Alloy In Simulated Body Fluid Research Articles

Corrosion Rate and Mechanism of Degradation of Chitosan/TiO2 Coatings Deposited on MgZnCa Alloy in Hank's Solution.

Overly fast corrosion degradation of biodegradable magnesium alloys has been a major problem over the last several years. The development of protective coatings by using biocompatible, biodegradable, and non-toxic material such as chitosan ensures a reduction in the rate of corrosion of Mg alloys in simulated body fluids. In this study, chitosan/TiO2 nanocomposite coating was used for the first time to hinder the corrosion rate of Mg19Zn1Ca alloy in Hank's solution. The main goal of this research is to investigate and explain the corrosion degradation mechanism of Mg19Zn1Ca alloy coated by nanocomposite chitosan-based coating. The chemical composition, structural analyses, and corrosion tests were used to evaluate the protective properties of the chitosan/TiO2 coating deposited on the Mg19Zn1Ca substrate. The chitosan/TiO2 coating slows down the corrosion rate of the magnesium alloy by more than threefold (3.6 times). The interaction of TiO2 (NPs) with the hydroxy and amine groups present in the chitosan molecule cause their uniform distribution in the chitosan matrix. The chitosan/TiO2 coating limits the contact of the substrate with Hank's solution.

Effect of Electrolytic Plasma Polishing on Surface Properties of Titanium Alloy

Effect of Electrolytic Plasma Polishing on Surface Properties of Titanium Alloy

Effect of Surface Nano Structuring on Corrosion and Tribocorrosion Behavior of Ti6Al4V Alloy in Simulated Body Fluid

Effect of Surface Nano Structuring on Corrosion and Tribocorrosion Behavior of Ti6Al4V Alloy in Simulated Body Fluid

Corrosion resistance of hybrid plasma electrolytic oxidation coatings on AZ31B magnesium alloy in simulated body fluid

This study examines the effects of a hydroxyapatite/anatase TiO2/CeO2 coating on the corrosion of AZ31B magnesium alloy in a simulated body fluid. Plasma electrolytic oxidation (PEO) is used to create the coating, and the surface properties are analysed using X-ray diffraction (XRD), atomic force microscopy (AFM) and field-emission scanning electron microscopy (FE-SEM). Contact angle measurements adapted to compare the uncoated substrate (144.74 ± 2.08°) with the coated substrates, which exhibit contact angles of (107.92 ± 2.16°), (95.88 ± 2.06°) and (66.05 ± 2.09°) for the respective coating durations. Increasing the thickness of the coating improves its corrosion resistance. Specifically, a 6-minute PEO coating significantly increases the thickness and provides better protection against corrosion for the AZ31B magnesium alloy. Cross-sectional scans of the coated samples revealed an increase in specimen thickness from 32.92 μm to77.17 μm. Potentiodynamic polarisation tests in a simulated body fluid reveal that the 6-minute coated sample shows the highest corrosion resistance, with the lowest corrosion current density (1.9037 × 10-06) compared to other coatings, indicating strong protection against corrosion. This research proposes a novel method to enhance the corrosion resistance of PEO coatings on magnesium alloys by depositing a thicker layer of hydroxyapatite, anatase TiO2 and CeO2. This approach results in a stronger and more effective protective system against corrosion.

Effect of Si addition on microstructure and performance of a biomedical Ti-Nb-Zr-Ta alloy prepared via powder hot extrusion

In this study, TNZT-xSi ((Ti53Nb35Zr7Ta5)100-xSix, x=0, 1.4, 2.3, wt.%) alloys are prepared by powder hot extrusion. The effect of Si addition on microstructure, mechanical properties, corrosion resistance and in vitro apatite formation ability of TNZT-xSi alloys is investigated. The as-extruded TNZT alloy mainly consists of elongated BCC grains. The addition of Si leads to the precipitation of fine (Ti, Zr)2Si (S2) particles from the BCC matrix. With the increase of Si content, the volume fraction of recrystallized grains rises significantly, and the microstructure of extruded alloys tends to transform from elongated to equiaxed grains. It’s indicated that the introduction of S2 particles activates the dynamic recrystallization process during hot extrusion and results in an obvious reduction in the overall grain size. Compared with the TNZT-0Si base alloy, the tensile strength of TNZT-2.3Si alloy is improved from 726MPa to 983MPa, with the elongation declining from 28.0% to 9.5%. The TNZT-xSi alloys exhibit higher corrosion potential (Ecorr) and lower corrosion current density (Icorr) than Ti-6Al-4V alloy in simulated body fluid, due to the formation of more stable oxides such as Nb2O5, ZrO2 and Ta2O5. Furthermore, TNZT-xSi alloys have apatite formation ability superior to Ti-6Al-4V. These results suggest that TNZT-xSi alloys may have the potential as a biomaterial for implant applications.

