Intermediate Alcohol Research Articles

Regulating active oxygen species and acidity of Ca doped LaMnO3 perovskite catalysts toward efficient n-butylamine oxidation

It is of great significance to design catalysts with high activity, N2 selectivity and stability for nitrogen-containing volatile organic compound (NVOC) catalytic purification. Meanwhile, the role of oxygen species in NVOC catalytic oxidation is still ambiguous. Herein, the oxygen species of La-Mn perovskite catalysts were engineered by doping Ca in La site to elucidate their role in catalytic n-butylamine oxidation. Results demonstrate that La0.9Ca0.1MnO3 exhibits the highest activity owing to its abundant adsorbed oxygen species and high surface area, achieving 100 % n-butylamine conversion (500 ppm; GHSV=60,000 mL g−1h−1) at 200 °C with N2 selectivity of ca. 95 %. More adsorbed oxygen species generated due to Ca doping accelerates the oxidation rate and C-C cleavage of alcohol and acetate intermediates, resulting in higher CO2 yield. Meanwhile, Ca-doping also modifies the acidity of catalysts, which affects the adsorption/desorption process of alkaline substances and yield of nitrogen-containing products. In addition, La0.9Ca0.1MnO3 shows superior stability, high water and SO2 resistance, and acceptable activity for other common NVOCs, demonstrating a promising catalyst for NVOC oxidation even under harsh operation conditions. Furthermore, the toxic effect of pollutant or products during n-butylamine catalytic oxidation on the growth of Chlorella Vulgaris was investigated and results suggest that catalytic oxidation is an environmentally friendly method for NVOC purification. This work sheds light on the relationships among oxygen species, catalyst acidity, and n-butylamine catalytic oxidation, which expand the understanding of rational design of efficient catalyst for NVOC oxidation.

Water mediated redox-neutral cleavage of arylalkenes via photoredox catalysis

Cleavage of carbon-carbon bonds remains a challenging task in organic synthesis. Traditional methods for splitting Csp2=Csp2 bonds into two halves typically involve non-redox (metathesis) or oxidative (ozonolysis) mechanisms, limiting their synthetic potential. Disproportionative deconstruction of alkenes, which yields one reduced and one oxidized fragment, remains an unexplored area. In this study, we introduce a redox-neutral approach for deleting a Csp2 carbon unit from substituted arylalkenes, resulting in the formation of an arene (reduction) and a carbonyl product (oxidation). This transformation is believed to proceed through a mechanistic sequence involving visible-light-promoted anti-Markovnikov hydration, followed by photoredox cleavage of Csp3-Csp3 bond in the alcohol intermediate. A crucial consideration in this design is addressing the compatibility between the highly reactive oxy radical species in the latter step and the required hydrogen-atom-transfer (HAT) reagent for both steps. We found that ethyl thioglycolate serves as the optimal hydrogen-atom shuttle, offering remarkable chemoselectivity among multiple potential HAT events in this transformation. By using D2O, we successfully prepared dideuteromethylated (-CD2H) arenes with good heavy atom enrichment. This work presents a redox-neutral alternative for alkene deconstruction, with considerable potential in late-stage modification of complex molecules.

The first total syntheses of lorneic acids C and D and improved synthetic routes to lorneic acids A and J

We report the first total syntheses of lorneic acids C and D, each in 4 steps, from commercially-available 2-bromo-5-methyl benzaldehyde in 61 % and 36 % overall yields, respectively. A key feature of the syntheses includes a Suzuki cross-coupling to introduce the carboxylic sidearms in the natural products. Additionally, our group previously reported the construction of lorneic acids A and J, in 7 steps, with 23 % overall yields that included a lengthy 3-step sequence of reactions for the 1-carbon homologation of the allylic alcohols. Herein, we report second-generation synthetic routes towards lorneic acids A and J, each in 5 steps with 50 % and 46 % overall yields. In this case, a palladium-catalyzed carboxylation of allylic alcohol intermediates with formic acid secured the carboxylic acid sidearms. The new and improved routes shorten the total syntheses by 2 steps and double the yields of both natural products.

