Amount Of Use Research Articles

ANALISIS PENGGUNAAN AIR IRIGASI TETES BERTINGKAT EMPAT PADA USAHATANI TANAMAN CABAI DI PERMUKIMAN PERKOTAAN.

The use of a multilevel drip irrigation system for agriculture in urban residential areas needs to be done so that food availability can always be available, which must be supported by the use of appropriate planting media. This study aims to determine the amount of use by chili plants in polybag media irrigated by a four-level drip irrigation system with a mixture of soil and compost and livestock waste. Tests were carried out on the provision of drip irrigation, infiltration capacity and soil moisture produced at certain durations for each phase of plant growth (chili). The composition of the soil planting media to the compost is 60%: 40%, 70%: 30%, 80%: 20%. The test was carried out on a PVC drip irrigation network with emitters in a 2m x 4m x 2m room with 96 polybags, water sources from a 150 liter tank with a height of 2.5 m. Data analysis was carried out on irrigation discharge data, uniformity, irrigation depth and soil moisture against irrigation water use. The test results show that the amount of irrigation water used for chili plants in the early growth phase is around 40 liters, the use of water in the vegetative plant growth phase is around 60 liters to 120 liters, in the generative phase it is 130 liters to 300 liters and in the fruiting phase until the harvest phase, around 325 liters - 500 liters of water are used. The use of irrigation water is the cumulative amount from early irrigation to post-harvest. The highest water use needs to be given to plants on the first and fourth floors in the dry season and in the rainy season the lowest irrigation water use is for plants on the first and fourth floors.

Incorporating Singaporean habits and practices for cosmetics and personal care products into a global consumer aggregate exposure model

Understanding consumer habits and practices of cosmetics and personal care products (PCP) is essential to generate realistic product exposure data for the safety assessment of ingredients such as fragrance materials. Product usages can vary across regions due to differences in cultural norms, seasonal and climate conditions, and the availability of different product forms, yet there is limited data published on cosmetics and PCP use outside of North America and Europe. This study reports the habits and practices of cosmetics and PCP (such as frequency and amount of use) in Singapore where participants (n=494, aged 21-64 years) recorded their product usages and had their products weighed over a two-week period. Overall, similar use patterns were observed across demographic groups within the Singapore population for most of the products surveyed, as were the expected usage amounts. Additionally, the Singaporean dataset was mapped onto the Creme-RIFM aggregate exposure model to assess exposure estimates. Preliminary comparisons with product exposures observed in the United States (US) and Europe suggest that exposures in Singapore are comparable. Findings from this study will contribute to the Creme-RIFM model, expanding its geographic scope and applicability for the global safety assessment of fragrance ingredients and fragranced products.

Phrase Frame Use in EFL Learners’ Argumentative Essays: A Corpus-Based Comparative Study

Recently, there has been a growing interest in the features and development of multi-word formulaic sequences for foreign language learners in the field of second language acquisition. While considerable amount of research has been conducted on continuous formulaic sequences both domestically and abroad, scant attention has been rendered to discontinuous phrase frames. Adopting a corpus linguistic perspective, the current study compares and analyses second language learners from different backgrounds with native speakers, focusing on the phrase frame features identified in the argumentative essays written by Chinese and German EFL learners. With a corpus-based approach, the four-word phrase frames are extracted from the English TOEFL essay texts of Chinese and German students using AntConc 4.1.4 corpus analysis software. The top 100 most frequently occurring phrase frames are manually filtered and then classified according to their structural and functional features to identify similarities and differences in terms of overall frequency, structure, and function features of phrase frames between two groups of learners and with those of native writers. The findings reveal that L2 learners significantly employ more fixed and predictable phrase frames than their native writers, with German L2 learners using more phrase frames than their Chinese L2 counterparts. In terms of functional features, German L2 learners use more stance and discourse organizing expressions than Chinese L2 learners. Awareness of the essay genre, English proficiency, and the time-limited writing environment are contributing factors to these features. Therefore, the study suggests that the accuracy and variety of phrase frame usage are more representative of L2 learners’ acquisition and writing quality than their quantity of use. This study facilitates an understanding of different EFL learners’ phraseological competence through the lens of their p-frame use and provides pedagogical insights accordingly into teaching and learning argumentative essays in EFL contexts.

