Analysis Of Breast Cancer Incidence Research Articles

Features of the incidence of breast cancer in the Republic of Kazakhstan

Aim of the study. Analysis of breast cancer incidence in Kazakhstan for the period 2020 – 2022.Materials and methods. The study included all registered cases of breast cancer morbidity and mortality in the Republic of Kazakhstan for the period 2020-2022. Data for analysis were taken from the official statistical source: Statistical collection «Health of the population of the Republic of Kazakhstan and the activities of healthcare organizations in 2020»; Statistical collection “Health of the population of the Republic of Kazakhstan and the activities of healthcare organizations in 2021-2022.” The search depth was 3 years, from 2020 to 2022. A direct standardization method using a global population standard was used to calculate standardized morbidity and mortality rates.Results and discussion. As a result of studying statistical data for 2020-2022, it was found that cancer incidence rates per 100 thousand population in 2022, compared with 2021, increased by 5.2%, and compared to 2020 increased by 13.5%. In the structure of incidence, both in 2020 and 2021, and in 2022, breast cancer occupied 1st place, with an increase in dynamics from 2020 to 2022 from 8.76 to 9.73 per 100 thousand population.An analysis of the incidence of breast cancer by stages of the disease in the context of regions of Kazakhstan showed that high rates of stages I and II of breast cancer were established in the Kyzylorda, Pavlodar, and Atyrau regions. The lowest incidence rates of stage I and II breast cancer were observed in Akmola, Mangistau and Turkestan regions.Conclusions. According to the results of our review, many studies indicate that this disease continues to be the most frequently diagnosed malignant neoplasm and the leading cause of death among women in various countries of the world, including Kazakhstan. The conclusion of this article is that the incidence and mortality from breast cancer continues to be an urgent epidemiological problem in Kazakhstan, requiring further scientific research to identify risk factors.

Temporal Pattern and Age-Period-Cohort Analysis of Breast Cancer Incidence in Iranian Women (2009-2017).

Breast cancer accounted for 28.1% of all female cancers in 2020 in Iran. This study was conducted to evaluate the time trend of breast cancer incidence and to identify the changes of breast cancer incidence in age, period, and birth cohorts in Iran, in the 2009-2017 timeframe. Annual cancer statistics for female breast cancer were obtained from the Iranian National Population-based Cancer Registry (INPCR) database from 2009 to 2017. The age-period-cohort (APC) analysis was used to evaluate the time trend of breast cancer incidence in age, period and birth cohorts between 2009 and 2017. R package (Epi) was used to analyze data. Results were considered statistically significant at P<0.05. The age effect showed an increased incidence of breast cancer until the age of 45, and after this age the speed of increase was slower until 65 years. There was an increased diagnosis in 2015-2017 (period effect) for many age groups, especially in the 70- and over 80-year-old group. Our findings indicated that breast cancer incidence peaks in the age of 45 in Iranian women, which is a decade earlier compared to the Western world. The period effect in 2015-2017 can be explained by the fact that in 2014, the former Iranian pathology-based cancer registry was upgraded to a population-based cancer registry, which resulted in improved coverage of cancer registry and case finding.

A Statistical Review of Template Model Builder: A Flexible Tool for Spatial Modelling

SummaryThe integrated nested Laplace approximation (INLA) is a well‐known and popular technique for spatial modelling with a user‐friendly interface in the R‐INLA package. Unfortunately, only a certain class of latent Gaussian models are amenable to fitting with INLA. In this paper, we review template model builder (TMB), an existing technique and software package which is well‐suited to fitting complex spatio‐temporal models. TMB is relatively unknown to the spatial statistics community, but it is a flexible random effects modelling tool which allows users to define customizable and complex mixed effects models through C++ templates. After contrasting the methodology behind TMB with INLA, we provide a large‐scale simulation study assessing and comparing R‐INLA and TMB for continuous spatial models, fitted via the stochastic partial differential equations (SPDE) approximation. The results show that the predictive fields from both methods are comparable in most situations even though TMB estimates for fixed or random effects may have slightly larger bias than R‐INLA. We also present a smaller discrete spatial simulation study, in which both approaches perform well. We conclude with a joint analysis of breast cancer incidence and mortality data implemented in TMB which requires a model which cannot be fit with R‐INLA.