Enzymatic kinetic resolution of an intermediate alcohol of the drug Tegoprazan using lipase from Thermomyces lanuginosus

An enzymatic approach for the synthesis of intermediate alcohol of the drug tegoprazan in 99% ee at 20 °C in hexane has been developed utilizing commercially available immobilized Thermomyces lanuginosus lipase (TL lipase) as a biocatalyst and vinyl acetate as a acyl donor. This method involves the enantioselective esterification of (RS)-5,7-difluorochroman-4-ol with vinyl acetate using TL Lipase. This enzymatic approach provides the (S)-chiral alcohol in 44% yield with 99% enantiomeric excess (ee) and the (R)-acetate in 43% yield and >99% ee. It is a sustainable approach for the synthesis of enantiopure tegoprazan intermediate, contributing to the advancement of green chemistry. The recovered TL lipase was reused in 13 subsequent runs without loss of activity.

Production of jet fuel cycloalkanes from 5‐(hydroxymethyl)furfural via cascade catalysis on Mg(Al)(Zr)O supported CuCo

AbstractCatalytic conversion of biomass‐derived 5‐(hydroxymethyl)furfural (5‐HMF) into carbon‐increased hydrocarbons as drop‐in energy‐rich biofuels has received a great deal of concern for the development of sustainable chemical industry. Here, we demonstrate a one‐pot conversion of 5‐HMF into C9‐alkanes on one single catalyst, acidic–basic layered double oxides (Mg(Al)(Zr)O) supported CuCo alloy. The well‐defined multifunctional catalytic sites with harmonious combination carry out cascade catalysis, affording C9‐alkanes (including 30% of more value‐added branched‐cycloalkanes) in 83% yield. The basic–acidic sites on Mg(Al)(Zr)O show high activity for aldol condensation of 5‐HMF and acetone, producing 4‐[5‐(hydroxymethyl)‐2‐furanyl]‐3‐buten‐2‐one (HAc) in a yield of >99%. The engineered Co–Cu–Co linkages on supported CuCo perform efficient hydrodeoxygenation, affording C9‐alkanes in a selectivity of 96% from HAc. C9‐cycloalkanes are generated from the cyclization of the corresponding monohydric alcohol intermediates by the synergy of acidic and CuCo sites in the hydrodeoxygenation reaction.

Association of physical and sexual assault with mortality in two British birth cohorts

AimsThe association of assault in adulthood with all-cause mortality, and the relevance of intermediate psychological distress, alcohol use and cigarette smoking, is poorly understood. We used data from British birth...

Stored alcohol and fatty acid intermediates and the biosynthesis of sex pheromone aldehyde in the moth Chloridea virescens.

In most species of moths, the female produces and releases a volatile sex pheromone from a specific gland to attract a mate. Biosynthesis of the most common type of moth sex pheromone component (Type 1) involves de novo synthesis of hexadecanoate (16:Acyl), followed by modification to various fatty acyl intermediates, then reduction to a primary alcohol, which may be acetylated or oxidized to produce an acetate ester or aldehyde, respectively. Our previous work on the moth Chloridea virescens (Noctuidae) showed that females produce 90% of the major pheromone component, (Z)-11-hexadecenal (Z11-16:Ald), via a direct and rapid route of de novo biosynthesis with highly labile intermediates, and ca. 10% from an indirect route that likely mobilizes a pre-synthesized 16-carbon skeleton, possibly, (Z)-11-hexadecenoate (Z11-16:Acyl) or hexadecanoate (16:Acyl). In this paper, we use stable isotope tracer/tracee techniques to study the dynamics of the precursor alcohol (Z)-11-hexadecenol (Z11-16:OH) and stores of Z11-16:Acyl and 16:Acyl to determine their roles in biosynthesis of Z11-16:Ald. We found: (i) that intracellular Z11-16:OH is synthesized at roughly the same rate as Z11-16:Ald, indicating that translocation and oxidation of this moiety does not rate limit biosynthesis of Z11-16:Ald, (ii) intracellular Z11-16:OH consists of two pools, a highly labile one rapidly translocated out of the cell and converted to Z11-16:Ald, and a less labile one that mostly remains in gland cells, (iii) during pheromone biosynthesis, net stores of Z11-16:Acyl increase, suggesting it is not the source of Z11-16:Ald produced by the indirect route, and (iv) no evidence for the gland synthesizing stored 16:Acyl prior to (up to 2days before eclosion), or after, synthesis of pheromone commenced, suggesting the bulk of this stored moiety is synthesized elsewhere and transported to the gland prior to gland maturation. Thus, the pheromone gland of C. virescens produces very little stored fat over its functional lifetime, being optimized to produce sex pheromone.