Club Drugs and Psychiatric Outcomes: A Descriptive Case Series from Spain

Background: illegal drugs significantly contribute to global health issues, with health complications often occurring not only in regular users with Substance Use Disorders (SUDs) but also in first-time and occasional users. Methods: this study examines five clinical cases from a public hospital in Ibiza, Spain, where patients presented with acute psychiatric symptoms due to recreational drug use. Results: Contrary to previous studies on SUDs, our patients typically had higher education levels and stable employment. Most of them used multiple substances, with cannabis, cocaine, and alcohol being the most frequently used. There was also a common occurrence of consuming drugs with uncertain contents. Upon admission, typical symptoms included aggression, hallucinations, mood swings, and disorientation in time and space. Conclusions: Our findings underscore the significant mental health risks posed by illicit drugs, even for individuals with no prior psychiatric history. Factors like the drug’s potency, frequency and amount of use, past mental health issues, personality traits, and previous traumatic experiences might influence the onset of these symptoms.

Tobacco consumption behavior change during the COVID-19 pandemic is associated with perceived COVID threat

RationaleTobacco use is a risk factor for COVID-19 adverse outcomes. Despite health implications, data conflict regarding COVID-19 and tobacco consumption. We present results from a survey of health behaviors during the pandemic to identify how COVID-19 influenced tobacco behaviors.MethodsA nationally administered, internet-based survey was deployed between May–September 2020. Of respondents, we analyzed participants who reported current smoking and/or vaping. Our primary outcome of interest was change in tobacco or vape use using measures from the Behavioral Risk Factor Surveillance System, as well as whether participants reported that these changes were related to COVID-19. Our principal exposures were previously psychometrically evaluated measures of anxiety, depression, and novel perceived COVID-19 threat scale with additional adjustment for age. We employed multinomial logistic regression to determine associations between these factors and tobacco consumption.ResultsWe identified 500 respondents who reported ever smoking in their lifetime, 150 of which reported currently smoking at the time of the survey. Of 220 participants who reported any use of vapes, 110 reported currently vaping. Increased perceived threat of COVID-19 was associated with both increased (aRRincrease 1.75, 95% CI [1.07–2.86], P = 0.03) and decreased (aRRdecrease 1.72 [1.04–2.85], P = 0.03) tobacco consumption relative to no change. There were no significant relationships found between perceived threat of COVID-19 and vaping behavior.ConclusionsAs perceived COVID-19 threat increased, people were more likely to increase or decrease their smoking as opposed to continue at the same amount of use, even after controlling for anxiety and depression, both of which are known to affect smoking in either direction. Further study into motivators of changing tobacco consumption behaviors, and how barriers to care from safer-at-home policies and changes in care delivery moderate change in tobacco use will aid planning tobacco reduction interventions during the ongoing and future respiratory viral pandemics.Trial registrationThis manuscript is derived from baseline survey data obtained in the “Understanding Community Considerations, Opinions, Values, Impacts, and Decisions in COVID-19” study. ClinicalTrials.gov registration NCT04373135, registered 04/30/2020.

Emerging trends in cannabis administration for women with chronic pain

AbstractCannabis use among women who experience chronic pain is on the rise in the United States. However, little is known about women's motives and preferences for cannabis administration. The purpose of this study was to characterize cannabis use among women with chronic pain. This study examined self‐reported forms of cannabis administration and preferred source of cannabis, frequency and quantity of use, and self‐reported side effects, and type, level, and intensity of chronic pain among adult women in the United States. This study also compared women who use cannabis for chronic pain and those who do not across the level of chronic pain, length of chronic pain, and the number of types of chronic pain experienced. Participants showed a significant preference (60%) for using recreational cannabis to treat chronic pain but reported that medical cannabis was more effective. For participants who preferred medical cannabis 24.3% reported daily use, as compared to only 7.8% of recreational cannabis users. Smoking was the most common form of administration (62.1%), followed by edibles (25.3%), vaporizing in any form (7.4%), tinctures and concentrates (3.2%), and topicals (2.1%). Participants reported using 1–6 different forms of cannabis administration. Those who preferred smoking were significantly likely to use all other forms of administration. However, those who preferred alternatives to smoking were significantly likely to use all forms of administration except for smoking. Medical cannabis users preferred to obtain cannabis from a dispensary, while recreational users preferred to obtain cannabis from unlicensed sources. Additionally, participants who used cannabis for chronic pain reported a 74% reduction in past 30‐day opioid use. Future research is needed to investigate the health effects associated with single and combined forms of cannabis administration for women with chronic pain. Results can inform educational and intervention programs, treatment development, content regulation of products, policy formation, women's health research, and public health guidelines.

