Amorphous Research Articles

Absorption and quantum efficiency of GeSn nanopillar arrays for infrared detectors

Abstract This research investigates the optical absorption and quantum efficiency of germanium-tin (GeSn) materials with a tin(Sn) content of 4.5%, and their potential applications in infrared optoelectronic systems. It has two forms which are crystalline(c-GeSn) and amorphous(a-GeSn) states. The finite-difference time-domain (FDTD) method was used to simulate the absorption of c-GeSn and a-GeSn. By optimising the period, radius and height of the nanopillars, the optimal parameters were determined, and it was found that the c-GeSn nanopillars in that case had a very stable and excellent absorption in the near-infrared (NIR) band. Calculated by MATLAB that the cylindrical nanopillars could reach a maximum quantum efficiency of 3.67% at 1350 nm. It is anticipated that this study will contribute to the further understanding of GeSn and provide a theoretical basis for designing high-performance infrared photodetectors.

Measuring Oxygen Solubility in Amorphous and Semicrystalline Polyolefins Using Test Particle Insertion: A Comparative Study of Polyethylene and Isotactic Polypropylene.

The test particle insertion method is used to study the solubility of oxygen in two commonly used polymers: polyethylene (PE) and isotactic polypropylene (iPP). Amorphous samples for both polymers were prepared by means of Monte Carlo and molecular dynamics simulations, and the oxygen solubility was measured across different temperatures. The solubility-temperature dependence for iPP proved to be nonmonotonic due to the interplay between binding and reorganizational enthalpy, while for PE, it appeared to be monotonic based on the available data in the studied temperature range. A broad comparison to experiments and simulations is included. Further oxygen insertions were also performed in semicrystalline PE and iPP samples at ambient temperature, and the obtained values were compared to a linear relationship which correlates the solubility in the purely amorphous phase with the solubility in the crystalline phase. The solubility of PE closely follows the linear relationship, while iPP exhibits some divergence. All the semicrystalline samples were previously annealed at elevated temperatures for long periods (a few μs), and a strong effect of annealing was observed on the structure and the solubility of iPP. A well-developed iPP lamellar structure emerged at longer annealing times, while PE develops that structure already in the early crystallization stages. The solubility of semicrystalline iPP samples with lamellar morphology exhibited better agreement with extrapolated solubility values of the amorphous state─the extrapolation was made using a linear relationship connecting solubility in the purely amorphous phase and solubility in mixed phases (amorphous and crystalline). Results on the correlation of the solubility with the local structural ordering are also present.

Precision Self‐Assembly of Supramolecules with Heterogeneous Derivatives

AbstractSupramolecular self‐assembly with well‐defined building blocks like lipids, deoxyribonucleic acid, or ligands relies on accessible molecular structures and predictable interactions. However, assembling heterogeneous, undefined blocks, such as disordered proteins, amorphous solids, and catecholic derivatives, remains challenging due to their unpredictable assembly, leading to irreversible aggregation, severe precipitation, and unreliable performance. Here, the first programmable, sustainable, and durable self‐assembly strategy of supramolecules with heterogenous is presented, derived blocks via harmonizing multiple molecular interactions. This approach achieves reversible assembly/disassembly, ≈73.7% reduced precipitation, and salt‐ and alkaline‐durability under freeze‐thaw cycles in model catecholic derivatives, functioning effectively as robust adhesive primers and hydrogel interfacial strengtheners. Moreover, through molecular force measurements and computational simulations, the first general criterion and benchmark for high precision supramolecular self‐assembly is proposed, applicable to complex derivatives and interactions: with blocks bearing multiple binding sites existing, the co‐assembling blocks should bear at least two binding sites with minimum binding strength (≈17 to ≈37 kJ mol−1) to prevent disassembly. This study paves the way and provides benchmarks for precision self‐assembly of diverse supramolecules using heterogeneous derivatives for adhesion technology, nanomaterial synthesis and bio‐inspired applications.

Nanomechanical Crystalline AlN Resonators with High Quality Factors for Quantum Optoelectromechanics.