PPM Ir-f-phamidol-Catalyzed Asymmetric Hydrogenation of γ-Amino Ketones Followed by Stereoselective Cyclization for Construction of Chiral 2-Aryl-pyrrolidine Pharmacophores.

Transition metal catalysts with a million turnovers and excellent selectivity are rarely reported but are crucial for the industrial manufacture of optical pure pharmaceuticals, natural products, and fine chemicals. In this paper, we report an unprecedented aninoic Ir-f-phamidol catalyst for asymmetric hydrogenation of γ-amino ketones followed by stereoselective cyclization for construction of valuable chiral 2-aryl-pyrrolidine pharmacophores. The Ir-f-phamidol catalyst showed up to 1,000,000 TON and >99% ee, as well as excellent tolerance of substrates and protecting groups, providing various chiral amino alcohol intermediates. Upon optimization of the conditions, the stereoselective cyclization reaction was highly smooth and efficient (quantitative conversions, 92 to >99% ee). Finally, this solution was applied in the preparation of high-value chiral entities containing such chiral 2-aryl-pyrrolidine pharmacophores.

Insight into catalytic performance and reaction mechanism for 1,2-dichloroethane elimination over MnCoOx-supported catalyst

Designing transition metal composite oxide catalysts with high catalytic performance and stability in the catalytic oxidation of CVOCs is still a big challenge, especially by economic and convenient methods. To realize this, highly dispersed MnCoOx nanoparticles were prepared on the HZSM-5 to synthesize MnyCozOx/H5-50 catalyst and applied in the catalytic oxidation of 1,2-dichloroethane (1,2-DCE). The T90 of Mn1Co1Ox/H5-50 (215 °C) decreased by 53 and 45 °C compared with Mn2O3/H5-50 and Co3O4/H5-50, respectively. The outstanding catalytic activity and thermal stability of Mn1Co1Ox/H5-50 are attributed to the abundance of Mn4+, Co2+, and adsorbed oxygen, prominent redox ability, and suitable acidity. All of these features originated from the strong interaction in the highly dispersed MnCoOx solid solution. The DFT confirmed that the MnCoOx activated the C-Cl bond to accelerate the occurrence of dechlorination reactions and reduce the formation of intermediate products. In-situ DRIFTS proved that the elimination rate of vinyl alcohol or vinyl chloride intermediate was the key rate-determining step in the reaction process. The prepared Mn1Co1Ox/H5-50 catalyst could precisely achieve this objective at high temperature region and subsequently reduce the production of toxic by-products. This work provides valuable insights into the design of efficient and economical catalysts for the degradation of CVOCs.

Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpene 1,3-Aminoalcohol Regioisomers.

A series of novel diterpene-type 1,3-aminoalcohols and their regioisomers have been synthesised from natural stevioside in a stereoselective manner. The key intermediate β-keto alcohol was prepared using Wagner-Meerwein rearrangement of the epoxide derived from steviol methyl ester. The primary aminoalcohol was formed via Raney-nickel-catalysed hydrogenation of an oxime, and a versatile library of aminoalcohols was synthesised using a Schiff base with the primary amines. The aminoalcohol regioisomers were prepared from the mesylate of the β-keto alcohols. The corresponding primary aminoalcohol was formed via the palladium-catalysed hydrogenation of hydroxyl-azide, and click reactions of the latter were also carried out. The new compounds were characterised using 1D- and 2D-NMR techniques and HRMS measurements. The in vitro investigations showed high inhibition of cell growth in human cancer cell lines (HeLa, SiHa, A2780, MCF-7 and MDA-MB-231) in the case of naphthalic N-substituted derivatives. The antiproliferative effects were assayed using the MTT method.