Analysis of the aerothermal performance of modern commercial high-pressure turbine rotors using different levels of fidelity

In the field of design and optimization of sophisticated geometries such as film-cooled turbine blades of modern jet engines, Computational Fluid Dynamics (CFD) simulation is commonly employed. As the pursuit for higher turbine entry temperatures intensifies, it becomes crucial for computational analyses to offer accurate predictions of metal temperatures and heat transfer coefficients on these critical components. This study investigates the impact of key physical factors that characterize the operation of these components on the accuracy of the computational model. In particular, the effects of including the exchange of thermal energy between the fluid and solid domains, as well as modelling the unsteady interaction between the rotor and stator are studied. The research focuses on a fully featured one-and-a-half stage high-pressure turbine of a commercial jet engine, utilizing proprietary software for conducting 3D Reynolds-Averaged Navier-Stokes flow simulations. To model the fluid-solid thermal interaction, steady-state Conjugate Heat Transfer (CHT) simulations are performed. The CHT results are then compared with experimental data obtained from a thermal paint test, achieving good levels of agreement. Additionally, phase-lag simulations are executed under adiabatic-wall conditions to evaluate the influence of stator-rotor interaction on near-wall gas temperatures. This work shows that, by modelling the periodic unsteadiness at the stator-rotor interface with a phase-lag technique, the maximum near-wall gas temperature prediction is significantly increased, sometimes more than 100K, with respect to the steady-state model one. Findings from this work also suggest that simplified “strip” source terms used to model the presence of film cooling hole rows on the surface of a blade can be used with satisfactory accuracy only for nominal conditions. The mass flows delivered by each source strip should not be linearly scaled based on mainstream quantities for use in different conditions, but they should be recalculated from scratch for the new conditions.

Bound by Binders: Multicraft Organisation and Industrial Interdependence of Lime Production for Mortar in the Eastern Mediterranean during Late Antiquity

In the late antique period (fourth-seventh centuries AD), lime was produced and consumed in great quantities for use in building, medicine, tanning, fulling, mortuary practices, and as an agricultural fertiliser. As a result, lime kilns (and associated slaking pits) are common features of late antique contexts – both in urban and rural environments and involving public institutions and private enterprise. In this paper we consider the archaeological remains of lime production and use in the eastern Mediterranean, a region in which dozens of lime production sites have been recorded. Focusing on the example of lime mortar production specifically, and following evidence for the associated chaîne opératoire, we demonstrate the versatility of the lime production process and how it frequently involved and even relied upon multiple industries.

The Need to Adapt the Psychiatric Clinical Assessment to the Digital Age: A Practical Approach.

The use of electronic devices and social media is becoming a ubiquitous part of most people's lives. Although researchers are exploring the sequelae of such use, little attention has been given to the importance of digital media use in routine psychiatric assessments of patients. The nature of technology use is relevant to understanding a patient's lifestyle and activities, the same way that it is important to evaluate the patient's occupation, functioning, and general activities. The authors propose a framework for psychiatric inquiry into digital media use, emphasizing that such inquiry should focus on quality of use, including emotional and behavioral consequences, rather than simply the amount of use.

Remote monitoring system to support positive airway pressure therapy in patients with obstructive sleep apnea: a multi-center randomized controlled trial.

