Abstract College education and teaching management are experiencing a transition from traditional modes to informational modes. This paper constructs a management mode for university teaching informatization based on RFID technology and designs the workflow and functions for RFID. For the positioning of student RFID tags on campus, a time-gap ALOHA algorithm is proposed to reduce the collision rate by dividing the processing time of student tags into several time gaps. After obtaining the student tags, an improved K-weighted center-of-mass localization algorithm is proposed for multi-point localization, which makes the weight of multiple known nodes in the process of operation more reasonably distributed through the setting of the weight size. In the simulation test of campus student localization, when the number of beacon nodes is 40, the average error of the K-weighted prime is 6.5%, 4.25%, and 2.1% lower than that of the prime algorithm, weighted prime, and weighted differential prime, respectively.