Analysis Of Hazard Factors Research Articles

Exploratory Analysis of Hazard Factors Influencing the Safety Rating of Pedestrian Bridge

Exploratory Analysis of Hazard Factors Influencing the Safety Rating of Pedestrian Bridge

Retracted: Analysis of Hazard Factors Affecting the Quality of Life for Lung Cancer Patients after Chemotherapy.

[This retracts the article DOI: 10.1155/2022/6910126.].

Analysis of Hazard Factors Affecting the Quality of Life for Lung Cancer Patients after Chemotherapy.

Objective To explore the hazard factors affecting the quality of life for patients with lung cancer after chemotherapy, so as to provide evidence-based clinical proof to improve their quality of life. Methods The clinic data of lung cancer patients treated with chemotherapy from November 2020 to November 2021 in our hospital were selected for retrospective analysis. A questionnaire survey was administered to 74 patients who met the inclusion criteria. The general condition questionnaire made by the department was used to analyzed the patients' demographic characteristics and disease status. The quality of life questionnaire for Chinese cancer patients receiving chemobiotherapy (QLQ-CCC) was used to evaluate the patients' quality of life. Results The research objects selected for this study scored an average of (94.53 ± 22.65) points in the quality of life. It was found by logistic regression analysis that age, education level, marital status, pathological types, monthly family income, and metastasis were the independent influencing factors that lowered the quality of life of lung cancer patients after chemotherapy (P < 0.001). Conclusion Chemotherapy can lead to a decline in the quality of life of lung cancer patients, and there are many factors at play. Therefore, medical and nursing staff should focus on the overall condition of patients when carrying out clinical treatment.

Prolonged progression-free survival and overall survival are associated with diabetes mellitus but inversely associated with levels of blood glucose in patients with lung cancer.

BackgroundPrevious studies have provided conflicting evidence about the increased overall survival (OS) in lung cancer patients with diabetes mellitus (DM) compared with those without DM. This study assessed progression-free survival (PFS)/OS in lung cancer patients with or without DM and tentatively analyzed the impact of blood glucose levels on PFS/OS in lung cancer patients.MethodsData were collected from lung cancer patients based upon admission records from January 2010 to January 2012 and follow-up records from January 2010 to January 2015 in the Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai. The data included patient sex, age, body mass index (BMI), smoking status, history of DM, level of blood glucose, pathological type, clinical stage of cancer, chemotherapy regimen, and history of anti-DM drugs. The Cox regression model and Kaplan-Meier method were used for the analysis of hazard factors and PFS/OS. For comparison of PFS/OS in lung cancer with or without DM, patients were divided into three groups: lung cancer with DM, lung cancer without DM but with elevated level of blood glucose, lung cancer without DM or elevated level of blood glucose.ResultsIn total, the data from 200 lung cancer patients (138 males/62 females, aged 29.0 to 78.0 years, mean 60.0 ± 8.6 years) were collected. For the comparison of PFS/OS in lung cancer patients with or without DM, patients were divided into three groups: lung cancer with DM (n = 31); lung cancer without DM but with elevated levels of blood glucose (n = 40); and lung cancer without both DM and elevated levels of blood glucose (n = 128), whereas 1 patient dropped out of the study. All the patients underwent complete chemotherapy and were followed up for 36.0 to 60.0 months. Kaplan-Meier survival analysis showed that lung cancer patients with DM had increased PFS and OS compared with those without DM (log-rank, P < 0.05, P < 0.01); the median PFS in lung cancer with DM was 12.0 months (95% confidence interval [CI], 4.0–16.0) vs. 6.0 months in those without DM (95% CI, 5.8–6.3); and the median OS in lung cancer patients with DM was 37.0 months (95% CI, 29.0–46.6) vs. 12.0 months in those without DM (95% CI, 10.9–13.1). For the other two groups of patients without DM, there was a trend toward a shorter PFS and OS in patients with elevated blood glucose compared with those without elevated blood glucose. Cox regression showed that PFS in lung cancer patients was favorably associated with the usage of anti-DM drugs, BMI, clinical stage of cancer, and chemotherapy regimen (all P < 0.05) but was inversely associated with the level of blood glucose (P < 0.05).ConclusionsLung cancer patients with DM have prolonged PFS and OS compared with those without DM, and the level of blood glucose was inversely associated with PFS. The current results indicate that PFS may be a meaningful intermediate endpoint for OS and that the levels of blood glucose hopefully represent a prognostic factor in lung cancer patients.

