We develop a multigrid solver for the second biharmonic problem in the context of Isogeometric Analysis (IgA), where we also allow a zero-order term. In a previous paper, the authors have developed an analysis for the first biharmonic problem based on Hackbusch’s framework. This analysis can only be extended to the second biharmonic problem if one assumes uniform grids. In this paper, we prove a multigrid convergence estimate using Bramble’s framework for multigrid analysis without regularity assumptions. We show that the bound for the convergence rate is independent of the scaling of the zero-order term and the spline degree. It only depends linearly on the number of levels, thus logarithmically on the grid size. Numerical experiments are provided which illustrate the convergence theory and the efficiency of the proposed multigrid approaches.