% brown, with an average age of 90.98 days. The great majority (72.31%) of them were born at Hospital Universitário Antônio Pedro, and not being born at this hospital was significant when it came to being asymptomatic (69.23%, p=0.001); the most frequent symptom was jaundice. Conclusion: Improvement in the follow-up and investigation of the reported cases can significantly decrease this high percentage of missing information, improving the quality of the data. The vast majority of patients underwent prenatal care, and therefore, they were avoidable cases, since the maternal diagnosis in the peripartum period occurs when the chance for vertical transmission has already occurred and caused consequences for the child’s life.

MANAGERS PROFILE AND THEIR BUSINESS IN MICRO AND SMALL COMPANIES: A STUDY IN JOÃO PESSOA (PB)

Companies’ performance in complex and competitive markets has stimulated the search for new ways of structuring and measuring performance, so that it is possible to obtain a competitive advantage in the long run. Given this context, this study’s objective was to compare the use of performance indicators within different management structures in micro and small companies in the city of João Pessoa, in the state of Paraíba, which operate in the market as participants in franchises or individually. Aspects related to the company and the managers/owner-partners’ profile, competitiveness, comparison of the company with its competitors, comparison of the company with the previous year and the general performance are addressed. To this end, a questionnaire was applied to 43 companies. In order to compare the two types of management structures, we performed an analysis of absolute and relative frequencies. The survey results indicated that individual companies are performing “equal to the average”, and companies participating in franchises perform “much better than the average” when compared to their competitors and the previous year. The most relevant criteria in the performance analysis of the different management structures were customer satisfaction, employee satisfaction, and profitability. The least important were social and environmental responsibility. The profile of managers or owner-partners is not very different, but competitiveness offer a more critical environment for individual companies.

Incremento de la productividad en una empresa conservera de pescado.

Objetivo. Aplicar la ingeniería de métodos para incrementar la productividad del proceso de envasado en una empresa de conserva de pescado. Materiales y métodos. Se realizó una investigación aplicada con diseño de investigación preexperimental. Se utilizaron técnicas como el análisis de frecuencias absolutas y relativas, análisis de causa y raíz, estudio de tiempos, técnica del interrogatorio y análisis documental. Los instrumentos empleados fueron: diagrama de Pareto e Ishikawa, que ayudaron a identificar el proceso a mejorar para lograr el incremento de la productividad; cursograma analítico del operario, donde se registró la información del proceso de envasado, y se apoyó de un diagrama de recorrido para conocer la distribución del área; y hojas de análisis de tiempo que permitieron determinar los tiempos estándares. Resultados. Mediante el cursograma analítico se determinó que el 40.20 % representaban actividades que no agregan valor al producto; se obtuvo una productividad inicial promedio de 48.56 cajas/hora-hombre en relación a los meses de junio-agosto; se calculó un tiempo estándar de 645.33 segundos/caja; y mediante la técnica del interrogatorio se estableció un nuevo método de trabajo. Conclusiones. Con la aplicación del nuevo método de trabajo, se consiguió una distancia recorrida menor a la anterior y se estableció un mejor tiempo estándar producto de un efectivo método de trabajo que genera mejores resultados.

PSY30 IMPACT OF PSORIASIS INTEGRATED CLINIC (CLIPSO) STAFF IN ELIMINATE WASTEFUL SPENDING IN HEALTHCARE, MEDELLIN – COLOMBIA

describe the economic impact generated CLIPSO's staff by adequate prescription and switching treatment of psoriasis. a retrospective observational cross-sectional study in patients with moderate-severe psoriasis evaluated by CLIPSO's staff from May-2018 to December-2019. The staff is an interdisciplinary group formed by dermatologists, rheumatologists, internist physicians, pharmacists, nurses, physical therapists, nutritionists, and psychologists, which periodically meets to define in a consensus the most appropriate therapy for each patient. The patients evaluated were referred to the staff by an external or CLIPSO's dermatologists to the initiation or switching their treatment. We define an economic impact when the patients arrived with the expectation of beginning a biologic therapy and the staff defines begin with non-biologic systemic therapy or topical therapy. For the descriptive analysis of qualitative variables, relative and absolute frequencies were used, and quantitative variable summary measures (central tendency, scatter, position). A normality test was performed. The proportion of patients who do not switch their therapy and the savings generated by staff were calculated. R Core Team statistical package (2019) was used. during the study, the active population was 1007 patients, of which, 380/1007 (37.7%) were analyzed by staff. Of these, 74/380 patients (19.5%) arrived the expectation with biologic therapy spectating, but began with non-biologic systemic therapy alone or combination with topical therapy. Metotrexate (37.5%), Daivobet (29.7%), Acitretin (17.2%), Chemophototherapy (4.7%), Metotrexate+Daivobet (3.1%), Clobetasol (3.1%), Cyclosporine (1.6%) or Azathioprine (1.6%). 39/74 (52.7%) had a time of 12 months or more after the intervention (average 16±2.2 months) without beginning biologic therapy and with successful therapeutic, generating a total saving of 711.570 USD [1]. CLIPSO's staff generated an impact on eliminating wasteful spending by biologic therapy use in psoriasis.

