Alternative Sources Of Reinforcement Research Articles

Abstinence as Choice: Exploring Voluntary Abstinence from Alcohol Self-Administration Using the Resurgence-as-Choice Framework.

Resurgence is an increase in the rate of a previously suppressed behavior that occurs when an alternative source of reinforcement is made worse in some way. The Resurgence as Choice model offers a quantitative approach to understanding resurgence that may provide important insights into the variables that affect this form of relapse in the natural environment. Bringing this model to bear on relapse following reinforcement-based interventions for alcohol and other substance use disorders, however, may not be straightforward. Laboratory work on which the Resurgence as Choice model is based has almost exclusively focused on resurgence following extinction of target behavior, but abstinence from alcohol during intervention is often voluntary: Patients may drink alcohol and forfeit therapeutic reinforcers at any time. In this article, we first will review recent data from our group that demonstrate a method for studying resurgence following voluntary abstinence from alcohol seeking in rats. In a previous experiment, we reduced rats' alcohol-maintained lever pressing to low levels without placing it on extinction by arranging nondrug differential reinforcement of other behavior. Further, when we suspended nondrug reinforcement, resurgence of lever pressing occurred. Next, we will explore methods for modeling these outcomes using the Resurgence-as-Choice framework. We conclude that the data under consideration may not be sufficient to discriminate between candidate models of resurgence following voluntary abstinence and point to areas for future empirical and theoretical development. This work may provide a stronger bridge between preclinical and conceptual work on resurgence and clinical treatments for alcohol use disorder.

Examining effects of training duration on humans' resurgence and variability using a novel touchscreen procedure.

Resurgence occurs when a previously reinforced and then extinguished target response increases due to reducing/eliminating an alternative source of reinforcement or punishing an alternative response. We evaluated whether duration of reinforcement history for a target response (1) affects the degree to which resurgence is observed in humans and (2) produces different gradients of response generalization around target responding during extinction testing. We arranged a novel touchscreen interface in which university students could swipe a 3D soccer ball to spin any direction. In Phase 1, the first direction swiped became the target and produced points exchangeable for money for 3 or 1 min across 2 groups. The first swipe was recorded but had no programmed consequence in a third group. In Phase 2, swipes 180-degrees from the target resulted in points for 3 min in all groups. Point deliveries ceased for 2 min to test for resurgence in Phase 3. Target responses resurged during testing to a relatively greater extent with longer Phase-1 training but gradients of response generalization did not differ among groups. These findings extend prior research on the role of training duration on resurgence. We discuss methodological and conceptual issues surrounding the assessment of response generalization in resurgence.

Baclofen decreases compulsive alcohol drinking in rats characterized by reduced levels of GAT-3 in the central amygdala.

While most individuals with access to alcohol drink it recreationally, some vulnerable individuals eventually lose control over their intake and progressively develop compulsive alcohol drinking and decreased interest in alternative sources of reinforcement, two key features of addiction. The neural and molecular mechanisms underlying this vulnerability to switch from controlled to compulsive alcohol intake have not been fully elucidated. It has been shown that rats having reduced levels of expression of the gamma‐aminobutyric acid (GABA) transporter, GAT‐3, in the amygdala tend to persist in seeking and drinking alcohol even when adulterated with quinine, suggesting that pharmacological interventions aimed at restoring GABA homeostasis in these individuals may provide a targeted treatment to limit compulsive alcohol drinking. Here, we tested the hypothesis that the GABAB receptor agonist baclofen, which decreases GABA release, specifically reduces compulsive alcohol drinking in vulnerable individuals. In a large cohort of Sprague–Dawley rats allowed to drink alcohol under an intermittent two‐bottle choice procedure, a cluster of individuals was identified that persisted in drinking alcohol despite adulteration with quinine or when an alternative ingestive reinforcer, saccharin, was available. In these rats, which were characterized by decreased GAT‐3 mRNA levels in the central amygdala, acute baclofen administration (1.5 mg/kg, intraperitoneal) resulted in a decrease in compulsive drinking. These results indicate that low GAT‐3 mRNA levels in the central amygdala may represent an endophenotype of vulnerability to develop a compulsive drinking of alcohol that is shown here to be mitigated by baclofen.

Resurgence and alternative-reinforcer magnitude.

Resurgence is defined as an increase in the frequency of a previously reinforced target response when an alternative source of reinforcement is suspended. Despite an extensive body of research examining factors that affect resurgence, the effects of alternative-reinforcer magnitude have not been examined. Thus, the present experiments aimed to fill this gap in the literature. In Experiment 1, rats pressed levers for single-pellet reinforcers during Phase 1. In Phase 2, target-lever pressing was extinguished, and alternative-lever pressing produced either five-pellet, one-pellet, or no alternative reinforcement. In Phase 3, alternative reinforcement was suspended to test for resurgence. Five-pellet alternative reinforcement produced faster elimination and greater resurgence of target-lever pressing than one-pellet alternative reinforcement. In Experiment 2, effects of decreasing alternative-reinforcer magnitude on resurgence were examined. Rats pressed levers and pulled chains for six-pellet reinforcers during Phases 1 and 2, respectively. In Phase 3, alternative reinforcement was decreased to three pellets for one group, one pellet for a second group, and suspended altogether for a third group. Shifting from six-pellet to one-pellet alternative reinforcement produced as much resurgence as suspending alternative reinforcement altogether, while shifting from six pellets to three pellets did not produce resurgence. These results suggest that alternative-reinforcer magnitude has effects on elimination and resurgence of target behavior that are similar to those of alternative-reinforcer rate. Thus, both suppression of target behavior during alternative reinforcement and resurgence when conditions of alternative reinforcement are altered may be related to variables that affect the value of the alternative-reinforcement source.