Improvement in corrosion resistance of AZ91D Mg alloy in simulated body fluid by cerium-based/stearic acid composite coatings

Magnesium alloys have attracted attention due to their biocompatibility and biodegradability. In this work, composite coatings are developed to potentially improve the corrosion resistance of AZ91D Mg alloy in simulated physiological fluid. Cerium-based/stearic acid coatings were prepared by electrodeposition combined with a simple immersion method. The effect of stearic acid bath concentration on the contact angle and corrosion resistance of the composite coatings was evaluated. The results showed that the stearic acid treatment increased the hydrophobicity of the surfaces of the cerium-based simple coatings. The use of an appropriate stearic acid concentration is a key for the fabrication of hydrophobic surfaces. The duplex coatings were demonstrated to protect the substrate from corrosion in Ringer solution.

Three-stage degradation behavior and dealloying assisted galvanic corrosion mechanism of 300 MPa grade Zn-2Cu-xLi (x = 0.2-0.8) alloys in simulated body fluid

Corrosion behaviors of biodegradable Zn alloys with ternary phases are rarely studied. This paper reveals three-stage corrosion behavior of high-strength Zn-2Cu-(0.2–0.8)Li alloys immersed in simulated body fluid for 30 days. At stage Ⅰ, Zn phase is preferentially corroded due to cathodic Zn-Cu-Li ternary phases recently identified. At stage Ⅱ, corrosion is suppressed due to formation of protective layer containing LiOH and Li2CO3 with appropriate Pilling-Bedworth ratios. At stage Ⅲ, dealloying of Zn-Cu-Li phases rises their Cu contents, accelerating galvanic corrosion and resulting in large pits beyond 200 µm.

Preparation and properties of biodegradable biomedical metal zinc alloy

Abstract In this study, the effects of Mg addition on the organization refinement and mechanical properties of the alloys were investigated by designing Zn-Mg binary alloys with different compositions. Solution treatment and cold drawing successfully prepared fine wire materials with smooth surface and uniform organization. The material’s mechanical properties were further improved by treating the fine wires with an optimized annealing process. Electrochemical tests and in vitro degradation experiments showed that the degradation properties of the alloy in simulated body fluids were closely related to the alloy composition and microstructure. Cytotoxicity tests showed that the prepared Zn-Mg alloys were significantly cytotoxic to tumor cells. The corrosion weight loss analysis revealed the corrosion behavior of the alloy and its trend with time. Overall, this study provides critical experimental data and theoretical basis for preparing biodegradable biomedical metal-zinc alloys with excellent performance, and lays a solid foundation for future clinical applications.

The effect of solid solution treatment with coating on corrosion properties of AZ91 Mg alloy in simulated body fluid

The current study involves an attempt to reduce the corrosion rate of AZ91 Mg alloy that is used in biomedical applications, where it is known as biodegradable material and needs to increase its lifetime until healing can occur. Firstly, solid solution treatment at 450 °C for 8 hr. was worked to reduce the second phase represented by Mg17Al12 and then reduce the galvanic cells on the alloy’s surface. Secondly, coating with indium and titanium metals was done by DC sputtering. The characterization of treated and treated/coated specimens was accomplished by XRD, SEM/EDS, and AFM confirming the improvement of solid solution treated/In coated alloy surface compared with the treated uncoated and solid solution treated/Ti coated alloy. Corrosion properties were investigated by potentiostatic measurement indicating that the solid solution treated/In coated alloy gave lower corrosion current density (i.e., lower corrosion rate), protection efficiency equal to 38.31%, polarization resistance increased from 33.482 × 102 to 36.876 × 102 Ω.cm2 and lower porosity compared with coated specimen by Ti. The reason for this improvement comes from the full coverage of the surface by a compact regular layer of indium as well as the formation of the Mg3In phase. The porosity percentage PP% showed the high porosity for treated/Ti coated specimen which reached to 2104.1%.

