AIDS, in the last century the main threat to the health of people worldwide. In fact, after seeing the first cases of HIV in 1981, Discuss the mechanism of action to identify, control and treat it with the speed of the American Medical community in Los Angeles and then spread to other parts of the world. But the pace of HIV, most of their efforts so that to this day, according to the World Health Organization, Every minute, 6 people in the world due to HBV infection, lose their lives (Owen, 1999). The ability to manipulate the deadly nature of this disease is very high, runaway prevalence in all countries, and therefore very heavy losses, Has made in a decade, all the countries in coordination with international organizations unite against this disease even in 2000, the UN Security Council to meet to assess the situation (Hubble, 2003). It is believed that AIDS and HIV infection cause a huge psychological and social pressures for the individual patient, the family, especially their wives and professionals and health care providers these people. This is for the person with psychological and social pressures for such reactions: disbelief, denial, anger, irritability, anxiety and apprehension, fear and depression, Suicidal thoughts, poor health, social isolation and complain, behaviors, frustration, low self-esteem and cognitive deficits (by engaging the central nervous system infections caused by the disease) occur. This shows that the quality of life in people with HIV is low (Arenda, 2004). Suicidal thoughts, poor health, social isolation and complain, frustration, low self-esteem and cognitive deficits (by engaging the central nervous system infections caused by the disease) occur. This shows that the quality of life in people with HIV is low (Arenda, 2004). Curtis (2000) suggests that psychological factors may affect the vulnerability of a person for HIV positive. The role of psychological factors and interventions by encouraging healthy positive beliefs and behaviors may improve quality of life, reduce stress and overall psychological well-being and help people with knowledge of the matter (according to the Pirasteh, Motlagh, & Nikmanesh, 2012). The present study tried to predict psychological well-being, according to defense mechanisms and coping strategies in HIV positive people. Seems to be addressing the issue of HIV-positive people and identify the factors affecting their psychological well-being able to achieve the necessary information And for proper planning and provision of services tailored to the needs of these people in order to improve their psychological well-being, As well as individual awareness of the consequences of the disease and preventive programs by the scientific and medical communities due to its increasing prevalence, including the necessity of using this research. Of course, if HIV is detected predictors of psychological well-being of individuals becomes the easier way to deal with problems arising from it. Therefore, identifying factors that can be psychological well-being of people with hiv predict, In prevention, treatment and care interventions should be considered. This research can help people with AIDS face many problems in dealing with the disease, to be used.Statistical societyHIV+population consisted of all patients with psychological counseling center in Shiraz University of Medical Sciences in the year 1393 is. Inclusion criteria include: developing HIV + diagnosis treatment center in Shiraz University of Medical Sciences, crossing more than three months from the knowledge of a person from getting HIV +, at least elementary education.MethodThe study was descriptive and correlational.ParticipantsSampling method is purposive sampling total of 100 HIV + patients, who come to the University Psychological Counseling Center, were selected.InstrumentsStudy, three questionnaires were used to collect information that include:Psychological well-being questionnaire: Psychological well-being questionnaire by Reef (1995) University of Wisconsin Medical Science Center was built in 2002, was revised. …