The hydrodeoxygenation (HDO) of aldol condensation adducts is of key interest in the preparation of biofuels from biomass by catalytic routes. In this work, furfuryldeneacetoneis taken as model of biomass-derived condensation adduct with furanic rings, unsaturations and carbonyl functionalities. Four noble metal catalysts (alumina-supported Ru, Rh, Pd and Pt) were tested. Obtained results show that Rh and Ru catalysts are only active for the hydrogenation of aliphatic double bonds; whereas Pd, and specially Pt catalysts, are active for the total HDO of the adduct, yielding n-octane, with selectivities higher than 30% at 493K after 24h on stream (total conversion and carbon balance closure higher than 90%). Based on these results, a mechanism (considering serial, parallel and equilibrium steps) and the corresponding kinetic model have been proposed for explaining the different selectivity trends observed for these metals.