A Three‐Step Chemoenzymatic Cascade Synthesis of Miconazole Analogues Based on the Asymmetric Synthesis of β‐Heteroaryl Amino Alcohols via Ketoreductases

AbstractChiral β‐heteroaryl amino alcohols play a crucial role as intermediates in the synthesis of numerous bioactive pharmaceuticals, including cenobamate, oteseconazole, and miconazole. Nevertheless, there is a lack of literature documenting the establishment of a versatile approach for the synthesis of β‐heteroaryl amino alcohols and the aforementioned drugs. In this study, we successfully asymmetrically synthesized 50 pairs of chiral β‐heteroaryl amino alcohols using two engineered ketoreductases (KREDs) with opposite stereopreference. Based on this achievement, we developed a three‐step chemoenzymatic cascade route for synthesizing of chiral miconazole analogues from commercially available 2‐bromoacetophenone derivatives. By optimizing the solvent for the synthesis of α‐imidazolyl ketones in the first step, followed by the reduction of α‐imidazolyl ketones using KREDs in the second step and etherification in the third step, we obtained 20 chiral miconazole analogues with promising yields (26–84%) and impressive stereoselectivities (up to >99% ee). Notably, this route eliminates the need for the isolation of ketone and alcohol intermediates, and avoids the use of metal catalysts in the synthesis of chiral miconazole analogues. Furthermore, we successfully scaled up the preparation of (S)‐miconazole, achieving a 30% isolated yield and >99% ee. This method presents a novel synthetic approach for production chiral ether drugs and chiral β‐heteroaryl amino alcohols, offering new possibilities in pharmaceutical synthesis.

Aviation fuel production pathways from lignocellulosic biomass via alcohol intermediates – A technical analysis

In order to achieve the goal of limiting global warming to 1.5 °C, also the growing aviation industry needs to take measures to reduce their greenhouse gas emissions. Various renewably sourced aviation fuels can significantly reduce greenhouse gas emissions and most of them, except for example liquid hydrogen or LNG, can be used in the existing infrastructure without airport or aircraft modifications. As most of these renewably sourced fuel types are not (yet) produced at commercial scale, many technological assessment parameter (e.g. carbon or energy efficiency) are uncertain. Thus, the goal of this study is to compare two different process routes, both being based on biochemical and thermochemical conversion steps. The processes evaluated against conversion efficiency of the available raw feedstock and process energy requirements. The evaluation uses theoretical and biochemical carbon efficiency as well as energy efficiency as indicators. A steady-state flowsheet simulation for two biogenic process paths via biogas and bioethanol as intermediate products is carried out on the basis of literature data. In addition, the optional use of solid residue from the biotechnological process step by combustion for direct heat supply cases are studied. In the ethanol-based route, about 23% of the carbon in the feed can be recovered as kerosene, whereas this is only about 19% in the biogas route. Simultaneously, the ethanol-based route without the combustion of the residue has an energy efficiency of 28%, while the biogas route has an efficiency of 24%.

Donor-acceptor 2D polymer for simultaneous photocatalytic CO2 reduction and carbonylation reaction

The conversion of CO2 into compounds with greater added value is the focus of current research. Herein, we employ a straightforward solvothermal approach to create the two-dimensional polymer with a donor–acceptor (D-A) structure (MAN-PCT). Strong D-A interaction, a characteristic of MAN-PCT, contributes to ultrafast photoinduced charge separation. Notably, the P = N bond on the D unit acts as a reaction site and considerably reduces the distance traveled by photogenerated carriers as they migrate to the reactants. It also improves the adsorption of the produced CO, allowing it to continue to react with the benzyl alcohol intermediate. As a result, MAN-PCT showed not only excellent photocatalytic activity of CO2 to CO (3036 μmol g−1), but also a maximum yield of about 90% of the poly-substituted benzyl formate product under visible light illumination. MAN-PCT also exhibited excellent cycling stability (7 times, 12 h per cycle). This research offers a fresh method for creating polymeric photocatalysts that can transform CO2 into fine compounds with a high added value.

Ni − Promoted Cu/ZSM-5 for selective hydrodeoxygenation of furfural to produce 2 − Methylfuran

Catalytic hydrodeoxygenation (HDO) of furfural (FUR) to produce 2 − methylfuran (2 − MeF) is a green way to produce hydrocarbons with fuel − like properties. In this work, bimetallic Ni − Cu alloys supported on ZSM − 5 zeolite catalysts were prepared by wetness impregnation and used for HDO of FUR to produce 2 − MeF. Cu/ZSM − 5 catalyst favoured the adsorption of CO bonding in FUR through a tilted adsorption orientation, avoiding the saturation of furan ring. Moderate addition of Ni in Cu/ZSM-5 accelerated the conversion rate with enhanced adsorption of the FUR and H2, leading to high selectivity of 2 − MeF in the product through sequenced hydrogenation and deoxygenation procedures. Moreover, zeolite surface acid benefited the scission of CO bonding in the intermediate furfuryl alcohol (FOL), further promoting the yield of 2 − MeF. The optimized 2Ni − 6Cu/CZ catalyst (with 2 wt% Ni and 6 wt% Cu on ZSM − 5) gave 2 − MeF yield of 78.8 wt% at 220 °C after 30 min reaction. With further increased Ni concentrations, the hydrogenation of furan ring was accelerated with tetrahydrofurfuryl alcohol (THFOL) as the main product.

