Alternative Forms Of Regulation Research Articles

MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination.

In eukaryotes, DNA mismatch recognition is accomplished by the highly conserved MutSα (Msh2/Msh6) and MutSβ (Msh2/Msh3) complexes. Previously, in the yeast Saccharomyces cerevisiae, we determined that deleting MSH6 caused wild-type Msh2 levels to drop by ∼50%. In this work, we determined that Msh6 steady-state levels are coupled to increasing or decreasing levels of Msh2. Although Msh6 and Msh2 are reciprocally regulated, Msh3 and Msh2 are not. Msh2 missense variants that are able to interact with Msh6 were destabilized when Msh6 was deleted; in contrast, variants that fail to dimerize were not further destabilized in cells lacking Msh6. In the absence of Msh6, Msh2 is turned over at a faster rate and degradation is mediated by the ubiquitin-proteasome pathway. Mutagenesis of certain conserved lysines near the dimer interface restored the levels of Msh2 in the absence of Msh6, further supporting a dimer stabilization mechanism. We identified two alternative forms of regulation both with the potential to act via lysine residues, including acetylation by Gcn5 and ubiquitination by the Not4 ligase. In the absence of Gcn5, Msh2 levels were significantly decreased; in contrast, deleting Not4 stabilized Msh2 and Msh2 missense variants with partial function. The stabilizing effect on Msh2 by either the presence of Msh6 or the absence of Not4 are dependent on Gcn5. Taken together, the results suggest that the wild-type MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination.

The pornographic state: the changing nature of state regulation in addressing illegal and harmful online content

This article explores the failure of democratic nation-states to regulate corporate Internet intermediaries who essentially provide access to websites containing illegal and legal pornographic content. Existing literature credits this apparent diminishing regulatory role of states to neoliberalism. Drawing on Wacquant’s theory of ‘neoliberal statecrafting’ can explain the paucity of state media regulation while also accounting for when states do engage in alternative forms of regulation. Through a thematic analysis of key documents, media and interviews with ‘elite’ stakeholders in Australia and the United Kingdom, this research shows that private actors are generally exempt from state regulation, while individuals are simultaneously subject to punitive mechanisms for problematic and illegal uses of the Internet.

Governança ambiental e sistema financeiro internacional: significantes e significados de complexa comunicação na agenda contemporânea

A interação entre a Governança Ambiental e o Sistema Financeiro Internacional na Agenda Contemporânea aponta para nova forma de conjugar os termos linguagem e comportamento econômico, tema abordado de forma original nos escritos de Deirdre McCloskey na década de 1980. Instituições econômico-financeiras passam a incluir em sua pauta produtivo-financeira o meio ambiente (e.g. lançando pacotes de crédito favorecido a projetos ambientais ou mesmo opondo exigências quanto a práticas ambientais sustentáveis para a concessão de empréstimos). A repercussão para a teoria do direito é sentida a par da substituição de mecanismos tradicionais de sanção (cujo parâmetro fundamental é o da responsabilidade administrativa, civil e penal), por formas alternativas de regulação (como justiça restaurativa e regulação smart).

Ecological Status as a Legal Construct—Determining its Legal and Ecological Meaning: Figure 1.

For a meaningful discussion of the effectiveness of ecological objectives and ecological quality standards, their terms and purposes must be examined and clarified. This study explores the terms and content of ecological quality objectives and ecological quality standards, based on the Water Framework Directive’s legal conceptualization of ‘ecological status’. This exploration is accomplished by analysing and describing the Water Framework Directive’s ‘ecological status’ aspect from a legal-ecological perspective. The analysis of ‘ecological status’ and its main constructs forms the basis for a possible alternative form of regulation, which addresses the shortcomings identified in the analysis.

Framing standards, mobilizing users: Copyright versus fair use in transnational regulation

ABSTRACT Following the agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) intellectual property rights, and more specifically copyright, have become the subject of highly politicized conflicts. In this paper we analyze how these conflicts shifted from the political arena to private standard-setting sites, where two opposing coalitions of actors pursued competing initiatives – an industry coalition which aimed at enforcing copyright protection through Digital Rights Management and an emerging coalition of civil society actors which sought to develop a digital commons based on copyleft licenses. Paradoxically, the industry coalition, which had very successfully lobbied international organizations, ran into trouble developing and enforcing private regulation in the market place, while the civil society coalition proved to be more effective in the market than in the political sphere. The findings of our analysis indicate that the strategic use of organizational forms and collective action frames can be more decisive for the mobilization of users than material resources, and that the success of collective action frames depends on their compatibility with user practices. Based on the argument that regime shifting from intergovernmental to private governance can open up new and favorable spaces for weak actors to experiment with alternative forms of regulation, the paper contributes to the literature on the politics of regime complexity. The paper furthermore highlights the importance of studying non-elite actors and their day-to-day practices to gain a better understanding of changes within the international political economy.

