The objective of this study is to generate reliable Ki parametric images from a shortened [18F]FDG total-body PET for clinical applications using a self-supervised neural network algorithm. We proposed a self-supervised neural network algorithm with Patlak graphical analysis (SN-Patlak) to generate Ki images from shortened dynamic [18F]FDG PET without 60-min full-dynamic PET-based training. The algorithm deeply integrates neural network architecture with a Patlak method, employing the fitting error of the Patlak plot as the neural network's loss function. As the 0-60min blood time activity curve (TAC) required by the standard Patlak plot is unobtainable from shortened dynamic PET scans, a population-based "normalized time" (integral-to-instantaneous blood concentration ratio) was used for the linear fitting of Patlak plot of t* to 60min, and the modified Patlak plot equation was then incorporated into the neural network. Ki images were generated by minimizing the difference between the input layer (measured tissue-to-blood concentration ratios) and the output layer (predicted tissue-to-blood concentration ratios). The effects of t* (20 to 50min post injection) on the Ki images generated from the SN-Patlak and standard Patlak was evaluated using the normalized mean square error (NMSE), and Pearson's correlation coefficient (Pearson's r). The Ki images generated by the SN-Patlak are robust to the dynamic PET scan duration, and the Ki images generated by the SN-Patlak from just a 10-minute (50-60min post-injection) dynamic [18F]FDG total-body PET scan are comparable to those generated by the standard Patlak method from 40-min (20-60min post injection) with NMSE = 0.15 ± 0.03 and Pearson's r = 0.93 ± 0.01. The SN-Patlak parametric imaging algorithm is robust and reliable for quantification of 10-min dynamic [18F]FDG total-body PET.
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