Influence of Mechanical Torsion on MgCa1 Corrosion Behavior in Simulated Body Fluid

In this paper, the influence of mechanical torsion on the corrosion of MgCa1 alloy in simulated body fluid (SBF) is presented. The corrosion behavior is examined by microstructural observations, including a scanning electron microscope equipped with an energy dispersive spectroscopy detector and electrochemical studies, mainly impedance spectroscopy measurements and polarization curves. The experiments were performed for different time durations (4 h to 8 h) with and without torsion applied (within elastic deformation range in the form of rotary movements) to assign the differences between the corrosion behavior of the samples. It is shown that mechanical torsion (rotations) promotes the leaching of calcium from the grain boundaries in the samples, which decreases the overall alloy corrosion rate. On the other hand, grain boundaries leached out of calcium compounds influence the sample microstructure by enabling cracks formation and propagation. Therefore, rotated samples corroded at a lower rate but were more susceptible to catastrophic failure. It was then concluded that MgCa1 alloy may be a promising biodegradable material for medical implants, however, its durability in SBF with torsion applied is far from being satisfactory.

Morphological, microstructural, mechanical, and electrochemical optimization of a novel Mg–2Ca–1Mn–1 Sr alloy by P ion implantation for orthopedic implants

This study investigates the influence of phosphorous (P) ion implantation on the morphological, microstructural, mechanical, and electrochemical properties of a novel bioresorbable Mg–2Ca–1Mn–1 Sr (XMJ211) quaternary alloy in simulated body fluid (SBF) post-implantation for potential orthopedic implants. The novelty lies in both the unique alloy composition and systematically optimizing the alloy's performance through P ion implantation at varying fluences. XRD analysis revealed the increased volume fractions of secondary binary phases, such as Mg3P2, and a fractional decrease in grain size from approximately 71 µm to 39 µm with gradually increased P implantation. Mechanical hardness improved from approximately 60 HV to 75 HV with P addition due to grain refinement and increased second-phase binary particles. The EIS analysis confirmed an improvement in the bio-corrosion resistance of the alloy from 48 kΩ to 87 kΩ as P addition increased up to fluence 4, with diminishing effects at higher fluences. The study results successfully demonstrate a balance between the mechanical and electrochemical properties of the alloy with moderate amounts of P addition, positioning it as a promising bioresorbable biomaterial for orthopedic implants and eliminating the need for secondary implant removal surgery post-patient recovery. This research bridges the knowledge gap in the literature and introduces a novel approach to optimizing the performance of Mg-based alloys for biomedical applications.

Improvement in corrosion resistance of biocompatible Ti1.5Al0.3ZrNb refractory high entropy alloy in simulated body fluid by nanosecond laser shock processing

A biocompatible Ti1.5Al0.3ZrNb refractory high-entropy alloy (RHEA) with high specific strength and superior tensile ductility is developed. The activation of multiple slip systems and dislocations cross-slip facilitate dislocation interactions, improving the plastic deformability and continuous strain hardening ability of the Ti1.5Al0.3ZrNb RHEA. After laser shock processing (LSP), the surface roughness of the RHEA increases and significant grain refinement occurs on the surface, from micron-grains to nano-grains. Meanwhile, abundant dislocations and dislocation debris are generated. This surface morphology significantly improves the corrosion resistance of the RHEA in simulated body fluid. The corrosion current density of the LSP-Ti1.5Al0.3ZrNb is only ∼1/3 of the Ti1.5Al0.3ZrNb, and the resistance Rct is 2.29 × 105 Ω·cm2 in the LSP-Ti1.5Al0.3ZrNb, which is an order of magnitude higher than that of the Ti1.5Al0.3ZrNb. The improved corrosion resistance of LSP-Ti1.5Al0.3ZrNb is ascribed to multiple LSP-induced compressive residual stress, grain refinement and high-density dislocations. Combining the RHEAs with LSP techniques could offer the opportunity to break existing corrosion limitation, and obtain substantial performance improvement.