Hydrogenation of furfural to 1,5-pentanediol over CuCo bimetallic catalysts

AbstractA series of CuxCo3–xAl hydrotalcite-like catalysts with different Cu/Co molar ratios were synthesized by the urea homogeneous precipitation method and used for the direct hydrogenation-hydrogenolysis of furfural to 1,5-pentanediol. The results showed that the Cu/Co molar ratio of the catalyst had a significant effect on its textural properties and catalytic performance. The catalyst exhibited excellent catalytic performance when the molar ratio of Cu/Co was 1:29 (Cu0.1Co2.9Al), and the conversion of furfural was 100% together with 51.1% yield of pentanediol among which the yield of 1,5-pentanediol was 41.1%, under the reaction condition of 140 °C, 4 MPa H2 for 6 h. Extensive characterization techniques, including temperature-programmed reduction (H2-TPR), temperature-programmed desorption (H2-TPD), X-Ray photoelectron spectroscopy (XPS) and Raman confirmed that the excellent catalytic activity of Cu0.1Co2.9Al catalyst was attributed to the highest content of Cu0 and CoOx on its surface, and a synergistic catalytic effect was present between them. Typically, Cu0 was used to adsorb and activate H2, and CoOx with much oxygen vacancies promoted the adsorption and activation of C=O groups in furfural molecules, leading to the quick conversion of furfural to furfuryl alcohol. In addition, the oxygen vacancies anchored the –OH in the intermediate furfuryl alcohol to produce a C2-terminal oblique adsorption on the catalyst surface. Then it promoted the hydrogenation of C2=C3 with the weakening and cleavage of C2–O1 bond, and enhanced the selectivity of 1,5-pentanediol.

Probing the low temperature oxidation chemistry of RP-3 kerosene: Experimental and kinetic modeling investigation

Elucidating the formation of intermediates, especially active species like peroxy radicals and hydroperoxides, is crucial to explore the low temperature reaction network and validate the kinetic model. While low temperature oxidation kinetics of single hydrocarbon has been widely studied, the comprehensive speciation study on the transportation fuels is still lacking and challenging due to the complex compositions of real fuels. This work aims to investigate the speciation pool and develop predictable kinetic model for the low temperature oxidation of RP-3 kerosene. An atmospheric jet stirred reactor combined with synchrotron vacuum ultraviolet photoionization mass spectrometry was used to investigate the RP-3 kerosene oxidation in the temperature range of 480–770 K and equivalence ratios of 0.5, 1.0 and 2.0. Major products and key intermediates were quantified and categorized into several groups, including peroxy radicals, hydroperoxides, alkenes, alcohols, aldehydes, acids and aromatics. Furthermore, a three-component surrogate fuel consisting of 60.0% n-dodecane, 31.5% ethylcyclohexane, and 8.5% n-butylbenzene (by mole) was formulated to represent the RP-3 kerosene. A kinetic model for the three-component surrogate fuel was developed based on the comprehensively validated kinetic model of single components. This model was validated against the low temperature oxidation speciation data, ignition delay times and laminar flame speeds of RP-3 over wide range of conditions. Rate of production and sensitivity analysis were performed to explore the low temperature oxidation reaction network. The results indicate that the negative temperature coefficient behavior of RP-3 is dominated by the reactions of n-alkane, which is easier to proceed low temperature chain-propagation reactions leading to the production active OH radicals. The reaction network of each fuel component is effectively coupled from the view of OH regeneration and consumption, and finally affects the distribution of speciation pool during RP-3 low temperature oxidation. Regarding the characteristic speciation pool, it is found that the formation and consumption of peroxy radicals, hydroperoxides, alkene, aldehyde, and alcohol intermediates are controlled by the reaction network of alkane. While the formation and depletion of aromatic intermediates are affected by the interaction kinetics of fuel components with different chemical functionalities. These results improve the current understanding of the speciation pool and interaction kinetics during RP-3 low temperature oxidation. The kinetic model of RP-3 kerosene developed and validated in this work could be applied for numerical simulation of aero-engine.