Micro-scale Flood Hazard Assessment Based on Catastrophe Theory and an Integrated 2-D Hydraulic Model: A Case Study of Gongshuangcha Detention Basin in Dongting Lake Area, China

Assessments of urban flood hazards are crucial for planning and early warning flood system design. Moreover, hazard risk assessment is useful for emergency planning and insurance. There are two common methods for conducting flood hazard risk assessments (FHRA): those based on physical models and those based on parameters. Although physical models are able to simulate flood propagation processes accurately, they also have obvious shortcomings. Parameter-based FHRAs are more comprehensive because they emphasize the analysis of hazard factors. However, this approach also has various flaws, including its qualitative, macro-scale and high subjective nature. In this study, the strengths of both methods were combined to develop a new micro-scale FHRA. Taking the FHRA of the flood storage and detention area of Dongting Lake as an example, this study used high-precision digital elevation model (DEM) data generated from an airborne light detection and ranging (LiDAR) point cloud to construct a two-dimensional (2-D) flood propagation model. Micro-scale FHRAs were then performed using eight selected FHR indicators based on catastrophe theory. By automatically calculating the FHR value of each assessment unit based on hierarchical recursion, the catastrophe theory and catastrophe progression method effectively avoided uncertainty in weight assignment, which is an issue commonly faced by parameter-based methods. The FHRA results obtained under 144 different sequences of assessment indicators also show that the proposed method has a low sensitivity to the ranking of FHR indicators, as well as a high fault tolerance for different assessment results arising from subjective rankings by humans.

Will Hazard Factor Analysis Change the Approach to Pediatric Poison Exposures?

Exposures to poisons are one of the most common causes of increased morbidity and mortality rate worldwide, especially among children. We want to analyze the distribution of children poisonings admitted to intensive care. We considered all pediatrics’ poisoning cases through Milan Poison Control Centre during six years that required the intensive care monitoring. In case of major effects or death we calculated the Hazard Factor (HF). Descriptive statistic and Fisher exact test where indicated was adopted. We considered significant p value <0.05. We analyzed 451 cases within 130.921 calls. Half of exposures were unintentional (52.3% n = 236). The most dangerous HF calculated amounted to 6.09 (range 0–12.2). The daily and the yearly distribution of accidental and voluntary intake of substances seemed to show some cluster of incidence. Drugs administration mistakes are the most frequent events in the first 2 years of life. Intentional exposure is frequent after 13 years old. The HF contributes to clinical triage, monitor setting and therapeutic strategies. The individuation of the most dangerous substances may be useful to develop future interventions to prevent these events and to inform the population about a strict surveillance in specific hours of the afternoon when dangerous substances are present.

Sacral insufficiency fractures after high-dose carbon-ion based radiotherapy of sacral chordomas

BackgroundThis study aimed to analyse the frequency and clinical relevance of sacral insufficiency fractures (SIFs) after high-dose carbon-ion based irradiation of sacral chordomas.MethodsA total of 56 patients were included in this retrospective study. Twenty one patients (37%) were treated with definitive radiotherapy (RT), and 35 patients (63%) received postoperative RT using carbon ions, either in combination with photons or as single-modality treatment (median radiation dose 66 Gy RBE, range 60–74 Gy). Follow-up examinations including MRI of the pelvis were performed at 3-monthly intervals in the first year and consecutively at 6-monthly intervals. Median follow-up was 35.5 months (range 2–83).ResultsSIFs were diagnosed in 29 patients (52%) after a median follow-up of 11 months (range 1–62 months). Most sacral fractures (79%) occurred within 2 years after RT. For the overall study population, the fracture-free survival probability amounted to values of 0.68 (95% CI, 0.53–0.79) after 1 year, 0.46 (95% CI, 0.31–0.60) after 2 years, and 0.31 (95% CI, 0.16–0.47) after 5 years. Statistical analysis showed no significant difference regarding the fracture rates between patients who received an operation and postoperative RT and patients treated with definitive RT. About one third of the patients with SIFs (34%; 10 of 29 patients) had associated clinical symptoms, most notably pain. All patients with symptomatic fractures required strong analgesics and often intensive pain management.ConclusionsSacral fractures after high-dose carbon ion-based RT of sacral chordomas were shown to be a considerable radiogenic late effect, affecting about half of the treated patients. However, only one third of these fractures were clinically symptomatic requiring regular medical care and pain therapy.Further hazard factor analysis in the future with larger patient numbers will possibly enable the identification of high-risk patients for developing SIFs with the ultimate goal to prevent symptomatic fractures.

Performance-Based Evaluation of Large Steel-Framed Structures in the Overall Fire Process

This paper proposes a systematic analysis of fire hazards within an oversized steel-framed building that is taller and wider than usual, using a performance-based approach. We put forth both the method and the performance criteria for performance-based fire design of oversized steel-framed buildings and quantitatively evaluate the hazard factors (smoke temperature, smoke visibility, smoke toxicity, and structural collapse) in fire condition. FDS large eddy simulation and a modified temperature rise model of oversized steel structures were proposed for the quantitative analysis of hazard factors. Furthermore, we also studied evacuation process from oversized buildings and found that the Pathfinder model (developed based on water conservation model and behavior model) can accurately predict the evacuation process from oversized buildings based on our experimental study of an evacuation from a stadium. By comparing the time of occurrence of fire hazard factors (smoke temperature, smoke visibility, smoke toxicity, and structural collapse) and the time needed for safe evacuation, we could conduct a quantitative fire risk assessment on personal evacuation. And the time of occurrence of fire hazard factors can also provide a theoretical reference for emergency rescuers.

