High-quality development enhances economic quality and resource allocation efficiency through various effective and sustainable means, with particularly notable results in the manufacturing sector. Quality policies, through establishing standards, norms, and incentive measures, aim to foster technological innovation, efficient resource utilization, and quality improvement in manufacturing, thereby supporting its high-quality development. This study explores the impact of quality policies on high-quality development in manufacturing and their configurational pathways, providing theoretical foundations and practical guidance for optimizing policy combinations and promoting sustainable development. This analysis is based on quality policies released from 2013 to 2022 and sample data from 30 Chinese provinces. The findings reveal that quality policies significantly promote high-quality development in manufacturing, particularly through incentive, capacity building, and system changing instruments, while command instruments may exert certain pressures on high-quality development. Configuration analysis further indicates that a single instrument is insufficient to support high-quality development in manufacturing fully; the synergistic effect of multiple policy instruments is essential, and regions should optimize policy combinations according to their characteristics. This study provides valuable insights for sustainable development, offering a deeper understanding of the complex causal relationship between quality policies and high-quality development in manufacturing.