Su1696 Gastrointestinal Amyloidosis: Endoscopic Finding Is Associated With the Amyloidosis Type, Organ Involvement, and Prognosis Ji Won Kim*, Hye Mi Jung, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim, Sung Noh Hong Department of Internal Medicine, Samsung Medical Center, Seoul, Korea (the Republic of) Background and Aim: Although the gastrointestinal(GI) involvement of amyloidosis is very common, there is little information about endoscopic finding of GI amyloidosis. We categorized the endoscopic finding of GI amyloidosis and investigated the association of the type of amyloidosis, clinical manifestations and prognosis with endoscopic features of GI amyloidosis. Patients and Methods: Using prospective registry of amyloidosis in Samsung Medical Center, we identified 42 GI amyloidosis patients who confirmed by endoscopic biopsy (localized amyloidosis, nZ10; AL, nZ20; AA, nZ6, unclassifiable, nZ4, inherited, nZ2). Endoscopic finding was reviewed by two independent experienced endoscopists (H.M.J, S.N.H) and categorized into 5 types as follow: type 1, amyloid nodule (polypoid protrusions and thickening of the folds); type 2, granular infiltrative mucosa; type 3, erosive ulcerative type; type 4, subepithelial hemorrhage; type 5, normal looking mucosa. Results: Overall, endoscopic findings were most commonly seen as subepithelial hemorrhage (14/42, 33.3%). According to the amyloidosis type, type1, type2, type 3, type 4 and type 5 endoscopic finding was noticed 6(60%), 2(20%), 1(10%), and 0(0%) in localized amyloidosis, respectively, 3(15%), 2(10%), 3(15%), 8(40%), and 4(20%) in AL amyloidosis, respectively, and 0(0%), 1(16.7%), 3(50%), 2(33.3%), and 2(33.3%) in AA amyloidosis, respectively. When classifying into organs, type1, type2, type 3, type 4 and type 5 endoscopic finding was noticed 3(15%), 0(0%), 4(20%), 9(45%) and 4(20%) in cardiac involvement, respectively, 1(7.7%), 0(0%), 2(15.4%), 7(53.8%), and 3(23.1%) in nervous system involvement, respectively, and 7(53.8%), 3(23.1%), 1(7.7%), 2(15.4%), and 0(0%) in isolated GI tract involvement, respectively. The survival was poor in type 3,4 and 5 than for type 1 and 2( P Z 0.036). Conclusion: The endoscopic findings of GI amyloidosis is associated with the amyloidosis type, organ involvement, and patients’ survival