To develop and evaluate an intervention tailored to patients' needs to increase the rate of positive airway pressure (PAP) adherence in patients afflicted with obstructive sleep apnea (OSA), who undergo PAP therapy. A multi-center, 3 parallel-arm, randomized, controlled trial was conducted. Participants with OSA who undergo a PAP therapy were randomized to one of three groups: control arm (usual care), educational booklet arm, and mobile-based application arm. PAP usage, the percentage of days using the device for more than 4h, change in knowledge, risk perception, outcome expectancy, self-efficacy, and ESS were assessed before and one month after interventions in the three groups. Also, the application usage data were analyzed. The result showed the change in average PAP usage, knowledge, risk perception, and self-efficacy in the application group was significantly higher than the control and booklet groups. Also, the change in use for more than 4h in the application group was significantly higher than the control group. Comparing the actual and patients' self-report PAP use indicated patients' self-report about the use of the device is about 50min (0.8h) more than the actual amount of use. The study results indicated that the improvement of primary and secondary outcomes in adherence to PAP was significantly higher in the application group than in other study groups. Given the increasingly penetrating influence of smartphone-based technologies, it seems that mobile-based applications could potentially be adopted in the population of patients with OSA. IRCT2017092236314N1; https://en.irct.ir/trial/27185.

Identifying Three Psilocybin Use Patterns by Frequency and Quantity.

Patterns of psilocybin use in non-clinical settings are not well described in the literature. Psilocybin use can involve infrequent, large (i.e., macro) doses that produce hallucinogenic effects. In addition, some people report psilocybin use at particularly small (i.e., micro), sub-perceptual doses. Given the heterogeneity in reported use metrics, we sought to determine whether there are identifiable patterns of psilocybin use based on participants' self-described typical use frequencies and quantities and to describe how demographic characteristics are associated with each pattern of use. Participants were recruited from online communities via Reddit.com. We used Latent Profile Analysis to discern psilocybin use patterns defined by frequency and quantity of use. The analytic sample consisted of 664 participants (75.6% US residents; 83.1% white; 67.2% male). The Chipper Profile (18%) was associated with approximately 1-4 annual uses and using between 0.75g and 1.0g of dehydrated, psilocybin-containing mushrooms. The Tripper Profile (64%) was associated with approximately 2-6 annual uses and self-reported use quantities between 2-4g. The Microdoser Profile (18%) was related to substantively higher psilocybin use frequencies than the other profiles (between 2-4 times a week) and a lower range of preferred quantities (between 0.25g - 0.75g). Additionally, profiles differed by certain demographic measurements, lifetime psilocybin use, and timing of psilocybin use. Psilocybin use in non-clinical settings is heterogeneous. We identified three profiles that differed on frequency and quantity of use and their associated demographic characteristics. Next steps are to identify factors that affect one's likelihood of experiencing particular use outcomes and to explore use variability.

Degradation Characteristics of Nicosulfuron in Water and Soil by MnO2 Nano-Immobilized Laccase.

As a typical sulfonylurea herbicide, nicosulfuron is mainly used to control grass weeds and some broadleaf weeds in corn fields. However, as the amount of use continues to increase, it accumulates in the environment and eventually becomes harmful to the ecosystem. In the present study, a new metallic nanomaterial, δ-MnO2, was prepared, which not only has a similar catalytic mechanism as laccase but also has a significant effect on pesticide degradation. Therefore, the bicatalytic property of MnO2 can be utilized to improve the remediation of nicosulfuron contamination. Firstly, MnO2 nanomaterials were prepared by controlling the hydrothermal reaction conditions, and immobilized laccase was prepared by the adsorption method. Next, we investigate the effects of different influencing factors on the effect of immobilized laccase, MnO2, and free laccase on the degradation of nicosulfuron in water and soil. In addition, we also analyze the metabolic pathway of nicosulfuron degradation in immobilized laccase and the bicatalytic mechanism of MnO2. The results demonstrated that the degradation rate of nicosulfuron in water by immobilized laccase was 88.7%, and the optimal conditions were 50 mg/L, 25 h, 50 °C, and pH 5. For nicosulfuron in soil, the optimal conditions for the degradation by immobilized laccase were found to be 151.1 mg/kg, 46 °C, and pH 5.9; under these conditions, a degradation rate of 90.1% was attained. The findings of this study provide a theoretical reference for the immobilized laccase treatment of sulfonylurea herbicide contamination in water and soil.

