Background: The aim of this study was to test the difference in fracture resistance of 3 ceramic core materials used for simulated 3-unit all-ceramic FPDs with 2 fabrication techniques (lost-wax/heat-pressing and CAD/CAM methods) and 2 connector designs (round and sharp). Material and method: The present in vitro study was conducted in the Department of Prosthodontics and Crown & Bridge, Subharti Dental College & Hospital, Meerut, Uttar Pradesh. For the purpose of this study, 3 all ceramic core materials were selected viz. Yittrium-tetragonal zirconia polycrystals, Milled Lithium disilicate glass ceramic and Lost-wax/heat-pressed lithium disilicate glass ceramic. A total of 10 rectangular bars of dimensions 30 mm (L) x 5 mm (W) x 5 mm (H) from each material were manufactured. Of these 10 bars, 5 bars were fabricated with sharp notch connector and 5 bars were fabricated with round notch connector. The dimensions of all specimens were measured and verified individually by an electronic caliper with an accuracy of 0.05 mm. The radius of each connector was measured with a measuring tool. Results: The failure load was more in Press-R in comparison to Press-S and the difference was found to be statistically significant. The FS was more in CAD-R in comparison to CAD-S and the difference was found to be statistically significant. Conclusion: The round connector design in yittrium stabilized zirconia and heat pressed lithium disilicate both may be considered to be the all-ceramic core material of choice for FDP’s as they have highest failure load and flexural strength.