Ammonium Acetate In Presence Research Articles

An alternative process for one-pot multicomponent synthesis of substituted 2, 4, 5-triphenylimidazoles using activated Fuller's earth as catalyst and molecular modeling data

We have successfully achieved the synthesis of 2,4,5-trisubstituted imidazole by a three pot multicomponent reaction of benzil, aromatic benzaldehydes and ammonium acetate in presence of activated fuller's earth as a catalyst. The activation of fuller's earth is carried out by an organic acid, which sufficiently increased its adsorption properties. The advantages of this process are high yields, green system and efficient recovery of the catalyst, which can be reused 2–3 times without much significant effect on yield. Molecular Modelling studies viz., Lipinski rule of five, drug likeness, drug scores, toxicity profiles and other physico-chemical properties of drugs were performed using Molinspiration and Osiris software and compared with the data of standard drug molecule.

Microwave-Induced Expeditious Synthesis of Biologically Active Substituted Imidazoles using CuO-TiO2-GO Nanocomposite as a Recyclable Catalyst

An efficient, green and rapid protocol for one-pot synthesis of substituted imidazoles from isatin, aryl/hetero-aryl aldehydes and ammonium acetate in presence of CuO-TiO2-GO nanocomposite as catalyst under microwave irradiation has been reported in this article. The CuO-TiO2-GO nanocomposite was synthesized by the hydrothermal method. Further, the prepared composite was characterized by FT-IR, XRD, FESEM, EDS, TEM, Raman and TGA techniques. The protocol offered several advantages such as high rate of reaction, excellent yields, economic feasibility, simple work-up and reusability of catalyst up to six cycles. Further antimicrobial activities of the synthesized substituted imidazoles were evaluated by the broth dilution method.

Synthesis of 2,4,5-Triaryl- 1H-imidazole derivatives using SiO2-NaHSO4

A mixture of benzyl, aromatic aldehyde and ammonium acetate in presence of SiO2-NaHSO4 under solvent-free condition converted to 2,4,5-Triaryl-1H-Imidazoles. The short reaction time, cleaner reaction, and easy workup make this protocol practical and economically attractive.

Synthesis and characterization of novel photoactive poly(ether-amide)s based on highly substituted phenanthrimidazole

A new aromatic diamine monomer containing ether linkage based on the phenanthrimidazole ring, ‎1,1´-(4,4´- oxy bis(1,4-phenylene))bis(2-(4-aminophenyl)-1H-phenanthro[9,10-d]imidazole) was synthesized through four-‎components condensation of 4,4´-diamino diphenyl ether, 4-nitrobenzaldehyde, phenanthrene-9,10-dione and ammonium ‎acetate in presence of acetic acid, followed by palladium-catalyzed hydrazine monohydrate reduction. This new monomer ‎was further confirmed by FT-IR, 1H NMR, and 13C NMR spectroscopy. A series of new aromatic polyamides containing ‎phenanthrimidazole ring in the main chain was prepared by direct polycondensation of the prepared diamine with four ‎commercially available aromatic and aliphatic diacids. These polymers are essentially amorphous and were soluble in polar ‎aprotic solvents such as DMF, NMP, DMAc, and DMSO. Inherent viscosities of polyamides were in the range 0.42–0.53 ‎dL/g indicating the formation of medium molecular weight polymers. Polyamides exhibited glass-transition temperature (Tg) in ‎the range 260-280 °C. The 10% weight loss temperature in air atmosphere measured by TGA was in the range 454-526 °C ‎indicating their good thermal stabilities. The photophysical properties of diamine and polyamides were investigated by UV-Vsible and fluorescence spectroscopy.

A Four Components, One-Pot Synthesis of New Imidazole Molecular Tweezers Based on 2,4,6-Triarylpyridine as Hinge Region

In the present study, some new bis-imidazole derivatives have been prepared through four-components condensation of 2,6-bis (4-aminophenyl)-4-p-tolylpyridine, benzaldehyde derivatives, benzil and ammonium acetate in presence of acetic acid. The present methodology offers several advantages such as good yields, simple procedure, milder conditions and the possibility of introducing a variety of substituents at different positions of the imidazole and pyridine rings. These new compounds were confirmed by spectral methods 1H NMR, 13C NMR, FT-IR, and elemental. Also, optimized geometries and chemical shifts have been calculated for the ‎synthesized compounds using Density Functional Theory (DFT) method. Their optimized ‎geometries are not planar.‎

Highly efficient and simple protocol for synthesis of 2,4,5-triarylimidazole derivatives from benzil using fluorinated graphene oxide as effective and reusable catalyst

Efficient synthesis of 2,4,5-triarylimidazole derivatives with simple workup is described using benzil, different aldehydes, and ammonium acetate in presence of fluorinated graphene oxide (A-MFGO) as effective catalyst that can be easily recovered and reused for several times without significant loss in activity. The simple preparation of the catalyst, short reaction time, mild conditions, high yield, and low cost make this procedure economically attractive and highly suitable for synthesis of 2,4,5-triarylimidazole derivatives.