The influence of occupant control behaviour on thermal comfort under different heating charging modes in residential buildings in cold regions

In China's central heating, there are two modes for calculating heating costs, which are divided into Charging by flow mode which charges according to the amount of use and Charging by area mode which charges according to the floor area. The Charging by flow mode has been increasingly adopted by numerous urban central heating buildings. Thus it is worth investigating whether occupants experience varying levels of thermal comfort under these two modes. To address this, a field test and subjective questionnaire survey were conducted on residential buildings in cold regions of China during the heating season. The study assessed 134 residential occupants utilizing radiator heating, comprising 66 in Charging by area and 68 in Charging by flow modes. A collection of 1206 valid data points was obtained, with 609 in Charging by area mode and 597 in Charging by flow mode. The findings reveal noteworthy disparities in the duration, area, and strength of heating equipment usage between the two modes. While there are no marked variances in the interior and exterior environmental conditions under both modes, residents in the Charging by flow mode experience enhanced thermal comfort, acceptability and expectation, as well as better air quality satisfaction. Perceived control can greatly enhance individuals' thermal sensation in temperatures below 18 °C and above 24 °C. The impact of perceived control on thermal expectation is linear with temperature adjustments. The heightened degree of sensing control in Charging by flow mode lowers residents' expectations of high temperatures, broadens the range of acceptable low temperatures and accomplishes energy conservation and carbon reduction while ensuring optimal comfort.

Effects of kinesio taping combined with upper extremity function training home program on upper limb function and self-efficacy in stroke patients: An experimental study.

The purpose of this study is to investigate the effects of kinesio taping and an upper extremity function home program on the upper extremity function and self-efficacy of stroke patients, and to present therapeutic evidence for home program intervention to improve upper extremity function. First, 53 stroke patients were randomly assigned to 2 groups: 26 experimental subjects and 27 controls. The experimental group performed kinesio taping on the dorsal part of the hand along with upper extremity functional training home program and the control group performed only upper extremity functional training home program. The intervention was conducted for a total of 30 sessions over 6 weeks. To evaluate changes in upper extremity function, wrist extensor muscle activation via the Surface Electromyography, the Chedoke Arm and Hand Activity Inventory-9 (CAHAI-9), and the motor activity log (including amount of use and quality of movement) were evaluated. In addition, the Self-Efficacy Scale (SES) was evaluated to examine the change in the self- efficacy of the study subjects. The experimental group participating in the kinesio taping and upper limb function home program showed a statistically significant improvement (P < .01) before and after the intervention in the Surface Electrography the Chedoke Arm and Hand Activity Inventory-9 evaluation item in the upper limb function change. The SES evaluation, a self-esteem evaluation, also showed a statistically significant improvement (P < .01) before and after the intervention. Chedoke Arm and Hand Activity Inventory-9, motor activity log (quality of movement), and SES evaluation showed statistically significant differences (P < .05) between the experimental and control groups. It was confirmed that the upper extremity function training home program performed in parallel with the kinesio taping technique had a positive effect on the recovery of upper extremity function and self-esteem in stroke patients. The kinesio taping technique provides stability to the wrist while performing a home program that patients can perform on their own at home and appears to improve upper extremity function more effectively than when performing the upper extremity function home program alone.

Exoskeleton-assisted upper limb rehabilitation after stroke: a randomized controlled trial

ABSTRACT Objectives The upper-limb exoskeleton training program which is repetetive and task-specific therapy can improve motor functions in patients with stroke. To compare the effect of an upper-limb exoskeleton training program with Bobath concept on upper limb motor functions in individuals with chronic stroke. Methods Participants were randomly assigned to exoskeleton group (EG, n = 12) or to Bobath group (BG, n = 12). Interventions were matched in terms of session duration and total number of sessions and performed 2 times per week for 6-weeks. Primary outcome was Fugl-Meyer- Upper Extremity (FMA-UE). Secondary outcomes were Modified Ashworth Scale (elbow and wrist flexor muscles), Motor Activity Log-30 which is consist of two parts as an amount of use (AOU) and quality of movement (QOM), and The Nottingham Extended Activities of Daily Living (NEADL) index. Results After 12-sessions of training, the mean (SD) FMA-UE score increased by 5.7 (2.9) in the EG, and 1.9 (1.5) points in the BG (p < .05). In total, 40% of participants (5/12) demonstrated a clinically meaningful improvement (≥5.25 points) in the FM-UE, while none of the participants reached MCID score in the bobath group. Changes in the AOU, QOM, and NEADL were significantly larger in the EG compared to BG (p < .05). 7/12 (58.33%) of participants for AOU and 5/12 (42%) of participants for QOM in the EG showed that clinically meaningful change. 5/12 of participants (42%) in the EG demonstrated ≥4.9-point increase in NEADL score. Discussion High-intensity repetitive arm and hand exercises with an exoskeleton device was safe and feasible. Exoskeleton-assisted training demonstrated significant benefits in improving upper limb functions and quality of life in individuals after stroke.