A trend analysis of breast cancer incidence in Sri Lanka, 2005-2019a

Official publication of the College of Community Physicians of Sri Lanka and was established in 1995. Full text articles available.Journal of the College of Community Physicians of Sri Lanka (JCCPSL) has been recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations. The journal is indexed in DOAJ.Manuscripts are only accepted online through the portal of the JCCPSL https://jccpsl.sljol.info/ . The prospective authors must read carefully the section on Author Guidelines and prepare their manuscript accordingly. To submit a manuscript or to check the status of a submission the authors must first be registered in the JCCPSL Editorial Management System using an existing or newly created username and password. Next, choose the ‘Start Submission’ link and follow the five-step article submission process which is a simple and self-guided process.

A population-based analysis of breast cancer incidence and survival by subtype in Ontario women.

Breast cancer (bca) is the type of cancer most frequently diagnosed among women in Canada. Breast cancer is categorized into various molecular subtypes by the expression of estrogen receptor (er), progesterone receptor (pgr), and her2 (human epidermal growth factor receptor 2). Currently, Canada has no national cancer registry with epidemiology data by subtype. Thus, we conducted a study to determine incidence, survival, and clinicopathologic characteristics by bca subtype [triple negative breast cancer (tnbc); her2+; and hormone receptor-positive (hr+), her2-] in Canadian women newly diagnosed with bca. Female patients diagnosed between 1 April 2012 and 31 March 2016 (fiscal 2012-2015) were identified in the Ontario Cancer Registry, and individual patient data were linked to data in provincial health administrative databases. Descriptive statistics and Kaplan-Meier curves were generated. In this cohort, 3277 women (9.5%) had tnbc, 4902 (14.3%) had her2+ bca, and 22,247 (64.8%) had hr+, her2-breast cancer. The annual incidence was 15 per 100,000 for the tnbc group, 21-23 per 100,000 for the her2+ group, and 97-105 per 100,000 for the hr+, her2- group. The lowest median overall survival (mos) of 8.9 months was observed in women with clinical stage iv tnbc. In comparison, the mos was 37.3 months in those with her2+ disease and 35.2 months in those with and hr+, her2- metastatic bca. In the present study, the most recent and largest administrative database analysis of a Canadian population to date, we observed a subtype distribution consistent with previously reported data, together with comparable annual incidence and overall survival patterns.

Epidemiologic analysis of breast cancer incidence, prevalence, and mortality in India: Protocol for a systematic review and meta-analyses.

Breast Cancer (BC) is the leading cause of deaths in Indian women. Emerging reports reveal alarming evidence of increasing incidence and mortality of BC among young Indian women in addition to the late presentation and poor prognosis. Despite the significant incidence, there is a lack of reliable data resources and comprehensive epidemiologic studies relating to BC. The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the incidence, prevalence, and mortality of BC in 29 states and seven union territories of India. Data sources used will be Cochrane Review, MEDLINE, PubMed, Scopus, Science Direct, Web of Science, and international and national cancer registries such as World Health Organization, International Agency for Research on Cancer (IARC), and National Centre for Disease Information and Research (NCDIR)-National Cancer Registry Program initiated by Indian Council of Medical Research. Relevant data will be extracted using a predefined data collection form. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. Odds ratios (ORs) will be used to measure effect size. The random or fixed-effects meta-analyses model will be employed to aggregate the pooled estimates (ORs) with 95% confidence intervals (CIs) separately. A forest plot will be produced to assess ORs and 95% CIs. Publication bias will be assessed using funnel plot, and Egger regression will be applied to test the symmetry of the funnel plot. This proposed study will be based on published studies and the data from cancer registries. Therefore, human research ethics approval is not required. The results of this study will be published in a peer-reviewed journal. CRD42018084003.

Population-Based Analysis of Breast Cancer Incidence and Survival Outcomes in Women Diagnosed with Lobular Carcinoma In Situ.

A diagnosis of lobular carcinoma in situ (LCIS) is associated with an increased risk of developing breast cancer, although little data exist on long-term patient outcomes, including those who develop subsequent breast malignancies. The Surveillance, Epidemiology, and End Results (SEER) database was used to identify women with a histological diagnosis of LCIS between 1983 and 2014. The incidence and clinicopathologic features of subsequent malignancies were then examined, and the Kaplan-Meier method and multivariable Cox PH regression used to obtain breast cancer-specific survival (BCSS) estimates and associated hazard ratios. Overall, 19,462 women swith a mean age at LCIS diagnosis of 53.7years, and a 10- and 20-year cumulative incidence of subsequent breast malignancy of 11.3% [95% confidence interval (CI) 10.7-11.9%] and 19.8% (95% CI 18.8-20.9) met the eligibility criteria. At a median follow-up of 8.1years (range 0-30.9) a total of 1837 primary breast cancers were diagnosed, of which 55.2% were diagnosed in the ipsilateral breast. Most breast cancers were of low/intermediate grade, hormone receptor-positive, and diagnosed in early stages. Of subsequent malignancies, invasive ductal carcinoma (IDC) distributed equally across both breasts, whereas invasive lobular carcinoma (ILC) was more likely to present in the ipsilateral breast (69.0% ILC vs. 49.2% IDC; p<0.001). On multivariable analysis, type of surgical treatment for LCIS had no affect on long-term survival (p=0.44). The 10- and 20-year BCSS for women with LCIS was 98.9 and 96.3%, respectively. Women with LCIS who are diagnosed with a subsequent primary breast cancer are often diagnosed in early stages and have excellent BCSS.