Brønsted-acidic ionic liquid: green protocol for synthesis of novel tetrasubstituted imidazole derivatives under microwave irradiation via multicomponent strategy

We present a facile and environmentally benign protocol for synthesis of variously substituted imidazole derivatives via multicomponent condensation of benzil, primary aromatic amine, substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde, and ammonium acetate in presence of 1-butyl-3-methyl-1-imidazolium tetrafluoroborate [BMIM][BF4] as catalyst under conventional reflux as well as microwave irradiation condition. The one-pot synthesis, facile solvent-free condition, and good isolated yield illustrate the utility of this green approach. The structural features are derived using analytical tools including fourier transform infrared (FTIR), Liquid chromatography-mass spectrometry (LCMS), and 1H and 13C nuclear magnetic resonance (NMR) spectroscopy.

One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity

A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were characterised by IR, 1H, 13C NMR, and MS data and tested for antimicrobial and antifungal activity.

A facile strategy for the synthesis of highly substituted imidazole using tetrabutyl ammoniumbromide as catalyst

A simple and facile strategy for the synthesis of highly substituted imidazoles has been developed by multi-component condensation of 1,2-diketone, aldehyde, amine, and ammonium acetate in presence of tetrabutyl ammonium bromide as catalyst.

Solvent‐free synthesis of new 2,4,6‐triarylpyridines catalyzed by a Brønsted acidic ionic liquid as a green and reusable catalyst

AbstractSome new 4‐(aryl)‐2,6‐di‐2‐naphthylpyridines and 4‐(aryl)‐2,6‐di‐2‐thienylpyridines have been prepared through three‐component condensation of 2‐acetylnaphthalene or 2‐acetylthiophene, aromatic aldehydes, and ammonium acetate in presence of 1‐(4‐sulfonylbutyl) pyridinium hydrogensulfate [(CH2)4SO3HPy][HSO4], a Brønsted acidic ionic liquid as a green and reusable catalyst in solvent‐free conditions. Also some new 4,4'‐(1,4‐phenylene)‐bis‐(2,6‐di‐aryl pyridine) was prepared. J. Heterocyclic Chem., (2011).

Microwaves in organic synthesis: Synthesis of pyridazinones, phthalazinones and pyridopyridazinones from 2‐oxo‐arylhydrazones under microwave irradiation

Abstractmagnified imageThe phenylhydrazones 1a‐d condensed with ethyl cyanoacetate to yield pyridazinones 2a‐d that reacted with sulphur in presence of piperidine to yield the aminothienopyridazineones 3a,b that reacted with electron poor olefins and acetylenes to yield phthalazines 10‐12. The condensed aminothiophenes 3a,b reacted with dimethylformamide dimethylacetal to yield amidines 13a,b. Compounds 2a,b condensed with dimethylformamide dimethylacetal to yield the trans enamines 16a,b that cyclized readily into the pyridopyridazinones 17a,b on treatment with ammonium acetate in presence of acetic acid. Compounds 2a‐d reacted also with benzylidenemalononitrile to yield the phthalazinones 21a‐d. The reactions were conducted both by microwave heating and conventional heating. Better yields in much shorter reaction times were achieved by microwave heating.

Preparation and Characterization of Some Cationic Starches

AbstractThree types of cationic starches were prepared via reacting starch with 3‐chloro‐2‐hydroxypropyl amine, 1,1,1,n‐Tris(3‐chloro‐2‐hydroxypropyl) amine and glycidyl trimethyl ammonium acetate in presence of sodium hydroxide. The different factors affecting these reactions were investigated. These factors include sodium hydroxide/amine, amine/starch molar ratios, liquor ratio, reaction duration and temperature. The amination extent and amination reaction efficiency percent were traced by estimating the nitrogen content of the aminated starch. Characterization of the prepared cationic starches such as solubility, moisture content, anion‐exchange capacity and metal ions sorption were studied.