High-quality factor (Qm) mechanical resonators are crucial for applications where low noise and long coherence time are required, as mirror suspensions, quantum cavity optomechanical devices, or nanomechanical sensors. Tensile strain in the material enables the use of dissipation dilution and strain engineering techniques, which increase the mechanical quality factor. These techniques have been employed for high-Qm mechanical resonators made from amorphous materials and, recently, from crystalline materials such as InGaP, SiC, and Si. A strained crystalline film exhibiting substantial piezoelectricity expands the capability of high-Qm nanomechanical resonators to directly utilize electronic degrees of freedom. In this work, nanomechanical resonators with Qm up to 2.9 × 107 made from tensile-strained 290 nm-thick AlN are realized. AlN is an epitaxially-grown crystalline material offering strong piezoelectricity. Nanomechanical resonators that exploit dissipation dilution and strain engineering to reach a Qm × fm-product approaching 1013 Hz at room temperature are demonstrated. A novel resonator geometry is realized, triangline, whose shape follows the Al-N bonds and offers a central pad patterned with a photonic crystal. This allows to reach an optical reflectivity above 80% for efficient coupling to out-of-plane light. The presented results pave the way for quantum optoelectromechanical devices at room temperature based on tensile-strainedAlN.

Thermoelastic fracture of two-dimensional hexagonal quasicrystal media weakened by a penny-shaped crack subjected to uniformly antisymmetric heat fluxes

This study focuses on the thermoelastic fracture behavior of quasicrystals, a class of solids that exhibit unique properties between traditional crystals and amorphous materials. The complex atomic structure of quasicrystals poses challenges in understanding their fracture mechanisms under thermoelastic loading conditions. Central to our investigation is an analytical examination of a penny-shaped crack in an infinite three-dimensional body composed of two-dimensional hexagonal quasicrystals, where the upper and lower crack surfaces are applied to a pair of uniformly antisymmetric heat fluxes. This crack problem requires simultaneous consideration of thermal-phason-phonon multiple field coupling. According to the symmetry of field variables with respect to the crack plane, the thermal-phason-phonon coupled crack problem is transformed into a mixed boundary value problem in the upper half space. The extended displacement discontinuities, encompassing both phonon and phason displacement discontinuities, as well as the temperature discontinuity, are chosen as the basic unknown variables to construct the boundary integral-differential equations governing the mixed boundary value problem. Based on these boundary governing equations and Fabrikant's potential theory method, the problem with the crack surface subjected to uniform antisymmetric heat fluxes is solved. The solutions of thermal-phason-phonon fields on the crack plane, and in the full space are given in closed-form. Numerical results are employed to validate the obtained analytical solutions and visually illustrate the spatial distribution of thermal-phonon-phason coupling fields in the vicinity of the crack. The study provides fundamental insights into the behavior of cracks in quasicrystals under thermal loading, with potential implications for the design of new materials and structures.

Nanoporous amorphous carbon nanopillars with lightweight, ultrahigh strength, large fracture strain, and high damping capability

Simultaneous achievement of lightweight, ultrahigh strength, large fracture strain, and high damping capability is challenging because some of these mechanical properties are mutually exclusive. Here, we utilize self-assembled polymeric carbon precursor materials in combination with scalable nano-imprinting lithography to produce nanoporous carbon nanopillars. Remarkably, nanoporosity induced via sacrificial template significantly reduces the mass density of amorphous carbon to 0.66 ~ 0.82 g cm−3 while the yield and fracture strengths of nanoporous carbon nanopillars are higher than those of most engineering materials with the similar mass density. Moreover, these nanopillars display both elastic and plastic behavior with large fracture strain. A reversible part of the sp2-to-sp3 transition produces large elastic strain and a high loss factor (up to 0.033) comparable to Ni-Ti shape memory alloys. The irreversible part of the sp2-to-sp3 transition enables plastic deformation, leading to a large fracture strain of up to 35%. These findings are substantiated using simulation studies. None of the existing structural materials exhibit a comparable combination of mass density, strength, deformability, and damping capability. Hence, the results of this study illustrate the potential of both dense and nanoporous amorphous carbon materials as superior structural nanomaterials.