Spatial Analysis of Breast Cancer Incidence in Iran.

Breast cancer (BC) is the most common cancer in females (27% of the total) and the main cause of death (16%) due to cancer in women in developed and developing countries. Variations in its incidence rate among geographical areas are due to various contributing factors. Since there have been a lack of studies on this topic in our country, the present spatial analysis of breast cancer incidence in Iran in 2009 was conducted using data from the national cancer registry system. The reported incidences of the disease were standardized according to the World Health Organization population and the direct method. Then data was inserted into the GIS software and finally, using the Hot Spot Analysis (Geties-Ord Gi), high-risk areas were drawn. Provinces with incidences 1.96 SD higher or lower than the national average were considered as hot spots or cold spots, at the significance level of 0.05%. In 2009, a total of 7,582 cases of BC occurred in Iran. The annual incidence was 33.2 per hundred thousand people. Our study showed that the highest incidence of BC in women occurred in the central provinces of the country, Tehran, Isfahan, Yazd, Markazi and Fars. The results of hot spots analysis showed that the distribution of high-risk BC was focused in central parts of Iran, especially Isfahan province (p <0.01). The other provinces were not significantly different from the national average. The higher incidence in central provinces may be due to greater exposure to carcinogens in urban areas, a Western lifestyle and high prevalence of other risk factors. Further epidemiological studies about the etiology and early detection of BC are essential.

Abstract A53: An analysis of breast cancer incidence in young women: A single site study

Abstract Background: Breast Cancer cases in women are on the rise. It is estimated to raise breast cancer cases in young women. There are no screening guidelines for women younger than 45 years old. Breast cancer in this age group is associated with higher morbidity and mortality compared to older women, thus the impact of the disease is significant. Methods: A retrospective chart review was conducted for women diagnosed and treated for breast cancer at clinic from 2012 to 2014. Patients were stratified by age, under 45 y.o and over 45 y.o., Subjects with different grade and disease subtypes(triple negative; ER/PR+/HER1-, ER/PR+/HER3+) were selected in those groups. Descriptive analysis was performed. Results: 130 patients were reviewed from 2012 to 2014. The analysis demonstrated that of all reviewed samples, breast cancer was detected in 23% of patients younger than 45 y.o. Data analysis also showed that ER/PR-, HER2 1+ (triple negative) samples were detected in 26% of women under 45 y.o., which is 18% more than in women over 45 y. o. (26% vs. 7.6%). ER/PR+/HER2 1+ 13% vs. 20% (difference 7%), ER/PR+/HER3+ 39% vs. 2.5%, G3 - 47% vs. 37.5; G2 - 43% vs. 60% respectively. Conclusions: This retrospective study indicates that breast cancer diagnosed in women younger than 45 y.o. is associated with an aggressive clinical and molecular subtype. Delay in diagnosis has been a concern among this age group given the lack of screening guidelines. In our country Georgia screening starts from 40 years. More awareness, screening programs and trainings to both practitioners and young women should be implemented. Note: This abstract was not presented at the conference. Citation Format: Tamta Makharadze. An analysis of breast cancer incidence in young women: A single site study. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research; Oct 17-20, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(2_Suppl):Abstract nr A53.

PO38 An analysis of breast cancer incidence in young women: a single site study

PO38 An analysis of breast cancer incidence in young women: a single site study

Breast cancer bone metastases: an epidemiologic study in selected radiation departments.

