Albumin For Fluid Resuscitation Research Articles

Barriers and facilitators to adopting high value practices and de-adopting low value practices in Canadian intensive care units: a multimethod study

ObjectiveTo compare and contrast illustrative examples of the adoption of high value practices and the de-adoption of low value practices.Design(1) Retrospective, population-based audit of low molecular weight heparin (LMWH) for...

Individual patient data comparative analysis of hydroxyethyl starch 130/0.4 v 4% albumin for fluid resuscitation in critically ill patients: statistical analysis plan

Individual patient data comparative analysis of hydroxyethyl starch 130/0.4 v 4% albumin for fluid resuscitation in critically ill patients: statistical analysis plan

Albumin for fluid resuscitation in patients with sepsis: what do we expect for?

Albumin for fluid resuscitation in patients with sepsis: what do we expect for?

Saline or albumin for fluid resuscitation in patients with traumatic brain injury

Background: The saline versus albumin fluid evaluation study suggested that patients with traumatic brain injury resuscitated with albumin had a higher mortality rate than those resuscitated with saline. We conducted a post hoc follow-up study of these patients with traumatic brain injury.

How SAFE is albumin for fluid resuscitation in critically ill patients with traumatic brain injury?

How SAFE is albumin for fluid resuscitation in critically ill patients with traumatic brain injury?

Saline or Albumin for Fluid Resuscitation in Traumatic Brain Injury

Saline or Albumin for Fluid Resuscitation in Traumatic Brain Injury

Saline or Albumin for Fluid Resuscitation in Patients with Traumatic Brain Injury

The Saline versus Albumin Fluid Evaluation study suggested that patients with traumatic brain injury resuscitated with albumin had a higher mortality rate than those resuscitated with saline. We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study. For patients with traumatic brain injury (i.e., a history of trauma, evidence of head trauma on a computed tomographic [CT] scan, and a score of < or =13 on the Glasgow Coma Scale [GCS]), we recorded baseline characteristics from case-report forms, clinical records, and CT scans and determined vital status and functional neurologic outcomes 24 months after randomization. We followed 460 patients, of whom 231 (50.2%) received albumin and 229 (49.8%) received saline. The subgroup of patients with GCS scores of 3 to 8 were classified as having severe brain injury (160 [69.3%] in the albumin group and 158 [69.0%] in the saline group). Demographic characteristics and indexes of severity of brain injury were similar at baseline. At 24 months, 71 of 214 patients in the albumin group (33.2%) had died, as compared with 42 of 206 in the saline group (20.4%) (relative risk, 1.63; 95% confidence interval [CI], 1.17 to 2.26; P=0.003). Among patients with severe brain injury, 61 of 146 patients in the albumin group (41.8%) died, as compared with 32 of 144 in the saline group (22.2%) (relative risk, 1.88; 95% CI, 1.31 to 2.70; P<0.001); among patients with GCS scores of 9 to 12, death occurred in 8 of 50 patients in the albumin group (16.0%) and 8 of 37 in the saline group (21.6%) (relative risk, 0.74; 95% CI, 0.31 to 1.79; P=0.50). In this post hoc study of critically ill patients with traumatic brain injury, fluid resuscitation with albumin was associated with higher mortality rates than was resuscitation with saline. (Current Controlled Trials number, ISRCTN76588266 [controlled-trials.com].).

A Notice to Hospitals advising of updated safety information about the use of albumin for fluid resuscitation in critically-ill patients

A Notice to Hospitals advising of updated safety information about the use of albumin for fluid resuscitation in critically-ill patients

A Notice to Hospitals advising of updated safety information about the use of albumin for fluid resuscitation in critically-ill patients

A Notice to Hospitals advising of updated safety information about the use of albumin for fluid resuscitation in critically-ill patients

Saline is as effective as albumin for fluid resuscitation in critically ill people

Summary Question What are the clinical effects of intravascular fluid resuscitation with albumin compared with saline in critically ill people? Study Design Randomised double blind controlled trial. Main results There was no significant difference in mortality at 28 days between treatments (726/3496 with albumin v 729/3500 with saline; RR 0.99, 95% CI 0.91 to 1.09). There was no significant difference between treatments for organ failure ( p = 0.85 ); length of stay in intensive care, duration of mechanical ventilation or duration of renal replacement therapy (see Results table). Authors’ conclusions After 28 days, saline is as clinically effective as albumin for intravascular fluid resuscitation of critically ill people.

