Abstract The main objective of moderation in the heat transfer equipment is to utilize the vitality and capital cost. The Cooling system's thermal performance is mainly based on the Performance of the heat exchanger. The cross-flow heat exchanger works more efficiently with a high rate of heat transfer when compared with shell and tube heat exchanger, spiral heat exchanger, and plate type heat exchanger. One method of enhancement of heat transfer rate in different types of heat exchangers is possible with the use of nano fluids instead of plain fluids. In extent, the study focuses on the specialist's improvement in experimental and analysis of cross-flow heat exchanger which incorporates structure, experimental outcomes with different fluids like air, water, Nano fluids and further more numerical analysis (CFD, COMSOL and ANN). Various investigations have revealed enhancements in heat transfer by a heat exchanger by means of the utilization of nanofluids acquired by suspending X2O3 type oxides, for example, Al2O3, TiO2 and SiO2 in water. Cross flow heat exchanger mostly used for hygienic standards at large canteens, hospitals, food industries and they will not exchange humidity like a rotary heat exchanger.