Utility of a brief measure of cannabis demand: Day-level associations with cannabis use

BackgroundCannabis demand (i.e., relative value) is usually assessed as a trait-level risk-factor for cannabis use and consequences. This study examined within-person variability in day-level intensity (i.e., amount consumed at zero cost) and Omax (i.e., maximum cannabis expenditure) and tested hypotheses that demand would be positively associated with day-level cannabis use. MethodsYoung adults (n=85) reporting past-month simultaneous alcohol and cannabis use completed two daily surveys for 30 days. Morning surveys assessed prior-day cannabis use and evening surveys assessed day-level demand (i.e., intensity, Omax). Multilevel models tested day-level effects of intensity and Omax on any cannabis use and flower use frequency and quantity (i.e., grams). ResultsApproximately 52 % and 46 % of variability in intensity and Omax, respectively, was due to within-person change. At the day-level, higher intensity and Omax were associated with higher likelihood of any cannabis use, regardless of formulation; Omax was associated with use of flower in particular; and intensity was associated with the highest quantity of use. At the person-level, only Omax was associated with flower use likelihood, and only intensity was associated with flower quantity across days. ConclusionsCannabis demand demonstrated day-to-day variability, conceivably in response to various internal states and external factors. Intensity and Omax were related to elevated likelihood of using any cannabis, particularly flower, at the day-level. Overall, these data illustrate the validity and utility of brief cannabis demand measures, which might be used to further understand cannabis’ reinforcing value at a fine-grained level.

The combination of mineral fertilizer with organic fertilizer improved soil phosphorus availability

Large amounts of use of mineral fertilizers (MF) have brought about environmental pollution and soil problems, like soil degradation and acidification. The partial substitution of MF with organic fertilizer is considered eco-friendly and more efficient in improving soil fertility. In our study, the effects of MF alone and the combination of MF and organic fertilizers (MOF) on soil phosphorus (P) availability in infertile soil with P deficiency were studied with the initial soil without any addition as the control. The addition of MF and MOF increased the soil labile P (resin-P and NaHCO3-Pi) by 101.8% and 320.1%, respectively, compared to the control after 180 days of treatment. Resin-P was the predominant P fraction in MOF, accounting for 28.0% of the total P. The proportions of residual-P in MOF were 5.6% and 8.3% lower than those in MF and control, respectively. The P activation coefficient in MOF was the highest (15.0%), and was the main contributor to soil P fractions based on redundancy analysis. Our results suggest that the combined application of organic and mineral fertilizers is more efficient in improving soil P availability than mineral fertilizer alone. We highlight the joint application was beneficial to improve soil P activation coefficient.

An Evaluation of the Changing Trends in Substance Use Behavior Among Patients in the Tertiary Care Setting After the Implementation of Liquor Prohibition in Bihar, India: A Cross-Sectional Study.

Background and objective Substance use disorders pose significant global public health challenges, with India being no exception. Bihar, one of India's most populous states, implemented alcohol prohibition in April 2016 to address the adverse effects of alcohol abuse. However, the impact of this policy on overall substance use behavior among patients in healthcare settings remains to be explored. This cross-sectional study aimed to evaluate the changing trends in substance use behavior among patients in the tertiary care setting following the prohibition of alcohol use in Bihar. Methods A total of 372 patients diagnosed with substance use disorders were recruited from tertiary care facilities in Bihar. Data on demographic characteristics, types of substances used, frequency and quantity of use, reasons for use, and awareness of prohibition laws were collected through structured interviews and reviews of medical records. Descriptive and inferential statistics were used for data analysis. Results The majority of the participants were male (n = 346, 93.01%), with a mean age of 38.5 years. While tobacco use remains stable, there are significant increases in opioid and cannabis consumption post-prohibition, highlighting unintended consequences (p-values - opioids: 0.008, cannabis: 0.021). Additionally, heightened daily and weekly substance use after prohibition is evident (p-values: daily: 0.008, weekly: 0.021), emphasizing the necessity for nuanced policy considerations. Reasons for substance use, including coping with stress and peer pressure, showed significant differences before and after the prohibition (p<0.05). Moreover, awareness of alcohol prohibition laws increased significantly after the implementation of the prohibition (p = 0.003). Conclusions Our findings suggest that while alcohol prohibition in Bihar did not significantly lead to any changes in terms of the types of substances used among patients in tertiary care settings, it did influence the frequency and quantity of tobacco and cannabis consumption. Increased awareness of prohibition laws underscores the importance of policy enforcement and public education initiatives in addressing substance use behavior.