Electrospun patches to deliver combination drug therapy for fungal infections

Fungal infections, though affecting healthcare globally, receive insufficient attention in clinical and academic settings. Invasive fungal infections, particularly caused by combat wounds, have been identified as a critical threat by the US Department of Defense. Monotherapy with traditional antifungals is often insufficient, and so combination therapies are explored to enhance treatment efficacy. However, systemic combination treatments can result in severe adverse effects, suggesting the need for localised delivery systems, such as drug-loaded electrospun patches, to administer antifungals directly to the infection site. This proof-of-concept study hypothesised that dual amorolfine and terbinafine therapy slowly releasing from electrospun patches would be an effective way of eradicating Candida albicans when the patch was applied directly to the fungal colony. The feasibility of creating electrospun materials loaded with amorolfine and terbinafine for combination antifungal therapy was investigated. Electrospinning was used to fabricate polycaprolactone (PCL) patches with varying drug loadings (2.5%, 5%, and 10% w/w) of amorolfine and terbinafine either individually or in combination. The incorporation of both drugs in the fibres was confirmed, with the drugs predominantly in an amorphous state. Results showed that combination therapy patches had a significantly greater and prolonged antifungal effect compared to monotherapy patches, with larger zones of inhibition and sustained efficacy over at least 7 days. This study therefore demonstrates that PCL-based electrospun patches containing amorolfine and terbinafine provide superior antifungal activity against C. albicans compared to monotherapy patches. This approach could lower required drug doses, reducing adverse effects, and enhance patient compliance due to prolonged drug release, leading to more effective antifungal therapy.

Ferroelastic ionic organic crystals that self-heal to 95%

The realm of self-healing materials integrates chemical and physical mechanisms that prevent wear and fracturing and extend the operational lifetime. Unlike the favorable rheology of amorphous soft materials that facilitates efficient contact between fragments, the efficiency of recovery of atomistically ordered materials is restricted by slower interfacial mass transport and the need for ideal physical alignment, which limits their real-world application. We report drastic enhancements in efficiency and recovery time in the self-healing of anilinium bromide, challenging these limitations. Crystals of this material recovered up to 49% within seconds and up to 95% after 100 min via ferroelastic detwinning. The spatial evolution of strain during cracking and healing was measured in real time using digital image correlation. Favorable alignment and strong ionic bonding across the interface of partially fractured crystals facilitate self-healing. This study elevates organic crystals close to the best-in-class self-healing polymers and sets an approach for durable crystal-based optoelectronics.

Phonon engineering of atomic-scale defects in superconducting quantum circuits.

Noise within solid-state systems at low temperatures can typically be traced back to material defects. In amorphous materials, these defects are broadly described by the tunneling two-level systems (TLSs) model. TLS have recently taken on further relevance in quantum computing because they dominate the coherence limit of superconducting quantum circuits. Efforts to mitigate TLS impacts have thus far focused on circuit design, material selection, and surface treatments. Our work takes an approach that directly modifies TLS properties. This is achieved by creating an acoustic bandgap that suppresses all microwave-frequency phonons around the operating frequency of a transmon qubit. For embedded TLS strongly coupled to the transmon qubit, we measure a pronounced increase in relaxation time by two orders of magnitude, with the longest T1 time exceeding 5 milliseconds. Our work opens avenues for studying the physics of highly coherent TLS and methods for mitigating noise within solid-state quantum devices.

Shear strength and optical bandgap in As2Se3 glasses permanently compacted under GPa pressures

The application of GPa pressures on glassy As2Se3, at temperatures just below and above its glass transition, leads to permanently compacted glasses that exhibit increased densification. Also, melt-quenching of the same glass under a pressure of 7 GPa gives rise to the formation of its crystalline β-phase. The structure of these As2Se3 compacted solids have been explored by X-ray diffraction. Measurements of 10 MHz ultrasound velocities reveal that the density increase is associated with a substantial hardening of the elastic continuum as well as a growing shear strength of glassy solids: the shear modulus G increases by more than 35 % and the Poisson's ratio ν decreases by more than 13 %. The optical properties have been investigated by UV–VIS diffuse reflectance spectroscopy, which shows a well defined linear reduction of the optical bandgap Eg with increased density. All of these observations have been explained by considering a disordered layered structure of glassy As2Se3, where densification produced by compaction under GPa pressures gives rise to a progressive strengthening of the interlayer interactions.

Light/Force-Responsive Room Temperature Phosphorescence in a Zinc-Organic Coordination Polymer.

A zinc-organic hybrid (1) with multifunctional room temperature phosphorescence (RTP) was synthesized. 1 presents light/force-sensitive RTP properties due to the photochromic behavior from gray to light yellow and the transition from crystalline to amorphous state, respectively. Furthermore, inkless printing and information encryption models were successfully constructed to prove their widespread application prospect.

