The Italian Association for Stress Analysis (AIAS) was founded in 1971 by researchers from academia, research centers, and industry. AIAS was intended as a community where to discuss, share, and develop scientific knowledge related to all technical aspects of stress analysis. In the years, from an initial focus on experimental techniques, AIAS contributed considerably to the development of modern numerical methods and computational techniques for mechanical engineering design. In 2015, AIAS turned in the Italian Scientific Society of Mechanical Engineering Design.Today, AIAS is an institutional partner that supports the instances from academia in the subject area of mechanical engineering design. Every year, AIAS organizes a technical conference offering the possibility to present research updates, share new ideas, and foster collaborations. The AIAS conference has become a fundamental event for all those interested in current developments in mechanical engineering design and stress analysis, where to meet researchers, testing equipment, and software developers.The 51st AIAS Conference edition was held in Padova, Italy again in presence after two years of online-only events due to the COVID-19 pandemic.The response of researchers and students has been outstanding: over 200 oral contributions have been presented during the three days of the conference, with four parallel sessions. In addition to the thematic sessions on AIAS traditional subjects, special sessions on additive manufacturing, energy methods for structural analysis, circular design in mechanical engineering, and mechanical behavior under extreme conditions, have been successfully organized with the contribution of the AIAS technical committees.Among all contributions presented at the conference, 48 have been selected to be published after peer review, in this volume. This was made possible thanks to the active participation of all AIAS members, to the work of the AIAS Scientific Committee and Conference Papers Review panel (Profs Giovanni Meneghetti, AIAS Scientific Coordinator, Luciano Afferrante, Francesco Bucchi, Filippo Cianetti, Enrico Armentani, Marco Sasso). Their outstanding contribution is gratefully acknowledged. Disclaimer AIAS2022 Conference was held in presence on Sept. 7-10, 2022. Presentations were arranged in four parallel sessions with a time slot of 15 min assigned to each presenter. Approximately 250 participants attended the conference during the three days event. All sessions have been continuously monitored by the organizers to provide technical support. The conference ran smoothly, and the participants’ feedback was very positive.