PSY31 HEALTH-RELATED QUALITY OF LIFE IN PATIENTS EVALUATED IN A PSORIASIS INTEGRATED CLINIC (CLIPSO), MEDELLIN-COLOMBIA

Describe the results of Health-Related Quality of Life (HRQoL) of CLIPSO's patients, using the Dermatology Life Quality Index (DLQI). An observational cross-sectional study in patients with moderate-severe psoriasis attending from May-2018 to November-2019. The DLQI was evaluated upon admission to CLIPSO and a second measure during the first year. The DLQI is a self-assessment questionnaire used to measure HRQoL evaluating symptoms, feelings, daily activities, personal relationships, and side effects. It is calculated adding up the score of each question with a maximum score of 30 (greater deterioration in HRQoL) and a minimum of 0. The score is classified as no effect (score 0-1), slight effect (score 2-5), moderate effect (score 6-10), very important effect (score 11-20), and extremely important effect (score 21-30). A descriptive analysis of relative and absolute frequencies was used, and quantitative variable summary measures. A normality test and association for paired samples (McNemar's and Spearman) was performed to define differences between initial and final DLQI. R Core Team statistical package (2019) was used. During the study 527 patients had at least two measurements of DLQI. In the first measure, 6.1% of patients were classified with an extremely important effect, of which 84.4% improved (28.2% changed to no effect, 15.6% slight effect, and the others changed to moderate effect or effect very important). 24.6% were classified as effect very important, of which 69.3% improved (33.1% changed to no effect, 17.7% slight effect, and 18.5% moderate effect). 21.6% were classified as a moderate effect, of which 72.9% improved (47.7% no effect and 25.3% slight effect). 21.2% was classified as a slight effect, of which 57.2% improved to no effect. Finally, 26.9% were classified as no effect, of which the 84.4% kept their classification (p-value <0.0000). HRQoL of CLIPSO's patients shows statistically significant and clinically relevant improvement.

Suporte básico de vida: conhecimento de enfermeiras (os) que atuam na estratégia de saúde da família

Objective: To analyze the knowledge of FHS nurses from a municipality of Recôncavo de Bahía against SBV. Method: This is a descriptive epidemiological research, conducted with 14 nurses from Basic Health Units and Family Health Units in a municipality of Bahia, using a questionnaire on sociodemographic, occupational and educational characteristics and about general and specific SBV education. Data were analyzed through descriptive analysis of variables, calculating absolute and relative frequencies and measures of central tendency and dispersion. Results: most had knowledge of how to check the victim's pulse on cardiac arrest (92.9%), the frequency of chest compressions if ventilation could not be guaranteed (57.1%), and the minimum depth of chest compressions ( 71.4%). 92.9% did not know the proper place for hand placement and chest compressions; 50% were aware of the situations in which AED could be used; 57.1% knew the PCR rates and 57.1% were shockable PCR rates. Conclusion: We found that nurses have satisfactory knowledge about the performance of SBV in relation to CRP. Descriptors: Urgency and emergency; Life Basic Support; Primary Care.

The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML.

Acute myeloid leukemia (AML) is a genetically heterogeneous disease with a clinical course predicted by recurrent cytogenetic abnormalities and/or gene mutations. The NPM1 insertion mutations define the largest distinct genetic subset, ∼30% of AML, and is considered a favorable risk marker if there is no (or low allelic ratio) FLT3 internal tandem duplication (FLT3 ITD) mutation. However, ∼40% of patients with mutated NPM1 without FLT3 ITD still relapse, and the factors that drive relapse are still not fully understood. We used a next‐generation sequencing panel to examine mutations at diagnosis; clearance of mutations after therapy, and gain/loss of mutations at relapse to prioritize mutations that contribute to relapse. Triple mutation of NPM1, DNMT3A and IDH1/2 showed a trend towards inferior overall survival in our discovery dataset, and was significantly associated with reduced OS in a large independent validation cohort. Analysis of relative variant allele frequencies suggests that early mutation and expansion of DNMT3A and IDH1/2 prior to acquisition of NPM1 mutation leads to increased risk of relapse. This subset of patients may benefit from allogeneic stem cell transplant or clinical trials with IDH inhibitors.