Spatial distribution of pesticide use based on crop rotation data in La Plata River basin: a case study from an agricultural region of Uruguay.

The intensive global use of pesticides presents an escalating threat to human health, ecosystems, and water quality. To develop national and local environmental management strategies for mitigating pollution caused by pesticides, it is essential to understand the quantities, timing, and location of their application. This study aims to estimate the spatial distribution of pesticide use in an agricultural region of La Plata River basin in Uruguay. Estimates of pesticide use were made by surveying doses applied to each crop. This information was spatialized through identifying agricultural rotations using remote sensing techniques. The study identified the 60 major agricultural rotations in the region and mapped the use and application amount of the nine most significant active ingredients (glyphosate, 2,4-dichlorophenoxyacetic acid, flumioxazin, S-metolachlor, clethodim, flumetsulam, triflumuron, chlorantraniliprole, and fipronil). The results reveal that glyphosate is the most extensively used pesticide (53.5% of the area) and highest amount of use (> 1.44kg/ha). Moreover, in 19% of the area, at least seven active ingredients are applied in crop rotations. This study marks the initial step in identifying rotations and estimating pesticide applications with high spatial resolution at a regional scale in agricultural regions of La Plata River basin. The results improve the understanding of pesticide spatial distribution based on data obtained from agronomists, technicians, and producers and provide a replicable methodological approach for other geographic and productive contexts. Generating baseline information is key to environmental management and decision making, towards the design of more robust monitoring systems and human exposure assessment.

Effectiveness of Intermittent Theta Burst Stimulation to Enhance Upper Extremity Recovery After Stroke: A Pilot Study

ObjectivesTo first investigate the effectiveness of modified constraint-ınduced movement therapy (mCIMT) in low-functioning patients with stroke (PwS). Second, we aimed to investigate the efficiency of intermittent theta-burst stimulation (iTBS), applied on intermittent days, in addition to the mCIMT in PwS. DesignA randomized, sham-controlled, single-blinded study. SettingOutpatient clinic. ParticipantsFifteen PwS (age [mean±SD]: 66.3±9.2 years; 53% female) who were in the first 1 to 12 months after the incident were included in the study. InterventionsPwS were divided into 3 groups: (1) mCIMT alone; (2) mCIMT + sham iTBS; (3) mCIMT + iTBS. Each group received 15 sessions of mCIMT (1 hour/session, 3 sessions/week). iTBS was applied with 600 pulses on impaired M1 before mCIMT. Main Outcome MeasuresUpper extremity (UE) impairment was assessed with the Fugl-Meyer Test (FMT-UE), whereas the motor function was evaluated with the Wolf-Motor Function Test (WMFT). Motor Activity Log-28 (MAL-28) was used to evaluate the amount of use and how well (How Well Scale) the impaired UE movements. ResultsWith-in-group analysis revealed that all groups had statistically significant improvements based on the FMT-UE and MAL-28 (p<.05). However, the performance time and arm strength variables of WMFT were only increased in the mCIMT + iTBS group (p<.05). The only between-group difference was observed in the intracortical facilitation in favor of the mCIMT + iTBS group (p<.05). The effect size of iTBS was f=0.18. ConclusionsOur findings suggest that mCIMT with and without the application of iTBS has increased the UE motor function in low-functioning PwS. iTBS applied on intermittent days may have additional benefits as an adjunct therapy for facilitating cortical excitability, increasing the speed and strength of the impaired UE as well as decreasing disability.