Evaluation of tribocorrosion performance of Ti6Al4V alloy in simulated inflammatory and hyperglycemic microenvironments

The poor tribocorrosion resistance of the Ti6Al4V alloy limits its wide applications in orthopedics. In addition, the tribocorrosion performance and mechanism of the Ti6Al4V alloy are not clear in some clinically specific pathological settings, such as peri-implantitis and diabetes. In this work, the tribocorrosion performances of the Ti6Al4V alloy in simulated body fluids (SBF) containing H2O2 and glucose were investigated to analyze the degradation behavior in the simulated inflammatory and hyperglycemic microenvironment. The tribocorrosion tests were carried out on a tribometer equipped with a three-electrode system electrochemical workstation. The material volume loss of the Ti6Al4V alloy in the high glucose environment (6 g/L) is 3.1 times more than that in the glucose-free environment, while H2O2 does not increase the material volume loss. The continuous corrosion product film on the Ti6Al4V surface in the SBF with H2O2 acts as a lubricant in mechanical wear, while the Ca and Mg-containing mineralized film formed in the high glucose environment increases the coefficient of friction (COF) during sliding. These results suggest that diabetic patients may be at a higher risk of the implant failure due to the tribocorrosion. This finding also provides a valuable reference for the placement of titanium-based implants in specific pathological settings in orthopedics.

Effect of MgF2 coating on stress corrosion cracking behavior of Mg−Zn−Ca alloy in simulated body fluid

The stress corrosion cracking behavior of Mg−3wt.%Zn−0.2wt.%Ca (MZC) alloy and fluoride (MgF2) coated Mg−3wt.%Zn−0.2wt.%Ca alloy (MZC-MF) for bone implant applications was investigated using slow strain- rate tensile (SSRT) tests in simulated body fluid (SBF). The results show that MgF2 coating could significantly improve the corrosion resistance and prolonged fracture failure time of MZC alloy. MgF2 coating also greatly reduced the stress corrosion cracking sensitivity of MZC alloy in SBF. Compared to MZC alloy, stress corrosion cracking sensitivity index (Iscc) of MZC-MF alloy decreased by 21% (ultimate tensile strength, UTS), 22% (time to failure, tf), 23% (elongation after fracture, δ), 7% (reduction ratio of cross-sectional area after fracture, ϕ) and 15% (inner product work, A), respectively.

Corrosion Performance of Ti6Al7Nb Alloy in Simulated Body Fluid for Implant Application Characterized Using Macro- and Microelectrochemical Techniques

In this paper, the applicability of Ti6Al7Nb as a more biocompatible alternative for bone and dental implants than Ti6Al4V and pure titanium in terms of corrosion resistance and electrochemical inertness is investigated. The chemical inertness and corrosion resistance of the Ti6Al7Nb biomaterial were characterized by a multi-scale electrochemical approach during immersion in simulated physiological environments at 37 °C comparing its behavior to that of c.p. Ti, Ti6Al4V, and stainless steel. The establishment of a passive regime for Ti6Al7Nb results from the formation of a thin layer of metal oxide on the surface of the material which prevents the action of aggressive species in the physiological medium from direct reaction with the bulk of the alloy. Conventional electrochemical methods such as potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) provide quantified information on the surface film resistance and its stability domain that encompasses the potential range experienced in the human body; unfortunately, these methods only provide an average estimate of the exposed surface because they lack spatial resolution. Although local physiological environments of the human body are usually simulated using different artificial physiological solutions, and changes in the electrochemical response of a metallic material are observed in each case, similar corrosion resistances have been obtained for Ti6Al7Nb in Hank’s and Ringer’s solutions after one week of immersion (with a corrosion resistance of the order of MΩ cm2). Additionally, scanning electrochemical microscopy (SECM) provides in situ chemical images of reactive metal and passive dielectric surfaces to assess localized corrosion phenomena. In this way, it was observed that Ti6Al7Nb exhibits a high corrosion resistance consistent with a fairly stable passive regime that prevents the electron transfer reactions necessary to sustain the metal dissolution of the bulk biomaterial. Our results support the proposition of this alloy as an efficient alternative to Ti6Al4V for biomaterial applications.