To quantify radiation treatments for bone metastases from breast cancer in three Sicilian provinces (Messina, Catania, Ragusa) with respect to the general population and the incidence and prevalence of breast cancer in this macro-area in a 8-year period. All bone metastasis patients treated using radiotherapy in 8 radiation departments operating in the provinces of Messina, Catania and Ragusa were collected. Among these, metastases from breast carcinoma were analyzed according to year of irradiation. An analysis of breast cancer incidence and prevalence with respect to inhabitants in this macro-area was conducted using literature and census data. From January 2004 to December 2011, irradiation was delivered in 4419 bone metastasis patients. Among these, 1617 had a primary breast cancer with a median treatment per year of 206.5 (range, 164-251); 211 patients were treated in 2004 and 206 in 2011. In 2004, there were 1,048,957 female residents in the three provinces and 1,065,422 in 2011. The reported breast cancer incidence and prevalence in Sicily was respectively 100.79/100,000 and 908.54/100,000 in 2004 and 108.41/100,000 and 1091.29/100,000 in 2010. There has been an increase in both incidence and prevalence of breast cancer in Sicily. Nevertheless, it seems that there was no increment in skeletal-related events requiring irradiation in such patients in eastern Sicily radiation departments.

Application of area to point Kriging to breast cancer incidence in Ashanti Region of Ghana

This paper provides a spatial analysis of breast cancer incidence in the Ashanti region area during the period of 2010 to 2011. Breast cancer disease has prevalence in Ghana particularly in the major cities including Ashanti region. Geographical units vary in shape and size and incidence count is non homogeneous in nature. For this reason, assigned area to point kriging approach is adopted as methodology. There is a large range of spatial autocorrelation in ages above 40 years than that of below 40 years in the various administrative units. The surrounding administrative units in the regional capital are less endemic for women whose ages are above 40 years. However, for those whose ages are below 40 years in all the surrounding administrative units are endemic but the capital is not. Most of the endemic districts share boundaries with Kumasi metropolis, the regional capital, where the only Teaching hospital is located. Most of the districts do not have good health facilities where women report for early treatment. Key words: Area to point kriging, breast cancer, area to area, kriging.

First Epidemiological Analysis of Breast Cancer Incidence and Tumor Characteristics after Implementation of Population-Based Digital Mammography Screening

PURPOSE: To epidemiologically evaluate the impact of digital mammography screening on incidence rates and tumor characteristics for breast cancer. MATERIALS AND METHODS: The first German digital screening units in the clinical routine were evaluated during the implementation period by using data from the cancer registry to compare the incidence rate of breast cancers and prognostic characteristics. 74 % of women aged 50 - 69 within the region of Muenster/Coesfeld/Warendorf were invited between 10 / 2005 and 12 / 2007 for initial screening; 55 % participated (n = 35 961). RESULTS: In 2002 - 2004 the average breast cancer incidence rate (per 100 000) was 297.9. During the implementation of screening, the rate rose to 532.9 in 2007. Of the 349 cancers detected with screening, 76 % (265 / 349) were invasive compared to 90 % (546 / 608) of cases not detected with screening during the same period. 37 % (97 / 265) of cancers detected in the screening program had a diameter of ≤ 10 mm and 75 % (198 / 265) were node-negative compared to 15 % (79 / 546) and 64 % (322 / 503), respectively, in cancers detected outside the screening program. The distribution of invasive tumor size (pT categories) and the nodal status differed with statistical significance between cancers detected in and outside the program (p = 0.005 and p = 0.004, respectively). CONCLUSION: Epidemiological data shows that the implementation of a population-based screening program led to a relevant increase in the age-specific breast cancer incidence rate. The characteristics of breast cancers detected in the screening program comply with the requirements of the European guidelines and are significantly favorable compared to tumors diagnosed outside the program. These findings indicate that digital mammography screening fulfills the requirements for an early tumor detection tool.

First Epidemiological Analysis of Breast Cancer Incidence and Tumor Characteristics after Implementation of Population-Based Digital Mammography Screening

To epidemiologically evaluate the impact of digital mammography screening on incidence rates and tumor characteristics for breast cancer. The first German digital screening units in the clinical routine were evaluated during the implementation period by using data from the cancer registry to compare the incidence rate of breast cancers and prognostic characteristics. 74 % of women aged 50 - 69 within the region of Muenster/Coesfeld/Warendorf were invited between 10 / 2005 and 12 / 2007 for initial screening; 55 % participated (n = 35 961). In 2002 - 2004 the average breast cancer incidence rate (per 100,000) was 297.9. During the implementation of screening, the rate rose to 532.9 in 2007. Of the 349 cancers detected with screening, 76 % (265 / 349) were invasive compared to 90 % (546 / 608) of cases not detected with screening during the same period. 37 % (97 / 265) of cancers detected in the screening program had a diameter of <or= 10 mm and 75 % (198 / 265) were node-negative compared to 15 % (79 / 546) and 64 % (322 / 503), respectively, in cancers detected outside the screening program. The distribution of invasive tumor size (pT categories) and the nodal status differed with statistical significance between cancers detected in and outside the program (p = 0.005 and p = 0.004, respectively). Epidemiological data shows that the implementation of a population-based screening program led to a relevant increase in the age-specific breast cancer incidence rate. The characteristics of breast cancers detected in the screening program comply with the requirements of the European guidelines and are significantly favorable compared to tumors diagnosed outside the program. These findings indicate that digital mammography screening fulfills the requirements for an early tumor detection tool.