Analog and digital resistive switching in W/TiO2/ITO devices: the impact of crystallinity and Indium diffusion

The resistance-switching memristor with capabilities of information storage and brain-inspired computing has prime importance in recent research. In this study, the impact of crystallinity and Indium diffusion on the existence of analog and digital resistive switching in a W/TiO2/ITO device has been reported. The memristor devices are fabricated by depositing titania films by sol–gel and spin-coating techniques. The films annealed at 250 °C and 400 °C were characterized using x-ray diffraction, Raman spectroscopy, scanning electron microscopy, and x-ray photoelectron spectroscopy (XPS). The characteristic anatase phase started appearing after annealing at 400 °C, whereas the 250 °C annealed sample was in the amorphous state. The electrical characterization revealed significant differences in the switching characteristics of amorphous and crystalline samples, especially in the switching interface, compliance properties, and current conduction mechanism. The grain boundary assisted oxygen vacancy migration, and the diffusion of indium ions from the ITO bottom electrode helped the crystalline sample to show highly stable and reproducible resistive switching compared to amorphous film. The XPS studies confirmed the indium ion diffusion in the crystalline sample. The oxygen vacancy-induced barrier modulation and conductive filament formation caused characteristic switching in amorphous and crystalline samples, respectively. Schottky emission in the amorphous film and SCLC mechanism in the crystalline film confirmed the experimental results. This study provides a distinctive viewpoint and an innovative strategy for developing multifunctional resistive switching devices.

Sustainable treatment of boron from oilfield produced water for optimum recovery using zirconium chloride oxo-precipitation

This study focuses on the recovery of boron from oilfield-produced water employing the chemical oxo-precipitation method. Zirconium chloride was used to recover boron as a sustainable approach. The study aimed to optimize the parameters to achieve the highest possible boron recovery. It also sought to investigate the impact of operating parameters, including pH, time, oxidizing agent, and dosage of the precipitant, on boron recovery. The optimal operating conditions were optimized through response surface methodology (RSM). A comparative study was conducted with barium chloride (chemical oxo-precipitation) and calcium hydroxide (conventional precipitation). The results indicated that the highest boron recovery was achieved at 97% by utilizing chemical oxo-precipitation with zirconium chloride. Meanwhile, barium chloride and calcium hydroxide recovered boron at 89% and 88%, respectively. The precipitates were characterized by Fourier transform infrared (FTIR), x-ray fluorescence (XRF), scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDX). The XRF and EDX characterization analysis confirmed the highest boron recovery at 97% with zirconium chloride. SEM showed that zirconium chloride precipitated visible amorphous insoluble solids. The chemical-oxo-precipitation procedure outperforms barium chloride and calcium hydroxide precipitation. The zirconium chloride oxo-precipitation method was proved to be a greener solution for boron recovery.

Phase formation, microstructure and mechanical properties of TaB2–SiC composites synthesized by reaction hot pressing: Effects of SiC contents and oxygen impurity

TaB2–SiC composites with 0–20 wt% SiC contents were prepared by reaction hot pressing using Ta, B and SiC powders as starting materials. Densification, constituent phases, microstructure and mechanical properties, namely Vickers hardness, fracture toughness and flexure strength, were evaluated by means of inspection of sintering shrinkage, density measurement, XRD, SEM, TEM, HRTEM, EDS, SAED, indentation and three-point bending tests. Phase formation, including dominant (TaB2, SiC) and minor (TaC, glassy SiO2) phases, was checked by thermodynamic assessment relevant with Ta2O5 and B2O3 impurities introduced into the reaction system by the starting powders. The results showed that mixtures of Ta, B and SiC powders would initiate self-propagating combustion synthesis (SPCS) at about 900 °C; a transient hold at 800 °C for 1 h could suppress this reaction. Volatilization of B2O3 impurity in association with local high temperature due to SPCS helped reduce the TaC and glassy SiO2 minor phase formation. TaB2–SiC composites could reach 99 % relative densities with 3 wt% SiC addition and above. Compositions with <7.5 wt% SiC additions showed uniform dispersion of SiC particles at multi-TaB2 grain junctions while compositions with higher SiC content revealed SiC segregation. Bending strength of 503 MPa and fracture toughness of 6.69 MPa⋅m1/2 could be reached with 7.5–20 wt% SiC addition.

