The collapse of slopes caused by earthquakes can lead to landslides, resulting in significant damage to both lives and structures. Seismic reinforcement of these slopes can protect social systems during an earthquake. In South Korea, where more than 70% of the land is mountainous, the stability of slopes is of paramount importance compared to other countries. While many seismic designs are based on peak ground acceleration (PGA), there is relatively little consideration given to the extent of PGA’s influence, and few studies have been done. This study aims to assess the seismic amplification of slopes with multilayers using a 1 g shaking table and verify the results through numerical analysis after confirming the impact of PGA at specific points. Typically, slope model experiments are conducted on single-layered ground models. However, actual ground conditions consist of multiple layers rather than a single layer, so a multi-layered model was created with different properties for the upper and lower layers. Two multi-layered ground models consisting of two layers were created, one with a flat ground surface and the other with a sloped surface. The properties of the two layers in each model were configured as a single layer to create the slope models. The peak ground acceleration (PGA) of the four ground models was compared, revealing that seismic wave amplification increases as it moves upward, and the amplification is even greater when transitioning from the lower to the upper ground layers, leading to different dynamic behavior of the slope. Through the contour lines, the influence of PGA was further confirmed, and it was found that approximately 60% of the PGA impact occurs at the topmost part of the slope on average. Analysis of the earthquake waves showed that the top of the slope experienced an average amplification of about 31.75% compared to the input motion, while the lower part experienced an average amplification of about 27.85%. Numerical analysis was performed using the ABAQUS program, and the results were compared with the 1 g shaking table experiments through spectral acceleration (SA), showing good agreement with the experimental results.