Adverse drug reactions and therapeutic errors in older adults: A hazard factor analysis of poison center data

The severity of hazards posed by medications implicated in poisoning in older adults was characterized. Toxic Exposure Surveillance System (TESS) cases from 1993 through 2002 involving a single substance in patients age 60 years or older and coded as an adverse drug reaction (ADR) or therapeutic error were analyzed. Hazard factors were determined for each exposure reason by calculating the sum of the major effects and deaths for each substance category and subcategory and dividing this by the total number of exposures for the respective category or subcategory. Hazard factors were calculated for 12,737 ADRs and 51,846 therapeutic errors. The overall rates of major effects and deaths were 7.5% and 1.6% in the ADR and therapeutic error groups, respectively. In the ADR group, five TESS categories had a hazard factor of > or =2.0: anesthetics, anticoagulants, antineoplastics, cardiovascular drugs, and radiopharmaceuticals. In the therapeutic error group, five drug categories also had a hazard factor of > or =2.0: anesthetics, anticoagulants, antineoplastics, asthma therapies, and serums/toxoids/vaccines. Six pharmaceutical categories were associated with hazard factors of > or =2.0 in both the ADR and therapeutic error groups. An analysis of ADRs and therapeutic errors involving older adults and reported to poison control centers from 1993 through 2002 revealed overall rates of major effects and death of 7.5% and 1.6% in the ADR and therapeutic error groups, respectively. Antineoplastics, aminophylline or theophylline, cardiac glycosides, heparin, morphine, and warfarin were implicated in more than 50 cases and associated with hazard factors of > or =2.0 for both exposure groups.

Poisoning in Older Adults: A 5-Year Experience of US Poison Control Centers

Poisoning in older adults has received relatively little attention. To describe poison exposures in older adults reported to US poison centers and identify substances that pose a unique risk to this population. A retrospective review of human exposures for patients aged >or=60 years reported to the American Association of Poison Control Center's Toxic Exposure Surveillance System from 1993 to 1997 was performed. Frequencies and cross-tabulations were used to describe the data. Hazard factor analysis was conducted to identify medications that pose risk in this population. Statistical analysis included chi(2) and Fisher's exact test for hazard factors. A total of 298,713 poison exposure cases were reported to US poison centers involving individuals aged >or=60 years between 1993 and 1997. The proportion of cases in this age group also steadily increased from 2.5% of all cases in 1993 to 3.4% of all cases in 1997. The mean age of the patients was 64.7 years, and 34.1% were males. Hazard factor analysis was conducted on unintentional exposures and adverse reactions to pharmaceutical agents to determine medications that posed increased risk to older adults. The substance categories that had the highest hazard factor were radiopharmaceuticals, asthma therapies, anti-coagulants, anesthetics, and antidepressants. Therapeutic errors and adverse reactions to medications are common reasons for major effects and fatal outcomes among older adults reported to poison centers. Understanding poisoning issues specific to this population may help direct future outreach education efforts.

Comparison of Pediatric Poisoning Hazards: An Analysis of 3.8 Million Exposure Incidents A Report from the American Association of Poison Control Centers

This analysis of life-threatening and fatal pediatric poisonings was conducted to aid poison prevention educational efforts, guide product reformulations and aversive agent use, reassess over-the-counter status for selected pharmaceuticals, and identify research areas for clinical advances in the treatment of pediatric poisonings. A hazard factor was devised to assess more objectively the pediatric poisoning hazard posed by pharmaceutical and nonpharmaceutical products. By considering the frequency and extent of injury following actual exposures, the hazard factor reflects more than the acute toxicity of individual ingredients and is also influenced by such variables as packaging, accessibility, availability (as a reflection of marketing), formulations, and closure types. Of the 3,810,405 exposures involving children younger than 6 years of age reported to poison centers in 1985 through 1989, 2117 patients experienced a major outcome (life-threatening effect or residual disability) and an additional 111 fatalities occurred. The three most commonly implicated substance categories, accounting for 30.4% of reported exposures, include cosmetics and personal care products, cleaning substances, and plants. All had low hazard factors, with significant hazards being limited to a small number of products identified herein. Thus this analysis of hazard factors demonstrates that frequent exposure does not imply toxicity. Iron supplements were the single most frequent cause of pediatric unintentional ingestion fatalities, accounting for 30.2% of reported pediatric pharmaceutical unintentional ingestion fatalities reported over an 8-year period. Antidepressants, cardiovascular medications, and methyl salicylate follow in frequency of pediatric pharmaceutical deaths. Hydrocarbons (including five lamp oil deaths) and pesticides were each implicated in 12 pediatric ingestion fatalities during the 8-year period.(ABSTRACT TRUNCATED AT 250 WORDS)