Screening the efficacy of platinum-based nanomaterial synthesized from Allium sativum to control plant pathogens

Emerging challenge posed by multidrug-resistant Bacillus spp. phytopathogens on agriculture and their commodities exerts pressure on global food security. This mandates the search for other alternatives to existing antibiotics. This study reports a novel method of green synthesis of platinum nanoparticles (PtHGNM) using aqueous extract of Himalayan garlic (Allium sativum). Physicochemical characterization techniques including UV-visible spectrometry, FT-IR, XRD, DLS, zeta potential, and FESEM-EDAX disclosed the biogenic fabrication of a stable and amorphic nano platinum material. This nanoparticle exhibited high bactericidal efficacy and effectively inhibited biofilm formation by the model plant-borne pathogens used in this study. We estimated the membrane integrity, oxidative enzymes and stress parameters of bacteria to elucidate the underlying mechanism of action of PtHGNM. This research uncovered the potential of biogenic nanoparticles for sustainable plant disease management and paved the way for further analysis of its properties and mechanism of its action.

Plasticity and strength of an equiatomic and a non-equiatomic HfNbTaTiZr high entropy alloy during uniaxial loading : a molecular dynamics simulation study

Abstract Understanding plasticity and strength of high entropy alloys of&amp;#xD;HfNbTaTiZr is extremely significant in building nuclear reactors, gas turbines,&amp;#xD;aerospace deivces etc. Here we study an equiatomic (Hf 0.20 -Nb 0.20 -Ta 0.20 -Ti 0.2 -Zr 0.20 )&amp;#xD;and a non-equiatomic (Hf 0.35 -Nb 0.20 -Ta 0.15 -Ti 0.15 -Zr 0.15 ) mixture of two alloys under&amp;#xD;uniaxial tensile loading from molecular dynamics simulations. Modified Embedded&amp;#xD;atom potential is used to model both these bcc alloys and all simulations are performed&amp;#xD;at 300 K with three different tensile strain rates - 0.0002, 0.0005 and 0.001 ps −1 . Radial&amp;#xD;distribution functions, bond-orientational parameters and OVITO are used to analyse&amp;#xD;the MD trajectories. At 0.001 ps −1 strain, both these alloys deform similarly, but&amp;#xD;differences are observed at 0.0005 and 0.0002 ps −1 strains. At these rates, both alloys&amp;#xD;deform elastically till 3%, thereafter they deform plastically till 15-20% strain. Yield&amp;#xD;strengths are comparable in the elastic limit but in the plastic limit non-equiatomic&amp;#xD;alloy have higher strength. In equiatomic alloy, bcc phase transforms to fcc whereas&amp;#xD;in non-equiatomic alloy bcc phase transforms to both fcc and hcp. Formation of&amp;#xD;hcp atoms (50%) decrease the plasticity of the non-equiatomic alloy but increases its&amp;#xD;strength. We also observe that in both these alloys and at all strain rates, bcc atoms&amp;#xD;transform to fcc/hcp atoms through an intermediate amorphous like state. Local&amp;#xD;coordination and orientation of all atom change similarly in equiatomic mixture. But in&amp;#xD;non-equiatomic mixture local orientation in Hf, Ti and Zr changes differently compared&amp;#xD;to Nb and Ta.&amp;#xD;

Characterization and modeling of laser transmission welded polyetherketoneketone (PEKK) joints: Influence of process parameters and annealing on weld properties

Welding high-performance thermoplastics has gained popularity across various industries such as automotive, aerospace, and medical. Laser transmission welding (LTW) has emerged as an effective method for joining thermoplastic parts due to its precise control and high joint quality. PAEK (polyaryletherketone) are wide spreading over various industrial applications as a substitute to metals and thermosets when high durability and performance are required. Polyetherketoneketone (PEKK) is one of these PAEK and it has received less attention than PEEK until now. PEKK, being a semi-crystalline thermoplastic, requires additional care during processing due to its propensity to crystallize. This study presents both experimental and numerical investigations into LTW of PEKK molded parts, aiming to understand the influence of welding parameters and crystallinity on weld joint morphology and mechanical properties. PEKK plates, prepared in amorphous and semi-crystalline states, are subjected to LTW using a 975 nm diode laser. Material characterization confirms differences in crystallinity between the samples, which affect their thermal and optical properties, which are crucial for welding. Welding tests are conducted with varying laser power (between 75 and 95 W) and semi-transparent part thickness (2 and 4 mm). The morphology of joints is analysed. Assemblies undergo post-weld annealing treatment to examine its influence on weld crystallinity and consequent mechanical properties. Results reveal an anisotropic distribution of crystallinity within the heat-affected zone (HAZ). The depths of the molten layer (ML) and semi-crystalline layer (scL) vary with laser power and assembly type. A notable decrease in weld strength with laser power is highlighted, while annealing leads to enhanced crystallinity and improved weld strength. Despite variations, high weld strengths are achieved with annealing. Computational modelling elucidates the complex interplay between laser irradiation, temperature distribution, and crystallization kinetics observed experimentally. Overall, this comprehensive investigation provides valuable insights into optimizing LTW parameters for PEKK parts.