Major changes in breast cancer incidence in the United States over the period 2002 to 2004

1533 Background: We have recently reported that a steep decrease in the incidence of breast cancer occurred in the United States in 2003 relative to 2002 (BCRT 100: S5, 2006). This decrease was most evident in patients older than 50, and largely occurred because of a decrease in the incidence of estrogen receptor positive breast cancer. This decrease occurred after the report in 2002 of the results of first of the Women s Health Initiative trials of postmenopausal hormone therapy (HT). This publication showed that use of a combined estrogen/progestin combination was associated with increased risk of breast cancer and heart disease and led to an immediate and substantial decrease in the use of HT in the US. Dramatic shifts in breast cancer incidence are unusual, and provide unique opportunities to test models that have been developed to explain trends in breast cancer incidence and mortality. We have been engaged in modeling trends in breast cancer incidence and mortality, in collaborative effects such as the Cancer Intervention and Surveillance Modeling Network (CISNET), to understand these and other processes (NEJM 353:1784–1792,2005). These models have practical implications for understanding the impact of changes in risk factors, use of prevention strategies, screening, and treatment of breast cancer. Methods: SEER public use incidence data from 1990 to the end of 2003 will be updated with information from the release in the spring of 2007 of incidence data for 2004. We will analyze the full data set through 2004 and report on the trends in incidence of breast cancer in the population as a whole and by subsets (such as age, estrogen receptor status, stage etc). We will also use the most recent and detailed data about HT use and screening mammography during this period as part of modeling. Results: We are awaiting SEER data from 2004 which will be released by April of 2007. Conclusions: Our first SEER based multi-year analysis of breast cancer incidence following the change in HT use in the US will be presented. Modeling of these trends in incidence will be discussed in the context of understanding the role of various contributors to the change in breast cancer incidence and what insights on the evolution of preclinical disease might be possible. No significant financial relationships to disclose.

Die Brustkrebsmortalität der Frauen in den Kreisen Schleswig-Holsteins von 1981 bis 1995

The present descriptive study evaluates breast cancer mortality among women in the northernmost German Federal State of Schleswig-Holstein over the period from 1981 to 1995 based on data provided by the Schleswig-Holstein State Office for Statistics. Starting from the results of the second Cancer Atlas for the Federal Republic of Germany [11], covering the period 1976-1980, breast cancer mortality rates rose sharply until the beginning of our investigation. A moderate rise in breast-cancer mortality in Schleswig-Holstein continued until the third period under investigation (1987-1989), while after that time breast cancer mortality decreased again towards the end of the investigation period. In Schleswig-Holstein as a whole, the mortality rate increased by approximately 12% during the last 20 years. When reviewing age-specific breast-cancer mortality for each rural district ('Kreis') or, respectively, for each self-administrative town (kreisfreie Stadt), different patterns were observed, particularly among younger women. In the 40- to 44-year and 45- to 49-year age group a rise in breast cancer mortality was observed in several, but not all districts. Mortality patterns do not tend to be representative for breast cancer incidence because mortality reflects only a small proportion of the women actually suffering from breast cancer. The standardised incidence of breast cancer in Germany--calculated on the basis of data provided by the Saarland cancer registry--is currently over 60/100,000 and is thus 2-3 times the mortality rate. However, presently it is not possible to evaluate the breast cancer incidence (Schleswig-Holstein) because the first population-based cancer registration was initiated only in 1999. In contrast to other German Federal States, notification of all cancer cases is compulsory in Schleswig-Holstein. A valid analysis of breast cancer incidence should be possible in 5-10 years conditional on a registration rate of at least 90%. Further investigations into the causes of breast cancer should be carried out to test specific hypotheses on exposure to risk factors, including nutrition and life style to clarify the regional differences observed in this study.