Investigating Effect of ECAP Process on Corrosion Behavior of WE43 Magnesium Alloy in Simulated Body Fluid

Investigating Effect of ECAP Process on Corrosion Behavior of WE43 Magnesium Alloy in Simulated Body Fluid

Evaluation of the Influence of Eggshell (ES) Concentration on the Degradation Behavior of Mg-2.5Zn Biodegradable Alloy in Simulated Body Fluid.

Currently, permanent vascular stents are fabricated using titanium and stainless steel implants that are nondegradable and offer high stability, but they have certain disadvantages. For example, the prolonged exposition of aggressive ions in the physiological media and the existence of defects in the oxide film create conditions for corrosion to occur, thus triggering unwanted biological events and compromising the mechanical integrity of the implants. Moreover, when the implant does not need to be permanent, there is the need to submit the patient for a second surgery for implant removal. As a solution for nonpermanent implants, biodegradable magnesium alloys have been deemed a promising substitute, for example, for cardiovascular-related applications and the construction of orthopedic devices. A biodegradable magnesium alloy (Mg-2.5Zn) reinforced by zinc and eggshell was employed in this study as an environment-conscious magnesium (eco) composite (Mg-2.5Zn-xES). Disintegrated melt deposition (DMD) was used to fabricate the composite. Experimental studies were conducted to investigate the biodegradation performance of Mg-Zn alloys containing 3 and 7 wt % eggshell (ES) in simulated body fluid (SBF) at 37 °C. Different corrosion techniques were used to study the corrosion behavior of the Mg-2.5Zn-xES composites, including weight loss measurements, hydrogen evolution, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and scanning vibrating electrode technique (SVET). Scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) were employed to scrutinize the corroded surfaces' morphology and composition. The outcomes indicated that Mg-2.5Zn-3ES possesses the lowest degradation activity.

Influence of the Alloying Elements on the Corrosion Behavior of As-Cast Magnesium–Gallium–Zinc Alloys in Simulated Body Fluid

The in vitro corrosion rate of as-cast ternary Mg-Ga-Zn alloys in simulated body fluid (SBF) was evaluated. The effects of Ga3+ and Zn2+ on the formation, growth and stability of Ca, P-rich compounds on the surface of the ternary alloys, and the effect of these compounds on corrosion rate, were studied. Ternary Mg-Ga-Zn alloys (Ga from 0.375 to 1.5 wt% and Zn from 1.5 to 6 wt%) were obtained and then immersed in SBF to evaluate the corrosion rate using the weight loss method. The species formed on the alloys surface were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FT-IR). The formation of amorphous Ca, P-rich compounds on the alloys was observed. The species formed are related to the corrosion rate and the ions released into the SBF. The Mg, Ga and Zn ions released into the SBF during the corrosion process of the studied alloys play an important role in the growth of the Posner’s clusters, propitiating the reduction in size of the Ca, P-rich agglomerates. The corrosion rate of these as-cast ternary alloys increased as the intermetallics formed increased. The amount and size of the intermetallics formed depend on the Ga and Zn concentration in the alloys.

Corrosion Behavior of Micro-arc Oxidation-Coated AZ80 Magnesium Alloy in Simulated Body Fluid at Different Flow Rates

Corrosion Behavior of Micro-arc Oxidation-Coated AZ80 Magnesium Alloy in Simulated Body Fluid at Different Flow Rates

Microstructure-dependent corrosion fatigue crack growth behavior of Ti-6Al-4V alloy in simulated body fluid

The fatigue crack growth rate (FCGR) of Ti-6Al-4V alloys in simulated body fluid (SBF) was first determined by direct current potential drop (DCPD) method. The results show that the acceleration effect of SBF corrosion environment on FCGR of lamellar structure is far greater than that of equiaxed and bimodal structures, especially in Paris region, which is mainly due to the high corrosion sensitivity of the lamellar α/β phase boundary to SBF under fatigue loading.