Whether Albumin Therapy Improves or Worsens Survival of Critically Ill Patients Is Not Known

Summaries for Patients7 August 2001Whether Albumin Therapy Improves or Worsens Survival of Critically Ill Patients Is Not KnownSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-3-200108070-00003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What is the problem and what is known about it so far?Albumin is a protein normally found in blood. Solutions of human albumin can be given to patients through their veins (intravenously). These products are expensive and sometimes difficult to get. Albumin is usually given to people who are very ill, such as those who have severe burns, serious trauma, major surgery, shock, life-threatening infections, or liver failure. Treatment with albumin may increase blood protein levels, circulating blood volume, and blood pressure when they are abnormally low. However, whether albumin improves or worsens the chance of survival of critically ... Author, Article, and Disclosure InformationAffiliations: The summary below is from the full report titled, “Patient Survival after Human Albumin Administration. A Meta-Analysis of Randomized, Controlled Trials.” It is in the 7 August 2001 issue of Annals of Internal Medicine (volume 135, pages 149-164). The authors are MM Wilkes and RJ Navickis.Summaries for Patients are a service provided by Annals to help patients better understand the complicated and often mystifying language of modern medicine.Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician. The summaries may be reproduced for not-for-profit educational purposes only. Any other uses must be approved by the American College of Physicians-American Society of Internal Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPatient Survival after Human Albumin Administration Mahlon M. Wilkes and Roberta J. Navickis Metrics Cited byThe SAFE Study: a landmark trial of the safety of albumin in intensive careThe SAFE study: saline vs. albumin for fluid resuscitation in the critically ill 7 August 2001Volume 135, Issue 3Page: I-25KeywordsAlbuminsBlood volumeBurnsLiverPatientsProteinsShockSurvival analysisTrauma surgeryVeins ePublished: 7 August 2001 Issue Published: 7 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...

Indications and role of albumin for vascular loading during postoperative intensive care

Prospective clinical trials comparing human albumin to other plasma volume expanders during the three first postoperative days in adult patients were analysed. Fifteen studies were selected. Nine of them concerned the evaluation during the immediate postoperative period, after cardiac surgery with cardiopulmonary bypass (CPB). Only one trial referred to hyperoncotic albumin and therefore did not allow to produce recommendations. However, a priori hyperoncotic albumin should not be used for plasma volume expansion. All other studies compared isooncotic albumin to crystalloid or hydroxyethylstarches (HES). It is concluded that albumin can be recommended neither after vascular (aortic abdominal surgery), nor abdominal surgery and can be replaced by Ringer lactate solution in a volume 1.5 to 2 times higher than with albumin. After cardiac surgery, mainly uncomplicated coronary artery bypass graft or valve replacement, albumin can be substituted by HES. These conclusions are only valid for blood losses below 50% of blood volume. The place of isooncotic albumin for fluid resuscitation in case of blood loss exceeding 50% of blood volume cannot be specified.

Effects of Pentastarch and Albumin Infusion on Cardiorespiratory Function and Coagulation in Patients with Severe Sepsis and Systemic Hypoperfusion

Twenty consecutive patients with severe sepsis were randomized to fluid challenge with 5% albumin or 10% low MW hydroxyethyl starch (pentastarch) solutions. Fluid challenge was administered iv as 250 ml of test colloid every 15 min until the pulmonary artery wedge pressure (WP) was greater than or equal to 15 mm Hg or a maximum dose of 2000 ml was infused. Hemodynamic, respiratory, and coagulation profiles were measured before and after fluid infusion. The amount of colloid required to achieve a WP of 15 mm Hg was comparable between groups. Both colloid infusions resulted in similar increases in cardiac output, stroke output, and stroke work. The effect of fluid infusion with pentastarch on coagulation was not significantly different from albumin, although pentastarch was associated with a 45% decrease in factor VIII:c. We conclude that pentastarch is equivalent to albumin for fluid resuscitation of patients with severe sepsis.

After the accident, after the ambulance, what kind of care?

ABSTRACT In the past decade and a half, a network of more than 300 trauma care centers has developed as part of the national Emergency Medical Services system. The result is that standards for such care are becoming more uniform. Mortality for accidents that maim has dropped, and highway accidents and burn injuries in general have received much special attention.At the recent American College of Surgeons meeting in Chicago, a multi-day symposium on trauma care attracted much of the membership. Chairman of the symposium was Robert J. Freeark, MD, of Loyola University of Chicago's Stritch School of Medicine. Among other topics, the aftermath of high-speed collision injuries was discussed.The Contused Lung and Fluid Resuscitation One of the big issues in trauma care is whether to use albumin for fluid resuscitation, Freeark told JAMA MEDICAL NEWS. Neurosurgeons keep telling us we need albumin. But the issue is controversial. Albumin is