A laser welding with wire filler feeding was developed to replace traditional arc welding process for joining aluminium alloy railcar body components. A three-dimensional (3D) thermo-elastic-plastic finite element (FE) model was applied to compute the plastic strains of weld zone in a downsized aluminium alloy plate with butt-joint, T-joint and fillet-joint configurations, respectively, combined with corresponding experimental validations. The achieved plastic strains at the weld zone were then input as inherent strain loadings into elastic structural FE model of fully sized aluminium alloy railcar body components to predict the welding induced distortion with the experimentally measured out-of-plane distortions. The experimentally validated FE model was then further applied for optimizing the inverse pre-deformation of plates to counteract the welding induced deformation, finally to mitigate the welding distortion issues.