It is a long-standing challenge to balance the structural load capacity and toughness in the design of lightweight multi-cell tubes. To tackle this challenge, we provide two kinds of complex lattice-inspired composite multi-cell tubes. The composite multi-cell tubes consist of inner polylactic acid (PLA) complex lattice-inspired multi-cell tubes and outside aluminum tubes. The energy absorption capacity of these multi-cell tubes was evaluated under quasi-static axial compression. The effect of cross-sectional topology and thermal exposure were considered in the experiment. The results show that the integration of PLA tubes within aluminum tubes significantly enhances their energy absorption performance, effectively addressing the limitations posed by the low fracture strain of PLA. The synergistic effect between the aluminum and PLA tubes mitigates the fracture instability and distributes the load more evenly, resulting in improved specific energy absorption (SEA) and mean crushing force (MCF) up to 103.32% and 184.38%, respectively. In these composite tubes, a global self-similar layout can markedly enhance its energy absorption. However, their mechanical properties decrease significantly at 323K compared to room temperature. Overall, this research provides a novel approach to enhancing the mechanical performance of PLA tubes, paving the way for their application in engineering fields requiring lightweight and high-strength structures.