Photocatalytic selective conversion of furfural to γ-butyrolactone through tetrahydrofurfuryl alcohol intermediates over Pd NP decorated g-C3N4

A sustainable strategy for valorisation of biomass-derived furfural into valuable chemicals and fuel (furfuryl alcohol, tetrahydrofurfuryl alcohol, and γ-butyrolactone) using a renewable energy source (sunlight) and LEDs.

Stabilizing the interfacial Cu0-Cu+ dual sites toward furfural hydrodeoxygenation to 2-methylfuran via fabricating nest-like copper phyllosilicate precursor

Furfural hydrodeoxygenation (HDO) to 2-methylfuran (2-MF) is one of the most momentous routes in upgrading of biomass platform molecules, where the most universally employed active metal—Cu often suffers from thermal sintering and poor stability in spite of its brilliant effect on the activation of carbonyl. In this study, we designed a highly active and stable Cu/SiO2 nanocatalyst by fabricating nest-like nanotubes (CuSi-N) through a two-step method: preparation of amorphous copper phyllosilicate through ammonia evaporation, followed by a further hydrothermal crystallization with the assistance of P123. Notably, the CuSi-N catalyst gives a 2-MF space–time yield of 46.6 mmol·gcat−1·h−1, which is much larger than CuSi-A prepared by the conventional ammonia-evaporation method. A combination study (Raman spectra, TEM, H2-TPR, XPS, CO-DRIFTS and NH3-TPD) verifies that the nest-like precursor enhances the CuOx-SiO2 interaction, which results in a promoted Cu+ abundance as well as thermal stability of the active sites. In situ FTIR spectra of adsorbed molecules, coupled with density functional theory calculations, prove that Cu+ sites are responsible for the adsorption and activation of both furfural (FAL) and intermediate furfuryl alcohol (FOL) while Cu0 sites account for H2 dissociation. This work discloses the significance of the synergy effect of Cu0-Cu+ dual sites of Cu/SiO2 catalysts which could be employed for the other HDO reactions in the upgrading process of biomass.

Nickel-Catalyzed Direct Synthesis of N-Substituted Indoles from Amino Alcohols and Alcohols.

A one-pot cascade approach for the synthesis of N-substituted indoles from amino alcohols and alcohols under additive and base-free conditions with the liberation of water as the only stoichiometric byproduct is reported. The commercially available bench-stable Ni(OTf)2 salt in combination with 1,2-bis(dicyclohexylphosphino)ethane (dcype) is very effective for this unprecedented catalytic transformation. A broad range of substrates including aromatic and aliphatic primary alcohols, cyclic and acyclic secondary alcohols, and various substituted 2-aminophenyl ethyl alcohols are employed in the reaction conditions to provide a diverse range of N-alkylated indoles. Mechanistic studies revealed that the reaction proceeds through tandem N-alkylation via hydrogen autotransfer followed by the cyclization of N-alkylated alcohol intermediate.

One-Pot Production of 1,5-Pentanediol from Furfural Through Tailored Hydrotalcite-Based Catalysts

The one-pot production of a relevant chemical such as 1,5-pentanediol (1,5-PDO) from sustainable sources (furfural) is a key reaction to compete with existing fossil sources. This work provides new evidence on the influence of the starting reagent, the features of layered double hydrotalcite (LDH)-derived catalysts in the form of mixed metal oxides (MMO) and of reaction conditions on the productivity of 1,5-PDO under batch conditions. Unlike reported studies, these results suggest the direct pathway through furfuryl alcohol intermediates, allowing the one-pot production from furfural at lower temperature than analogous systems. Productivity is maximized when Co2+ species partially substitute Mg2+ species in parent LDH, yielding promising pentanediol yields under mild reaction conditions. MMOs containing Co2+ sites show marked differences compared to analogous bivalent metals, which is here attributed to the position in which reaction intermediates such as furfuryl alcohol are adsorbed onto surface specie. This is consistent with characterized surface species by XRD, temperature programmed reduction under H2, and chemisorption experiments using CO or CO2 as probe molecules, indicative of a proper balance between metal and basic sites onto MMOs. The reported data aim to provide new reaction evidence to contribute into the search of sustainable 1,5-PDO sources.Graphical