Alicyclic Carbonyl Compounds Research Articles

A novel one-pot three-component approach to 4-amino-functionalized spiropyrimidine-2-thiones

A series of 4-amino-functionalized spiropyrimidine-2-thione derivatives were simply produced by the one-pot three-component reaction of alicyclic carbonyl compounds, nitriles containing an acidic methylene, and thiourea in the presence of NaOMe in MeOH.

Tryptamine: a Reactive Matrix for MALDI Mass Spectrometry

A possibility of using tryptamine as a reactive matrix for the analysis of non-polar carbonyl compounds by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has been shown. Presence of a terminal primary amine group in the tryptamine molecule predetermines the formation of Schiff bases from aliphatic and alicyclic carbonyl compounds. No additional matrix compounds are necessary to register MALDI mass spectra, because the excess of the derivatization agent plays the role of a matrix. MALDI mass spectra demonstrate high efficiency of desorption/ionization of the derivatives. To discover reactive matrices, a set of aromatic primary amines (mainly substituted anilines) has been tested, but they have not demonstrated matrix properties.

Fast method for synthesis of alkyl and aryl-N-methylnitrones.

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.

ChemInform Abstract: Aromatics Formation from Alumina‐Catalyzed Reactions of Methanol with Aliphatic and Alicyclic Carbonyl Compounds.

AbstractAt 250‐260 °C the series of reactions (alkylation, dealkylation, condensation, and cleavage) of acetone (I) with MeOH (II) over Al2O3 leads to a mixture of simple ketones such as (III) and (IV) and the aromatics (V) and (VI).

Aromatics formation from alumina-catalyzed reactions of methanol with aliphatic and alicyclic carbonyl compounds

Reactions of aliphatic and alicyclic carbonyl compounds with methanol over alumina and modified alumina (fluorided and Na +-doped) catalysts have been studied. At 250–260 °C (low conversions) all carbonyl compounds, by a series of alkylation, dealkylation, condensation, and cleavage processes, lead to similar mixtures of simple ketones and products arising from them. At 350 °C (100% conversion) hexamethylbenzene is formed in very good yield. In the absence of methanol, 3,5-dimethylphenol is the major product. Mechanistic studies have been carried out and the evidence for the reaction route carbonyl compounds → acetone → isophorone → 3,5-dimethylphenol → hexamethylbenzene is presented. Efficient and simple methods for the preparation of 3,5-dimethylphenol and HMB are also described.

ChemInform Abstract: THE CYCLOPROPANATION OF SILYL ENOL ETHERS. A POWERFUL SYNTHETIC TOOL

AbstractDer Artikel befaßt sich mit verbesserten Simmons‐Smith‐Reaktionen, der Cyclopropanierung von Silylenolaten gesättigter Aldehyde und Ketone sowie der Synthese von Hydroxybicyclo(n,1,0)alkenen.

The cyclopropanation of silyl enol ethers. A powerful synthetic tool

Abstract

Synthesis of α, β-Unsaturated Esters by Application of Wittig Reaction

Thirteen kinds of aldehyde and ketone, including some basic and/or alicyclic carbonyl compounds, were subjected to Wittig reaction, using ethoxycarbonylmethyl-triphenyl-phosphonium bromide and sodium ethoxide in dehyd. ethanol at room temperature in nitrogen atmosphere, and corresponding α, β-unsaturated ethyl esters were formed as expected.