As instructors, we are quite familiar with students coming to our classes loaded with preconceived notions. For instance, some believe that male instructors are better at math, while others think that markets, if left on their own, will produce wealth for everyone. Teaching about gender and politics of the Middle East and North Africa (MENA) region at an American college is no different. Students come to class rarely knowing the basic facts, history, or culture of the region, mostly because the K–12 educational curriculum in the United States does not typically cover the MENA region. However, students’ lack of formal education on the MENA region does not mean they are unexposed to its issues, which are frequent topics in American media. Unfortunately, students often hold misconceptions and deep biases about women, culture, and politics in the region, and these misconceptions impair the learning process by acting as a “psychological block” for the students. As Haddad and Schwedler (2013, 211) put it, “our years of teaching undergraduates have taught us how images of harems, pyramids, and desert warriors wielding sabers on camelback still shape many Americans’ perceptions of the region.” This essay discusses some of the challenges that instructors teaching gender and politics in the MENA region face in an American college classroom. No single course can eradicate old paradigms and prejudices. However, this piece proposes some strategies for effective teaching about gender and politics of the MENA region.