A comparative study was carried out by establishing an overall bridge spatial finite element model and a transverse frame model on transverse structural characteristics of Kunyang Bridge on Wenzhou-Fuzhou Railway line. The longitudinal variation of transverse stress in box-girder shows peaks distribution. The absolute values of transverse stress decrease gradually at peaks and valleys in overall tendency as it’s close to the mid span. The calculation results of the rigid support frame method can envelop the calculation results of the overall bridge spatial finite element model in side span region without suspenders.It verifies the reasonability of the rigid support frame method to calculate transverse stress of this region. And the width of transverse frame should designate one third of suspender spacing or more in transverse stress calculations of central span region with suspenders.