Health determinants in adults in Chimbote, Peru: A descriptive study.

To describe health determinants in adults from the jurisdictions of the North and South Pacific Health Networks in the city of Chimbote. A non-controlled descriptive study was carried out. Health determinants were classified in the following categories: bio-socioeconomic characteristics, lifestyle, and social and community support. For the descriptive analysis of categorical variables, relative and absolute frequencies were used. A total of 1 496 adults were included in the study. In the bio-socioeconomic determinants category, 62.2% were women and 53.3% were older adults. In the lifestyle determinants category, 52.4% did not smoke and had not ever smoked regularly, 50.5% did not consume alcoholic bever-ages, and 66.9% had 6 to 8 hours of sleep. In the social/community support determinants category, 53% had been treated at a health facility in the previous 12 months, 47.5% considered the distance between the health facility where they were treated and their home to be average, and 64.6% had public health insurance (SIS) from Perus Ministry of Health (MINSA). Most participants completed high school but this level of education did not result in access to higher-scale salaries. In addition, most partici-pants owned their own homes as well as access to basic services but lived in overcrowded conditions. A sedentary lifestyle and high-carbohydrate diet were predominant in this sample, highlighting the need for education to improve health.

Profile of women with cervical cancer attended for treatment in oncology center

Abstract Objectives: to evaluate the sociodemographic, clinical, histopathological, cytopathological and microbiological profile of women with cervical cancer treated at Oncology Center in Pernambuco, located in the city of Caruaru-PE. Methods: a retrospective study was carried out to evaluate the medical records of women with cervical cancer treated for radiotherapy and/or chemotherapy between January 2014 and December 2016. For the analysis of variables, the absolute and relative frequencies were calculated. Results: there was a predominance of cases in the age range between 40 and 59 years (45.37%), non-white race/color (91.75%) and incomplete primary education (44.32%). Squamous carcinoma was present in 85.19% of the cases, with a moderately differentiated histological grade being the most common (53.41%). Most women underwent radiotherapy and associated chemotherapy (72.72%) and had 3 or more pregnancies before diagnosis (73.44%). Cytopathology has more frequently identified high-grade squamous intraepithelial lesion (HSIL) cases (45.83%) and cocci and/or bacilli (66.67%) were the most evident microorganisms. Conclusions: the results showed that the perimenopause age, low educational level, multiparity, cytopathologic result of HSIL and histopathological examination evidencing moderately differentiated squamous cell carcinoma were among the characteristics most related to cervical cancer in the population studied.

Perfil clínico funcional de pacientes con artritis reumatoide derivados a Fisiatría en control en Centro Reumatólogico Avanzado (CREA) del Hospital Clínico Universidad de Chile

Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease that primarily affects the joints causing varying degrees of disability. Non-pharmacological management is increasing evidence of its usefulness impacting functionality. Objectives: To characterize the clinical / functional profile of patients with rheumatoid arthritis derived physiatrist assessment in the Clinical Hospital University of Chile. Methods: We reviewed the clinical records of patients with RA derivatives Physical Medicine, extraction demographics, medical history, physical examination and functionality. Statisticians analysis of central tendency, dispersion, absolute and relative frequencies. Results: 85 medical records were analyzed. 88.2% were women with an average age of 54.05 ± 11.42 years. 38.8% have at least one comorbidity. 34.1% of patients takes between 6 and 15 years of disease. The average drug related AR is 5.6 per patient, being more Disease Modifying Antirheumatic Drugs (DMARDs) found. 35.2% presented falls in the past year. Pain is a symptom found in the history and physical examination with a VAE (venous air embolism) 4.4 ± 2.43 at the time of consultation and 6.7 ± 3.3 in crisis. 20% received kinesic therapy and only 7% occupational therapy. 45.3% of patients having a value of HAQ (health assesment questionnaire) who scored as moderate disability, even if their self-perception of independence reaches 65.9%. Conclusion: The analysis allows us to perform a demographic, clinical and functional profile that allows us to guide rehabilitation actions.

Profile of readjusted workersat a public hospital in Southern Brazil.

To establish the sociodemographic, occupational and clinical profile of labor readjusted workers at a public hospital. Cross-sectional study conducted with 40 labor readjusted workers at a university hospital in SouthernBrazil. Datacollection was performed by means of an instrument with questions for sociodemographic, occupational and clinical profile. Descriptive analysis of relative and absolute frequencies was performed. Female sex (72.5%), age range 54 to 59 years old (35%) and technical education level (37.5%) predominated. Most labor readjusted workers were members of the nursing staff (62.5%), and the main reasons for readjustment were musculoskeletal mental and behavioral disorders. One might infer that labor readjustment might related to factors present in the hospital work environment.