The Water Framework Directive--A Directive for the Twenty-First Century?

For a meaningful discussion of the effectiveness of ecological objectives and ecological quality standards, their terms and purposes must be examined and clarified. This study explores the terms and content of ecological quality objectives and ecological quality standards, based on the Water Framework Directive’s legal conceptualization of ‘ecological status’. This exploration is accomplished by analysing and describing the Water Framework Directive’s ‘ecological status’ aspect from a legal-ecological perspective. The analysis of ‘ecological status’ and its main constructs forms the basis for a possible alternative form of regulation, which addresses the shortcomings identified in the analysis.

The Trouble with Cases

For several decades now a debate has raged about policy-making by litigation. Spurred by the way in which tobacco, environmental, and other litigation has functioned as an alternative form of regulation, the debate is about whether policy-making or regulation by litigation is more or less socially desirable than more traditional policy-making by ex ante rule-making by legislatures or administrative agencies. In this paper we enter the debate, but not to come down on one side or another, all things considered, of the litigation versus ex ante rule-making regulatory debate. Rather, we seek to show that any form of regulation that is dominated by high-salience particular cases is highly likely, because of the availability heuristic and related problems of representativeness, to make necessarily general policy on the basis of unwarranted assumptions about the typicality of one or a few high-salience cases or events. And although this problem is virtually inevitable in regulation by litigation, it is far from absent even in ex ante rule-making, because such rule-making increasingly takes place in the wake of, and dominated by, particularly notorious and often unrepresentative outlier events. In weighing the value of regulation by ex ante rule-making against the value of regulation by litigation, it is important for society to recognize that any regulatory form is less effective just insofar as it is unable to transcend the distorting effect of high-salience unrepresentative examples.

Regulatory effects on the market penetration and capacity of reliability differentiated service

This paper investigates the effects of alternative forms of regulation on the market penetration and capacity that are determined by a profit-maximizing monopolist providing reliability differentiated service to consumers. Both price cap and rate of return regulation lead to larger capacity and market penetration than in the absence of regulation. These forms of regulation also lead to larger consumer surplus than in the absence of regulation. A minimum reliability standard reduces market penetration, and this reduction may lead to a decrease in consumer surplus.

Regulation and Taxation of Casinos under State-Monopoly, Private Monopoly and Casino Association Regimes

This paper considers alternative forms of regulation and taxation of the casino sector. The model considers the situation of a typical tourist destination country that is using casinos to attract and entertain foreign tourists. The objective is to invest in the sector efficiently while maximizing the amount of government revenue or profits accruing to the country. The regulator must determine how the price of gambling will be set, how many casinos will be allowed to enter the industry and the form and rates of taxation. Four alternative forms of regulation are considered: price regulation, state-owned monopoly, private monopoly and casino association regulation. Turnover taxes on the amount of funds gambled and also annual taxation of the fixed costs of the casinos are evaluated. Applications of the models are carried out for North Cyprus. The conclusion is that the economic efficiency costs and the revenue losses from the absence of effective regulation in these tourist destinations can be very substantial with welfare costs equal to the approximately 75 percent of the tax revenue generated by this sector. Furthermore it shows that while a tax on turnover can be efficient in the case of a competitive industry or a cartel association form of regulation, it will be distortionary if a multi-plant private monopoly is controlling the sector. In contrast a tax on fixed costs will lead to an efficient result in the case of a competitive industry, but it will lead to economic inefficiencies if the sector is regulated by a casino association that controls the number of casino entering the sector.

What can ‘benchmarking’ offer the open method of co-ordination?

Benchmarking offers actors a means of resolving the horizontal and vertical collective action problems that often bedevil the development and implementation of decision-making. It has assumed a vital role in the EU’s ‘open method of co-ordination’ with its focus on the identification and dissemination of ‘best practice’ through mutual learning and peer review, offering new solutions for policy management in an increasingly complex, diverse and uncertain environment. Yet the evolution of benchmarking from management tool to regulatory instrument is also problematic, and not just because it remains conceptually ambiguous and technically difficult to effect in practice. More fundamentally, the mechanisms of control that underpin benchmarking in large companies are generally unavailable to public policy-makers. As a result, benchmarking must be looser at EU level, and perhaps ultimately viewed as a complementary rather than an alternative form of regulation.

Regulatory regimes and efficiency in US local telephony

The paper assesses the efficiency consequences of different regulatory regimes for US local telephony. Specifically, alternative regulatory regimens (price-cap regulation and incentive regulation) are contrasted with traditional rate-of-return regulation (ROR). Relative efficiency scores are obtained from the Data Envelopment Analysis (DEA) approach. The regression analysis on the determinants of efficiency, after controlling for technical change effects, indicates that alternative forms of regulation appear to induce a higher level of efficiency for the regulated firms than ROR.