Purpose: Evaluate the outcome of OHCA (Out of Hospital Cardiac Arrest) in the ambulance station of Lund before and after the introduction of LUCAS ™ in the prehospital setting. Material and method: The district area is 767 km 2 and has a population of 186 000 inhabitants. LUCAS was introduced in 2002 and has gradually been the method of choice for CPR. From a database including all pre-hospital missions, the OHCA cases with resuscitation attempt were retrospectively collected for a period of 7 years (2000 –2006). Period I includes years 2000 –2002 (n=85) and is regarded as a period without LUCAS-CPR. Period II (n=187) including years 2003–2006 is regarded as a period with LUCAS-CPR. In Period I, 11% of the OHCA patients admitted to the emergency department received LUCAS-CPR and in Period II it was 85%. Result: The mean incidence of OHCA per 10.000 inhabitants was 6.7 during Period I and 6.8 during Period II. Compared with Period I, the number of patients with resuscitation attempt increased with 68% (from 28.3/year to 46.8/year) and patients admitted to the emergency department increased with 63% (from 14/year to 22.5/year) during Period II. The number of patients surviving >30 days increased by 77%, from 3.0 per year (Period I) to 5.3 per year (Period II). If the OHCA took place more than 10 km from the hospital no patient survived >30 days during Period I whereas 9 patients survived >30 days during Period II. Conclusion: LUCAS markedly enhances the number of CPR treatments and makes it possible to bring victims to the hospital with vital circulation even if the distance to hospital is over 10 km. The introduction of LUCAS, improved education, changes of CPR-algorithm, in-hospital handling (body cooling) and in some cases causal treatment (PCI, bypass surgery) increase the >30 day survival by 77%.