Robust Solid–Solid Phase Change Coating Encapsulated Glass Fiber Fabric with Electromagnetic Interference Shielding for Thermal Management and Message Encryption

AbstractElectromagnetic interference (EMI) shielding composites with both thermal response/management functions and message transfer/encryption behavior are ideal for use in fields such as aerospace, construction engineering, and military equipment. In this work, a self‐cross‐linking supramolecular solid–solid phase change polyethylene glycol (ScPEG) coating is prepared based on multiple hydrogen bonds, which is used for encapsulating glass fiber fabric (GFF) modified with silver nanowires (AgNWs). The solid–solid phase change coating is obtained through the hydrolysis‐condensation of PEG with a reactive silanol end group. Polyethylene glycol molecular chains can store and release heat by switching between the crystalline and amorphous state. The silanol groups can form supramolecular networks through the physical cross‐linking of multiple hydrogen bonds, resulting in an excellent thermal stability. In particular, hydrogen bonds between ScPEG and AgNW‐modified GFF (A‐GFF) enhance interfacial interactions, and the resulting robust structure enables an efficient stress transfer. ScPEG‐coated A‐GFF can achieve a tensile strength of up to 191 MPa and a tunable EMI shielding effectiveness (SE) of 40 to 72 dB depending on the number of fabric layers. Moreover, the fabric exhibits a flexible thermal response characteristic, an outstanding thermal management capability, and potential message encryption behavior.

Two-level system loss: Significant not only at millikelvin

Tow-level system (TLS) loss in amorphous dielectric materials has been intensively studied at millikelvin temperatures due to its impact on superconducting qubit devices and incoherent detectors. However, the significance of TLS loss in superconducting transmission lines at liquid helium temperatures remains unclear. This study investigates TLS loss in amorphous SiO2 at liquid helium temperatures (about 4 K) within a frequency range of 130–170 GHz, using niobium microstrip and coplanar waveguide resonators. Our results demonstrate notable power and temperature dependence of dielectric loss, with the dielectric loss and quasiparticle loss exchanging dominance at around 4 K. These findings are consistent with TLS models and provide crucial insight for the design of superconducting devices operating at liquid helium temperatures.

Binary and Ternary Inclusion Complexes of Niflumic Acid: Synthesis, Characterization, and Dissolution Profile

Although niflumic acid (NA) is one of the most used non-steroidal anti-inflammatory drugs, it suffers from poor solubility, low bioavailability, and significant adverse effects. To address these limitations, the complexation of NA with cyclodextrins (CDs) is a promising strategy. However, complexing CDs with low molecular weight drugs like NA can lead to low CE. This study explores the development of inclusion complexes of NA with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD), including the effect of converting NA to its sodium salt (NAs) and adding hydroxypropyl methylcellulose (HPMC) on complex formation. Inclusion complexes were prepared using co-evaporation solvent and freeze-drying methods, and their CE and Ks were determined through a phase solubility study. The complexes were characterized using physicochemical analyses, including FT-IR, DSC, SEM, XRD, DLS, UV-Vis, 1H-NMR, and 1H-ROESY. The dissolution profiles of the complexes were also evaluated. The analyses confirmed complex formation for all systems, demonstrating drug–cyclodextrin interactions, amorphous drug states, morphological changes, and improved solubility and dissolution profiles. The NAs-2HP-β-CD-HPMC complex exhibited the highest CE and Ks values, a 1:1 host-guest molar ratio, and the best dissolution profile. The results indicate that the NAs-2HP-β-CD-HPMC complex has potential for delivering NA, which might enhance its therapeutic effectiveness and minimize side effects.