A review of resurgence literature with human participants.

Resurgence is the reemergence of a previously reinforced behavior when an alternative source of reinforcement is discontinued or decreased (Lattal & St. Peter Pipkin, 2009). Lattal and St. Peter Pipkin (2009) published a review in which they discussed the applied relevance of the resurgence literatu

Renewal, resurgence, and alternative reinforcement context

Resurgence, relapse induced by the removal of alternative reinforcement, and renewal, relapse induced by a change in contextual stimuli, are typically studied separately in operant conditioning paradigms. In analogous treatments of operant problem behavior, aspects of both relapse phenomena can operate simultaneously. Therefore, the purpose of this study was to examine a novel method for studying resurgence and renewal in the same experimental preparation. An alternative source of reinforcement was available during extinction for one group of rats (a typical resurgence preparation). Another group experienced an operant renewal preparation in which the extinction context was distinguished via olfactory and visual stimuli. A third group experienced alternative reinforcement delivery in the new context, a novel combination of typical resurgence and renewal preparations. Removal of alternative reinforcement and/or a change in context induced relapse relative to an extinction-only control group. When alternative reinforcement was delivered in a novel context, the alternative response was less persistent relative to when extinction of the alternative response took place in the context in which it was trained. This methodology might be used to illustrate shared (or distinct) mechanisms of resurgence and renewal, and to determine how delivering alternative reinforcement in another context may affect persistence and relapse.

Incorporating Nondrug Social & Recreational Activities in Outpatient Chemical Dependency Treatment

“Contingency Management programs (CMP) and non-drug social and recreational activities (NDSRA) are interventions premised on behavior theory that rely on external sources of reinforcement alternative to drug-based forms to decrease drug use. CMP usually employs vouchers as reinforcement for negative toxicologies. Despite research support, CMP alone may be insufficient to achieve abstinence. Although evidence supporting NDSRA is limited, it is promising because it assists patients to employ “fun” real world activities (e.g. films, plays, circus) as alternative sources of reinforcement. Both CMP and NDSRA are currently used at Coney Island Hospital’s Outpatient Chemical Dependency Services (CIHCDS) in New York City. The NDSRA program is fairly extensive (>40 events per year) and includes group excursions (868 patient participants in 2009) under the supervision of one or more therapists. A description of program design and clinical observations of its impact follows a brief review of relevant research.”

Central reinforcing effects of ethanol are blocked by catalase inhibition

Recent studies have systematically indicated that newborn rats are highly sensitive to ethanol's positive reinforcing effects. Central administrations of ethanol (25–200 mg %) associated with an olfactory conditioned stimulus (CS) promote subsequent conditioned approach to the CS as evaluated through the newborn's response to a surrogate nipple scented with the CS. It has been shown that ethanol's first metabolite, acetaldehyde, exerts significant reinforcing effects in the central nervous system. A significant amount of acetaldehyde is derived from ethanol metabolism via the catalase system. In newborn rats, catalase levels are particularly high in several brain structures. The present study tested the effect of catalase inhibition on central ethanol reinforcement. In the first experiment, pups experienced lemon odor either paired or unpaired with intracisternal (IC) administrations of 100 mg% ethanol. Half of the animals corresponding to each learning condition were pretreated with IC administrations of either physiological saline or a catalase inhibitor (sodium-azide). Catalase inhibition completely suppressed ethanol reinforcement in paired groups without affecting responsiveness to the CS during conditioning or responding by unpaired control groups. A second experiment tested whether these effects were specific to ethanol reinforcement or due instead to general impairment in learning and expression capabilities. Central administration of an endogenous kappa opioid receptor agonist (dynorphin A-13) was used as an alternative source of reinforcement. Inhibition of the catalase system had no effect on the reinforcing properties of dynorphin. The present results support the hypothesis that ethanol metabolism regulated by the catalase system plays a critical role in determination of ethanol reinforcement in newborn rats.

Altruism is a social behavior

Altruism and cooperation are explained as learned behaviors arising from a pattern of repeated acts whose acquired value outweighs the short-term gains following single acts. But animals and young children, tempted by immediate gains, have difficulty learning behaviors of self-control. An alternative source of reinforcement, shared by animals and humans, arises from social interaction that normally accompanies cooperation and altruism in nature.

Human sensitivity to reinforcement: A comment on Kollins, Newland, and Critchfield’s (1997) quantitative literature review

In a quantitative review of human operant experiments, Kollins, Newland, and Critchfield (1997) found that humans are less sensitive to reinforcement contingencies than nonhumans are. Human performances were not as consistent with the matching law, and they were more variable from subject to subject. Some of the variables correlated with reduced human sensitivity were surprising. These included collection of the data under more controlled conditions (laboratory rather than naturalistic settings), and inclusions of discriminative stimuli correlated with alternative sources of reinforcement. We discuss these unexpected findings in the light of criticisms that have been leveled against meta-analytic literature reviews (e.g., the wisdom of grouping studies with widely diverse methods), and we suggest ways of improving future analyses of the behavior-analytic literature.